Publications by authors named "Christoph Bock"

100Publications

Emergence of coronavirus disease 2019 (COVID-19) in Austria.

Wien Klin Wochenschr 2020 Aug 20. Epub 2020 Aug 20.

Österreichische Agentur für Gesundheit und Ernährungssicherheit (AGES), Spargelfeldstr. 191, 1220, Vienna, Austria.

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http://dx.doi.org/10.1007/s00508-020-01723-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439636PMC
August 2020

Knowledge-primed neural networks enable biologically interpretable deep learning on single-cell sequencing data.

Genome Biol 2020 Aug 3;21(1):190. Epub 2020 Aug 3.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.1186/s13059-020-02100-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397672PMC
August 2020

Cell-Type Specificity of Genomic Imprinting in Cerebral Cortex.

Neuron 2020 Sep 23;107(6):1160-1179.e9. Epub 2020 Jul 23.

Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2020.06.031DOI Listing
September 2020

Structural cells are key regulators of organ-specific immune responses.

Nature 2020 07 1;583(7815):296-302. Epub 2020 Jul 1.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.1038/s41586-020-2424-4DOI Listing
July 2020

Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets.

Genome Biol 2020 05 6;21(1):106. Epub 2020 May 6.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, 1090, Vienna, Austria.

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http://dx.doi.org/10.1186/s13059-020-02006-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201533PMC
May 2020

Anti-Apoptotic Molecule BCL2 Is a Therapeutic Target in Steroid-Refractory Graft-Versus-Host Disease.

J Invest Dermatol 2020 Apr 2. Epub 2020 Apr 2.

Department of Dermatology, Medical University of Vienna, Vienna, Austria; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2020.02.029DOI Listing
April 2020

Quantitative comparison of within-sample heterogeneity scores for DNA methylation data.

Nucleic Acids Res 2020 05;48(8):e46

Big Data in BioMedicine Group, Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich, 85354 Freising, Germany.

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http://dx.doi.org/10.1093/nar/gkaa120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192612PMC
May 2020

Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF.

Immunity 2020 02 7;52(2):295-312.e11. Epub 2020 Jan 7.

Regensburg Center for Interventional Immunology (RCI), Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany; Chair for Immunology, Regensburg University, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany; Immune Tolerance Group, Tumor Immunology Program, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026712PMC
February 2020

Longitudinal molecular trajectories of diffuse glioma in adults.

Nature 2019 12 20;576(7785):112-120. Epub 2019 Nov 20.

The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.

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http://dx.doi.org/10.1038/s41586-019-1775-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897368PMC
December 2019

Genome-scale CRISPR screens are efficient in non-homologous end-joining deficient cells.

Sci Rep 2019 10 31;9(1):15751. Epub 2019 Oct 31.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, 1090, Vienna, Austria.

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http://dx.doi.org/10.1038/s41598-019-52078-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823505PMC
October 2019

Peptide translocation by the lysosomal ABC transporter TAPL is regulated by coupling efficiency and activation energy.

Sci Rep 2019 08 15;9(1):11884. Epub 2019 Aug 15.

Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Max-von-Laue Str. 9, 60438, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1038/s41598-019-48343-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695453PMC
August 2019

RnBeads 2.0: comprehensive analysis of DNA methylation data.

Genome Biol 2019 03 14;20(1):55. Epub 2019 Mar 14.

Max Planck Institute for Informatics, Saarland Informatics Campus, 66123, Saarbrücken, Germany.

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http://dx.doi.org/10.1186/s13059-019-1664-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419383PMC
March 2019

HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response.

Gastroenterology 2019 06 2;156(8):2313-2329.e7. Epub 2019 Mar 2.

INSERM U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France; Université de Strasbourg, Strasbourg, France; Institut Hospitalo-Universitaire, Pôle Hépato-digestif, Nouvel Hôpital Civil, Strasbourg, France; Institut Universitaire de France (IUF), Paris, France. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.02.038DOI Listing
June 2019

NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity.

J Immunol 2019 03 4;202(6):1724-1734. Epub 2019 Feb 4.

Department of Biomedical Science, Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210 Vienna, Austria;

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http://dx.doi.org/10.4049/jimmunol.1701649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398083PMC
March 2019

Integrative Proteomic Profiling Reveals PRC2-Dependent Epigenetic Crosstalk Maintains Ground-State Pluripotency.

Cell Stem Cell 2019 01 21;24(1):123-137.e8. Epub 2018 Nov 21.

Department of Molecular Biology, Faculty of Science, Radboud University, Radboud Institute for Molecular Life Sciences (RIMLS), 6525GA Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.10.017DOI Listing
January 2019

Two-Micron Continuous-Wave Laser-Assisted Neuroendoscopy: Clinical Experience of Two Institutions in 524 Procedures.

World Neurosurg 2019 Feb 20;122:e81-e88. Epub 2018 Sep 20.

Division of Pediatric Neurosurgery, Department of Neurosurgery, Georg August University Hospital of Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1016/j.wneu.2018.09.064DOI Listing
February 2019

Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells.

Cell Stem Cell 2018 Aug 19;23(2):276-288.e8. Epub 2018 Jul 19.

MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, EH16 4UU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084406PMC
August 2018

An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion.

Cell Stem Cell 2018 Jun 24;22(6):879-892.e6. Epub 2018 May 24.

Department of Microbiology, Immunobiology and Genetics, Center for Molecular Biology of the University of Vienna, Max F. Perutz Laboratories, Vienna Biocenter (VBC), 1030 Vienna, Austria. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909183022
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http://dx.doi.org/10.1016/j.stem.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988582PMC
June 2018

MIRA: an R package for DNA methylation-based inference of regulatory activity.

Bioinformatics 2018 08;34(15):2649-2650

Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.

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http://dx.doi.org/10.1093/bioinformatics/bty083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061852PMC
August 2018

Structural characterization of the intrinsically disordered domain of Mycobacterium tuberculosis protein tyrosine kinase A.

FEBS Lett 2018 04 25;592(7):1233-1245. Epub 2018 Mar 25.

Goethe-University Frankfurt am Main, Institute for Organic Chemistry and Chemical Biology, Centre for Biomolecular Magnetic Resonance (BMRZ), Frankfurt am Main, Germany.

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http://dx.doi.org/10.1002/1873-3468.13022DOI Listing
April 2018

A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis.

J Autoimmun 2018 01 28;86:51-61. Epub 2017 Sep 28.

Division of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2017.09.008DOI Listing
January 2018

VCF.Filter: interactive prioritization of disease-linked genetic variants from sequencing data.

Nucleic Acids Res 2017 07;45(W1):W567-W572

Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, 1090 Vienna, Austria.

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http://dx.doi.org/10.1093/nar/gkx425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570181PMC
July 2017

DeepBlueR: large-scale epigenomic analysis in R.

Bioinformatics 2017 Jul;33(13):2063-2064

Max Planck Institute for Informatics.

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http://dx.doi.org/10.1093/bioinformatics/btx099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870546PMC
July 2017

Pooled CRISPR screening with single-cell transcriptome readout.

Nat Methods 2017 03 18;14(3):297-301. Epub 2017 Jan 18.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://www.nature.com/articles/nmeth.4177
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http://dx.doi.org/10.1038/nmeth.4177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334791PMC
March 2017

DNA Methylation Dynamics of Human Hematopoietic Stem Cell Differentiation.

Cell Stem Cell 2016 12 17;19(6):808-822. Epub 2016 Nov 17.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; Max Planck Institute for Informatics, Saarland Informatics Campus, 66123 Saarbrücken, Germany; Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145815PMC
December 2016

Preserve personal freedom in networked societies.

Authors:
Christoph Bock

Nature 2016 09;537(7618)

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences in Vienna.

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http://dx.doi.org/10.1038/537009aDOI Listing
September 2016

Epigenetic Homogeneity Within Colorectal Tumors Predicts Shorter Relapse-Free and Overall Survival Times for Patients With Locoregional Cancer.

Gastroenterology 2016 11 10;151(5):961-972. Epub 2016 Aug 10.

Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, L'Hospitalet, Barcelona, Catalonia, Spain; Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain; Institucio Catalana de Recerca i Estudis Avançats, Barcelona, Catalonia, Spain. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.08.001DOI Listing
November 2016

Parallel reverse genetic screening in mutant human cells using transcriptomics.

Mol Syst Biol 2016 08 1;12(8):879. Epub 2016 Aug 1.

Nuffield Department of Clinical Medicine, Ludwig Cancer Research Ltd. University of Oxford, Oxford, UK CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria Nuffield Department of Clinical Medicine, Target Discovery Institute University of Oxford, Oxford, UK

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119491PMC
http://dx.doi.org/10.15252/msb.20166890DOI Listing
August 2016

Multi-Omics of Single Cells: Strategies and Applications.

Trends Biotechnol 2016 08 20;34(8):605-608. Epub 2016 May 20.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://dx.doi.org/10.1016/j.tibtech.2016.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959511PMC
August 2016

DeepBlue epigenomic data server: programmatic data retrieval and analysis of epigenome region sets.

Nucleic Acids Res 2016 Jul 15;44(W1):W581-6. Epub 2016 Apr 15.

Max Planck Institute for Informatics, 66123 Saarbrücken, Germany.

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http://dx.doi.org/10.1093/nar/gkw211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987868PMC
July 2016

Single-cell transcriptomes reveal characteristic features of human pancreatic islet cell types.

EMBO Rep 2016 Feb 21;17(2):178-87. Epub 2015 Dec 21.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria Christian Doppler Laboratory for Chemical Epigenetics and Antiinfectives, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

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http://dx.doi.org/10.15252/embr.201540946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784001PMC
February 2016

Differential DNA Methylation Analysis without a Reference Genome.

Cell Rep 2015 Dec 8;13(11):2621-2633. Epub 2015 Dec 8.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria; Max Planck Institute for Informatics, 66123 Saarbrücken, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.11.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695333PMC
December 2015

Assembly of the MHC I peptide-loading complex determined by a conserved ionic lock-switch.

Sci Rep 2015 Nov 27;5:17341. Epub 2015 Nov 27.

Institute of Biochemistry, Biocenter, Goethe-University Frankfurt am Main, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1038/srep17341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661472PMC
November 2015

LOLA: enrichment analysis for genomic region sets and regulatory elements in R and Bioconductor.

Bioinformatics 2016 Feb 27;32(4):587-9. Epub 2015 Oct 27.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria and Max Planck Institute for Informatics, 66123 Saarbrücken, Germany.

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http://bioinformatics.oxfordjournals.org/content/early/2015/
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http://pubman.mpdl.mpg.de/pubman/item/escidoc:2257668:2/comp
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http://bioinformatics.oxfordjournals.org/lookup/doi/10.1093/
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http://dx.doi.org/10.1093/bioinformatics/btv612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743627PMC
February 2016

ChIPmentation: fast, robust, low-input ChIP-seq for histones and transcription factors.

Nat Methods 2015 Oct 17;12(10):963-965. Epub 2015 Aug 17.

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

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http://www.nature.com/articles/nmeth.3542
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http://dx.doi.org/10.1038/nmeth.3542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589892PMC
October 2015

Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.

N Engl J Med 2015 Jun;372(25):2409-22

From the Division of Immunology (K.D., J.C., S.K., M.J.M., K.C., K.F., T.A.C., R.S.G., L.D.N.) and Manton Center for Orphan Disease Research (L.D.N.), Boston Children's Hospital, and Department of Molecular Biology, Massachusetts General Hospital (T.K.O.), Boston, Harvard Stem Cell Institute, Harvard University, Cambridge (L.D.N.), and Department of Pediatrics, University of Massachusetts Medical School, Worcester (A.M.C.) - all in Massachusetts; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences (C.D.C., I.B., N.K.S., M.S., C.B., K.B.), Department of Pediatrics and Adolescent Medicine, Medical University of Vienna (K.B.), and CeRUD Vienna Center for Rare and Undiagnosed Diseases (K.B.) - all in Vienna; St. Giles Laboratory of Human Genetics of Infectious Disease, Rockefeller Branch, Rockefeller University (S.-Y.Z., M.A., S.O., B.B., Y.I., L.A., J.-L.C.), and Institute for Genomic Medicine, Columbia University (S. Petrovski, D.B.G.) - both in New York; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM Unité 1163 (S.-Y.Z., V.P., L.A., J.-L.C.), Paris Descartes University, Sorbonne Paris Cité, Imagine Institute (S.-Y.Z., F.R., P.L., L.A., J.-L.C.), and Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children (J.-L.C.) - all in Paris; Howard Hughes Medical Institute, Chevy Chase, MD (J.-L.C.); Department of Molecular and Translational Medicine, University of Brescia, Brescia (S. Parolini, O.P., G.T.), and Department of Experimental Medicine and Center of Excellence for Biomedical Research, University of Genoa, Genoa (A.M.) - both in Italy; Folkhälsan Institute of Genetics and Research Programs Unit, Molecular Neurology (E.H.), Institute for Molecular Medicine Finland (J.S.), Children's Hospital (M.K.), Research Programs Unit, Diabetes and Obesity Research Program (M.K.), and Folkhälsan Research Center (M.K.), University of Helsinki and Helsinki University Central Hospital, Helsinki, Tampere Center

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http://dx.doi.org/10.1056/NEJMoa1413462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480434PMC
June 2015

Dissecting the role of aberrant DNA methylation in human leukaemia.

Nat Commun 2015 May 22;6:7091. Epub 2015 May 22.

1] Harvard Medical School, Boston, Massachusetts 02115, USA [2] Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts 02138, USA [3] Cancer Science Institute, National University of Singapore, Singapore 66123, Singapore.

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http://dx.doi.org/10.1038/ncomms8091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443494PMC
May 2015