Christopher A Ross

Christopher A Ross

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Christopher A Ross

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G2019S-LRRK2 mutation enhances MPTP-linked Parkinsonism in mice.

Hum Mol Genet 2020 Mar;29(4):580-590

Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine,Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1093/hmg/ddz271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068031PMC
March 2020

GTP-binding inhibitors increase LRRK2-linked ubiquitination and Lewy body-like inclusions.

J Cell Physiol 2020 Mar 17. Epub 2020 Mar 17.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1002/jcp.29632DOI Listing
March 2020

Physiological and pathological roles of LRRK2 in the nuclear envelope integrity.

Hum Mol Genet 2019 Dec;28(23):3982-3996

Dept. of Biochemistry, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

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http://dx.doi.org/10.1093/hmg/ddz245DOI Listing
December 2019

Research Domain Criteria: Strengths, Weaknesses, and Potential Alternatives for Future Psychiatric Research.

Mol Neuropsychiatry 2019 Oct 13;5(4):218-236. Epub 2019 Aug 13.

Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1159/000501797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873013PMC
October 2019

Increased Protein Insolubility in Brains From a Subset of Patients With Schizophrenia.

Am J Psychiatry 2019 09 6;176(9):730-743. Epub 2019 May 6.

The Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (L.G. Nucifora, Lee, Peters, Yang, Margolis, Pevsner, Ross, Sawa, F.C. Nucifora); the Departments of Psychiatry and Neurology, University of Pittsburgh, and the VISN 4 Mental Illness Research, Education, and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh (MacDonald, Sweet); the Department of Neurology, Kennedy Krieger Institute, Baltimore (Norris, Pevsner); the Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore (Norris, Pevsner, Ross, Sawa); Protein Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Frederick, Md. (Orsburn); the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Gleason, Tamminga); the Department of Neurology, Johns Hopkins University School of Medicine, Baltimore (Margolis, Ross, Sawa, F.C. Nucifora); Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore (Lee, Sawa); the Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore (Ross).

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http://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2019.18
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http://dx.doi.org/10.1176/appi.ajp.2019.18070864DOI Listing
September 2019

Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor.

Neurobiol Dis 2019 09 17;129:118-129. Epub 2019 May 17.

Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States of America; Departments of Neurology, Neuroscience and Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States of America. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09699961183061
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http://dx.doi.org/10.1016/j.nbd.2019.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996243PMC
September 2019

Movement Disorder Society Task Force Viewpoint: Huntington's Disease Diagnostic Categories.

Mov Disord Clin Pract 2019 Sep 23;6(7):541-546. Epub 2019 Aug 23.

Huntington's Disease Centre, University College London Queen Square Institute of Neurology London United Kingdom.

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http://dx.doi.org/10.1002/mdc3.12808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749806PMC
September 2019

Differential Changes in Functional Connectivity of Striatum-Prefrontal and Striatum-Motor Circuits in Premanifest Huntington's Disease.

Neurodegener Dis 2019 14;19(2):78-87. Epub 2019 Aug 14.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1159/000501616DOI Listing
August 2019

Regional subcortical shape analysis in premanifest Huntington's disease.

Hum Brain Mapp 2019 04 30;40(5):1419-1433. Epub 2018 Oct 30.

Center for Imaging Science, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1002/hbm.24456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420821PMC
April 2019

Altered functional connectivity between sub-regions in the thalamus and cortex in schizophrenia patients measured by resting state BOLD fMRI at 7T.

Schizophr Res 2019 04 6;206:370-377. Epub 2018 Nov 6.

Department of Psychiatry and Behavioral Sciences and Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09209964183061
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http://dx.doi.org/10.1016/j.schres.2018.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500777PMC
April 2019

Altered brain iron content and deposition rate in Huntington's disease as indicated by quantitative susceptibility MRI.

J Neurosci Res 2019 04 29;97(4):467-479. Epub 2018 Nov 29.

F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland.

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http://dx.doi.org/10.1002/jnr.24358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367012PMC
April 2019

Cysteamine Protects Neurons from Mutant Huntingtin Toxicity.

J Huntingtons Dis 2019 ;8(2):129-143

Department of Psychiatry and Behavioral Sciences, Division of Neurobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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https://www.medra.org/servlet/aliasResolver?alias=iospress&a
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http://dx.doi.org/10.3233/JHD-180312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039181PMC
January 2019

Research Domain Criteria: Cutting Edge Neuroscience or Galen's Humors Revisited?

Mol Neuropsychiatry 2018 Dec 11;4(3):158-163. Epub 2018 Oct 11.

Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1159/000493685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323392PMC
December 2018

G2019S LRRK2 Increases Stress Susceptibility Through Inhibition of DAF-16 Nuclear Translocation in a 14-3-3 Associated-Manner in .

Front Neurosci 2018 7;12:782. Epub 2018 Nov 7.

Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

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http://dx.doi.org/10.3389/fnins.2018.00782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234837PMC
November 2018

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI-Application in Premanifest Huntington's Disease.

J Vis Exp 2018 06 9(136). Epub 2018 Jun 9.

Center for Imaging Science, Johns Hopkins University; Institute for Computational Medicine, Johns Hopkins University; Department of Biomedical Engineering, Johns Hopkins University.

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http://dx.doi.org/10.3791/57256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101648PMC
June 2018

Mechanisms underlying neurodegeneration in Huntington disease: applications to novel disease-modifying therapies.

Handb Clin Neurol 2017 ;144:15-28

Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Translational Neurobiology Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Laboratory of Genetic Neurobiology and Johns Hopkins Schizophrenia Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

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http://dx.doi.org/10.1016/B978-0-12-801893-4.00002-XDOI Listing
March 2018

Resting-state functional MRI reveals altered brain connectivity and its correlation with motor dysfunction in a mouse model of Huntington's disease.

Sci Rep 2017 12 1;7(1):16742. Epub 2017 Dec 1.

Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.

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http://dx.doi.org/10.1038/s41598-017-17026-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711837PMC
December 2017

Potential biomarker breakthrough for Huntington's disease.

Lancet Neurol 2017 08 7;16(8):573-574. Epub 2017 Jun 7.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/S1474-4422(17)30195-3DOI Listing
August 2017

Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats.

J Proteome Res 2017 08 3;16(8):2692-2708. Epub 2017 Jul 3.

Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine , 600 North Wolfe Street, CMSC 8-121, Baltimore, Maryland 21287, United States.

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http://dx.doi.org/10.1021/acs.jproteome.6b00991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560079PMC
August 2017

Analysis of differential gene expression mediated by clozapine in human postmortem brains.

Schizophr Res 2017 07 27;185:58-66. Epub 2016 Dec 27.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N. Wolfe St., Baltimore, MD 21287, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09209964163059
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http://dx.doi.org/10.1016/j.schres.2016.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541388PMC
July 2017

Mutant Huntingtin Disrupts the Nuclear Pore Complex.

Neuron 2017 Apr;94(1):93-107.e6

Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595097PMC
April 2017

DNA repair: A unifying mechanism in neurodegeneration.

Nature 2017 01 21;541(7635):34-35. Epub 2016 Dec 21.

Departments of Psychiatry, Neurology, Neuroscience and Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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http://www.nature.com/articles/nature21107
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http://dx.doi.org/10.1038/nature21107DOI Listing
January 2017

Linking white matter and deep gray matter alterations in premanifest Huntington disease.

Neuroimage Clin 2016 26;11:450-460. Epub 2016 Feb 26.

Center for Imaging Science, The Johns Hopkins University, Baltimore, MD, USA; Institute for Computational Medicine, The Johns Hopkins University, Baltimore, MD, USA; Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.nicl.2016.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827723PMC
December 2016

A Mutation in NPAS3 That Segregates with Schizophrenia in a Small Family Leads to Protein Aggregation.

Mol Neuropsychiatry 2016 Oct 27;2(3):133-144. Epub 2016 Jul 27.

Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Md., USA.

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http://dx.doi.org/10.1159/000447358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109994PMC
October 2016

Quantitative Proteomic Analysis Reveals Similarities between Huntington's Disease (HD) and Huntington's Disease-Like 2 (HDL2) Human Brains.

J Proteome Res 2016 09 3;15(9):3266-83. Epub 2016 Aug 3.

Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine , 600 North Wolfe Street, CMSC 8-121, Baltimore, Maryland 21287, United States.

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http://dx.doi.org/10.1021/acs.jproteome.6b00448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555151PMC
September 2016

DISC1, astrocytes and neuronal maturation: a possible mechanistic link with implications for mental disorders.

J Neurochem 2016 08;138(4):518-24

Departments of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1111/jnc.13663DOI Listing
August 2016

Transcriptome sequencing reveals aberrant alternative splicing in Huntington's disease.

Hum Mol Genet 2016 08 4;25(16):3454-3466. Epub 2016 Jul 4.

Department of Microbiology, Immunology, & Molecular Genetics, University of California Los Angeles, Los Angeles, CA, USA

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http://dx.doi.org/10.1093/hmg/ddw187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179942PMC
August 2016

Sox11 Reduces Caspase-6 Cleavage and Activity.

PLoS One 2015 27;10(10):e0141439. Epub 2015 Oct 27.

Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, CMSC 8-121, 600 North Wolfe Street, Baltimore, MD, 21287, United States of America; Department of Neurology, Johns Hopkins University School of Medicine, CMSC 8-121, 600 North Wolfe Street, Baltimore, MD, 21287, United States of America; Department of Pharmacology, Johns Hopkins University School of Medicine, CMSC 8-121, 600 North Wolfe Street, Baltimore, MD, 21287, United States of America; Department of Neuroscience, Johns Hopkins University School of Medicine, CMSC 8-121, 600 North Wolfe Street, Baltimore, MD, 21287, United States of America; Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, CMSC 8-121, 600 North Wolfe Street, Baltimore, MD, 21287, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141439PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624725PMC
June 2016

Melatonin attenuates hLRRK2-induced sleep disturbances and synaptic dysfunction in a Drosophila model of Parkinson's disease.

Mol Med Rep 2016 May 16;13(5):3936-44. Epub 2016 Mar 16.

Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China.

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http://dx.doi.org/10.3892/mmr.2016.4991DOI Listing
May 2016

Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A (1)H MRS Study at 7 Tesla.

Schizophr Res 2016 Apr 28;172(1-3):101-5. Epub 2016 Feb 28.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neurology and Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2016.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821673PMC
April 2016

PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD).

Cell Cycle 2015 ;14(11):1716-29

a Division of Neurobiology; Department of Psychiatry; Johns Hopkins University School of Medicine ; CMSC 8-121; Baltimore , MD , USA.

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http://dx.doi.org/10.1080/15384101.2015.1033595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615115PMC
March 2016

Gabriele Schilling (September 5, 1968-July 4, 2014).

J Huntingtons Dis 2014 ;3(3):225-7

Baltimore Huntington's Disease Center, Division of Neurobiology, Department of Psychiatry, and Departments of Neurology, Neuroscience and Pharmacology, and Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.3233/JHD-149005DOI Listing
February 2016

Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson's disease models.

Hum Mol Genet 2016 Feb 6;25(4):672-80. Epub 2016 Jan 6.

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, MD 21201, USA,

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http://hmg.oxfordjournals.org/content/early/2016/01/10/hmg.d
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http://www.hmg.oxfordjournals.org/lookup/doi/10.1093/hmg/ddv
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http://dx.doi.org/10.1093/hmg/ddv504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743687PMC
February 2016

RAN Translation in Huntington Disease.

Neuron 2015 Nov;88(4):667-77

Center for NeuroGenetics, University of Florida, Gainesville, FL 32610, USA; Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA; Department of Neurology, University of Florida, Gainesville, FL 32610, USA; Genetics Institute, University of Florida, Gainesville, FL 32610, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2015.10.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684947PMC
November 2015

Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65.

Sci Rep 2015 Jul 28;5:12521. Epub 2015 Jul 28.

1] Department of Psychiatry and Behavioral Sciences, Division of Neurobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA [2] Program of Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/srep12521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517393PMC
July 2015

Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease.

Hum Mol Genet 2015 May 21;24(9):2508-27. Epub 2015 Jan 21.

Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA, Department of Neuroscience,

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http://dx.doi.org/10.1093/hmg/ddv016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383863PMC
May 2015

Huntington disease.

Nat Rev Dis Primers 2015 04 23;1:15005. Epub 2015 Apr 23.

Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK.

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http://dx.doi.org/10.1038/nrdp.2015.5DOI Listing
April 2015

Synaptic dysregulation in a human iPS cell model of mental disorders.

Nature 2014 Nov 17;515(7527):414-8. Epub 2014 Aug 17.

1] Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [3] Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [4] The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/nature13716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501856PMC
November 2014

Regional atrophy associated with cognitive and motor function in prodromal Huntington disease.

J Huntingtons Dis 2013 ;2(4):477-89

Departments of Psychiatry, Neurology, Psychology and Neuroscience, The University of Iowa Carver College of Medicine, Iowa City, IA, USA.

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http://dx.doi.org/10.3233/JHD-130076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412155PMC
September 2014

Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity.

PLoS One 2014 5;9(2):e88284. Epub 2014 Feb 5.

Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America ; Departments of Neurology, Pharmacology and Neuroscience and Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088284PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914950PMC
September 2014

Diagnostic criteria for Huntington's disease based on natural history.

Mov Disord 2014 Sep 27;29(11):1335-41. Epub 2014 Aug 27.

George-Huntington-Institute, Technology-Park, Muenster, Germany; Department of Neurodegenerative Diseases and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1002/mds.26011DOI Listing
September 2014

Huntington's disease: a field on the move. Introduction.

Mov Disord 2014 Sep 27;29(11):1333-4. Epub 2014 Aug 27.

George Huntington Institute, Technology Park, Muenster, Germany; Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1002/mds.26017DOI Listing
September 2014

Determinants of functional disability in Huntington's disease: role of cognitive and motor dysfunction.

Mov Disord 2014 Sep;29(11):1351-8

Division of Neurobiology, Department of Psychiatry, Departments of Neurology, Neuroscience, and Pharmacology, and Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/mds.26012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197404PMC
September 2014

Prefrontal executive function associated coupling relates to Huntington's disease stage.

Cortex 2013 Nov-Dec;49(10):2661-73. Epub 2013 Jun 26.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Division of Psychiatry Research and Psychogeriatric Medicine, University of Zürich, Zürich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cortex.2013.05.015DOI Listing
July 2014

Prefrontal brain network connectivity indicates degree of both schizophrenia risk and cognitive dysfunction.

Schizophr Bull 2014 May 18;40(3):653-64. Epub 2013 Jun 18.

*To whom correspondence should be addressed; Division of Psychiatry Research and Psychogeriatric Medicine, University of Zürich, Minervastrasse 145, CH-8032 Zürich, Switzerland; tel: +41-44-3891-453, fax: +41-44-3891-447, e-mail:

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http://dx.doi.org/10.1093/schbul/sbt077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984516PMC
May 2014

Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis.

Hum Brain Mapp 2014 Mar 20;35(3):792-809. Epub 2012 Dec 20.

Center for Imaging Science, Institute for Computational Medicine and Department of Applied Mathematics and Statistics, Johns Hopkins University, WSE, Baltimore, Maryland.

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http://dx.doi.org/10.1002/hbm.22214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715588PMC
March 2014

Elevated arteriolar cerebral blood volume in prodromal Huntington's disease.

Mov Disord 2014 Mar 11;29(3):396-401. Epub 2013 Jul 11.

The Russell H. Morgan Department of Radiology and Radiological Science, Division of Magnetic Resonance Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/mds.25591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834086PMC
March 2014

Transcriptome-wide discovery of microRNA binding sites in human brain.

Neuron 2014 Jan 2;81(2):294-305. Epub 2014 Jan 2.

Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA; Department of Neurology, University of Iowa, Iowa City, IA 52242, USA; Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA; Program in Molecular and Cellular Biology, University of Iowa, Iowa City, IA 52242, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2013.10.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108341PMC
January 2014

Gross feature recognition of Anatomical Images based on Atlas grid (GAIA): Incorporating the local discrepancy between an atlas and a target image to capture the features of anatomic brain MRI.

Neuroimage Clin 2013 14;3:202-11. Epub 2013 Aug 14.

The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA ; Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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http://dx.doi.org/10.1016/j.nicl.2013.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791278PMC
November 2013

Targeting H3K4 trimethylation in Huntington disease.

Proc Natl Acad Sci U S A 2013 Aug 19;110(32):E3027-36. Epub 2013 Jul 19.

Department of Psychiatry and Human Behavior and UCI Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1073/pnas.1311323110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740882PMC
August 2013

Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease.

Hum Mol Genet 2013 Jun 27;22(12):2462-70. Epub 2013 Feb 27.

Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1093/hmg/ddt098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658168PMC
June 2013

Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease.

J Neurochem 2013 May 5;125(3):410-9. Epub 2013 Mar 5.

Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1111/jnc.12190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642978PMC
May 2013

Frontal cortical synaptic communication is abnormal in Disc1 genetic mouse models of schizophrenia.

Schizophr Res 2013 May 6;146(1-3):264-72. Epub 2013 Mar 6.

Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience and Human Behavior, Brain Research Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024, United States.

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http://dx.doi.org/10.1016/j.schres.2013.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622830PMC
May 2013

Gene expression alterations in bipolar disorder postmortem brains.

Bipolar Disord 2013 Mar 30;15(2):177-87. Epub 2013 Jan 30.

Department of Psychiatry and Comprehensive Depression Center Molecular and Behavioral Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1111/bdi.12039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582727PMC
March 2013

LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: suppression by curcumin.

Neurobiol Dis 2012 Sep 2;47(3):385-92. Epub 2012 Jun 2.

Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi, PR China.

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http://dx.doi.org/10.1016/j.nbd.2012.05.020DOI Listing
September 2012

Striatal neuronal loss correlates with clinical motor impairment in Huntington's disease.

Mov Disord 2012 Sep 13;27(11):1379-86. Epub 2012 Sep 13.

Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1002/mds.25159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3455126PMC
September 2012

Brain metabolite alterations and cognitive dysfunction in early Huntington's disease.

Mov Disord 2012 Jun 30;27(7):895-902. Epub 2012 May 30.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1002/mds.25010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383395PMC
June 2012

Spatiotemporal mapping of brain atrophy in mouse models of Huntington's disease using longitudinal in vivo magnetic resonance imaging.

Neuroimage 2012 May 9;60(4):2086-95. Epub 2012 Feb 9.

Division of NMR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2012.01.141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321064PMC
May 2012

Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein.

J Biol Chem 2012 May 20;287(19):16017-28. Epub 2012 Mar 20.

Division of Neurobiology, Department of Psychiatry, Children's Medical Surgical Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1074/jbc.M111.252577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346083PMC
May 2012

Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis.

Cell Cycle 2012 May 15;11(10):2006-21. Epub 2012 May 15.

Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.4161/cc.20423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359124PMC
May 2012

Impaired cortico-striatal functional connectivity in prodromal Huntington's Disease.

Neurosci Lett 2012 Apr 7;514(2):204-9. Epub 2012 Mar 7.

Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.neulet.2012.02.095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331724PMC
April 2012

Age, CAG repeat length, and clinical progression in Huntington's disease.

Mov Disord 2012 Feb 15;27(2):272-6. Epub 2011 Dec 15.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/mds.24024DOI Listing
February 2012

Loss of junctophilin-3 contributes to Huntington disease-like 2 pathogenesis.

Ann Neurol 2012 Feb;71(2):245-57

Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1002/ana.22598DOI Listing
February 2012

Factors contributing to institutionalization in patients with Huntington's disease.

Mov Disord 2011 Aug 29;26(9):1711-6. Epub 2011 Apr 29.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1002/mds.23716DOI Listing
August 2011

Dictyostelium huntingtin controls chemotaxis and cytokinesis through the regulation of myosin II phosphorylation.

Mol Biol Cell 2011 Jul 11;22(13):2270-81. Epub 2011 May 11.

Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1091/mbc.E10-11-0926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128529PMC
July 2011

Structural MRI detects progressive regional brain atrophy and neuroprotective effects in N171-82Q Huntington's disease mouse model.

Neuroimage 2011 Jun 12;56(3):1027-34. Epub 2011 Feb 12.

Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2011.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372851PMC
June 2011

Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism.

Pharmacol Res 2011 May 12;63(5):439-44. Epub 2011 Jan 12.

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, MD 21201, United States.

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http://dx.doi.org/10.1016/j.phrs.2011.01.004DOI Listing
May 2011

Association between Age and Striatal Volume Stratified by CAG Repeat Length in Prodromal Huntington Disease.

PLoS Curr 2011 May 11;3:RRN1235. Epub 2011 May 11.

Center for Integrative Brain Research, Seattle Children's Research Institute; Department of Psychiatry, The University of Iowa Carver College of Medicine; Department of Biostatistics, The University of Iowa, College of Public Health; Department of Psychiatry, Pediatrics, and Neurology, The University of Iowa Carver College of Medicine and Division of Neurobiology, Department of Psychiatry, Johns Hopkins University.

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http://dx.doi.org/10.1371/currents.RRN1235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092625PMC
May 2011

Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin.

J Biol Chem 2011 Apr 10;286(14):12578-89. Epub 2011 Feb 10.

Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1074/jbc.M110.185348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069459PMC
April 2011

A compact beta model of huntingtin toxicity.

J Biol Chem 2011 Mar 5;286(10):8188-96. Epub 2011 Jan 5.

Division of Neurobiology, Department of Psychiatry, Children's Medical Surgical Center, Johns Hopkins University School of Medicine, Baltimore, Mayland 21287, USA.

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http://dx.doi.org/10.1074/jbc.M110.192013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048705PMC
March 2011