Christoph Kaether

Christoph Kaether

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Christoph Kaether

Christoph Kaether

Publications by authors named "Christoph Kaether"

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A disease causing ATLASTIN 3 mutation affects multiple endoplasmic reticulum-related pathways.

Cell Mol Life Sci 2019 Apr 21;76(7):1433-1445. Epub 2019 Jan 21.

Leibniz Institut für Alternsforschung-Fritz Lipmann Institut, Beutenbergstr. 11, 07745, Jena, Germany.

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http://link.springer.com/10.1007/s00018-019-03010-x
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http://dx.doi.org/10.1007/s00018-019-03010-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420906PMC
April 2019

Klotho expression is a prerequisite for proper muscle stem cell function and regeneration of skeletal muscle.

Skelet Muscle 2018 07 4;8(1):20. Epub 2018 Jul 4.

Leibniz-Institute on Aging - Fritz-Lipmann-Institute, Beutenbergstrasse 11, 07745, Jena, Germany.

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http://dx.doi.org/10.1186/s13395-018-0166-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030782PMC
July 2018

The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels.

Sci Rep 2017 01 24;7:41248. Epub 2017 Jan 24.

Leibniz Institut für Alternsforschung-Fritz Lipmann Institut, 07743 Jena, Germany.

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http://dx.doi.org/10.1038/srep41248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259745PMC
January 2017

The Oncogenic Fusion Proteins SET-Nup214 and Sequestosome-1 (SQSTM1)-Nup214 Form Dynamic Nuclear Bodies and Differentially Affect Nuclear Protein and Poly(A)+ RNA Export.

J Biol Chem 2016 10 9;291(44):23068-23083. Epub 2016 Sep 9.

From the Department of Molecular Biology, Faculty of Medicine and the Göttingen Center for Molecular Biosciences (GZMB), Georg August University, Göttingen, Humboldtallee 23, 37073 Göttingen, Germany,

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http://dx.doi.org/10.1074/jbc.M116.735340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087727PMC
October 2016

Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.

Biochem Biophys Res Commun 2016 09 5;478(4):1751-7. Epub 2016 Sep 5.

Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo 153-8902, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.09.018DOI Listing
September 2016

Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence.

Biol Res 2016 Jul 28;49(1):34. Epub 2016 Jul 28.

Leibniz Institute for Age Research-Fritz Lipmann Institute e.V. (FLI), Beutenbergstrasse 11, 07745, Jena, Germany.

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http://dx.doi.org/10.1186/s40659-016-0095-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963952PMC
July 2016

Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum.

Biochem Pharmacol 2014 Oct 12;91(4):490-500. Epub 2014 Aug 12.

Institute of Pharmacy, Friedrich Schiller University Jena, Philosophenweg 14, 07743 Jena, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2014.07.028DOI Listing
October 2014

A coimmunization vaccine of Aβ42 ameliorates cognitive deficits without brain inflammation in an Alzheimer's disease model.

Alzheimers Res Ther 2014 12;6(3):26. Epub 2014 May 12.

Key Laboratory of Medical Molecular Virology of MOH and MOE, Fudan University Shanghai Medical College, 131 Dong An Road, Shanghai 200032, China.

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http://dx.doi.org/10.1186/alzrt256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075150PMC
July 2014

Trafficking and proteolytic processing of APP.

Cold Spring Harb Perspect Med 2012 May;2(5):a006270

DZNE-German Center for Neurodegenerative Diseases, 80336 Munich, Germany; Adolf Butenandt-Institute, Biochemistry, Ludwig-Maximilians University, 80336 Munich, Germany.

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http://dx.doi.org/10.1101/cshperspect.a006270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331683PMC
May 2012

Disrupted-in-Schizophrenia 1 (DISC1) is necessary for the correct migration of cortical interneurons.

J Neurosci 2012 Jan;32(2):738-45

Institut für Allgemeine Zoologie und Tierphysiologie, Universität Jena, 07743 Jena, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.5036-11.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6621064PMC
January 2012

Polar transmembrane-based amino acids in presenilin 1 are involved in endoplasmic reticulum localization, Pen2 protein binding, and γ-secretase complex stabilization.

J Biol Chem 2011 Nov 13;286(44):38390-6. Epub 2011 Sep 13.

Leibniz Institut für Altersforschung-Fritz Lipmann Institut, 07743 Jena, Germany.

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http://dx.doi.org/10.1074/jbc.M111.252429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207410PMC
November 2011

Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled alpha-subunits.

Proc Natl Acad Sci U S A 2011 Jan 27;108(2):621-5. Epub 2010 Dec 27.

Leibniz Institut für Altersforschung-Fritz Lipmann Institut, 07743 Jena, Germany.

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http://dx.doi.org/10.1073/pnas.1001624108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021032PMC
January 2011

Notch1 signaling is mediated by importins alpha 3, 4, and 7.

Cell Mol Life Sci 2010 Sep 8;67(18):3187-96. Epub 2010 May 8.

Leibniz Institute for Age Research, Fritz Lipmann Institute, Beutenbergstr. 11, 07745, Jena, Germany.

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http://dx.doi.org/10.1007/s00018-010-0378-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128743PMC
September 2010

NOD2-C2 - a novel NOD2 isoform activating NF-kappaB in a muramyl dipeptide-independent manner.

BMC Res Notes 2010 Aug 10;3:224. Epub 2010 Aug 10.

Genome Analysis, Leibniz Institute for Age Research - Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany.

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http://dx.doi.org/10.1186/1756-0500-3-224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931527PMC
August 2010

Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity.

Proc Natl Acad Sci U S A 2010 Feb 19;107(5):1942-7. Epub 2010 Jan 19.

Leibniz Institute for Age Research, Fritz Lipmann Institute, 07745 Jena, Germany.

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http://dx.doi.org/10.1073/pnas.0904532106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836607PMC
February 2010

Klotho is a substrate for alpha-, beta- and gamma-secretase.

FEBS Lett 2009 Oct 6;583(19):3221-4. Epub 2009 Sep 6.

Leibniz Institut für Altersforschung-Fritz Lipmann Institut, Beutenbergstr. 11, 07745 Jena, Germany.

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http://dx.doi.org/10.1016/j.febslet.2009.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757472PMC
October 2009

Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1.

EMBO Rep 2007 Aug 6;8(8):743-8. Epub 2007 Jul 6.

Laboratory for Alzheimer's and Parkinson's Disease Research, Department of Biochemistry, Center For Integrated Protein Science Munich and Adolf-Butenandt-Institute, Ludwig-Maximilians-Universität, München 80336, Germany.

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http://dx.doi.org/10.1038/sj.embor.7401027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978084PMC
August 2007

Assembly, trafficking and function of gamma-secretase.

Neurodegener Dis 2006 ;3(4-5):275-83

Laboratory for Alzheimer's and Parkinson's Disease Research, Department of Biochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, Munich, Germany.

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https://www.karger.com/Article/FullText/95267
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http://dx.doi.org/10.1159/000095267DOI Listing
December 2006

Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides.

Traffic 2006 Jul 25;7(7):873-88. Epub 2006 May 25.

Max Planck Unit for Structural Molecular Biology, c/o DESY, Notkestrasse 85, 22607 Hamburg, Germany.

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http://dx.doi.org/10.1111/j.1600-0854.2006.00434.xDOI Listing
July 2006

Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface.

Traffic 2006 Apr;7(4):408-15

Department of Biochemistry, Adolf-Butenandt-Institute, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, 80336 München, Germany.

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http://dx.doi.org/10.1111/j.1600-0854.2006.00396.xDOI Listing
April 2006

The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.

J Neurosci 2006 Apr;26(14):3821-8

Laboratory for Alzheimer's and Parkinson's Disease Research, Department of Biochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, 80336 Munich, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.5354-05.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6674133PMC
April 2006

Stable chromosomal association of MSL2 defines a dosage-compensated nuclear compartment.

Chromosoma 2005 Nov 12;114(5):352-64. Epub 2005 Nov 12.

Department of Molecular Biology, Adolf Butenandt-Institute, Schillerstr. 44, 80336, Munich, Germany.

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http://dx.doi.org/10.1007/s00412-005-0020-xDOI Listing
November 2005

Gamma-secretase complex assembly within the early secretory pathway.

J Biol Chem 2005 Feb 10;280(8):6471-8. Epub 2004 Dec 10.

Adolf-Butenandt-Institut, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-Universität, Schillerstrasse 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M409106200DOI Listing
February 2005

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity.

EMBO J 2004 Dec 18;23(24):4738-48. Epub 2004 Nov 18.

Laboratory for Alzheimer's and Parkinson's Disease Research, Department of Biochemistry, Adolf-Butenandt-Institute, Ludwig-Maximilians-Universität, München, Germany.

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http://dx.doi.org/10.1038/sj.emboj.7600478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC535090PMC
December 2004

A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation.

J Cell Biol 2004 Dec;167(5):809-12

Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig Maximilans University, München, Germany.

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http://dx.doi.org/10.1083/jcb.200410090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172467PMC
December 2004

Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.

J Biol Chem 2004 Sep 21;279(36):37311-5. Epub 2004 Jun 21.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstr. 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M406228200
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http://dx.doi.org/10.1074/jbc.M406228200DOI Listing
September 2004

Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain.

J Biol Chem 2003 Dec 5;278(52):52519-23. Epub 2003 Nov 5.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.C300435200
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http://dx.doi.org/10.1074/jbc.C300435200DOI Listing
December 2003

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.

J Biol Chem 2002 Nov 9;277(47):44754-9. Epub 2002 Sep 9.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M206872200DOI Listing
November 2002

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.

J Cell Biol 2002 Aug 29;158(3):551-61. Epub 2002 Jul 29.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1083/jcb.200201123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173840PMC
August 2002

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.

Proc Natl Acad Sci U S A 2002 Jun 4;99(12):8025-30. Epub 2002 Jun 4.

Adolf Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://www.pnas.org/cgi/doi/10.1073/pnas.112686799
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http://dx.doi.org/10.1073/pnas.112686799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC123014PMC
June 2002

Selective delivery of secretory cargo in Golgi-derived carriers of nonepithelial cells.

Traffic 2002 Apr;3(4):279-88

Department of Neurobiology, Interdisciplinary Center of Neuroscience, University of Heidelberg, INF 364, Germany.

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http://dx.doi.org/10.1034/j.1600-0854.2002.030405.xDOI Listing
April 2002