Christoph Sarrazin

Christoph Sarrazin

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Christoph Sarrazin

Publications by authors named "Christoph Sarrazin"

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Elimination of hepatitis C virus has limited impact on the functional and mitochondrial impairment of HCV-specific CD8+ T cell responses.

J Hepatol 2019 Nov 8;71(5):889-899. Epub 2019 Jul 8.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; German Centre for Infection Research, Hannover, Germany (DZIF), Partner-site Hannover-Braunschweig, Germany; Department of Gastroenterology and Hepatology, Essen University Hospital, Essen, Germany; Integrated Research and Treatment Centre Transplantation (IFB-Tx), Hannover Medical School, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2019.06.025DOI Listing
November 2019

Efficacy of Retreatment After Failed Direct-acting Antiviral Therapy in Patients With HCV Genotype 1-3 Infections.

Clin Gastroenterol Hepatol 2019 Nov 6. Epub 2019 Nov 6.

Department of Internal Medicine 1, University Hospital Frankfurt, Frankfurt, Germany; German Center for Infection Research (DZIF), External Partner Site Frankfurt, Germany; Medizinische Klinik 2, St. Josefs-Hospital, Wiesbaden, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2019.10.051DOI Listing
November 2019

Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants.

Hepatology 2019 Sep 5;70(3):771-787. Epub 2019 Jun 5.

Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1002/hep.30647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772116PMC
September 2019

Risk factors for resistance development against lamivudine during long-term treatment of chronic hepatitis B virus infections.

Eur J Gastroenterol Hepatol 2019 Jul;31(7):845-852

Section of Hepatology, Department of Gastroenterology and Rheumatology, University Hospital Leipzig, Leipzig.

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http://dx.doi.org/10.1097/MEG.0000000000001351DOI Listing
July 2019

SEC14L2, a lipid-binding protein, regulates HCV replication in culture with inter- and intra-genotype variations.

J Hepatol 2019 Apr 23;70(4):603-614. Epub 2018 Nov 23.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; Institute of Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; German Center for Infection Research, DZIF, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2018.11.012DOI Listing
April 2019

The 'Disappearing' Liver on CEUS: Nothing to Worry About.

Ultrasound Int Open 2019 Mar 26;5(2):E78-E79. Epub 2019 Sep 26.

Department of Internal Medicine II, St. Josefs-Hospital, Wiesbaden, Germany.

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http://dx.doi.org/10.1055/a-1005-7459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763500PMC
March 2019

Key role of renal biopsy in management of progressive chronic kidney disease in liver graft recipients.

J Nephrol 2019 Feb 26;32(1):129-137. Epub 2018 Jun 26.

Medizinische Klinik III, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1007/s40620-018-0506-2DOI Listing
February 2019

Absence of HBV Reactivation in Patients With Resolved HBV Infection Following DAA Therapy for Hepatitis C: A 1-Year Follow-up Study.

Open Forum Infect Dis 2019 Jan 15;6(1):ofy340. Epub 2018 Dec 15.

Department of Internal Medicine, University Hospital Frankfurt, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1093/ofid/ofy340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329904PMC
January 2019

Differential modulation of hepatitis C virus replication and innate immune pathways by synthetic calcitriol-analogs.

J Steroid Biochem Mol Biol 2018 10 7;183:142-151. Epub 2018 Jun 7.

Department of Medicine 1, J.W. Goethe University Hospital, D-60590, Frankfurt a.M., Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2018.06.008DOI Listing
October 2018

Treatment of chronic hepatitis C.

J Hepatol 2018 08 8;69(2):544-546. Epub 2018 Jun 8.

Christoph Sarrazin, Department of Internal Medicine and Livercenter, St. Josefs-Hospital Wiesbaden and Viral Hepatitis Research Group, Goethe-University Hospital Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.jhep.2018.04.011DOI Listing
August 2018

Application of Hemoadsorption in a Case of Liver Cirrhosis and Alcohol-Related Steatohepatitis with Preexisting Hepatitis C Infection.

Blood Purif 2017 25;44(1):30-31. Epub 2017 Feb 25.

Department of Nephrology, Medical Clinic III, University Hospital Frankfurt, Frankfurt, Germany.

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http://dx.doi.org/10.1159/000455064DOI Listing
July 2018

Interferon-free treatment choice according to baseline RASs leads to high SVR rates in HCV genotype 1 infected patients.

J Infect Chemother 2018 Jul 5;24(7):524-530. Epub 2018 Apr 5.

University Hospital Frankfurt, Department of Gastroenterology and Hepatology, 60590 Frankfurt, Germany; St. Josefs Hospital, Department of Gastroenterology, 65189 Wiesbaden, Germany.

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http://dx.doi.org/10.1016/j.jiac.2018.02.008DOI Listing
July 2018

S3-Leitlinie „Prophylaxe, Diagnostik und Therapie der Hepatitis-C-Virus (HCV) -Infektion“.

Z Gastroenterol 2018 07 9;56(7):e53-e115. Epub 2018 Jul 9.

Medizinische Klinik 1, Universitätsklinikum Frankfurt am Main.

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http://dx.doi.org/10.1055/a-0598-5242DOI Listing
July 2018

Risk of de novo Hepatocellular Carcinoma after HCV Treatment with Direct-Acting Antivirals.

Liver Cancer 2018 May 1;7(2):190-204. Epub 2018 Mar 1.

Schwerpunkt Gastroenterologie und Hepatologie, Medizinische Klinik 1, Universitätsklinikum Frankfurt, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1159/000486812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985411PMC
May 2018

Patterns of Resistance-Associated Substitutions in Patients With Chronic HCV Infection Following Treatment With Direct-Acting Antivirals.

Gastroenterology 2018 03 13;154(4):976-988.e4. Epub 2017 Nov 13.

Department of Internal Medicine 1, University Hospital Frankfurt, Frankfurt, Germany, German Center for Infection Research (DZIF), External Partner Site Frankfurt, Germany; Medizinische Klinik II, St. Josefs-Hospital, Wiesbaden, Germany. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.11.007DOI Listing
March 2018

Origin, prevalence and response to therapy of hepatitis C virus genotype 2k/1b chimeras.

J Hepatol 2017 10 13;67(4):680-686. Epub 2017 Jun 13.

Goethe-University Hospital, Medical Clinic 1, Frankfurt, Germany; St. Josefs-Hospital, Medical Clinic 2, Wiesbaden, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.05.027DOI Listing
October 2017

Predictive Value of Computed Tomography Scans and Clinical Findings for the Need of Endoscopic Necrosectomy in Walled-off Necrosis From Pancreatitis.

Pancreas 2017 09;46(8):1039-1045

From the *Medizinische Klinik 1, Universitätsklinikum Frankfurt, Goethe-Universität; †Institut für diagnostische und interventionelle Radiologie, Goethe-Universität, Frankfurt/Main; ‡Zentrum 4, Institut für Radiologie, Alb-Fils Kliniken, Göppingen; and §Gastroenterologie, Robert-Bosch-Krankenhaus, Stuttgart, Germany.

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http://dx.doi.org/10.1097/MPA.0000000000000881DOI Listing
September 2017

Scavenger receptor class B member 1 (SCARB1) variants modulate hepatitis C virus replication cycle and viral load.

J Hepatol 2017 08 29;67(2):237-245. Epub 2017 Mar 29.

Department of Gastroenterology, Hepatology und Endocrinology, Hannover Medical School, Hannover, Germany; German Center for Infection Research (DZIF), Hannover-Braunschweig Site, Germany; Institute for Molecular Biology, Hannover Medical School, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.03.020DOI Listing
August 2017

Conversion From Sirolimus to Everolimus in Long-Term Liver Graft Recipients.

J Clin Pharmacol 2017 07 30;57(7):837-845. Epub 2017 Jan 30.

Medizinische Klinik 1, Universitätsklinikum Frankfurt, Frankfurt, Germany.

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http://dx.doi.org/10.1002/jcph.871DOI Listing
July 2017

HCV core antigen as an alternate test to HCV RNA for assessment of virologic responses to all-oral, interferon-free treatment in HCV genotype 1 infected patients.

J Virol Methods 2017 07 27;245:14-18. Epub 2017 Mar 27.

National Reference Center for Viral Hepatitis B C and D Department of Virology Hôpital Henri Mondor Université Paris-Est and INSERM U955, Créteil, France.

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http://dx.doi.org/10.1016/j.jviromet.2017.03.002DOI Listing
July 2017

High prevalence of antibodies to core+1/ARF protein in HCV-infected patients with advanced cirrhosis.

J Gen Virol 2017 Jul 15;98(7):1713-1719. Epub 2017 Jul 15.

Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece.

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http://dx.doi.org/10.1099/jgv.0.000851DOI Listing
July 2017

Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis.

Gastroenterology 2017 06 6;152(8):1975-1984.e8. Epub 2017 Mar 6.

Norwegian PSC Research Center and Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.02.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546611PMC
June 2017

Hepatitis C "true" late relapse beyond 48weeks of sustained virologic response after direct acting antiviral therapy.

J Hepatol 2017 04 9;66(4):862-863. Epub 2017 Jan 9.

Department of Internal Medicine I, University of Tübingen, Tübingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.01.002DOI Listing
April 2017

Reply to: "HCV RNA kinetics on-treatment do not predict sustained virologic response in HCV genotype 3 patients receiving sofosbuvir and ribavirin".

J Hepatol 2016 11 25;65(5):1059-1060. Epub 2016 Jul 25.

Department of Medicine 1, University Hospital Frankfurt, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.jhep.2016.07.018DOI Listing
November 2016

Reply.

Hepatology 2016 10 15;64(4):1378-9. Epub 2016 Apr 15.

J. W. Goethe University, Department of Gastroenterology and Hepatology, Frankfurt, Germany.

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http://dx.doi.org/10.1002/hep.28536DOI Listing
October 2016

Direct retrograde cholangioscopy with a new prototype double-bending cholangioscope.

Endoscopy 2016 Oct 19;48(10):929-33. Epub 2016 Jul 19.

Medizinische Klinik I, University Hospital Frankfurt, Frankfurt, Germany.

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http://dx.doi.org/10.1055/s-0042-110395DOI Listing
October 2016

Complete Response of Hepatocellular Carcinoma in a Patient With End-stage Liver Disease treated With Nivolumab: Whishful thinking or Possible?

Am J Gastroenterol 2016 Aug;111(8):1208-9

Division of Gastroenterology, Department of Internal Medicine, Goethe University Hospital, Frankfurt, Germany.

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http://dx.doi.org/10.1038/ajg.2016.214DOI Listing
August 2016

Persistence of HCV in Acutely-Infected Patients Depletes C24-Ceramide and Upregulates Sphingosine and Sphinganine Serum Levels.

Int J Mol Sci 2016 Jun 13;17(6). Epub 2016 Jun 13.

Pharmazentrum Frankfurt, Institut für Allgemeine Pharmakologie, Goethe University Hospital, Frankfurt am Main, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.3390/ijms17060922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926455PMC
June 2016

Lactic acidosis in patients with hepatitis C virus cirrhosis and combined ribavirin/sofosbuvir treatment.

J Hepatol 2016 Apr 30;64(4):790-9. Epub 2015 Nov 30.

Medizinische Klinik 1, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.jhep.2015.11.034DOI Listing
April 2016

Management of HCV-Associated Liver Cirrhosis.

Visc Med 2016 Apr 8;32(2):96-104. Epub 2016 Apr 8.

Medizinische Klinik 1, Universitätsklinikum Frankfurt, Frankfurt/M., Germany.

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http://dx.doi.org/10.1159/000445330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926885PMC
April 2016

The importance of resistance to direct antiviral drugs in HCV infection in clinical practice.

J Hepatol 2016 Feb 26;64(2):486-504. Epub 2015 Sep 26.

J. W. Goethe-University Hospital, Medizinische Klinik 1, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.09.011DOI Listing
February 2016

Relationship between vitamin D status and response to hepatitis C virus therapy.

Hepatology 2015 Nov 22;62(5):1642-3. Epub 2015 Apr 22.

Department of Gastroenterology, Alfred Hospital, Prahran, Victoria, Australia.

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http://dx.doi.org/10.1002/hep.27797DOI Listing
November 2015

[Costs of modern treatment of chronic hepatitis C].

Med Monatsschr Pharm 2015 Sep;38(9):347-9

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September 2015

No Distal Migration in Unfixed Versus Fixed Cell Structure Covered Self-Expanding Metal Stents for Treatment of Benign Biliary Disease.

Dig Dis Sci 2015 Aug 14;60(8):2495-501. Epub 2015 Apr 14.

Department of Internal Medicine I, Johann Wolfgang Goethe-University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany,

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http://dx.doi.org/10.1007/s10620-015-3656-2DOI Listing
August 2015

Reply to: "Evidence supporting a beneficial role of vitamin D in chronic hepatitis C".

J Hepatol 2015 Aug 18;63(2):531-2. Epub 2015 Apr 18.

The Alfred Hospital, Department of Hepatology, Melbourne, Victoria 3004, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.04.012DOI Listing
August 2015

Oxidized Low-Density Lipoprotein Is a Novel Predictor of Interferon Responsiveness in Chronic Hepatitis C Infection.

Cell Mol Gastroenterol Hepatol 2015 May 14;1(3):285-294.e1. Epub 2015 Mar 14.

Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany; German Center for Infection Research (DZIF), Hannover, Germany; Institute for Molecular Biology, Medizinische Hochschule Hannover, Hannover, Germany.

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http://dx.doi.org/10.1016/j.jcmgh.2015.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301270PMC
May 2015

Intracellular accumulation of subviral HBsAg particles and diminished Nrf2 activation in HBV genotype G expressing cells lead to an increased ROI level.

J Hepatol 2015 Apr 28;62(4):791-8. Epub 2014 Nov 28.

Paul Ehrlich Institut, Division of Virology, D-63325 Langen, Germany; DZIF, German Center for Infection Research, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2014.11.028DOI Listing
April 2015

Variations in serum sphingolipid levels associate with liver fibrosis progression and poor treatment outcome in hepatitis C virus but not hepatitis B virus infection.

Hepatology 2015 Mar 28;61(3):812-22. Epub 2015 Jan 28.

Pharmazentrum Frankfurt, Institut für Allgemeine Pharmakologie und Toxikologie, Frankfurt am Main, Germany; Goethe University Hospital, Medizinische Klinik 1, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1002/hep.27587DOI Listing
March 2015

A heterogeneous hierarchy of co-regulatory receptors regulates exhaustion of HCV-specific CD8 T cells in patients with chronic hepatitis C.

J Hepatol 2015 Jan 15;62(1):31-40. Epub 2014 Aug 15.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2014.08.008DOI Listing
January 2015

Vitamin D level and sustained virologic response to interferon-based antiviral therapy in chronic hepatitis C: a systematic review and meta-analysis.

J Hepatol 2014 Dec 15;61(6):1247-52. Epub 2014 Aug 15.

Department of Gastroenterology, Alfred Hospital, Melbourne, Australia; Department of Gastroenterology, Monash University, Melbourne, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278140054
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http://dx.doi.org/10.1016/j.jhep.2014.08.004DOI Listing
December 2014

Role of telaprevir plasma levels for predicting response to antiviral therapy in patients with hepatitis C virus genotype 1 infection.

Scand J Gastroenterol 2014 Dec 11;49(12):1473-9. Epub 2014 Nov 11.

Medizinische Klinik 1, Universitätsklinikum Frankfurt , Theodor-Stern-Kai 7, 60590 Frankfurt am Main , Germany.

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http://dx.doi.org/10.3109/00365521.2014.978363DOI Listing
December 2014