Christophe Caux

Christophe Caux

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Christophe Caux

Publications by authors named "Christophe Caux"

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CD73 expression in normal and pathological human hepatobiliopancreatic tissues.

Cancer Immunol Immunother 2019 Mar 4;68(3):467-478. Epub 2019 Jan 4.

Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, rue du Bugnon 25, 1011, Lausanne, Switzerland.

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http://link.springer.com/10.1007/s00262-018-2290-1
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http://dx.doi.org/10.1007/s00262-018-2290-1DOI Listing
March 2019

Correction to: CD73 expression in normal and pathological human hepatobiliopancreatic tissues.

Cancer Immunol Immunother 2019 03;68(3):529

Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, rue du Bugnon 25, 1011, Lausanne, Switzerland.

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http://dx.doi.org/10.1007/s00262-019-02309-9DOI Listing
March 2019

Lymphopenia in Cancer Patients and its Effects on Response to Immunotherapy: an opportunity for combination with Cytokines?

J Immunother Cancer 2019 Mar 28;7(1):85. Epub 2019 Mar 28.

Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Cancer Research Center of Lyon (CRCL), Centre Léon Bérard, F-69008, Lyon, France.

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http://dx.doi.org/10.1186/s40425-019-0549-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437964PMC
March 2019

Neoepitopes-based vaccines: challenges and perspectives.

Eur J Cancer 2019 Feb 12;108:55-60. Epub 2019 Jan 12.

Université Claude Bernard Lyon 1, Lyon, France; Inserm U1052/CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France; Centre Léon Bérard, Lyon, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09598049183155
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http://dx.doi.org/10.1016/j.ejca.2018.12.011DOI Listing
February 2019

[Some important breakthroughs in oncology and hematology in 2018: A selection by the editorial board of Bulletin du Cancer].

Bull Cancer 2019 Jan 3;106(1):12-23. Epub 2019 Jan 3.

AP-HP, hôpitaux universitaires Paris Centre, hôpital Cochin, unité d'oncologie thoracique, service de pneumologie, 75014 Paris, France; Paris Descartes Université, centre de recherche des Cordeliers, équipe « cancer, immune control and escape », Inserm UMRS1138, 75006 Paris, France.

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https://linkinghub.elsevier.com/retrieve/pii/S00074551183040
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http://dx.doi.org/10.1016/j.bulcan.2018.12.005DOI Listing
January 2019

Nouvelles perspectives dans l’immunothérapie des cancers.

Bull Cancer 2018 Dec;105 Suppl 1:S1-S2

Service de thérapie cellulaire et d'hématologie clinique adulte, CHU Clermont-Ferrand, site Estaing, Université d'Auvergne, EA7453 CHELTER, 63000 Clermont-Ferrand, France.

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http://dx.doi.org/10.1016/S0007-4551(18)30384-9DOI Listing
December 2018

MDR1 in immunity: friend or foe?

Oncoimmunology 2018 6;7(12):e1499388. Epub 2018 Sep 6.

Centre Léon Bérard, Cancer Research Center of Lyon (CRCL), Univ Lyon, Université Claude Bernard Lyon 1, Lyon France.

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https://www.tandfonline.com/doi/full/10.1080/2162402X.2018.1
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http://dx.doi.org/10.1080/2162402X.2018.1499388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279327PMC
September 2018

Emerging Role of the Unfolded Protein Response in Tumor Immunosurveillance.

Trends Cancer 2017 07 6;3(7):491-505. Epub 2017 Jul 6.

Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de recherche en cancérologie de Lyon, Lyon, 69008, France. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2017.05.005DOI Listing
July 2017

A Milestone Review on How Macrophages Affect Tumor Growth.

Cancer Res 2016 11;76(22):6439-6442

Innovation in Immuno-monitoring and Immunotherapy Platform (PI3), Léon Bérard Cancer Center, Lyon, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2631DOI Listing
November 2016

Follicular B Lymphomas Generate Regulatory T Cells via the ICOS/ICOSL Pathway and Are Susceptible to Treatment by Anti-ICOS/ICOSL Therapy.

Cancer Res 2016 08 31;76(16):4648-60. Epub 2016 May 31.

Centre de recherche en Cancérologie de Marseille, Inserm U1068/CNRS U7258, Marseille, France. Aix Marseille Université, Marseille, France. Institut Paoli - Calmettes, Marseille, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0589DOI Listing
August 2016

A novel regulation of PD-1 ligands on mesenchymal stromal cells through MMP-mediated proteolytic cleavage.

Oncoimmunology 2016 Mar 29;5(3):e1091146. Epub 2015 Oct 29.

Université de Lyon, Lyon, France; Université Lyon 1, ISPB, Lyon, France; INSERM U1052, Center de Recherche en Cancérologie de Lyon, Lyon, France; CNRS UMR5286, Center de Recherche en Cancérologie de Lyon, Lyon, France.

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http://dx.doi.org/10.1080/2162402X.2015.1091146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839348PMC
March 2016

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway.

Sci Signal 2016 Feb 16;9(415):ra19. Epub 2016 Feb 16.

Centre International de Recherche en Infectiologie (CIRI), 69007 Lyon, France. INSERM U1111, 69007 Lyon, France. Ecole Normale Supérieure de Lyon, 69007 Lyon, France. Université Lyon 1, 69007 Lyon, France. CNRS, UMR5308, 69007 Lyon, France.

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http://dx.doi.org/10.1126/scisignal.aad1884DOI Listing
February 2016

Breast Cancer Cell-Derived GM-CSF Licenses Regulatory Th2 Induction by Plasmacytoid Predendritic Cells in Aggressive Disease Subtypes.

Cancer Res 2015 Jul 14;75(14):2775-87. Epub 2015 May 14.

INSERM U932, Institut Curie, Paris, France. Institut Curie, Department of Immunology, Paris, France. Center of Clinical Investigations, Curie-IGR, Paris-Villejuif, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-2386DOI Listing
July 2015

Human natural killer cells promote cross-presentation of tumor cell-derived antigens by dendritic cells.

Int J Cancer 2015 Mar 6;136(5):1085-94. Epub 2014 Aug 6.

Inserm UMR-S1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France; UNIV UMR1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France; Université de Lyon, Lyon, France; Centre Léon Bérard, Lyon, France.

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http://dx.doi.org/10.1002/ijc.29087DOI Listing
March 2015

Paradigm shift in oncology: targeting the immune system rather than cancer cells.

Mutagenesis 2015 Mar;30(2):205-11

Centre de Recherche en Cancérologie de Lyon, 28 Promenade Léa et Napoléon Bullukian, 69008 Lyon, France and Léon Bérard Comprehensive Cancer Center, 28 rue Laennec, 69008 Lyon, France

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http://dx.doi.org/10.1093/mutage/geu073DOI Listing
March 2015

Disequilibrium of BMP2 levels in the breast stem cell niche launches epithelial transformation by overamplifying BMPR1B cell response.

Stem Cell Reports 2015 Feb 15;4(2):239-54. Epub 2015 Jan 15.

CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, 69000 Lyon, France; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, 69000 Lyon, France; Université de Lyon, 69000 Lyon, France; Department of Immunity, Virus, and Microenvironment, 69000 Lyon, France; Université de Lyon 1, ISPB, 69000 Lyon, France. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2014.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325271PMC
February 2015

TLR9 transcriptional regulation in response to double-stranded DNA viruses.

J Immunol 2014 Oct 5;193(7):3398-408. Epub 2014 Sep 5.

International Center for Infectiology Research, University of Lyon, Lyon 69007, France; Inserm, U1111, Lyon 69007, France; Ecole Normale Supérieure de Lyon, Lyon 69007, France; Université Claude Bernard Lyon 1, Centre International de Recherche en Infectiologie, Lyon 69100, France; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5308, Lyon 69007, France; Oncovirus et l'immunité innée, Hospices Civils de Lyon Sud, Pierre Benite, 69495 France;

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http://dx.doi.org/10.4049/jimmunol.1400249DOI Listing
October 2014

Human XCR1+ dendritic cells derived in vitro from CD34+ progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells.

J Immunol 2014 Aug 9;193(4):1622-35. Epub 2014 Jul 9.

Centre d'Immunologie de Marseille-Luminy, UNIV UM2, Aix-Marseille Université, Parc Scientifique et Technologique de Luminy, 13288 Marseille, France; INSERM, Unité Mixte de Recherche 1104, 13288 Marseille, France; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7280, 13288 Marseille, France; LabEx DCBIOL, 13288 Marseille, France

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http://dx.doi.org/10.4049/jimmunol.1401243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120898PMC
August 2014

Intratumoral immunization: a new paradigm for cancer therapy.

Clin Cancer Res 2014 Apr;20(7):1747-56

Authors' Affiliations: Centre de Recherche en Cancérologie de Lyon, UMR INSERM U1052 CNRS 5286, Centre Léon Bérard, Université de Lyon, Lyon, France; and Division of Oncology, Stanford University, Department of Medicine, Stanford, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979477PMC
April 2014

Autocrine role for Gas6 with Tyro3 and Axl in leiomyosarcomas.

Target Oncol 2013 Dec 25;8(4):261-9. Epub 2013 Jan 25.

Pole des Sciences Cliniques & Centre de Recherche en Cancerologie de Lyon, INSERM UMR5286 Equipe 11, Centre Léon Bérard, Lyon, France.

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http://dx.doi.org/10.1007/s11523-012-0249-2DOI Listing
December 2013

ICOS is associated with poor prognosis in breast cancer as it promotes the amplification of immunosuppressive CD4 T cells by plasmacytoid dendritic cells.

Oncoimmunology 2013 Mar;2(3):e23185

Université de Lyon; Lyon, France ; ISPB; Université de Lyon 1; Lyon, France ; INSERM U1052; Centre de Recherche en Cancérologie de Lyon; Lyon, France ; CNRS UMR5286; Centre de Recherche en Cancérologie de Lyon; Lyon, France ; LabEx DEVweCAN; Lyon, France ; Centre Léon Bérard; Lyon, France.

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http://dx.doi.org/10.4161/onci.23185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661154PMC
March 2013

Plasmacytoid dendritic cells deficient in IFNα production promote the amplification of FOXP3 regulatory T cells and are associated with poor prognosis in breast cancer patients.

Oncoimmunology 2013 Jan;2(1):e22338

Université de Lyon; Lyon, France ; Université Lyon 1; ISPB; Lyon, France ; INSERM U1052; Centre de Recherche en Cancérologie de Lyon; Lyon, France ; CNRS UMR5286; Centre de Recherche en Cancérologie de Lyon; Lyon, France ; LabEx DEVweCAN; Lyon, France ; Centre Léon Bérard; Lyon, France.

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http://dx.doi.org/10.4161/onci.22338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583914PMC
January 2013

Innate immune recognition of breast tumor cells mediates CCL22 secretion favoring Treg recruitment within tumor environment.

Oncoimmunology 2012 Aug;1(5):759-761

Université de Lyon; Lyon, France ; Université Lyon 1; ISPB; Lyon, France ; Team 11; CRCL INSERM U-1052/CNRS 5286; Lyon, France ; LabEx DEVweCAN; Centre Léon Bérard; Lyon, France ; Centre Léon Bérard; Lyon, France.

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http://dx.doi.org/10.4161/onci.19680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429586PMC
August 2012

Plasmacytoid dendritic cells infiltrating ovarian cancer are associated with poor prognosis.

Oncoimmunology 2012 May;1(3):380-382

Université de Lyon; Lyon, France ; Université Lyon 1; ISPB; Lyon, France ; INSERM; U1052; Centre de Recherche en Cancérologie de Lyon; Lyon, France ; Cnrs; UMR5286; Centre de Recherche en Cancérologie de Lyon; Lyon, France ; LabEx DEVweCAN; Lyon, France ; Department of Medical Oncology; Centre Léon Bérard; Lyon, France.

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http://dx.doi.org/10.4161/onci.18801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382863PMC
May 2012

Targeting regulatory T cells.

Target Oncol 2012 Mar 12;7(1):15-28. Epub 2012 Feb 12.

Université de Lyon, F-69000, Lyon, France.

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http://dx.doi.org/10.1007/s11523-012-0208-yDOI Listing
March 2012

Recent successes of cancer immunotherapy: a new dimension in personalized medicine?

Target Oncol 2012 Mar 15;7(1):1-2. Epub 2012 Feb 15.

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http://dx.doi.org/10.1007/s11523-012-0211-3DOI Listing
March 2012

Targeting pattern recognition receptors in cancer immunotherapy.

Target Oncol 2012 Mar 8;7(1):29-54. Epub 2012 Mar 8.

Université de Lyon, Université Lyon I, UMR INSERM 1052 CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, Lyon, France.

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http://link.springer.com/10.1007/s11523-012-0213-1
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http://dx.doi.org/10.1007/s11523-012-0213-1DOI Listing
March 2012

Impaired Toll-like receptor 7 and 9 signaling: from chronic viral infections to cancer.

Trends Immunol 2010 Oct 9;31(10):391-7. Epub 2010 Sep 9.

INSERM UMR891, Centre de Recherche en Cancérologie de Marseille, Institut Paoli-Calmettes, Université Méditerranée, 27 Boulevard Leï Roure, 13273 Marseille, France.

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http://www.cell.com/trends/immunology/pdf/S1471-4906(10)0010
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http://linkinghub.elsevier.com/retrieve/pii/S147149061000108
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http://dx.doi.org/10.1016/j.it.2010.07.004DOI Listing
October 2010

Differences in tumor regulatory T-cell localization and activation status impact patient outcome.

Cancer Res 2009 Oct 6;69(20):7895-8. Epub 2009 Oct 6.

Inserm, U590, Centre Léon Bérard, Equipe Cytokines et Cancers, Université Lyon 1, ISPB, and IFR62, Lyon, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-1642DOI Listing
October 2009

High diversity of the immune repertoire in humanized NOD.SCID.gamma c-/- mice.

Eur J Immunol 2009 Aug;39(8):2136-45

Université Pierre et Marie Curie - Paris 6, Centre National de la Recherche Scientifique UMR 7211, Paris, France.

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http://dx.doi.org/10.1002/eji.200939480DOI Listing
August 2009

Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs.

Proc Natl Acad Sci U S A 2007 May 26;104(19):8047-52. Epub 2007 Apr 26.

Infections and Cancer Biology Group, International Agency for Research on Cancer (IARC-WHO), 150 Cours Albert Thomas, 69372 Lyon Cedex 08, France.

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http://dx.doi.org/10.1073/pnas.0700664104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1876569PMC
May 2007

Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH.

J Biol Chem 2005 Nov 6;280(46):38133-45. Epub 2005 Sep 6.

Laboratory for Immunological Research, Schering-Plough Research Institute, 27 Chemin des Peupliers, 69571 Dardilly Cedex, France.

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http://dx.doi.org/10.1074/jbc.M507163200DOI Listing
November 2005

Critical role of ITIM-bearing FcgammaR on DCs in the capture and presentation of native antigen to B cells.

Immunity 2005 Nov;23(5):463-4

INSERM U404 "Immunité et Vaccination", IFR-128 Biosciences Lyon Gerland, 21 avenue Tony Garnier, 69365 Lyon Cedex 07, France.

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http://dx.doi.org/10.1016/j.immuni.2005.10.005DOI Listing
November 2005

Distinct and overlapping roles of interleukin-10 and CD25+ regulatory T cells in the inhibition of antitumor CD8 T-cell responses.

Cancer Res 2005 Sep;65(18):8479-86

Laboratory for Immunological Research, Schering-Plough Research Institute, Dardilly, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-1319DOI Listing
September 2005

Fc receptor gamma-chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responses.

Blood 2005 May 13;105(9):3623-32. Epub 2005 Jan 13.

Laboratory for Immunological Research, Schering-Plough, 27 chemin des peupliers, BP11, 69571 Dardilly cedex, France.

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http://dx.doi.org/10.1182/blood-2004-07-2809DOI Listing
May 2005

Human dendritic cells express neuronal Eph receptor tyrosine kinases: role of EphA2 in regulating adhesion to fibronectin.

Blood 2003 Dec 7;102(13):4431-40. Epub 2003 Aug 7.

Laboratory for Immunological Research, Schering-Plough, 27 chemin des peupliers, BP 11, 69571 Dardilly, France.

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http://dx.doi.org/10.1182/blood-2003-02-0500DOI Listing
December 2003

Corticosteroids prevent generation of CD34+-derived dermal dendritic cells but do not inhibit Langerhans cell development.

J Immunol 2002 Jun;168(12):6181-8

Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.168.12.6181DOI Listing
June 2002

Chemokines in cancer.

Cytokine Growth Factor Rev 2002 Apr;13(2):143-54

Schering-Plough Laboratory for Immunological Research, BP 11, 27 chemin des Peupliers, 69571 Dardilly, France.

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April 2002

Tumour escape from immune surveillance through dendritic cell inactivation.

Semin Cancer Biol 2002 Feb;12(1):33-42

Schering-Plough Research Institute, Laboratory for Immunological Research, Dardilly, France.

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http://linkinghub.elsevier.com/retrieve/pii/S1044579X0190400
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http://dx.doi.org/10.1006/scbi.2001.0400DOI Listing
February 2002

Langerhans cells: still a fundamental paradigm for studying the immunobiology of dendritic cells.

Trends Immunol 2002 Jan;23(1):6-8

Laboratory of Immunology, Istituto Dermopatico dell'Immacolata, IRCCS, I-00167, Rome, Italy.

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January 2002

Regulation of dendritic cell recruitment by chemokines.

Transplantation 2002 Jan;73(1 Suppl):S7-11

Schering-Plough, Laboratory for Immunological Research, Dardilly, France.

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January 2002