Christoph Laske

Christoph Laske

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Christoph Laske

Christoph Laske

Publications by authors named "Christoph Laske"

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Early Detection of Alzheimer's Disease Based on the Patient's Creative Drawing Process: First Results with a Novel Neuropsychological Testing Method.

J Alzheimers Dis 2018 ;63(2):675-687

Institute for Research and Development in the Art Therapies Nürtingen-Geislingen University, Nürtingen, Germany.

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http://dx.doi.org/10.3233/JAD-170946DOI Listing
June 2019

Combining electrical stimulation and cognitive control training to reduce concerns about subjective cognitive decline.

Brain Stimul 2019 Jul - Aug;12(4):1083-1085. Epub 2019 Apr 24.

University Hospital Tübingen, Department of Psychiatry and Psychotherapy, Neurophysiology & Interventional Neuropsychiatry, Calwerstrasse 14, 72076, Tübingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2019.04.008DOI Listing
April 2019

The BDNF SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease.

Mol Psychiatry 2019 Mar 21. Epub 2019 Mar 21.

Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.

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http://dx.doi.org/10.1038/s41380-019-0404-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754794PMC
March 2019

Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease.

Alzheimers Dement 2018 11 25;14(11):1427-1437. Epub 2018 Sep 25.

Section for Dementia Research, Department of Cellular Neurology, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.

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http://dx.doi.org/10.1016/j.jalz.2018.06.3059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322213PMC
November 2018

Editorial:Advanced Methods of Biomedical Signal Processing for Early Detection of Alzheimer's Disease.

Curr Alzheimer Res 2017 ;14(9):914-915

Section for Dementia Research Department of Cellular Neurology Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy University of Tuebingen 72076 Tuebingen. Germany.

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http://dx.doi.org/10.2174/156720501409170822113104DOI Listing
October 2018

Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer's Disease Dementia in Individuals With Mild Cognitive Impairment.

Biol Psychiatry 2018 03 27;83(5):447-455. Epub 2017 Mar 27.

Paris Institute of Translational Neurosciences IHU-A-ICM, Pitié-Salpêtrière University Hospital; AXA Research Fund & Université Pierre et Marie Curie Chair, Sorbonne Universités, Université Pierre et Marie Curie Paris 06, Inserm, CNRS, Institut du Cerveau et de la Moelle; Département de Neurologie, Institut de la Mémoire et de la Maladie d'Alzheimer, Hôpital Pitié-Salpêtrière, Paris, France.

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http://dx.doi.org/10.1016/j.biopsych.2017.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656540PMC
March 2018

Diagnostic Value of a Tablet-Based Drawing Task for Discrimination of Patients in the Early Course of Alzheimer's Disease from Healthy Individuals.

J Alzheimers Dis 2017 ;55(4):1463-1469

German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.

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http://dx.doi.org/10.3233/JAD-160921DOI Listing
February 2018

Structural Ultrasound of the Medial Temporal Lobe in Alzheimer's Disease.

Ultraschall Med 2017 Jun 7;38(3):294-300. Epub 2016 Jun 7.

Department of Neurodegeneration, Hertie Institute for Clinical Brain Research (HIH), University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1055/s-0042-107150DOI Listing
June 2017

Cerebral Glucose Metabolism is Associated with Verbal but not Visual Memory Performance in Community-Dwelling Older Adults.

J Alzheimers Dis 2016 03;52(2):661-72

Centre of Excellence for Alzheimer's disease Research & Care, School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.

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http://dx.doi.org/10.3233/JAD-151084DOI Listing
March 2016

Platelets as potential link between diabetes and Alzheimer's disease.

Curr Alzheimer Res 2014 ;11(9):862-8

Department of Psychiatry and Psychotherapy, University Hospital of Tubingen, Calwer Street 14, 72076 Tubingen, Germany.

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July 2015

Increased cerebrospinal fluid calpain activity and microparticle levels in Alzheimer's disease.

Alzheimers Dement 2015 May 4;11(5):465-74. Epub 2014 Sep 4.

Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.jalz.2014.06.003DOI Listing
May 2015

Innovative diagnostic tools for early detection of Alzheimer's disease.

Alzheimers Dement 2015 May 15;11(5):561-78. Epub 2014 Nov 15.

Department of Internal Medicine & Institute for Aging and Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA.

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http://dx.doi.org/10.1016/j.jalz.2014.06.004DOI Listing
May 2015

Amyloid-beta (1-40) and the risk of death from cardiovascular causes in patients with coronary heart disease.

J Am Coll Cardiol 2015 Mar;65(9):904-16

Institute of Cardiovascular Regeneration, Centre of Molecular Medicine, J.W. Goethe University Frankfurt, Frankfurt am Main, Germany; Department of Cardiology, J.W. Goethe University Frankfurt, Frankfurt am Main, Germany; German Center of Cardiovascular Research, Frankfurt, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2014.12.035DOI Listing
March 2015

Increased myeloperoxidase plasma levels in patients with Alzheimer's disease.

J Alzheimers Dis 2014 ;39(3):557-64

Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany Section for Dementia Research, Hertie-Institute of Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany.

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http://dx.doi.org/10.3233/JAD-131469DOI Listing
October 2014

Phase 3 trials of solanezumab and bapineuzumab for Alzheimer's disease.

Authors:
Christoph Laske

N Engl J Med 2014 04;370(15):1459

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http://dx.doi.org/10.1056/NEJMc1402193DOI Listing
April 2014

Association of platelet activation with vascular cognitive impairment: implications in dementia development?

Curr Vasc Pharmacol 2014 Jan;12(1):152-4

Department of Internal Medicine III - Cardiology and Molecular Cardiology, Goethe University of Frankfurt, Theodor-Ster-Kai 7, Frankfurt/Main D-60590, Germany.

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January 2014

Dysregulation of neurotrophic and haematopoietic growth factors in Alzheimer's disease: from pathophysiology to novel treatment strategies.

Curr Alzheimer Res 2014 Jan;11(1):27-39

Department of Psychiatry and Psychotherapy, University of Tubingen, Calwer Street 14, D-72076 Tubingen, Germany.

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January 2014

Vascular pathophysiology of Alzheimer's disease.

Curr Alzheimer Res 2014 Jan;11(1):1-3

Department of Psychiatry and Psychotherapy, University of Tubingen, Calwer Street 14, D-72076 Tubingen, Germany.

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January 2014

Immune profiling in blood identifies sTNF-R1 performing comparably well as biomarker panels for classification of Alzheimer's disease patients.

J Alzheimers Dis 2013 ;34(2):367-75

Section for Dementia Research, Hertie-Institute of Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Germany.

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http://dx.doi.org/10.3233/JAD-121558DOI Listing
October 2013

Biomarkers in Alzheimer's disease and lewy body disorders with dementia.

Int J Alzheimers Dis 2013 9;2013:473181. Epub 2013 Jan 9.

Department of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Calwer Str. 14, 72076 Tuebingen, Germany.

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http://dx.doi.org/10.1155/2013/473181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556405PMC
February 2013

Blood-based biomarkers in Alzheimer disease: where are we now and where have we to go?

Authors:
Christoph Laske

JAMA Neurol 2013 Jan;70(1):133

Section for Dementia Research, Hertie Institute for Clinical Brain Research, Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1001/2013.jamaneurol.67DOI Listing
January 2013

Clinical and biomarker changes in Alzheimer's disease.

Authors:
Christoph Laske

N Engl J Med 2012 11;367(21):2050; author reply 2051-2

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http://dx.doi.org/10.1056/NEJMc1211767DOI Listing
November 2012

Alzheimer disease: blood-based biomarkers in AD--a silver lining on the horizon.

Authors:
Christoph Laske

Nat Rev Neurol 2012 Oct 14;8(10):541-2. Epub 2012 Aug 14.

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http://dx.doi.org/10.1038/nrneurol.2012.173DOI Listing
October 2012

Elevated angiopoietin-1 serum levels in patients with Alzheimer's disease.

Int J Alzheimers Dis 2012 10;2012:324016. Epub 2012 Oct 10.

Department of Psychiatry and Psychotherapy, University of Tübingen, 72076 Tuebingen, Germany.

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http://dx.doi.org/10.1155/2012/324016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474986PMC
October 2012

Platelet activation in Alzheimer's disease: from pathophysiology to clinical value.

Curr Vasc Pharmacol 2012 Sep;10(5):626-30

Department of Psychiatry and Psychotherapy, University of Tübingen, Calwer-Str. 14, D-72076 Tübingen, Germany.

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September 2012

Amyloid-β peptides in plasma and cognitive decline after 1 year follow-up in Alzheimer's disease patients.

J Alzheimers Dis 2010 ;21(4):1263-9

Department of Psychiatry and Psychotherapy Eberhard-Karls Universität Tübingen, Tübingen, Germany.

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January 2012

Decreased α-synuclein serum levels in patients with Lewy body dementia compared to Alzheimer's disease patients and control subjects.

Dement Geriatr Cogn Disord 2011 13;31(6):413-6. Epub 2011 Jul 13.

Department of Psychiatry and Psychotherapy, University of Tübingen, Osianderstrasse 24, Tübingen, Germany.

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http://dx.doi.org/10.1159/000329763DOI Listing
December 2011

Influence of lithium treatment on GDNF serum and CSF concentrations in patients with early Alzheimer's disease.

Curr Alzheimer Res 2011 Dec;8(8):853-9

Depatment of Anesthesiology and Intensive Care, University of Tübingen, Germany.

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December 2011

Identification of a blood-based biomarker panel for classification of Alzheimer's disease.

Int J Neuropsychopharmacol 2011 Oct 5;14(9):1147-55. Epub 2011 Apr 5.

Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1017/S1461145711000459DOI Listing
October 2011

Adipocytokines and CD34 progenitor cells in Alzheimer's disease.

PLoS One 2011 25;6(5):e20286. Epub 2011 May 25.

Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard-Karls-Universität Tübingen, Tübingen, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020286PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102092PMC
September 2011

Blood-based biomarkers in Alzheimer disease.

Authors:
Christoph Laske

Arch Neurol 2011 May;68(5):685-6; author reply 686

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http://dx.doi.org/10.1001/archneurol.2011.78DOI Listing
May 2011

Higher BDNF serum levels predict slower cognitive decline in Alzheimer's disease patients.

Int J Neuropsychopharmacol 2011 Apr 22;14(3):399-404. Epub 2010 Sep 22.

Department of Psychiatry and Psychotherapy, Eberhard-Karls Universität Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1017/S1461145710001008DOI Listing
April 2011

Predictive value of platelet activation for the rate of cognitive decline in Alzheimer's disease patients.

J Cereb Blood Flow Metab 2010 Nov 18;30(11):1817-20. Epub 2010 Aug 18.

Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard-Karls Universität Tübingen, Otfried-Mueller-Straße 10, Tübingen, Germany.

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http://dx.doi.org/10.1038/jcbfm.2010.140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023934PMC
November 2010

Exercise-induced normalization of decreased BDNF serum concentration in elderly women with remitted major depression.

Int J Neuropsychopharmacol 2010 Jun 13;13(5):595-602. Epub 2010 Jan 13.

Department of Psychiatry and Psychotherapy, University of Tübingen, Germany.

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http://dx.doi.org/10.1017/S1461145709991234DOI Listing
June 2010

Glial cell-line derived neurotrophic factor (GDNF) concentrations in cerebrospinal fluid and serum of patients with early Alzheimer's disease and normal controls.

J Alzheimers Dis 2009 ;18(2):331-7

Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.3233/JAD-2009-1146DOI Listing
December 2009

Increase of SCF plasma concentration during donepezil treatment of patients with early Alzheimer's disease.

Int J Neuropsychopharmacol 2009 Nov 7;12(10):1319-26. Epub 2009 Jul 7.

Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1017/S1461145709990216DOI Listing
November 2009

Decreased plasma levels of granulocyte-colony stimulating factor (G-CSF) in patients with early Alzheimer's disease.

J Alzheimers Dis 2009 ;17(1):115-23

Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.3233/JAD-2009-1017DOI Listing
August 2009

Increase of BDNF serum concentration in lithium treated patients with early Alzheimer's disease.

J Alzheimers Dis 2009 ;16(3):649-56

Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.3233/JAD-2009-1004DOI Listing
May 2009

Inverse association of cortisol serum levels with T-tau, P-tau 181 and P-tau 231 peptide levels and T-tau/Abeta 1-42 ratios in CSF in patients with mild Alzheimer's disease dementia.

Eur Arch Psychiatry Clin Neurosci 2009 Mar 19;259(2):80-5. Epub 2008 Sep 19.

Dept. of Psychiatry and Psychotherapy, University of Tuebingen, Osianderstr. 24, 72076, Tuebingen, Germany.

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http://dx.doi.org/10.1007/s00406-008-0838-3DOI Listing
March 2009

Increased occurrence of weaknesses in attention testing in patients with Hashimoto's thyroiditis compared to patients with other thyroid illnesses.

Psychoneuroendocrinology 2008 Nov 25;33(10):1432-6. Epub 2008 Sep 25.

Department of Psychiatry and Psychotherapy, University of Tübingen, Osianderstrasse 24, 72076 Tübingen, Germany.

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http://dx.doi.org/10.1016/j.psyneuen.2008.08.009DOI Listing
November 2008

Decreased plasma and cerebrospinal fluid levels of stem cell factor in patients with early Alzheimer's disease.

J Alzheimers Dis 2008 Nov;15(3):451-60

Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany.

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November 2008

Decreased CXCL12 (SDF-1) plasma levels in early Alzheimer's disease: a contribution to a deficient hematopoietic brain support?

J Alzheimers Dis 2008 Sep;15(1):83-95

Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.

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September 2008

Association of platelet-derived soluble glycoprotein VI in plasma with Alzheimer's disease.

J Psychiatr Res 2008 Jul 12;42(9):746-51. Epub 2007 Sep 12.

Department of Psychiatry and Psychotherapy, University of Tuebingen, Osianderstrasse 24, D-72076 Tuebingen, Germany.

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http://dx.doi.org/10.1016/j.jpsychires.2007.07.017DOI Listing
July 2008

Autoantibody reactivity in serum of patients with major depression, schizophrenia and healthy controls.

Psychiatry Res 2008 Feb 21;158(1):83-6. Epub 2007 Dec 21.

Department of Psychiatry and Psychotherapy, University of Tübingen, Osianderstr. 24, Tübingen D-72076, Germany.

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http://dx.doi.org/10.1016/j.psychres.2006.04.023DOI Listing
February 2008

Increased BDNF serum concentration in fibromyalgia with or without depression or antidepressants.

J Psychiatr Res 2007 Oct 4;41(7):600-5. Epub 2006 Apr 4.

Department of Psychiatry and Psychotherapy, University of Tuebingen, Osianderstrasse 24, D-72076 Tuebingen, Germany.

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http://dx.doi.org/10.1016/j.jpsychires.2006.02.007DOI Listing
October 2007

BDNF serum and CSF concentrations in Alzheimer's disease, normal pressure hydrocephalus and healthy controls.

J Psychiatr Res 2007 Aug 22;41(5):387-94. Epub 2006 Mar 22.

Department of Psychiatry and Psychotherapy, University of Tuebingen, Osianderstr. 24, D-72076 Tuebingen, Germany.

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http://dx.doi.org/10.1016/j.jpsychires.2006.01.014DOI Listing
August 2007

Altered lymphocyte distribution in Alzheimer's disease.

J Psychiatr Res 2007 Jan-Feb;41(1-2):174-8. Epub 2006 Mar 3.

University of Tuebingen, Psychiatry and Psychotherapy, Osianderstrasse 24, 72076 Tuebingen, Germany.

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http://dx.doi.org/10.1016/j.jpsychires.2006.01.010DOI Listing
February 2007