Publications by authors named "Christoph Schaniel"

41Publications

Limited Mitochondrial Activity Coupled With Strong Expression of CD34, CD90 and EPCR Determines the Functional Fitness of Expanded Human Hematopoietic Stem Cells.

Front Cell Dev Biol 2020 15;8:592348. Epub 2020 Dec 15.

Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

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December 2020

Ex Vivo Expansion of Adult Hematopoietic Stem and Progenitor Cells with Valproic Acid.

Methods Mol Biol 2021 ;2185:267-280

Division of Hematology/Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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January 2021

A human H1-HBB11-GFP reporter embryonic stem cell line (WAe001-A-2) generated using TALEN-based genome editing.

Stem Cell Res 2020 05 6;45:101837. Epub 2020 May 6.

Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Cellular, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

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May 2020

Induction of developmental hematopoiesis mediated by transcription factors and the hematopoietic microenvironment.

Ann N Y Acad Sci 2020 04 17;1466(1):59-72. Epub 2019 Oct 17.

Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York City, New York.

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April 2020

Genomic Integrity Safeguards Self-Renewal in Embryonic Stem Cells.

Cell Rep 2019 08;28(6):1400-1409.e4

Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA; Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Electronic address:

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August 2019

Oncogenic role of SFRP2 in p53-mutant osteosarcoma development via autocrine and paracrine mechanism.

Proc Natl Acad Sci U S A 2018 11 1;115(47):E11128-E11137. Epub 2018 Nov 1.

Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;

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November 2018

Modeling Hematological Diseases and Cancer With Patient-Specific Induced Pluripotent Stem Cells.

Front Immunol 2018 28;9:2243. Epub 2018 Sep 28.

Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

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October 2019

A Marfan syndrome human induced pluripotent stem cell line with a heterozygous FBN1 c.4082G>A mutation, ISMMSi002-B, for disease modeling.

Stem Cell Res 2017 08 3;23:73-76. Epub 2017 Jul 3.

Black Family Stem Cell Institute, 1 Gustave L. Levy Place, Box 1496, New York, NY 10029, United States; Department of Pharmacological Sciences, 1 Gustave L. Levy Place, Box 1496, New York, NY 10029, United States; Graduate School of Biomedical Sciences, 1 Gustave L. Levy Place, Box 1496, New York, NY 10029, United States; Department of Cell, Developmental and Regenerative Biology, 1 Gustave L. Levy Place, Box 1496, New York, NY 10029, United States; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1496, New York, NY 10029, United States. Electronic address:

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August 2017

A human MIXL1 green fluorescent protein reporter embryonic stem cell line engineered using TALEN-based genome editing.

Stem Cell Res 2016 07 26;17(1):93-96. Epub 2016 May 26.

Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1496, New York, NY 10029, United States; Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1496, New York, NY 10029, United States; Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1496, New York, NY 10029, United States; Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1496, New York, NY 10029, United States. Electronic address:

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July 2016

Genomic imprinting defect in Zfp57 mutant iPS cell lines.

Stem Cell Res 2016 Mar 21;16(2):259-63. Epub 2016 Jan 21.

Black Family Stem Cell Institute, Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Department of Oncological Sciences, Graduate School of Biological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

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March 2016

Hematopoietic Reprogramming In Vitro Informs In Vivo Identification of Hemogenic Precursors to Definitive Hematopoietic Stem Cells.

Dev Cell 2016 Mar;36(5):525-39

Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1496, New York, NY 10029, USA; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1496, New York, NY 10029, USA. Electronic address:

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March 2016

Myeloid Dysregulation in a Human Induced Pluripotent Stem Cell Model of PTPN11-Associated Juvenile Myelomonocytic Leukemia.

Cell Rep 2015 Oct 8;13(3):504-515. Epub 2015 Oct 8.

The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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October 2015

Tbx3 Controls Dppa3 Levels and Exit from Pluripotency toward Mesoderm.

Stem Cell Reports 2015 Jul 18;5(1):97-110. Epub 2015 Jun 18.

Developmental and Regenerative Biology, The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Graduate School, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Pharmacology and System Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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July 2015

Modeling familial cancer with induced pluripotent stem cells.

Cell 2015 Apr;161(2):240-54

Department of Developmental and Regenerative Biology and The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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April 2015

Biology and mechano-response of tendon cells: Progress overview and perspectives.

J Orthop Res 2015 Jun 28;33(6):785-92. Epub 2015 Apr 28.

Department of Orthopaedic Surgery, Albert Einstein College of Medicine, Bronx, New York; Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York.

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June 2015

A genome-wide RNAi screen identifies opposing functions of Snai1 and Snai2 on the Nanog dependency in reprogramming.

Mol Cell 2014 Oct 15;56(1):140-52. Epub 2014 Sep 15.

The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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October 2014

Divisional history and hematopoietic stem cell function during homeostasis.

Stem Cell Reports 2014 Apr 20;2(4):473-90. Epub 2014 Mar 20.

Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1496, New York, NY 10029, USA ; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1496, New York, NY 10029, USA.

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April 2014

Induction of a hemogenic program in mouse fibroblasts.

Cell Stem Cell 2013 Aug 13;13(2):205-18. Epub 2013 Jun 13.

Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1496, New York, NY 10029, USA.

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August 2013

Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming.

Proc Natl Acad Sci U S A 2012 Oct 17;109(40):16202-7. Epub 2012 Sep 17.

Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, and The Graduate School of Biological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA.

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October 2012

Combining competition assays with genetic complementation strategies to dissect mouse embryonic stem cell self-renewal and pluripotency.

Nat Protoc 2012 Mar 22;7(4):729-48. Epub 2012 Mar 22.

Department of Developmental and Regenerative Biology, The Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, New York, USA.

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March 2012

Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells.

Blood 2011 Sep 7;118(9):2420-9. Epub 2011 Jun 7.

Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY, USA.

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September 2011

Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells.

Nat Biotechnol 2011 Mar 27;29(3):267-72. Epub 2011 Feb 27.

Department of Gene and Cell Medicine and Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, New York, USA.

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March 2011

Toward a complete in silico, multi-layered embryonic stem cell regulatory network.

Wiley Interdiscip Rev Syst Biol Med 2010 Nov-Dec;2(6):708-33

Department of Gene and Cell Medicine and The Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.

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January 2011

Exploration of self-renewal and pluripotency in ES cells using RNAi.

Methods Enzymol 2010 ;477:351-65

Department of Gene and Cell Medicine, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, USA.

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December 2010

Genetic models to study quiescent stem cells and their niches.

Ann N Y Acad Sci 2009 Sep;1176:26-35

Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.

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September 2009

Delivery of short hairpin RNAs--triggers of gene silencing--into mouse embryonic stem cells.

Nat Methods 2006 May;3(5):397-400

Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.

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May 2006

Stability and plasticity of wild-type and Pax5-deficient precursor B cells.

Immunol Rev 2002 Sep;187:87-95

Division of Immunology, Pharmazentrum, University of Basel, Klingelbergstrasse 50, CH-4056 Basel/Switzerland.

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September 2002

A stem cell molecular signature.

Science 2002 Oct 12;298(5593):601-4. Epub 2002 Sep 12.

Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

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October 2002

Plasticity of Pax-5(-/-) pre-B I cells.

Cells Tissues Organs 2002 ;171(1):38-43

Basel Institute for Immunology, Basel, Switzerland.

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January 2003

In vitro and in vivo plasticity of Pax5-deficient pre-B I cells.

Immunol Lett 2002 Jun;82(1-2):35-40

Basel Institute for Immunology, Basel, Switzerland.

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June 2002

A new paradigm for the closed-loop intraoperative administration of analgesics in humans.

IEEE Trans Biomed Eng 2002 Apr;49(4):289-99

Automatic Control Laboratory, Swiss Federal Institute of Technology (ETH) Zentrum, Zürich.

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April 2002