Christoph Wanner

Christoph Wanner

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Christoph Wanner

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Oral Chaperone Therapy Migalastat for Treating Fabry Disease: Enzymatic Response and Serum Biomarker Changes After 1 Year.

Clin Pharmacol Ther 2019 May 13;105(5):1224-1233. Epub 2019 Jan 13.

Department of Internal Medicine I and Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, Germany.

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http://doi.wiley.com/10.1002/cpt.1321
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http://dx.doi.org/10.1002/cpt.1321DOI Listing
May 2019

Retinopathy Outcomes With Empagliflozin Versus Placebo in the EMPA-REG OUTCOME Trial.

Diabetes Care 2019 Apr 31;42(4):e53-e55. Epub 2019 Jan 31.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.2337/dc18-1355DOI Listing
April 2019

A randomized controlled trial of the effect of spironolactone on left ventricular mass in hemodialysis patients.

Kidney Int 2019 Apr 31;95(4):983-991. Epub 2019 Jan 31.

Comprehensive Heart Failure Center, University and University Hospital Würzburg, Würzburg, Germany; Department of Medicine I, Division of Nephrology, University Hospital Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1016/j.kint.2018.11.025DOI Listing
April 2019

Dyshidrosis is associated with reduced amplitudes in electrically evoked pain-related potentials in women with Fabry disease.

Clin Neurophysiol 2019 Apr 4;130(4):528-536. Epub 2019 Feb 4.

Department of Neurology, University of Würzburg, Germany; Fabry Center for Interdisciplinary Therapy (FAZIT), University of Würzburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2019.01.008DOI Listing
April 2019

Therapeutic goals in Fabry disease: Recommendations of a European expert panel, based on current clinical evidence with enzyme replacement therapy.

Mol Genet Metab 2019 Mar 11;126(3):210-211. Epub 2018 Apr 11.

University College London and Barts Heart Centre, London, United Kingdom.

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http://dx.doi.org/10.1016/j.ymgme.2018.04.004DOI Listing
March 2019

The effect of enzyme replacement therapy on clinical outcomes in paediatric patients with Fabry disease - A systematic literature review by a European panel of experts.

Mol Genet Metab 2019 Mar 26;126(3):212-223. Epub 2018 Apr 26.

French Referral Center for Fabry disease, Division of Medical Genetics and INSERM U1179, University of Versailles, Paris-Saclay University, Montigny, France.

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http://dx.doi.org/10.1016/j.ymgme.2018.04.007DOI Listing
March 2019

Empagliflozin reduces the risk of a broad spectrum of heart failure outcomes regardless of heart failure status at baseline.

Eur J Heart Fail 2019 Mar 14;21(3):386-388. Epub 2019 Feb 14.

Centre d'Investigations Cliniques Plurithématique Inserm 1433, Université de Lorraine, Nancy, France.

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http://dx.doi.org/10.1002/ejhf.1419DOI Listing
March 2019

Influence of Microvascular Disease on Cardiovascular Events in Type 2 Diabetes.

J Am Coll Cardiol 2019 Mar 5. Epub 2019 Mar 5.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jacc.2019.03.002DOI Listing
March 2019

Will the FAbry STabilization indEX make its way to everyday clinical practice?

Clin Kidney J 2019 Feb 24;12(1):61-64. Epub 2018 Dec 24.

Department of Internal Medicine I, Division of Nephrology, University Hospital Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1093/ckj/sfy126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366128PMC
February 2019

Differences in Dialysis Efficacy Have Limited Effects on Protein-Bound Uremic Toxins Plasma Levels over Time.

Toxins (Basel) 2019 Jan 16;11(1). Epub 2019 Jan 16.

Division of Nephrology, University Hospital Würzburg, 97080 Würzburg, Germany.

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http://dx.doi.org/10.3390/toxins11010047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356521PMC
January 2019

Hot topics in Fabry disease.

Postgrad Med J 2018 Dec 17;94(1118):709-713. Epub 2018 Dec 17.

Department of Internal Medicine, Divisions of Nephrology and Cardiology, University Hospital Würzburg, Würzburg, Germany

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http://dx.doi.org/10.1136/postgradmedj-2018-136056DOI Listing
December 2018

Farewell Editorial.

J Ren Nutr 2018 Nov;28(6):367-368

University Hospital Wuerzburg, Department of Medicine, Division of Nephrology, Wuerzburg, Germany.

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http://dx.doi.org/10.1053/j.jrn.2018.07.002DOI Listing
November 2018

SGLT2 inhibitors: the future for treatment of type 2 diabetes mellitus and other chronic diseases.

Diabetologia 2018 10 22;61(10):2134-2139. Epub 2018 Aug 22.

Department of Internal Medicine I, Cardiology, University Hospital Aachen, RWTH Aachen University, Aachen, Germany.

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http://dx.doi.org/10.1007/s00125-018-4678-zDOI Listing
October 2018

Baseline and on-statin treatment lipoprotein(a) levels for prediction of cardiovascular events: individual patient-data meta-analysis of statin outcome trials.

Lancet 2018 10 4;392(10155):1311-1320. Epub 2018 Oct 4.

Vascular Medicine Program, Sulpizio Cardiovascular Center, Division of Cardiology, Department of Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(18)31652-0DOI Listing
October 2018

Improvement in Cardiovascular Outcomes With Empagliflozin Is Independent of Glycemic Control.

Circulation 2018 Oct;138(17):1904-1907

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Ontario, Canada (B.Z.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035759DOI Listing
October 2018

The ABCs in the Mapping Progress in Reducing Cardiovascular Risk with Kidney Disease: An Introductory Remark on Expert Perspectives.

Authors:
Christoph Wanner

Clin J Am Soc Nephrol 2018 Sep 15;13(9):1421-1422. Epub 2018 Aug 15.

Division of Nephrology, Department of Medicine, University Hospital Würzburg, Würzburg, Germany; and

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http://dx.doi.org/10.2215/CJN.09090718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140576PMC
September 2018

Renal Outcomes of Antidiabetic Treatment Options for Type 2 Diabetes-A Proposed MARE Definition.

Kidney Int Rep 2018 Sep 22;3(5):1030-1038. Epub 2018 Apr 22.

Division of Nephrology, University Hospital, Würzburg, Germany.

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http://dx.doi.org/10.1016/j.ekir.2018.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127417PMC
September 2018

Fabry disease under enzyme replacement therapy-new insights in efficacy of different dosages.

Nephrol Dial Transplant 2018 Aug;33(8):1362-1372

Department of Internal Medicine I, Divisions of Cardiology and Nephrology, Comprehensive Heart Failure Center, Fabry Center for Interdisciplinary Therapy (FAZIT), University Hospital and University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1093/ndt/gfx319DOI Listing
August 2018

Chronic kidney disease and arrhythmias: highlights from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Kidney Int 2018 08 21;94(2):231-234. Epub 2018 Jun 21.

Stanford University School of Medicine and Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2018.05.005DOI Listing
August 2018

Characterization of vertigo and hearing loss in patients with Fabry disease.

Orphanet J Rare Dis 2018 08 15;13(1):137. Epub 2018 Aug 15.

Department of Otorhinolaryngology, Head and Neck Surgery "Otto Körner", University Medical Center Rostock, Doberaner Straße 137-139, D-18057, Rostock, Germany.

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http://dx.doi.org/10.1186/s13023-018-0882-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094894PMC
August 2018

Empagliflozin in women with type 2 diabetes and cardiovascular disease - an analysis of EMPA-REG OUTCOME®.

Diabetologia 2018 07 30;61(7):1522-1527. Epub 2018 Apr 30.

Division of Cardiology, St Michael's Hospital, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00125-018-4630-2DOI Listing
July 2018

Prognostic Value of High-Sensitivity Versus Conventional Cardiac Troponin T Assays Among Patients With Type 2 Diabetes Mellitus Undergoing Maintenance Hemodialysis.

Am J Kidney Dis 2018 Jun 6;71(6):822-830. Epub 2018 Jan 6.

Division of Nephrology, Department of Medicine 1, University Hospital Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1053/j.ajkd.2017.10.016DOI Listing
June 2018

Uraemic symptom burden and clinical condition in women and men of ≥65 years of age with advanced chronic kidney disease: results from the EQUAL study.

Nephrol Dial Transplant 2018 Jun 13. Epub 2018 Jun 13.

ERA-EDTA Registry, Department of Medical Informatics, Academic Medical Center, Amsterdam Public Health Research Institute, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/ndt/gfy155DOI Listing
June 2018

Mediterranean diet as the diet of choice for patients with chronic kidney disease.

Nephrol Dial Transplant 2018 May;33(5):725-735

Division of Renal Medicine, CLINTEC and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1093/ndt/gfx085DOI Listing
May 2018

Treatment of hypertrophic cardiomyopathy caused by cardiospecific variants of Fabry disease with chaperone therapy.

Eur Heart J 2018 May;39(20):1861-1862

Department of Internal Medicine I and Comprehensive Heart Failure Center, University Hospital Würzburg, Oberdürrbacher Straße 6, 97080 Würzburg, Germany.

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http://dx.doi.org/10.1093/eurheartj/ehy072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963304PMC
May 2018

Clinical impact of the alpha-galactosidase A gene single nucleotide polymorphism -10C>T: A single-center observational study.

Medicine (Baltimore) 2018 May;97(21):e10669

Department of Internal Medicine I, Division of Cardiology and Nephrology and Comprehensive Heart Failure Center Würzburg, University Hospital Würzburg.

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http://dx.doi.org/10.1097/MD.0000000000010669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392711PMC
May 2018

Lucerastat, an Iminosugar for Substrate Reduction Therapy: Tolerability, Pharmacodynamics, and Pharmacokinetics in Patients With Fabry Disease on Enzyme Replacement.

Clin Pharmacol Ther 2018 Apr 28;103(4):703-711. Epub 2017 Aug 28.

Fabry Center for Interdisciplinary Therapy (FAZiT), Comprehensive Heart Failure Center (CHFC), and Department of Internal Medicine I, Divisions of Cardiology and Nephrology, University Hospital Würzburg, Würzburg, Germany.

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http://doi.wiley.com/10.1002/cpt.790
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http://dx.doi.org/10.1002/cpt.790DOI Listing
April 2018

Lowering LDL cholesterol reduces cardiovascular risk independently of presence of inflammation.

Kidney Int 2018 04 14;93(4):1000-1007. Epub 2017 Nov 14.

Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2017.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978933PMC
April 2018

Characterization of Fractionation Membranes in an Animal Model of Double Filtration Lipoprotein Apheresis.

Ther Apher Dial 2018 Apr 9;22(2):189-195. Epub 2018 Jan 9.

Department of Medicine I, Division of Nephrology, University Hospital Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1111/1744-9987.12649DOI Listing
April 2018

Diabetic kidney disease in 2017: A new era in therapeutics for diabetic kidney disease.

Authors:
Christoph Wanner

Nat Rev Nephrol 2018 Feb 8;14(2):78-80. Epub 2018 Jan 8.

Department of Medicine, Division of Nephrology, Würzburg University Hospital, Oberdürrbacherstr. 6, 97080 Würzburg, Germany.

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http://dx.doi.org/10.1038/nrneph.2017.182DOI Listing
February 2018

[Chronic Kidney Disease - Update 2018].

Dtsch Med Wochenschr 2018 02 6;143(3):169-173. Epub 2018 Feb 6.

Medizinische Klink III, Nephrologische Abteilung, Klinikum Coburg.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-124831
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http://dx.doi.org/10.1055/s-0043-124831DOI Listing
February 2018

Empagliflozin and Clinical Outcomes in Patients With Type 2 Diabetes Mellitus, Established Cardiovascular Disease, and Chronic Kidney Disease.

Circulation 2018 01 13;137(2):119-129. Epub 2017 Sep 13.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada (B.Z.) and Division of Endocrinology, University of Toronto, Canada (B.Z.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.028268DOI Listing
January 2018

Long-Term Survivor Characteristics in Hemodialysis Patients with Type 2 Diabetes.

Am J Nephrol 2018 10;47(1):30-39. Epub 2018 Jan 10.

Department of Internal Medicine I, Division of Nephrology, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1159/000485842DOI Listing
January 2018

Cardiac and renal dysfunction is associated with progressive hearing loss in patients with Fabry disease.

PLoS One 2017 21;12(11):e0188103. Epub 2017 Nov 21.

Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Comprehensive Hearing Center, University Hospital Würzburg, Würzburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0188103PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697846PMC
December 2017

CaRe high - Cascade screening and registry for high cholesterol in Germany.

Atheroscler Suppl 2017 Nov 1;30:72-76. Epub 2017 Jun 1.

D•A•CH-Gesellschaft Prävention von Herz-Kreislauf-Erkrankungen e.V., Hamburg, Germany; Synlab Academy, Synlab Holding Germany GmbH, Mannheim, Germany; Clinical Institut for Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria; Medical Clinic V (Nephrology, Hypertension, Rheumatology, Endocrinology, Diabetology), Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1016/j.atherosclerosissup.2017.05.015DOI Listing
November 2017

Chronic kidney disease.

Nat Rev Dis Primers 2017 Nov 23;3:17088. Epub 2017 Nov 23.

Medizinische Klinik and Poliklinik IV, Klinikum der Ludwig Maximilians University (LMU) München - Innenstadt, Ziemssenstr. 1, 80336 München, Germany.

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http://dx.doi.org/10.1038/nrdp.2017.88DOI Listing
November 2017

Sympathomodulatory effects of sodium-glucose transporter-2 inhibitors in the kidneys and beyond.

J Hypertens 2017 10;35(10):1966-1967

aDepartment of Nephrology, University Medical Center, Utrecht, The Netherlands bDepartment of Medicine, Division of Nephrology, University Hospital, Wuerzburg, Germany cClinica Medica, Università Milano-Biocca dIRCCS Multimedica, Sesto San Giovanni, Milan, Italy.

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http://dx.doi.org/10.1097/HJH.0000000000001454DOI Listing
October 2017

α-Galactosidase A Genotype N215S Induces a Specific Cardiac Variant of Fabry Disease.

Circ Cardiovasc Genet 2017 Oct;10(5)

From the Department of Internal Medicine I and Comprehensive Heart Failure Center (CHFC) (D.O., D.L., K.H., T.S., J.M., K.L., G.E., C.W., P.N.), Fabry Center for Interdisciplinary Therapy (FAZIT) (D.O., D.L., K.H., N.Ü., T.S., J.M., C.S., G.E., C.W., P.N.), and Department of Neurology (N.Ü., C.S.), University Hospital Würzburg, Germany; West German Heart and Vascular Center Essen, University Hospital Essen, Germany (K.L.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (K.L.); Department of Molecular Pathology, University Hospital of Tübingen, Germany (R.K.); and Department of Cellular and Molecular Pathology, German Cancer Research Center (DKFZ), Heidelberg, Germany (H.-J.G.).

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https://www.ahajournals.org/doi/10.1161/CIRCGENETICS.116.001
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http://dx.doi.org/10.1161/CIRCGENETICS.116.001691DOI Listing
October 2017

The effect of empagliflozin on muscle sympathetic nerve activity in patients with type II diabetes mellitus.

J Am Soc Hypertens 2017 Sep 21;11(9):604-612. Epub 2017 Jul 21.

Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany.

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http://dx.doi.org/10.1016/j.jash.2017.07.005DOI Listing
September 2017

[Epidemiology of Chronic Kidney Disease - Ever More Patients?]

Dtsch Med Wochenschr 2017 Sep 29;142(17):1276-1281. Epub 2017 Aug 29.

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http://dx.doi.org/10.1055/s-0043-113464DOI Listing
September 2017

Soluble Urokinase Plasminogen Activator Receptor and Outcomes in Patients with Diabetes on Hemodialysis.

Clin J Am Soc Nephrol 2017 Aug 11;12(8):1265-1273. Epub 2017 May 11.

Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.

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http://dx.doi.org/10.2215/CJN.10881016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544516PMC
August 2017

A Janus-headed electrolyte and 'RALES' disease'.

ESC Heart Fail 2017 Aug 26;4(3):195-197. Epub 2017 Jun 26.

Divisions of Nephrology and Cardiology, 1st Department of Medicine, Comprehensive Heart Failure Centre (CHFC), Würzburg University Hospital, Würzburg, Germany.

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http://dx.doi.org/10.1002/ehf2.12173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542742PMC
August 2017

Uromodulin in the Bloodstream: Old Wine in a New Wineskin.

J Am Soc Nephrol 2017 07 7;28(7):1955-1957. Epub 2017 Jun 7.

Department of Internal Medicine I, Division of Nephrology, Würzburg University Hospital, Würzburg, Germany

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http://dx.doi.org/10.1681/ASN.2017040447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491303PMC
July 2017

EMPA-REG OUTCOME: The Nephrologist's Point of View.

Authors:
Christoph Wanner

Am J Cardiol 2017 07 30;120(1S):S59-S67. Epub 2017 May 30.

Department of Medicine, Division of Nephrology, Würzburg University Clinic, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.amjcard.2017.05.012DOI Listing
July 2017

EMPA-REG OUTCOME: The Nephrologist's Point of View.

Authors:
Christoph Wanner

Am J Med 2017 Jun 16;130(6S):S63-S72. Epub 2017 May 16.

Department of Medicine, Division of Nephrology, Würzburg University Clinic, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2017.04.007DOI Listing
June 2017

Empagliflozin and Cerebrovascular Events in Patients With Type 2 Diabetes Mellitus at High Cardiovascular Risk.

Stroke 2017 05 6;48(5):1218-1225. Epub 2017 Apr 6.

From the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada (B.Z.); Division of Endocrinology (B.Z.) and St Michael's Hospital, Division of Cardiology (D.F.), University of Toronto, Canada; Section of Endocrinology, Yale University School of Medicine, New Haven, CT (S.E.I.); The Biostatistics Center, The George Washington University, Rockville, MD (J.M.L.); Comprehensive Heart Failure Center and Renal Division, University of Wuerzburg and Hospital, Germany (C.W.); Boehringer Ingelheim Pharma GmbH and Co. KG, Ingelheim, Germany (S.K., M.M., H.J.W., U.C.B.); Boehringer Ingelheim Norway KS, Asker (O.E.J.); Department of Neurology and Neurological Sciences, Stanford Stroke Center, CA (G.W.A.); and Department of Neurology and Stroke Center, University Hospital Essen, Germany (H.C.D.).

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http://dx.doi.org/10.1161/STROKEAHA.116.015756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404404PMC
May 2017

[Chronic Kidney Disease].

Dtsch Med Wochenschr 2017 Feb 10;142(3):193-196. Epub 2017 Feb 10.

Medizinische Klink III, Nephrologische Abteilung, Klinikum Coburg.

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http://dx.doi.org/10.1055/s-0042-123170DOI Listing
February 2017