Christoph Bock

Christoph Bock

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Christoph Bock

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Peptide translocation by the lysosomal ABC transporter TAPL is regulated by coupling efficiency and activation energy.

Sci Rep 2019 Aug 15;9(1):11884. Epub 2019 Aug 15.

Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Max-von-Laue Str. 9, 60438, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1038/s41598-019-48343-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695453PMC
August 2019

HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response.

Gastroenterology 2019 06 2;156(8):2313-2329.e7. Epub 2019 Mar 2.

INSERM U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France; Université de Strasbourg, Strasbourg, France; Institut Hospitalo-Universitaire, Pôle Hépato-digestif, Nouvel Hôpital Civil, Strasbourg, France; Institut Universitaire de France (IUF), Paris, France. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.02.038DOI Listing
June 2019

NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity.

J Immunol 2019 Mar 4;202(6):1724-1734. Epub 2019 Feb 4.

Department of Biomedical Science, Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210 Vienna, Austria;

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http://dx.doi.org/10.4049/jimmunol.1701649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398083PMC
March 2019

RnBeads 2.0: comprehensive analysis of DNA methylation data.

Genome Biol 2019 03 14;20(1):55. Epub 2019 Mar 14.

Max Planck Institute for Informatics, Saarland Informatics Campus, 66123, Saarbrücken, Germany.

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http://dx.doi.org/10.1186/s13059-019-1664-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419383PMC
March 2019

Two-Micron Continuous-Wave Laser-Assisted Neuroendoscopy: Clinical Experience of Two Institutions in 524 Procedures.

World Neurosurg 2019 Feb 20;122:e81-e88. Epub 2018 Sep 20.

Division of Pediatric Neurosurgery, Department of Neurosurgery, Georg August University Hospital of Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1016/j.wneu.2018.09.064DOI Listing
February 2019

Integrative Proteomic Profiling Reveals PRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency.

Cell Stem Cell 2019 01 21;24(1):123-137.e8. Epub 2018 Nov 21.

Department of Molecular Biology, Faculty of Science, Radboud University, Radboud Institute for Molecular Life Sciences (RIMLS), 6525GA Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.10.017DOI Listing
January 2019

MIRA: an R package for DNA methylation-based inference of regulatory activity.

Bioinformatics 2018 08;34(15):2649-2650

Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.

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http://dx.doi.org/10.1093/bioinformatics/bty083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061852PMC
August 2018

Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells.

Cell Stem Cell 2018 Aug 19;23(2):276-288.e8. Epub 2018 Jul 19.

MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, EH16 4UU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084406PMC
August 2018

An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion.

Cell Stem Cell 2018 Jun 24;22(6):879-892.e6. Epub 2018 May 24.

Department of Microbiology, Immunobiology and Genetics, Center for Molecular Biology of the University of Vienna, Max F. Perutz Laboratories, Vienna Biocenter (VBC), 1030 Vienna, Austria. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909183022
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http://dx.doi.org/10.1016/j.stem.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988582PMC
June 2018

Structural characterization of the intrinsically disordered domain of Mycobacterium tuberculosis protein tyrosine kinase A.

FEBS Lett 2018 04 25;592(7):1233-1245. Epub 2018 Mar 25.

Goethe-University Frankfurt am Main, Institute for Organic Chemistry and Chemical Biology, Centre for Biomolecular Magnetic Resonance (BMRZ), Frankfurt am Main, Germany.

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http://dx.doi.org/10.1002/1873-3468.13022DOI Listing
April 2018

A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis.

J Autoimmun 2018 01 28;86:51-61. Epub 2017 Sep 28.

Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2017.09.008DOI Listing
January 2018

DeepBlueR: large-scale epigenomic analysis in R.

Bioinformatics 2017 Jul;33(13):2063-2064

Max Planck Institute for Informatics.

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http://dx.doi.org/10.1093/bioinformatics/btx099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870546PMC
July 2017

VCF.Filter: interactive prioritization of disease-linked genetic variants from sequencing data.

Nucleic Acids Res 2017 07;45(W1):W567-W572

Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, 1090 Vienna, Austria.

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http://dx.doi.org/10.1093/nar/gkx425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570181PMC
July 2017

Pooled CRISPR screening with single-cell transcriptome readout.

Nat Methods 2017 03 18;14(3):297-301. Epub 2017 Jan 18.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://www.nature.com/articles/nmeth.4177
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http://dx.doi.org/10.1038/nmeth.4177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334791PMC
March 2017

DNA Methylation Dynamics of Human Hematopoietic Stem Cell Differentiation.

Cell Stem Cell 2016 12 17;19(6):808-822. Epub 2016 Nov 17.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; Max Planck Institute for Informatics, Saarland Informatics Campus, 66123 Saarbrücken, Germany; Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145815PMC
December 2016

Epigenetic Homogeneity Within Colorectal Tumors Predicts Shorter Relapse-Free and Overall Survival Times for Patients With Locoregional Cancer.

Gastroenterology 2016 11 10;151(5):961-972. Epub 2016 Aug 10.

Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, L'Hospitalet, Barcelona, Catalonia, Spain; Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain; Institucio Catalana de Recerca i Estudis Avançats, Barcelona, Catalonia, Spain. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.08.001DOI Listing
November 2016

Preserve personal freedom in networked societies.

Authors:
Christoph Bock

Nature 2016 09;537(7618)

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences in Vienna.

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http://dx.doi.org/10.1038/537009aDOI Listing
September 2016

Multi-Omics of Single Cells: Strategies and Applications.

Trends Biotechnol 2016 08 20;34(8):605-608. Epub 2016 May 20.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.1016/j.tibtech.2016.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959511PMC
August 2016

Parallel reverse genetic screening in mutant human cells using transcriptomics.

Mol Syst Biol 2016 08 1;12(8):879. Epub 2016 Aug 1.

Nuffield Department of Clinical Medicine, Ludwig Cancer Research Ltd. University of Oxford, Oxford, UK CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria Nuffield Department of Clinical Medicine, Target Discovery Institute University of Oxford, Oxford, UK

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119491PMC
http://dx.doi.org/10.15252/msb.20166890DOI Listing
August 2016

DeepBlue epigenomic data server: programmatic data retrieval and analysis of epigenome region sets.

Nucleic Acids Res 2016 Jul 15;44(W1):W581-6. Epub 2016 Apr 15.

Max Planck Institute for Informatics, 66123 Saarbrücken, Germany.

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http://dx.doi.org/10.1093/nar/gkw211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987868PMC
July 2016

LOLA: enrichment analysis for genomic region sets and regulatory elements in R and Bioconductor.

Bioinformatics 2016 Feb 27;32(4):587-9. Epub 2015 Oct 27.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria and Max Planck Institute for Informatics, 66123 Saarbrücken, Germany.

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http://bioinformatics.oxfordjournals.org/content/early/2015/
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http://pubman.mpdl.mpg.de/pubman/item/escidoc:2257668:2/comp
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http://bioinformatics.oxfordjournals.org/lookup/doi/10.1093/
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http://dx.doi.org/10.1093/bioinformatics/btv612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743627PMC
February 2016

Single-cell transcriptomes reveal characteristic features of human pancreatic islet cell types.

EMBO Rep 2016 Feb 21;17(2):178-87. Epub 2015 Dec 21.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria Christian Doppler Laboratory for Chemical Epigenetics and Antiinfectives, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

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http://dx.doi.org/10.15252/embr.201540946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784001PMC
February 2016

Differential DNA Methylation Analysis without a Reference Genome.

Cell Rep 2015 Dec 8;13(11):2621-2633. Epub 2015 Dec 8.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria; Max Planck Institute for Informatics, 66123 Saarbrücken, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.11.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695333PMC
December 2015

Assembly of the MHC I peptide-loading complex determined by a conserved ionic lock-switch.

Sci Rep 2015 Nov 27;5:17341. Epub 2015 Nov 27.

Institute of Biochemistry, Biocenter, Goethe-University Frankfurt am Main, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1038/srep17341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661472PMC
November 2015

ChIPmentation: fast, robust, low-input ChIP-seq for histones and transcription factors.

Nat Methods 2015 Oct 17;12(10):963-965. Epub 2015 Aug 17.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://www.nature.com/articles/nmeth.3542
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http://dx.doi.org/10.1038/nmeth.3542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589892PMC
October 2015

Team work at its best – TAPL and its two domains.

Biol Chem 2015 Sep;396(9-10):967-74

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http://dx.doi.org/10.1515/hsz-2014-0319DOI Listing
September 2015

An extended combinatorial 15N, 13Cα, and 13C' labeling approach to protein backbone resonance assignment.

J Biomol NMR 2015 Jul 8;62(3):263-79. Epub 2015 May 8.

Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Max-von-Laue-Str. 9, 60438, Frankfurt, Germany.

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http://dx.doi.org/10.1007/s10858-015-9941-8DOI Listing
July 2015

Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern.

Dev Biol 2015 Jun 24;402(2):291-305. Epub 2015 Apr 24.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH-BT25.3, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2015.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454777PMC
June 2015

Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.

N Engl J Med 2015 Jun;372(25):2409-22

From the Division of Immunology (K.D., J.C., S.K., M.J.M., K.C., K.F., T.A.C., R.S.G., L.D.N.) and Manton Center for Orphan Disease Research (L.D.N.), Boston Children's Hospital, and Department of Molecular Biology, Massachusetts General Hospital (T.K.O.), Boston, Harvard Stem Cell Institute, Harvard University, Cambridge (L.D.N.), and Department of Pediatrics, University of Massachusetts Medical School, Worcester (A.M.C.) - all in Massachusetts; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (C.D.C., I.B., N.K.S., M.S., C.B., K.B.), Department of Pediatrics and Adolescent Medicine, Medical University of Vienna (K.B.), and CeRUD Vienna Center for Rare and Undiagnosed Diseases (K.B.) - all in Vienna; St. Giles Laboratory of Human Genetics of Infectious Disease, Rockefeller Branch, Rockefeller University (S.-Y.Z., M.A., S.O., B.B., Y.I., L.A., J.-L.C.), and Institute for Genomic Medicine, Columbia University (S. Petrovski, D.B.G.) - both in New York; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM Unité 1163 (S.-Y.Z., V.P., L.A., J.-L.C.), Paris Descartes University, Sorbonne Paris Cité, Imagine Institute (S.-Y.Z., F.R., P.L., L.A., J.-L.C.), and Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children (J.-L.C.) - all in Paris; Howard Hughes Medical Institute, Chevy Chase, MD (J.-L.C.); Department of Molecular and Translational Medicine, University of Brescia, Brescia (S. Parolini, O.P., G.T.), and Department of Experimental Medicine and Center of Excellence for Biomedical Research, University of Genoa, Genoa (A.M.) - both in Italy; Folkhälsan Institute of Genetics and Research Programs Unit, Molecular Neurology (E.H.), Institute for Molecular Medicine Finland (J.S.), Children's Hospital (M.K.), Research Programs Unit, Diabetes and Obesity Research Program (M.K.), and Folkhälsan Research Center (M.K.), University of Helsinki and Helsinki University Central Hospital, Helsinki, Tampere Center

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http://dx.doi.org/10.1056/NEJMoa1413462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480434PMC
June 2015

Dissecting the role of aberrant DNA methylation in human leukaemia.

Nat Commun 2015 May 22;6:7091. Epub 2015 May 22.

1] Harvard Medical School, Boston, Massachusetts 02115, USA [2] Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts 02138, USA [3] Cancer Science Institute, National University of Singapore, Singapore 66123, Singapore.

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http://dx.doi.org/10.1038/ncomms8091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443494PMC
May 2015

Improving reference epigenome catalogs by computational prediction.

Nat Biotechnol 2015 Apr;33(4):354-5

1] Max Planck Institute for Informatics, Saarbrücken, Germany. [2] CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, and the Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1038/nbt.3194DOI Listing
April 2015

Single-cell DNA methylome sequencing and bioinformatic inference of epigenomic cell-state dynamics.

Cell Rep 2015 Mar 26;10(8):1386-97. Epub 2015 Feb 26.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria; Max Planck Institute for Informatics, 66123 Saarbrücken, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542311PMC
March 2015

Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1.

Cell Rep 2015 Feb 19;10(7):1082-95. Epub 2015 Feb 19.

Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, 1090 Vienna, Austria; Department of Pediatrics, Medical University of Vienna, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.01.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542316PMC
February 2015

Comprehensive analysis of DNA methylation data with RnBeads.

Nat Methods 2014 Nov 28;11(11):1138-1140. Epub 2014 Sep 28.

Max Planck Institute for Informatics, Saarbrücken, Germany.

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http://dx.doi.org/10.1038/nmeth.3115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216143PMC
November 2014

Aberrant DNA methylation reprogramming during induced pluripotent stem cell generation is dependent on the choice of reprogramming factors.

Cell Regen (Lond) 2014 7;3(1). Epub 2014 Feb 7.

Ontario Institute for Cancer Research, Toronto, Ontario M4G 0A3 Canada ; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2 M9 Canada.

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http://dx.doi.org/10.1186/2045-9769-3-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230737PMC
November 2014

Time-shared experiments for efficient assignment of triple-selectively labeled proteins.

J Magn Reson 2014 Nov 30;248:81-95. Epub 2014 Sep 30.

Institute of Biophysical Chemistry & Center for Biomolecular Magnetic Resonance, Goethe University, Max-von-Laue-Str. 9, D-60438 Frankfurt, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jmr.2014.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254601PMC
November 2014

Notch inhibition allows oncogene-independent generation of iPS cells.

Nat Chem Biol 2014 Aug 22;10(8):632-639. Epub 2014 Jun 22.

Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1038/nchembio.1552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310751PMC
August 2014

BiQ Analyzer HiMod: an interactive software tool for high-throughput locus-specific analysis of 5-methylcytosine and its oxidized derivatives.

Nucleic Acids Res 2014 Jul 29;42(Web Server issue):W501-7. Epub 2014 May 29.

Department of Genetics, Saarland University, Saarbrücken 66123, Germany

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http://dx.doi.org/10.1093/nar/gku457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086109PMC
July 2014

Synergy and competition between cancer genome sequencing and epigenome mapping projects.

Authors:
Christoph Bock

Genome Med 2014 30;6(5):41. Epub 2014 May 30.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria ; Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria ; Max Planck Institute for Informatics, 66123 Saarbrücken, Germany.

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http://dx.doi.org/10.1186/gm557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062064PMC
July 2014

Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal.

Cell Stem Cell 2014 May;14(5):673-88

Stem Cells and Regenerative Medicine Center, Department of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Dan L. Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070311PMC
May 2014

Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease.

Hippocampus 2014 Apr 28;24(4):363-8. Epub 2014 Jan 28.

Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1002/hipo.22245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233982PMC
April 2014

Somatic mutations of calreticulin in myeloproliferative neoplasms.

N Engl J Med 2013 Dec 10;369(25):2379-90. Epub 2013 Dec 10.

From CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (T.K., A.S.H., H.N., J.D.M., N.C.C.T., T.B., D.C., G.I.V., K.B., F.S., C.C., M. Six, A.S., C.B., G.S.-F., R.K.) and the Department of Internal Medicine I, Division of Hematology and Blood Coagulation, Medical University of Vienna (H.G., B.G., M. Schalling, R.K.) - both in Vienna; and the Department of Hematology Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo (E.R., D.P., C.M., I.C.C., E.S., V.F., C.E., L.M., C.P., M.C.), and the Department of Molecular Medicine, University of Pavia (L.M., M.C.) - both in Pavia, Italy.

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http://dx.doi.org/10.1056/NEJMoa1311347DOI Listing
December 2013

A prognostic DNA methylation signature for stage I non-small-cell lung cancer.

J Clin Oncol 2013 Nov 30;31(32):4140-7. Epub 2013 Sep 30.

Juan Sandoval, Jesus Mendez-Gonzalez, F. Javier Carmona, Sergi Sayols, Sebastian Moran, Holger Heyn, Miguel Vizoso, Antonio Gomez, Montse Sanchez-Cespedes, and Manel Esteller, Bellvitge Biomedical Research Institute; Josefina Mora, Hospital de la Santa Creu i Sant Pau; Manel Esteller, University of Barcelona and Institucio Catalana de Recerca i Estudis Avançats, Barcelona; Miquel Taron and Rafael Rosell, Catalan Institute of Oncology, Badalona, Catalonia; Marina Pollan, Instituto de Salud Carlos III, Madrid; Maria J. Pajares and Luis M. Montuenga, University of Navarra; Wenceslao Torre, Clínica University de Navarra, Pamplona, Spain; Ernest Nadal, Guoan Chen, and David G. Beer, University of Michigan Medical School, Ann Arbor, MI; Yassen Assenov and Fabian Müller, Max Planck Institute, Saarbrücken, Germany; Christoph Bock, Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria; Lucia A. Muscarella, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy; Triantafillos Liloglou, Michael Davies, and John K. Field, The University of Liverpool Cancer Research Centre, Liverpool, United Kingdom; Elisabeth Brambilla, Centre Hospitalier Universitaire A Michallon, Grenoble, France; Luca Roz, IRCCS Foundation National Cancer Institute, Milan; Marco Lo Iacono and Giorgio V. Scagliotti, University of Torino, Orbassano (Torino), Italy.

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http://dx.doi.org/10.1200/JCO.2012.48.5516DOI Listing
November 2013

Conformational stabilization of the membrane embedded targeting domain of the lysosomal peptide transporter TAPL for solution NMR.

J Biomol NMR 2013 Oct 7;57(2):141-54. Epub 2013 Sep 7.

Institute of Biochemistry, Biocenter, Goethe-University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1007/s10858-013-9774-2DOI Listing
October 2013

Recommendations for the design and analysis of epigenome-wide association studies.

Nat Methods 2013 Oct;10(10):949-55

1] Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.

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http://search.proquest.com/openview/9eb6080ebfd0ecdda97a57d6
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http://dx.doi.org/10.1038/nmeth.2632DOI Listing
October 2013

Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging.

Cell Stem Cell 2013 Apr 14;12(4):413-25. Epub 2013 Feb 14.

Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02116, USA.

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http://www.idi.harvard.edu/uploads/investigators/Beerman_et_
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http://linkinghub.elsevier.com/retrieve/pii/S193459091300020
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http://dx.doi.org/10.1016/j.stem.2013.01.017DOI Listing
April 2013

DNA methylation: a matter of culture.

Nat Struct Mol Biol 2013 Mar;20(3):249-51

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.1038/nsmb.2531DOI Listing
March 2013

Comparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues.

Epigenetics 2012 Dec 18;7(12):1355-67. Epub 2012 Oct 18.

Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University, Nijmegen, The Netherlands.

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http://dx.doi.org/10.4161/epi.22562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528691PMC
December 2012