Christoph Klein

Christoph Klein

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Christoph Klein

Publications by authors named "Christoph Klein"

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Microfluidic enrichment, isolation and characterization of disseminated melanoma cells from lymph node samples.

Int J Cancer 2019 Jul 14;145(1):232-241. Epub 2019 Jan 14.

Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.

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http://dx.doi.org/10.1002/ijc.32092DOI Listing
July 2019

Transcatheter Valve-in-Valve and Valve-in-Ring Interventions for Failing Bioprostheses and Annuloplasty Rings.

Surg Technol Int 2019 May;34:313-320

Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany, DZHK (German Center for Cardiovascular Research), partner site Berlin, Germany.

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May 2019

Genetic Deficiency and Biochemical Inhibition of ITK Affect Human Th17, Treg, and Innate Lymphoid Cells.

J Clin Immunol 2019 May 25;39(4):391-400. Epub 2019 Apr 25.

Faculty of Medicine, Department of Pediatrics, Division of Pediatric Hematology-Oncology, Erciyes University, 38030, Melikgazi, Kayseri, Turkey.

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http://dx.doi.org/10.1007/s10875-019-00632-5DOI Listing
May 2019

Epstein-Barr Virus Smooth Muscle Tumors as Manifestation of Primary Immunodeficiency Disorders.

Front Immunol 2018 27;9:368. Epub 2018 Feb 27.

Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.3389/fimmu.2018.00368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835094PMC
April 2019

A Novel Technique for Transcatheter Aortic Valve Replacement in Pure Aortic Regurgitation.

Ann Thorac Surg 2019 Mar 1;107(3):e177-e179. Epub 2018 Sep 1.

Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany; DZHK (German Center for Cardiovascular Research), partner site Berlin, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S00034975183117
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http://dx.doi.org/10.1016/j.athoracsur.2018.06.086DOI Listing
March 2019

LAMTOR2 (p14) Controls B Cell Differentiation by Orchestrating Endosomal BCR Trafficking.

Front Immunol 2019 18;10:497. Epub 2019 Mar 18.

Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.00497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431647PMC
March 2019

Synthesis of μ -Oxo-Bridged Iron(III) Tetraphenylporphyrin-Spacer-Nitroxide Dimers and their Structural and Dynamics Characterization by using EPR and MD Simulations.

Chemistry 2019 Feb 21;25(10):2586-2596. Epub 2019 Jan 21.

Institute of Physical and Theoretical Chemistry, University of Bonn, Wegelerstr. 12, 53115, Bonn, Germany.

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http://dx.doi.org/10.1002/chem.201805016DOI Listing
February 2019

Therapy resistance beyond cellular dormancy.

Nat Cell Biol 2019 Feb;21(2):117-119

Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1038/s41556-019-0276-7DOI Listing
February 2019

Intravital imaging of glioma border morphology reveals distinctive cellular dynamics and contribution to tumor cell invasion.

Sci Rep 2019 Feb 14;9(1):2054. Epub 2019 Feb 14.

Hubrecht Institute-KNAW & University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/s41598-019-38625-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375955PMC
February 2019

Alternative Splicing Rescues Loss of Common Gamma Chain Function and Results in IL-21R-like Deficiency.

J Clin Immunol 2019 Feb 21;39(2):207-215. Epub 2019 Mar 21.

Dr. von Hauner Children's Hospital, Department of Pediatrics, University Hospital, LMU Munich, Lindwurmstrasse 4, 80337, Munich, Germany.

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http://dx.doi.org/10.1007/s10875-019-00606-7DOI Listing
February 2019

Comprehensive Genetic Results for Primary Immunodeficiency Disorders in a Highly Consanguineous Population.

Front Immunol 2018 15;9:3146. Epub 2019 Jan 15.

Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

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http://dx.doi.org/10.3389/fimmu.2018.03146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340972PMC
January 2019

Loss of murine Gfi1 causes neutropenia and induces osteoporosis depending on the pathogen load and systemic inflammation.

PLoS One 2018 7;13(6):e0198510. Epub 2018 Jun 7.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute for Medical Genetics and Human Genetics, Berlin, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198510PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991660PMC
December 2018

Modelling reaction time distribution of fast decision tasks in schizophrenia: Evidence for novel candidate endophenotypes.

Psychiatry Res 2018 11 18;269:212-220. Epub 2018 Aug 18.

Laboratory of Cognitive Neuroscience, University Mental Health Research Institute, Athens, Greece; Psychiatry Department, National and Kapodistrian University of Athens, Medical School, Athens, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.psychres.2018.08.067DOI Listing
November 2018

Testing the bottleneck account for post-error slowing beyond the post-error response.

Biol Psychol 2018 10 16;138:81-90. Epub 2018 Aug 16.

Department of Psychology and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Israel.

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http://dx.doi.org/10.1016/j.biopsycho.2018.08.010DOI Listing
October 2018

Novel Mutations in RASGRP1 are Associated with Immunodeficiency, Immune Dysregulation, and EBV-Induced Lymphoma.

J Clin Immunol 2018 Aug 20;38(6):699-710. Epub 2018 Jul 20.

Pediatric Department A and the Immunology Service, Jeffrey Modell Foundation Center; Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, 52621, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1007/s10875-018-0533-8DOI Listing
August 2018

Children with social anxiety disorder show blunted pupillary reactivity and altered eye contact processing in response to emotional faces: Insights from pupillometry and eye movements.

J Anxiety Disord 2018 08 19;58:61-69. Epub 2018 Jul 19.

Department of Clinical Child and Adolescent Psychology, Leipzig University, Germany; Leipzig Research Center for Early Child Development, Leipzig University, Germany.

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http://dx.doi.org/10.1016/j.janxdis.2018.07.001DOI Listing
August 2018

Correction to: Novel Mutations in RASGRP1 Are Associated with Immunodeficiency, Immune Dysregulation, and EBV-Induced Lymphoma.

J Clin Immunol 2018 Aug;38(6):711

Pediatric Department A and the Immunology Service, JeffreyModell Foundation Center; Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, 52621, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1007/s10875-018-0541-8DOI Listing
August 2018

Mapping Active Gene-Regulatory Regions in Human Repopulating Long-Term HSCs.

Cell Stem Cell 2018 Jul;23(1):132-146.e9

Department of Translational and Functional Cancer Genomics, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Translational Medical Oncology, NCT-Dresden, University Hospital, Carl Gustav Carus, Technische Universität Dresden, Dresden and DKFZ, Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.06.003DOI Listing
July 2018

IPEX due to an exon 7 skipping FOXP3 mutation with autoimmune diabetes mellitus cured by selective T cell engraftment.

Clin Immunol 2018 06 19;191:52-58. Epub 2018 Mar 19.

Pediatric Hematology/Oncology/Immunology, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2018.03.008DOI Listing
June 2018

Response time distribution parameters show posterror behavioral adjustment in mental arithmetic.

Acta Psychol (Amst) 2018 May 13;186:8-17. Epub 2018 Apr 13.

Department of Psychology and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.

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http://dx.doi.org/10.1016/j.actpsy.2018.04.001DOI Listing
May 2018

The sentinel lymph node spread determines quantitatively melanoma seeding to non-sentinel lymph nodes and survival.

Eur J Cancer 2018 03 6;91:1-10. Epub 2018 Jan 6.

Experimental Medicine and Therapy Research, University of Regensburg, Franz-Josef Strauß Allee 11, 93053 Regensburg, Germany; Fraunhofer Institute of Toxicology and Experimental Medicine Regensburg ITEM-R, Division Personalized Tumour Therapy, Am Biopark 9, Regensburg, 93053, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.12.002DOI Listing
March 2018

[Paediatrics in light of the Convention on the Rights of the Child].

Authors:
Christoph Klein

Gesundheitswesen 2018 Feb 16;80(2):191-196. Epub 2017 Oct 16.

Dr. von Haunersches Kinderspital - Kinderklinik und Kinderpoliklinik der LMU, München.

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http://dx.doi.org/10.1055/s-0043-118782DOI Listing
February 2018

Patients with rare diseases: from therapeutic orphans to pioneers of personalized treatments.

EMBO Mol Med 2018 01;10(1):1-3

Undiagnosed Diseases Program and National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.15252/emmm.201708365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760852PMC
January 2018

Targeted Gene Panel Sequencing for Early-onset Inflammatory Bowel Disease and Chronic Diarrhea.

Inflamm Bowel Dis 2017 12;23(12):2109-2120

1Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany; 2Center for Chronic Immunodeficiency (CCI), DZIF Satellite Center, Medical Center, Faculty of Medicine, Germany; 3Paediatric Gastroenterology, Klinikum Nürnberg, Nuremberg, Germany; 4Laboratory of Applied Molecular Biology and Immunology, University of Abou-Bekr Belkaïd, Tlemcen, Algeria; 5Department of Pediatrics, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; 6Clinic of Pediatric Allergy and Immunology, Marmara University Pendik Training and Research Hospital, Istanbul, Turkey; 7Department of Gastroenterology and Clinical Nutrition, Birmingham Children's Hospital, Birmingham, United Kingdom; 8Department of Paediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 9Department of Immunology, Royal Free Hospital, London, United Kingdom; 10Primary Immunodeficiencies Unit, Hospital Dona Estefania, Pediatric University Hospital, and CEDOC, Chronic Diseases Research Center, NOVA Medical School, Lisbon, Portugal; 11Department of Pediatric Gasteroentrology and Hepatology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 12Helios Kliniken, Childrens Hospital, Krefeld, Germany; 13Pediatrics Department, Faculty of Medicine, Cairo University, Cairo, Egypt; 14Paediatric Gastroenterology/Hepatology, University of Freiburg, Freiburg, Germany; 15Institute of Medical Microbiology and Hygiene, University of Freiburg, Freiburg, Germany; 16Department of Pediatrics, University Medical Center Dresden, Technische Universität Dresden, Dresden, Germany; 17Department of Medicine II, University Hospital and Medical Faculty, University Freiburg, Freiburg, Germany; 18Department of Paediatrics, Centre for Diagnosis and Treatment of Primary Immunodeficiencies, Jessenius Faculty of Medicine, Commenius University in Bratislava, Martin, Slovakia; 19Department of Pediatrics, Faculty of Medicine, Ege University, Izmir, Turkey; 20Department of Allergy and Clinical Immunology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 21Pediatric Immunology Division, Uludag University Medical Faculty, Department of Pediatrics, Bursa, Turkey; 22Dr. von Hauner Children's Hospital, Department of Pediatrics, Ludwig-Maximilians-Universität Munich, Munich, Germany; 23Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; 24Center for Pediatrics, Department of Pediatric Hematology and Oncology, University Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; 25Department of Paediatric Immunology and Infectious Diseases, Our Lady's Children's Hospital, Dublin, Ireland; 26Department of Immunology, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 27Department of Paediatric Gastroenterology, St. George's Healthcare NHS Trust and University of London, London, United Kingdom; 28Department of Gastroenterology and Clinical Nutrition, Marmara University Medical Faculty, Istanbul, Turkey; 29Service of Clinical Laboratory, Division of Immunology, San Pedro De Alcántara Hospital, Cáceres, Spain; 30Bone Marrow Failure Group, Division of Pediatric Hematology and Oncology, University of Freiburg, Germany; 31Children's Hospital, University of Bonn, Germany; 32University College London Institute of Immunity and Transplantation, Royal Free Campus, London, United Kingdom; 33Department of Paediatrics, St. George's Hospital, University of London, London, United Kingdom; 34Department of Pediatrics, Universitair Ziekenhuis Brussel, Brussels, Belgium; 35Pediatric Pneumology and Immunology, Department of Immunology, Charité University Medicine Labor Berlin Charité Vivantes GmbH, Berlin, Germany; 36Department of Medicine I, University Medical Center Dresden, Technische Universität Dresden, Dresden, Germany; 37Center for Regenerative Therapies, Technische Universität Dresden, Dresden, Germany; and 38Institute of Laboratory Medicine, Brandenburg Hospital, Brandenburg Medical School, Brandenburg/Havel, Germany.

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http://dx.doi.org/10.1097/MIB.0000000000001235DOI Listing
December 2017

Comparison of 1-Year Survival and Frequency of Paravalvular Leakage Using the Sapien 3 Versus the Sapien XT for Transcatheter Aortic Valve Implantation for Aortic Stenosis.

Am J Cardiol 2017 Dec 9;120(12):2247-2255. Epub 2017 Oct 9.

Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.amjcard.2017.08.049DOI Listing
December 2017

Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD.

Inflamm Bowel Dis 2017 11;23(11):1950-1961

1Division of Pediatric Gastroenterology and Nutrition, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat-Gan, Israel; 2Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; 3Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts; 4VEO-IBD Consortium; 5Department of Pediatrics and Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts; 6Harvard Medical School, Boston, Massachusetts; 7Great Ormond Street Hospital London, London, England; 8Translational Gastroenterology Unit, University of Oxford, Oxford, England; 9Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, Gainesville, Florida; 10Division of Gastroenterology and Nutrition, The Children's Hospital at Montefiore, Bronx, New York; 11Pediatric Gastroenterology Unit, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel; 12Department of Pediatrics, Kurume University School of Medicine, Kurume, Japan; 13Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany; 14Department of Gastroenterology, Children's National Medical Center, Washington, DC; 15Division of Pediatric Hematology and Oncology, University of Michigan, Ann Arbor, Michigan; 16Hospital das Clınicas, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; 17Division of Gastroenterology, McMaster Children's Hospital, West Hamilton, Ontario, Canada; 18Dr von Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany; 19Division of Pathology, Boston Children's Hospital, Boston, Massachusetts; 20Department of Pediatrics, University of Oxford, Oxford, England; 21Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; 22Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada; 23Department of Biochemistry, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; and 24Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1097/MIB.0000000000001270DOI Listing
November 2017

Basiswissen zu Kindernotfällen.

Authors:
Christoph Klein

MMW Fortschr Med 2017 Sep;159(15):40

Kinder- und Kinderpoliklinik im Dr. von Haunerschen Kinderspital, Klinikum der Universität München, München, Deutschland.

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http://dx.doi.org/10.1007/s15006-017-0007-6DOI Listing
September 2017

Allogeneic stem cell transplantation in adolescents and young adults with primary immunodeficiencies.

J Allergy Clin Immunol Pract 2018 Jan - Feb;6(1):298-301.e2. Epub 2017 Sep 22.

Pediatric Hematology/Oncology/Immunology, Dr von Hauner University Children's Hospital, Ludwig-Maximillians-University, Munich, Germany.

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http://dx.doi.org/10.1016/j.jaip.2017.07.045DOI Listing
September 2017

Disseminated tumour cells with highly aberrant genomes are linked to poor prognosis in operable oesophageal adenocarcinoma.

Br J Cancer 2017 Aug 20;117(5):725-733. Epub 2017 Jul 20.

Department of General, Visceral and Paediatric Surgery, University Hospital and Medical Faculty of the Heinrich-Heine-University Duesseldorf, Moorenstr. 5, Duesseldorf 40225, Germany.

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http://www.nature.com/doifinder/10.1038/bjc.2017.233
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http://dx.doi.org/10.1038/bjc.2017.233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572184PMC
August 2017

Erratum to: Lessons learned from comparing molecular dynamics engines on the SAMPL5 dataset.

J Comput Aided Mol Des 2017 08;31(8):777

Department of Chemical Engineering, University of Virginia, Charlottesville, VA, USA.

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http://dx.doi.org/10.1007/s10822-017-0043-4DOI Listing
August 2017

Perfluoropolyethers: Development of an All-Atom Force Field for Molecular Simulations and Validation with New Experimental Vapor Pressures and Liquid Densities.

J Phys Chem B 2017 07 27;121(27):6588-6600. Epub 2017 Jun 27.

Department of Chemical and Biomolecular Engineering, Vanderbilt University , Nashville, Tennessee 37235, United States.

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http://dx.doi.org/10.1021/acs.jpcb.7b00891DOI Listing
July 2017

COMT genotype is differentially associated with single trial variability of ERPs as a function of memory type.

Biol Psychol 2017 07 23;127:209-219. Epub 2017 Jun 23.

Department of Psychology, Ernst-Moritz-Arndt-Universität Greifswald, Germany.

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http://dx.doi.org/10.1016/j.biopsycho.2017.06.002DOI Listing
July 2017

Poikiloderma with Neutropenia in Morocco: a Report of Four Cases.

J Clin Immunol 2017 May 28;37(4):357-362. Epub 2017 Mar 28.

Clinical Immunology Unit, Department of Pediatrics, Abderrahim Harouchi Children's Hospital, CHU Ibn Rochd, LICIA Laboratory of Clinical Immunology, Inflammation and Allergy, Faculty of Medecine and Pharmacy, Hassan II University of Casablanca, Rue Mohamed El Fidouzi, 20360, Casablanca, Morocco.

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http://dx.doi.org/10.1007/s10875-017-0385-7DOI Listing
May 2017

Preference of Genetic Diagnosis of CXCR4 Mutation Compared with Clinical Diagnosis of WHIM Syndrome.

J Clin Immunol 2017 04 28;37(3):282-286. Epub 2017 Mar 28.

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, 62 Qarib St., Keshavarz Blvd., Tehran, 14194, Iran.

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http://dx.doi.org/10.1007/s10875-017-0387-5DOI Listing
April 2017

Development and optimisation of a generic micro LC-ESI-MS method for the qualitative and quantitative determination of 30-mer toxic gliadin peptides in wheat flour for food analysis.

Anal Bioanal Chem 2017 Feb 28;409(4):989-997. Epub 2016 Oct 28.

Institut für Informatik AG Algorithmische Bioinformatik, Free University of Berlin, Takustr. 9, 14195, Berlin, Germany.

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http://dx.doi.org/10.1007/s00216-016-0013-zDOI Listing
February 2017

Kostmann's Disease and HCLS1-Associated Protein X-1 (HAX1).

Authors:
Christoph Klein

J Clin Immunol 2017 Feb 10;37(2):117-122. Epub 2016 Dec 10.

Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-Universität München, Lindwurmstrasse 4, 80337, Munich, Germany.

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http://dx.doi.org/10.1007/s10875-016-0358-2DOI Listing
February 2017

Lessons learned from comparing molecular dynamics engines on the SAMPL5 dataset.

J Comput Aided Mol Des 2017 01 27;31(1):147-161. Epub 2016 Oct 27.

Department of Chemical Engineering, University of Virginia, Charlottesville, VA, USA.

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http://biorxiv.org/content/biorxiv/early/2016/09/25/077248.f
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http://dx.doi.org/10.1007/s10822-016-9977-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581938PMC
January 2017

Children with rare diseases of neutrophil granulocytes: from therapeutic orphans to pioneers of individualized medicine.

Authors:
Christoph Klein

Hematology Am Soc Hematol Educ Program 2016 Dec;2016(1):33-37

Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.

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http://www.asheducationbook.org/cgi/doi/10.1182/asheducation
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http://dx.doi.org/10.1182/asheducation-2016.1.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142513PMC
December 2016

Mechanism of early dissemination and metastasis in Her2 mammary cancer.

Nature 2016 Dec 14;540(7634):588-592. Epub 2016 Dec 14.

Division of Hematology and Oncology, Department of Medicine, Department of Otolaryngology, Department of Oncological Sciences, Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, New York 10029, USA.

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http://dx.doi.org/10.1038/nature20609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471138PMC
December 2016

Single-cell analysis of CTCs with diagnostic precision: opportunities and challenges for personalized medicine.

Expert Rev Mol Diagn 2016 5;16(1):25-38. Epub 2015 Dec 5.

a Project Group "Personalized Tumor Therapy" , Fraunhofer Institute for Toxicology and Experimental Medicine , Regensburg , Germany.

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http://dx.doi.org/10.1586/14737159.2016.1121099DOI Listing
October 2016

Granulocyte-Macrophage Colony Stimulating Factor Bioactivity and Mucosal Homeostasis in Crohn's Disease: A Role for Genetic Variation.

Gastroenterology 2016 10 30;151(4):593-6. Epub 2016 Aug 30.

Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig-Maximilians Universität München, Munich, Germany.

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http://dx.doi.org/10.1053/j.gastro.2016.08.042DOI Listing
October 2016

Mice produced by mitotic reprogramming of sperm injected into haploid parthenogenotes.

Nat Commun 2016 09 13;7:12676. Epub 2016 Sep 13.

Laboratory of Mammalian Molecular Embryology, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK.

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http://dx.doi.org/10.1038/ncomms12676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027272PMC
September 2016

A novel Rab27a mutation binds melanophilin, but not Munc13-4, causing immunodeficiency without albinism.

J Allergy Clin Immunol 2016 08 23;138(2):599-601.e3. Epub 2016 Mar 23.

Baylor College of Medicine and Texas Children's Hospital, Department of Pediatrics, Section of Immunology, Allergy and Rheumatology and Center for Human Immunobiology, Houston, Tex. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.12.1337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976026PMC
August 2016

Development of Planning in Children with High-Functioning Autism Spectrum Disorders and/or Attention Deficit/Hyperactivity Disorder.

Autism Res 2016 07 7;9(7):739-51. Epub 2015 Oct 7.

Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany.

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http://dx.doi.org/10.1002/aur.1574DOI Listing
July 2016

Large B-Cell Lymphoma in an Adolescent Patient With Interleukin-10 Receptor Deficiency and History of Infantile Inflammatory Bowel Disease.

J Pediatr Gastroenterol Nutr 2016 07;63(1):e15-7

*Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital †Department of Pediatrics ‡Department of Medicine, Harvard Medical School, Boston, MA §Division of Pediatric Hematology and Oncology ||Division of Pathology, University of Michigan, Ann Arbor, MI ¶SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute #Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, ON, Canada **Dr von Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany ††Division of Gastroenterology, Brigham and Women's Hospital ‡‡interNational Early Onset Paediatric IBD Cohort Study (NEOPICS), Boston, MA.

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http://dx.doi.org/10.1097/MPG.0000000000000532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605893PMC
July 2016

Deterministic Whole-Genome Amplification of Single Cells.

Methods Mol Biol 2015 ;1347:69-86

Project Group, Personalized Tumor Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Regensburg, Germany.

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http://dx.doi.org/10.1007/978-1-4939-2990-0_5DOI Listing
June 2016

Variants in TRIM22 That Affect NOD2 Signaling Are Associated With Very-Early-Onset Inflammatory Bowel Disease.

Gastroenterology 2016 05 4;150(5):1196-1207. Epub 2016 Feb 4.

SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842103PMC
May 2016

[Pediatrics for the general practitioner].

Authors:
Christoph Klein

MMW Fortschr Med 2016 May;158(10):48

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http://dx.doi.org/10.1007/s15006-016-8279-9DOI Listing
May 2016

[Basic diagnostics for pediatric outpatients with susceptibility to infections and immundysregulation].

MMW Fortschr Med 2016 May;158(10):49-52

Immundefektambulanz, Dr. von Haunersches Kinderspital, Ludwig-Maximilians-Universität München, Lindwurmstr. 4, D-80999, München, Deutschland.

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http://dx.doi.org/10.1007/s15006-016-8280-3DOI Listing
May 2016

Diagnostic and Treatment Options for Severe IBD in Female X-CGD Carriers with Non-random X-inactivation.

J Crohns Colitis 2016 Jan 13;10(1):112-5. Epub 2015 Oct 13.

Pediatric Hematology/Oncology/Immunology/Stem Cell Transplantation, Dr von Hauner Children's Hospital, Ludwig-Maximilians University, Munich, Germany.

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http://dx.doi.org/10.1093/ecco-jcc/jjv186DOI Listing
January 2016

Identification of neuromotor deficits common to autism spectrum disorder and attention deficit/hyperactivity disorder, and imitation deficits specific to autism spectrum disorder.

Eur Child Adolesc Psychiatry 2015 Dec 2;24(12):1497-507. Epub 2015 Aug 2.

Department of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University of Freiburg, Hauptstr. 8, 79104, Freiburg, Germany.

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http://link.springer.com/content/pdf/10.1007/s00787-015-0753
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http://dx.doi.org/10.1007/s00787-015-0753-xDOI Listing
December 2015

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome.

J Exp Med 2015 Sep 24;212(10):1641-62. Epub 2015 Aug 24.

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065 Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Enfants Malades Hospital, 75015 Paris, France University Paris Descartes, Imagine Institute, 75006 Paris, France

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http://dx.doi.org/10.1084/jem.20140280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577846PMC
September 2015

Elevated P3b latency variability in carriers of ZNF804A risk allele for psychosis.

Neuroimage 2015 Aug 17;116:207-13. Epub 2015 Apr 17.

Department of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University of Freiburg, Hauptstrasse 8, Freiburg 79104, Germany; School of Psychology, Bangor University, Penrallt Road, Bangor, Gwynedd LL57 2AS, UK; Child and Adolescent Psychiatry, University of Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuroimage.2015.04.024DOI Listing
August 2015

Integrin expression in esophageal squamous cell carcinoma: loss of the physiological integrin expression pattern correlates with disease progression.

PLoS One 2014 14;9(11):e109026. Epub 2014 Nov 14.

Department of Surgery (A), Heinrich-Heine-University and University Hospital Düsseldorf, Düsseldorf, Germany; Department of General, Visceral, and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Pediatric Surgery, University Hospital Rostock, Rostock, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232252PMC
July 2015

Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3.

Blood 2015 Jun 1;125(25):3886-95. Epub 2015 Apr 1.

Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA; Department of Medicine, Harvard Medical School, Boston, MA; Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1182/blood-2014-12-618363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473116PMC
June 2015

Novel self-inactivating vectors for reconstitution of Wiskott-Aldrich syndrome.

Curr Gene Ther 2015 ;15(3):245-54

Institute of Experimental Hematology, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany.

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May 2015

Tunable transition from hydration to monomer-supported lubrication in zwitterionic monolayers revealed by molecular dynamics simulation.

Soft Matter 2015 May;11(17):3340-6

Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, Tennessee 37235, USA.

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http://dx.doi.org/10.1039/c4sm02883jDOI Listing
May 2015

Very early-onset inflammatory bowel disease: gaining insight through focused discovery.

Inflamm Bowel Dis 2015 May;21(5):1166-75

*Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, MassGeneral Hospital for Children, Boston, Massachusetts; †Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; ‡Dr von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany; §Division of Gastroenterology, Hepatology, and Nutrition, Department of Paediatrics, University of Toronto, Hospital for Sick Children, Toronto, ON, Canada; ‖SickKids Inflammatory Bowel Disease Center and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada; ¶Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Children's Hospital Boston, Boston, Massachusetts; **Division of Gastroenterology and Hepatology, Brigham & Women's Hospital, Boston, Massachusetts; and ††Department of Medicine, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1097/MIB.0000000000000329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165626PMC
May 2015

Variability of single trial brain activation predicts fluctuations in reaction time.

Biol Psychol 2015 Mar 30;106:50-60. Epub 2015 Jan 30.

Central Institute of Mental Health, Department of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty Mannheim/Heidelberg University, J5, D-68159 Mannheim, Germany; Department of Psychology, University of Potsdam, Germany.

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http://dx.doi.org/10.1016/j.biopsycho.2015.01.013DOI Listing
March 2015

Phage-mediated dispersal of biofilm and distribution of bacterial virulence genes is induced by quorum sensing.

PLoS Pathog 2015 Feb 23;11(2):e1004653. Epub 2015 Feb 23.

Division of Infectious Diseases, Department of Medicine, University Hospital, Freiburg, Germany; Department of Pediatrics, Dr. von Hauner Children´s Hospital, Ludwig-Maximilians University of Munich, Munich, Germany; German Center for Infection Research (DZIF), Partnersite Munich, Munich, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1004653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338201PMC
February 2015

TEMPORARY REMOVAL: Assessment of hematopoietic and neurologic pathophysiology of HCLS1-associated protein X-1 deficiency in a Hax1-knockout mouse model.

Exp Hematol 2014 Oct 28. Epub 2014 Oct 28.

Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.1016/j.exphem.2014.10.010DOI Listing
October 2014