Publications by authors named "Christoph Driessen"

85Publications

Up-regulation of multidrug resistance protein MDR1/ABCB1 in carfilzomib-resistant multiple myeloma differentially affects efficacy of anti-myeloma drugs.

Leuk Res 2020 Dec 31;101:106499. Epub 2020 Dec 31.

Experimental Oncology and Hematology, Department of Oncology and Hematology, Cantonal Hospital St. Gallen, Switzerland. Electronic address:

View Article and Find Full Text PDF
December 2020

HIV protease inhibitors for the treatment of multiple myeloma.

Clin Adv Hematol Oncol 2019 Nov;17(11):615-623

Department of Medical Oncology and Hematology, Cantonal Hospital St Gallen, St Gallen, Switzerland.

View Article and Find Full Text PDF
November 2019

Novel cell line models to study mechanisms and overcoming strategies of proteasome inhibitor resistance in multiple myeloma.

Biochim Biophys Acta Mol Basis Dis 2019 06 4;1865(6):1666-1676. Epub 2019 Apr 4.

University Hospital of Würzburg, Comprehensive Cancer Center Mainfranken, Translational Oncology, Würzburg, Germany.

View Article and Find Full Text PDF
June 2019

Management of cardiovascular risk in patients with multiple myeloma.

Blood Cancer J 2019 02 26;9(3):26. Epub 2019 Feb 26.

Hematology Service, University Hospital Salamanca, Casa del Bedel, Cardenal Pla y Deniel, 22, Planta Baja, Salamanca, 37008, Spain.

View Article and Find Full Text PDF
February 2019

Proteasome Inhibition in Multiple Myeloma: Head-to-Head Comparison of Currently Available Proteasome Inhibitors.

Cell Chem Biol 2019 03 3;26(3):340-351.e3. Epub 2019 Jan 3.

Experimental Oncology and Hematology, Department of Oncology and Hematology, Cantonal Hospital St. gallen, Rorschacher Strasse 95, St. Gallen 9007, Switzerland.

View Article and Find Full Text PDF
March 2019

Human leukocyte antigen variation is associated with adverse events of checkpoint inhibitors.

Eur J Cancer 2019 01 7;107:8-14. Epub 2018 Dec 7.

Department of Dermatology, University Hospital of Zürich, CH-8091, Zürich, Switzerland; Institute of Immunobiology, Kantonsspital St.Gallen, CH-9007, St. Gallen, Switzerland; Department of Oncology and Hematology, Kantonsspital St. Gallen, CH-9007, St. Gallen, Switzerland; Department of Dermatology, Kantonsspital St. Gallen, CH-9007, St. Gallen, Switzerland. Electronic address:

View Article and Find Full Text PDF
January 2019

An inhibitor of proteasome β2 sites sensitizes myeloma cells to immunoproteasome inhibitors.

Blood Adv 2018 10;2(19):2443-2451

Department of Medicine and Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth and Dartmouth-Hitchcock Medical Center, Lebanon, NH.

View Article and Find Full Text PDF
October 2018

Systemic treatment of a patient with relapsed and refractory extranodal NK/T-cell lymphoma (ENKL) and meningeosis leukemica with daratumumab.

Hematol Oncol 2018 Oct 3;36(4):713-714. Epub 2018 Aug 3.

Department of Oncology/Haematology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.

View Article and Find Full Text PDF
October 2018

Multiple myeloma: patient outcomes in real-world practice.

Br J Haematol 2016 Oct 13;175(2):252-264. Epub 2016 Jul 13.

'Seràgnoli' Institute of Hematology and Medical Oncology, Bologna University School of Medicine, Bologna, Italy.

View Article and Find Full Text PDF
October 2016

Development of new Malt1 inhibitors and probes.

Bioorg Med Chem 2016 08 28;24(15):3312-29. Epub 2016 Mar 28.

Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2300 RA Leiden, The Netherlands. Electronic address:

View Article and Find Full Text PDF
August 2016

A Set of Activity-Based Probes to Visualize Human (Immuno)proteasome Activities.

Angew Chem Int Ed Engl 2016 Mar 29;55(13):4199-203. Epub 2015 Oct 29.

Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

View Article and Find Full Text PDF
March 2016

Final Results of a Prospective Evaluation of the Predictive Value of Interim Positron Emission Tomography in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP-14 (SAKK 38/07).

J Clin Oncol 2015 Aug 6;33(23):2523-9. Epub 2015 Jul 6.

Christoph Mamot and Mario Bargetzi, Cantonal Hospital Aarau, Aarau; Dirk Klingbiel, Christine Biaggi, and Corinne Rusterholz, Swiss Group for Clinical Cancer Research Coordinating Center; Thomas Pabst, Inselspital Bern, Bern; Felicitas Hitz and Christoph Driessen, Cantonal Hospital St. Gallen, St. Gallen; Christoph Renner, Hirslanden Zürich; Thomas Hany, Magnetic Resonance Imaging Roentgen Zürich; Andrei Samarin, University Hospital Zürich, Zürich; Ulrich Mey, Cantonal Hospital Graubuenden, Chur; Miklos Pless, Cantonal Hospital Winterthur, Winterthur; Fatime Krasniqi and Stephan Dirnhofer, University Hospital of Basel, Basel; Emanuele Zucca, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland; and Federica Gigli and Giovanni Martinelli, European Institute of Oncology Milan, Milan, Italy.

View Article and Find Full Text PDF
August 2015

The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells.

Haematologica 2015 Oct 11;100(10):1350-60. Epub 2015 Jun 11.

Experimental Oncology and Hematology, Department of Oncology and Hematology, Kantonsspital St.Gallen, Switzerland Gorlaeus Laboratories, Leiden Institute of Chemistry and Netherlands Proteomics Centre, the Netherlands

View Article and Find Full Text PDF
October 2015

Improved survival of older patients with multiple myeloma in the era of novel agents.

Hematol Oncol 2016 Dec 21;34(4):217-223. Epub 2015 Apr 21.

Oncology and Hematology, Kantonsspital St. Gallen, St. Gallen, Switzerland.

View Article and Find Full Text PDF
December 2016

Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes.

J Med Chem 2014 Jul 15;57(14):6197-209. Epub 2014 Jul 15.

Gorlaeus Laboratories, Leiden Institute of Chemistry and Netherlands Proteomics Centre , Einsteinweg 55, 2333 CC Leiden, The Netherlands.

View Article and Find Full Text PDF
July 2014

Ritonavir, nelfinavir, saquinavir and lopinavir induce proteotoxic stress in acute myeloid leukemia cells and sensitize them for proteasome inhibitor treatment at low micromolar drug concentrations.

Leuk Res 2014 Mar 25;38(3):383-92. Epub 2013 Dec 25.

Department of Oncology and Hematology, Cantonal Hospital, St. Gallen, Switzerland; Department of Medicine II, University of Tübingen, Germany. Electronic address:

View Article and Find Full Text PDF
March 2014

Combined inhibition of p97 and the proteasome causes lethal disruption of the secretory apparatus in multiple myeloma cells.

PLoS One 2013 17;8(9):e74415. Epub 2013 Sep 17.

Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom ; Centre for Haematology, Department of Medicine, Imperial College London, London, United Kingdom.

View Article and Find Full Text PDF
May 2014

Dual inhibition of proteasomal and lysosomal proteolysis ameliorates autoimmune central nervous system inflammation.

Eur J Immunol 2008 Sep;38(9):2401-11

Experimental Neuroimmunology, Department of General Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

View Article and Find Full Text PDF
September 2008

A novel cell penetrating aspartic protease inhibitor blocks processing and presentation of tetanus toxoid more efficiently than pepstatin A.

Biochem Biophys Res Commun 2007 Dec 4;364(2):243-9. Epub 2007 Oct 4.

Medical and Natural Sciences Research Centre, University of Tübingen, Ob dem Himmelreich 7, 72074 Tübingen, Germany.

View Article and Find Full Text PDF
December 2007

A new approach for distinguishing cathepsin E and D activity in antigen-processing organelles.

FEBS J 2007 Jun 22;274(12):3138-49. Epub 2007 May 22.

Medical and Natural Sciences Research Centre, University of Tübingen, and Children's Hospital Department I, Germany.

View Article and Find Full Text PDF
June 2007

Specificity of human cathepsin S determined by processing of peptide substrates and MHC class II-associated invariant chain.

Biol Chem 2006 Oct-Nov;387(10-11):1503-11

Interfacultary Institute for Biochemistry, University of Tübingen, Medical and Natural Sciences Research Centre, Ob dem Himmelreich 7, D-72074 Tübingen, Germany.

View Article and Find Full Text PDF
December 2006

Probing the potential of platinum(II) complexes for the inhibition of thiol-dependent enzymatic activity.

J Inorg Biochem 2005 Jun;99(6):1384-9

Leiden Institute of Chemistry, Gorlaeus Laboratories,Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands.

View Article and Find Full Text PDF
June 2005

Activity and subcellular distribution of cathepsins in primary human monocytes.

J Leukoc Biol 2003 Feb;73(2):235-42

Department of Medicine II, University of Tübingen, Ob dem Himmelreich 7, 72074 Tübingen, Germany.

View Article and Find Full Text PDF
February 2003

Characterization of legumain.

Biol Chem 2002 Nov;383(11):1813-6

Institute of Physiological Chemistry, University of Tübingen, Ob dem Himmelreich 7, D-72074 Tübingen, Germany

View Article and Find Full Text PDF
November 2002

Specific role for cathepsin S in the generation of antigenic peptides in vivo.

Eur J Immunol 2002 02;32(2):467-76

Department of Pathology, Harvard Medical School, Armenise Building, 200 Longwood Avenue, Boston, MA 02115, USA.

View Article and Find Full Text PDF
February 2002