Christoph Schwarzer

Christoph Schwarzer

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Christoph Schwarzer

Publications by authors named "Christoph Schwarzer"

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Functional characterization of novel bumetanide derivatives for epilepsy treatment.

Neuropharmacology 2020 01 30;162:107754. Epub 2019 Aug 30.

Department of Pharmacology, Medical University of Innsbruck, Peter-Mayr-Str. 1a, 6020, Innsbruck, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2019.107754DOI Listing
January 2020

Impaired chloride homeostasis in epilepsy: Molecular basis, impact on treatment, and current treatment approaches.

Pharmacol Ther 2020 01 15;205:107422. Epub 2019 Oct 15.

Department of Pharmacology, Medical University of Innsbruck, Peter-Mayr-Str. 1a, 6020 Innsbruck, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2019.107422DOI Listing
January 2020

The Opioid System in Temporal Lobe Epilepsy: Functional Role and Therapeutic Potential.

Front Mol Neurosci 2017 7;10:245. Epub 2017 Aug 7.

Department of Pharmacology, Medical University of InnsbruckInnsbruck, Austria.

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http://journal.frontiersin.org/article/10.3389/fnmol.2017.00
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http://dx.doi.org/10.3389/fnmol.2017.00245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545604PMC
August 2017

Metallothioneins and renal ageing.

Nephrol Dial Transplant 2016 09 3;31(9):1444-52. Epub 2016 Feb 3.

Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.1093/ndt/gfv451DOI Listing
September 2016

Differential distribution of the sodium-activated potassium channels slick and slack in mouse brain.

J Comp Neurol 2016 07 15;524(10):2093-116. Epub 2015 Dec 15.

Department of Pharmacology, Medical University of Innsbruck, 6020, Innsbruck, Austria.

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http://doi.wiley.com/10.1002/cne.23934
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http://dx.doi.org/10.1002/cne.23934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982087PMC
July 2016

The G-protein biased partial κ opioid receptor agonist 6'-GNTI blocks hippocampal paroxysmal discharges without inducing aversion.

Br J Pharmacol 2016 06 21;173(11):1756-67. Epub 2016 Apr 21.

Department of Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1111/bph.13474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867738PMC
June 2016

Identification of potential novel interaction partners of the sodium-activated potassium channels Slick and Slack in mouse brain.

Biochem Biophys Rep 2015 Dec 9;4:291-298. Epub 2015 Oct 9.

Division of Molecular and Cellular Pharmacology, Medical University of Innsbruck, Peter-Mayr Str 1, Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.bbrep.2015.09.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669359PMC
December 2015

Differences in mitochondrial function in homogenated samples from healthy and epileptic specific brain tissues revealed by high-resolution respirometry.

Mitochondrion 2015 Nov 26;25:104-12. Epub 2015 Oct 26.

D. Swarovski Research Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, Anichstr. 35, 6020 Innsbruck, Austria; OROBOROS INSTRUMENTS, Schöpfstr. 18, 6020 Innsbruck, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2015.10.007DOI Listing
November 2015

STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neurons.

Mol Cell Neurosci 2015 Jul 20;67:104-15. Epub 2015 Jun 20.

University of Zagreb School of Medicine, Croatian Institute for Brain Research, Zagreb, Croatia. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2015.06.009DOI Listing
July 2015

A cycloartane glycoside derived from Actaea racemosa L. modulates GABAA receptors and induces pronounced sedation in mice.

J Pharmacol Exp Ther 2014 Nov 26;351(2):234-42. Epub 2014 Aug 26.

Department of Pharmacology and Toxicology, University of Vienna, Vienna, Austria (B.S., S.K., S.H.); Department of Pharmacology, Medical University Innsbruck, Innsbruck, Austria (I.K., C.S.); and Institute of Pharmacy/Pharmacognosy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, Austria (S.S.C., H.S.).

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http://dx.doi.org/10.1124/jpet.114.218024DOI Listing
November 2014

Reacquisition of cocaine conditioned place preference and its inhibition by previous social interaction preferentially affect D1-medium spiny neurons in the accumbens corridor.

Front Behav Neurosci 2014 24;8:317. Epub 2014 Sep 24.

Experimental Psychiatry Unit, Innsbruck Medical University Innsbruck, Austria ; Department of Psychology, Leopold-Franzens University of Innsbruck Innsbruck, Austria.

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http://dx.doi.org/10.3389/fnbeh.2014.00317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174134PMC
October 2014

Possible role of dynorphins in Alzheimer's disease and age-related cognitive deficits.

Neurodegener Dis 2014 22;13(2-3):82-5. Epub 2013 Aug 22.

Douglas Mental Health University Institute, McGill University, Montreal, Qué., Canada.

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http://dx.doi.org/10.1159/000353848DOI Listing
September 2014

GPER1 (GPR30) knockout mice display reduced anxiety and altered stress response in a sex and paradigm dependent manner.

Horm Behav 2014 Sep 16;66(4):628-36. Epub 2014 Sep 16.

Department of Pharmacology, Innsbruck Medical University, Peter-Mayr-Str. 1a, A-6020 Innsbruck, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.yhbeh.2014.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213071PMC
September 2014

Esters of valerenic acid as potential prodrugs.

Eur J Pharmacol 2014 Jul 27;735:123-31. Epub 2014 Mar 27.

Department of Pharmacology and Toxicology, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2014.03.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062961PMC
July 2014

Double deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice.

Neuropeptides 2014 Jun 14;48(3):143-51. Epub 2014 Mar 14.

Neuroscience Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia; School of Medical Sciences, University of NSW, Kensington, Sydney, NSW 2052, Australia; The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.npep.2014.03.001DOI Listing
June 2014

Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord.

Neuron 2014 May 10;82(3):573-86. Epub 2014 Apr 10.

Department of Neurobiology, University of Pittsburgh, 200 Lothrop St. Pittsburgh, PA 15213, USA; University of Pittsburgh Pain Center, University of Pittsburgh, 200 Lothrop St. Pittsburgh, PA 15213, USA; Department of Anesthesiology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.02.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022838PMC
May 2014

Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin.

Neuropsychopharmacology 2013 Jun 24;38(7):1296-307. Epub 2013 Jan 24.

Department of Physiology, School of Medicine-CIMUS-Instituto de Investigaciones Sanitarias (IDIS), CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), San Francisco s/n, Santiago de Compostela (A Coruña), University of Santiago de Compostela, Santiago de Compostela, Spain.

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http://dx.doi.org/10.1038/npp.2013.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656373PMC
June 2013

GABAA receptor modulation by piperine and a non-TRPV1 activating derivative.

Biochem Pharmacol 2013 Jun 25;85(12):1827-36. Epub 2013 Apr 25.

Department of Pharmacology and Toxicology, University of Vienna, Althanstraße 14, A-1090 Wien, Austria.

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http://dx.doi.org/10.1016/j.bcp.2013.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776227PMC
June 2013

Spatio-temporal expression of HOX genes in human hindgut development.

Dev Dyn 2013 Jan 19;242(1):53-66. Epub 2012 Nov 19.

Department of Anatomy, Histology and Embryology, Division of Clinical and Functional Anatomy, Innsbruck Medical University, Innsbruck, Austria.

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http://doi.wiley.com/10.1002/dvdy.23893
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http://dx.doi.org/10.1002/dvdy.23893DOI Listing
January 2013

The endogenous opioid dynorphin is required for normal bone homeostasis in mice.

Neuropeptides 2012 Dec 9;46(6):383-94. Epub 2012 Oct 9.

Neuroscience Research Program, Garvan Institute of Medical Research, 384 Victoria St., Darlinghurst, Sydney, NSW 2010, Australia.

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http://dx.doi.org/10.1016/j.npep.2012.08.010DOI Listing
December 2012

Role of tartrate-resistant acid phosphatase (TRAP) in long bone development.

Mech Dev 2012 Jul 8;129(5-8):162-76. Epub 2012 May 8.

Department of Anatomy, Histology and Embryology, Division of Clinical and Functional Anatomy, Innsbruck Medical University, A-6020 Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.mod.2012.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419267PMC
July 2012

Novel mutation in potassium channel related gene KCTD7 and progressive myoclonic epilepsy.

Ann Hum Genet 2012 Jul 21;76(4):326-31. Epub 2012 May 21.

Department of Medical Genetics, Molecular and Clinical Pharmacology, Division of Human Genetics, Medical University Innsbruck, Austria.

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http://dx.doi.org/10.1111/j.1469-1809.2012.00710.xDOI Listing
July 2012

Activation of the G-protein-coupled receptor GPR30 induces anxiogenic effects in mice, similar to oestradiol.

Psychopharmacology (Berl) 2012 Jun 7;221(3):527-35. Epub 2011 Dec 7.

Department of Pharmacology, Innsbruck Medical University, Peter-Mayr-Str. 1a, 6020, Innsbruck, Austria.

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http://dx.doi.org/10.1007/s00213-011-2599-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350630PMC
June 2012

Sprouty2 and -4 regulate axon outgrowth by hippocampal neurons.

Hippocampus 2012 Mar 14;22(3):434-41. Epub 2011 Jan 14.

Division of Neuroanatomy, Innsbruck Medical University, Muellerstrasse 59, A-6020 Innsbruck, Austria.

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http://dx.doi.org/10.1002/hipo.20910DOI Listing
March 2012

Kappa opioid receptor activation blocks progressive neurodegeneration after kainic acid injection.

Hippocampus 2011 Sep 1;21(9):1010-20. Epub 2010 Jun 1.

Department of Pharmacology, Innsbruck Medical University, A-6020 Innsbruck, Austria.

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http://dx.doi.org/10.1002/hipo.20813DOI Listing
September 2011

Efficient mRNA detection from human archival paraffin-embedded tissue: an update.

RNA 2010 Jul 24;16(7):1446. Epub 2010 May 24.

Department of Anatomy, Division of Clinical and Functional Anatomy, Innsbruck Medical University, 6020 Innsbruck, Austria.

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http://rnajournal.cshlp.org/cgi/doi/10.1261/rna.2216010
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http://dx.doi.org/10.1261/rna.2216010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885693PMC
July 2010

VEGF and its role in the early development of the long bone epiphysis.

J Anat 2010 May;216(5):611-24

Department of Anatomy, Histology and Embryology, Division of Clinical and Functional Anatomy, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1111/j.1469-7580.2010.01223.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871997PMC
May 2010

Lasp1 misexpression influences chondrocyte differentiation in the vertebral column.

Int J Dev Biol 2009 ;53(7):983-91

Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1387/ijdb.072435nhDOI Listing
October 2009

30 years of dynorphins--new insights on their functions in neuropsychiatric diseases.

Pharmacol Ther 2009 Sep 28;123(3):353-70. Epub 2009 May 28.

Department of Pharmacology, Innsbruck Medical University, Peter-Mayr-Str. 1a, A-6020 Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.pharmthera.2009.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872771PMC
September 2009

Breaking the seals: efficient mRNA detection from human archival paraffin-embedded tissue.

RNA 2009 Aug 23;15(8):1588-96. Epub 2009 Jun 23.

Division of Clinical and Functional Anatomy, Innsbruck Medical University, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.1261/rna.1278109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714753PMC
August 2009

Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone.

Neuropsychopharmacology 2009 Feb 17;34(3):775-85. Epub 2008 Sep 17.

Department of Pharmacology, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1038/npp.2008.142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873573PMC
February 2009

Epithelial and muscular regionalization of the human developing anorectum.

Anat Rec (Hoboken) 2007 Nov;290(11):1449-58

Department of Anatomy, Histology, and Embryology, Division of Clinical and Functional Anatomy, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1002/ar.20589DOI Listing
November 2007

Bone development in the femoral epiphysis of mice: the role of cartilage canals and the fate of resting chondrocytes.

Dev Dyn 2007 Aug;236(8):2077-88

Department of Anatomy, Histology and Embryology, Division of Clinical and Functional Anatomy, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1002/dvdy.21228DOI Listing
August 2007

Dynorphin knockout reduces fat mass and increases weight loss during fasting in mice.

Mol Endocrinol 2007 Jul 24;21(7):1722-35. Epub 2007 Apr 24.

Neuroscience Program, Garvan Institute of Medical Research, St. Vincent's Hospital, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia.

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http://dx.doi.org/10.1210/me.2006-0367DOI Listing
July 2007

Endogenous dynorphin in epileptogenesis and epilepsy: anticonvulsant net effect via kappa opioid receptors.

Brain 2007 Apr 8;130(Pt 4):1017-28. Epub 2007 Mar 8.

Department of Pharmacology, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1093/brain/awl384DOI Listing
April 2007

Identification and location of bone-forming cells within cartilage canals on their course into the secondary ossification centre.

J Anat 2006 Jun;208(6):695-707

Department of Anatomy, Histology and Embryology, Division of Clinical and Functional Anatomy, Medical University of Innsbruck, Austria.

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http://dx.doi.org/10.1111/j.1469-7580.2006.00578.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2100231PMC
June 2006

Distribution of prodynorphin mRNA and its interaction with the NPY system in the mouse brain.

Neuropeptides 2006 Apr 24;40(2):115-23. Epub 2006 Jan 24.

Neurobiology Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia.

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http://dx.doi.org/10.1016/j.npep.2005.11.006DOI Listing
April 2006

GABA and its receptors in epilepsy.

Adv Exp Med Biol 2004 ;548:92-103

Department of Pharmacology, University of Innsbruck, Austria.

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http://dx.doi.org/10.1007/978-1-4757-6376-8_7DOI Listing
August 2004

Y1 receptors regulate aggressive behavior by modulating serotonin pathways.

Proc Natl Acad Sci U S A 2004 Aug 16;101(34):12742-7. Epub 2004 Aug 16.

Neurobiology Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, Sydney NSW 2010, Australia.

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http://dx.doi.org/10.1073/pnas.0404085101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC515123PMC
August 2004

Synergistic effects of Y2 and Y4 receptors on adiposity and bone mass revealed in double knockout mice.

Mol Cell Biol 2003 Aug;23(15):5225-33

Neurobiology Program, Garvan Institute of Medical Research, St Vincent's Hospital, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC165708PMC
http://dx.doi.org/10.1128/mcb.23.15.5225-5233.2003DOI Listing
August 2003

Y2 receptor deletion attenuates the type 2 diabetic syndrome of ob/ob mice.

Diabetes 2002 Dec;51(12):3420-7

Neurobiology Program, Garvan Institute of Medical Research, St. Vincent's Hospital, 384 Victoria Street, Darlinghurst NSW 2010, Sydney, Australia.

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http://dx.doi.org/10.2337/diabetes.51.12.3420DOI Listing
December 2002

Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice.

Proc Natl Acad Sci U S A 2002 Jun 18;99(13):8938-43. Epub 2002 Jun 18.

Neurobiology Program, Garvan Institute of Medical Research, St. Vincent's Hospital, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia.

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http://dx.doi.org/10.1073/pnas.132043299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC124402PMC
June 2002

Y4 receptor knockout rescues fertility in ob/ob mice.

Genes Dev 2002 May;16(9):1077-88

Neurobiology Research Program, Garvan Institute of Medical Research, St. Vincent's Hospital, Darlinghurst, Sydney NSW 2010, Australia.

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http://dx.doi.org/10.1101/gad.979102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC186243PMC
May 2002