Christoph A Klein

Christoph A Klein

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Christoph A Klein

Christoph A Klein

Publications by authors named "Christoph A Klein"

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Targeted transcript quantification in single disseminated cancer cells after whole transcriptome amplification.

PLoS One 2019 20;14(8):e0216442. Epub 2019 Aug 20.

Fraunhofer Institute for Toxicology and Experimental Medicine, Project Group Personalized Tumor Therapy, Regensburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216442PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701776PMC
August 2019

Microfluidic enrichment, isolation and characterization of disseminated melanoma cells from lymph node samples.

Int J Cancer 2019 07 14;145(1):232-241. Epub 2019 Jan 14.

Division of Personalized Tumour Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine, 93053, Regensburg, Germany.

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http://dx.doi.org/10.1002/ijc.32092DOI Listing
July 2019

Therapy resistance beyond cellular dormancy.

Nat Cell Biol 2019 02;21(2):117-119

Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1038/s41556-019-0276-7DOI Listing
February 2019

Intravital imaging of glioma border morphology reveals distinctive cellular dynamics and contribution to tumor cell invasion.

Sci Rep 2019 Feb 14;9(1):2054. Epub 2019 Feb 14.

Hubrecht Institute-KNAW & University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/s41598-019-38625-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375955PMC
February 2019

The sentinel lymph node spread determines quantitatively melanoma seeding to non-sentinel lymph nodes and survival.

Eur J Cancer 2018 03 6;91:1-10. Epub 2018 Jan 6.

Experimental Medicine and Therapy Research, University of Regensburg, Franz-Josef Strauß Allee 11, 93053 Regensburg, Germany; Fraunhofer Institute of Toxicology and Experimental Medicine Regensburg ITEM-R, Division Personalized Tumour Therapy, Am Biopark 9, Regensburg, 93053, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.12.002DOI Listing
March 2018

Disseminated tumour cells with highly aberrant genomes are linked to poor prognosis in operable oesophageal adenocarcinoma.

Br J Cancer 2017 Aug 20;117(5):725-733. Epub 2017 Jul 20.

Department of General, Visceral and Paediatric Surgery, University Hospital and Medical Faculty of the Heinrich-Heine-University Duesseldorf, Moorenstr. 5, Duesseldorf 40225, Germany.

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http://www.nature.com/doifinder/10.1038/bjc.2017.233
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http://dx.doi.org/10.1038/bjc.2017.233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572184PMC
August 2017

Mechanism of early dissemination and metastasis in Her2 mammary cancer.

Nature 2016 Dec 14;540(7634):588-592. Epub 2016 Dec 14.

Division of Hematology and Oncology, Department of Medicine, Department of Otolaryngology, Department of Oncological Sciences, Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, New York 10029, USA.

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http://dx.doi.org/10.1038/nature20609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471138PMC
December 2016

Single-cell analysis of CTCs with diagnostic precision: opportunities and challenges for personalized medicine.

Expert Rev Mol Diagn 2016 5;16(1):25-38. Epub 2015 Dec 5.

a Project Group "Personalized Tumor Therapy" , Fraunhofer Institute for Toxicology and Experimental Medicine , Regensburg , Germany.

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http://dx.doi.org/10.1586/14737159.2016.1121099DOI Listing
October 2016

Mice produced by mitotic reprogramming of sperm injected into haploid parthenogenotes.

Nat Commun 2016 09 13;7:12676. Epub 2016 Sep 13.

Laboratory of Mammalian Molecular Embryology, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK.

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http://dx.doi.org/10.1038/ncomms12676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027272PMC
September 2016

Deterministic Whole-Genome Amplification of Single Cells.

Methods Mol Biol 2015 ;1347:69-86

Project Group, Personalized Tumor Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Regensburg, Germany.

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http://dx.doi.org/10.1007/978-1-4939-2990-0_5DOI Listing
June 2016

Integrin expression in esophageal squamous cell carcinoma: loss of the physiological integrin expression pattern correlates with disease progression.

PLoS One 2014 14;9(11):e109026. Epub 2014 Nov 14.

Department of Surgery (A), Heinrich-Heine-University and University Hospital Düsseldorf, Düsseldorf, Germany; Department of General, Visceral, and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Pediatric Surgery, University Hospital Rostock, Rostock, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109026PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232252PMC
July 2015

Immune humanization of immunodeficient mice using diagnostic bone marrow aspirates from carcinoma patients.

PLoS One 2014 15;9(5):e97860. Epub 2014 May 15.

Project Group Personalized Tumor Therapy, Fraunhofer Institute of Toxicology and Experimental Medicine, Regensburg, Germany; Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097860PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022674PMC
June 2015

Combined genome and transcriptome analysis of single disseminated cancer cells from bone marrow of prostate cancer patients reveals unexpected transcriptomes.

Cancer Res 2014 Dec 15;74(24):7383-94. Epub 2014 Oct 15.

Chair of Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany. Project Group Personalized Tumour Therapy, Fraunhofer Institute of Experimental Medicine and Toxicology, Regensburg, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0934DOI Listing
December 2014

Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres.

Blood 2014 Nov 16;124(22):3237-40. Epub 2014 Sep 16.

Leibniz Institute of Age Research, Fritz Lipmann Institute e.V., Jena, Germany; Research Group on Molecular Aging, Faculty of Medicine, Friedrich-Schiller-University, Jena, Germany;

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-04-56
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http://dx.doi.org/10.1182/blood-2014-04-568055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239332PMC
November 2014

Reliable single cell array CGH for clinical samples.

PLoS One 2014 21;9(1):e85907. Epub 2014 Jan 21.

Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany ; Project Group Personalized Tumor Therapy, Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Regensburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085907PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897541PMC
October 2014

Molecular profiling of single Sca-1+/CD34+,- cells--the putative murine lung stem cells.

PLoS One 2013 31;8(12):e83917. Epub 2013 Dec 31.

Chair for Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany ; Project Group "Personalized Tumor Therapy", Fraunhofer Institute for Experimental Medicine and Toxicology, Regensburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083917PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877111PMC
September 2014

Quantitative measurement of melanoma spread in sentinel lymph nodes and survival.

PLoS Med 2014 Feb 18;11(2):e1001604. Epub 2014 Feb 18.

Chair of Experimental Medicine and Therapy Research, Department of Pathology, University of Regensburg, Regensburg, Germany ; Project Group Personalized Tumor Therapy, Fraunhofer-Institut für Toxikologie und Experimentelle Medizin, Regensburg, Germany.

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http://dx.doi.org/10.1371/journal.pmed.1001604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928050PMC
February 2014

Cancer dormancy: time to explore its clinical relevance.

Breast Cancer Res 2013 Dec 20;15(6):321. Epub 2013 Dec 20.

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http://dx.doi.org/10.1186/bcr3590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979111PMC
December 2013

Diagnostic leukapheresis enables reliable detection of circulating tumor cells of nonmetastatic cancer patients.

Proc Natl Acad Sci U S A 2013 Oct 24;110(41):16580-5. Epub 2013 Sep 24.

Institute for Transplantation Diagnostics and Cell Therapeutics and Departments of Obstetrics and Gynecology and General, Visceral and Pediatric Surgery, Medical Faculty, University Hospital, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1073/pnas.1313594110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799344PMC
October 2013

Selection and adaptation during metastatic cancer progression.

Nature 2013 Sep;501(7467):365-72

Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1038/nature12628DOI Listing
September 2013

Metastasis awakening: the challenges of targeting minimal residual cancer.

Nat Med 2013 Mar;19(3):274-5

Fraunhofer-Institut für Toxikologie und Experimentelle Medizin, Project Group Personalized Tumor Therapy, Regensburg, Germany.

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http://dx.doi.org/10.1038/nm.3121DOI Listing
March 2013

Sequence error storms and the landscape of mutations in cancer.

Proc Natl Acad Sci U S A 2012 Sep 21;109(36):14289-90. Epub 2012 Aug 21.

Fraunhofer-Institut für Toxikologie und Experimentelle Medizin, Project Group Personalized Tumor Therapy, Regensburg 93053, Germany.

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http://dx.doi.org/10.1073/pnas.1212246109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437884PMC
September 2012

Transcriptome asymmetry within mouse zygotes but not between early embryonic sister blastomeres.

EMBO J 2011 May 5;30(9):1841-51. Epub 2011 Apr 5.

Laboratory of Mammalian Molecular Embryology, RIKEN Center for Developmental Biology, Kobe, Japan.

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http://dx.doi.org/10.1038/emboj.2011.92DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101998PMC
May 2011

Framework models of tumor dormancy from patient-derived observations.

Curr Opin Genet Dev 2011 Feb 8;21(1):42-9. Epub 2010 Dec 8.

Experimental Medicine and Therapy Research, Department of Pathology, University of Regensburg, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1016/j.gde.2010.10.011DOI Listing
February 2011

Expression of melanoma-antigen-A (MAGE-A) in disseminated tumor cells in regional lymph nodes of patients with operable non-small cell lung cancer.

Lung Cancer 2010 Mar 20;67(3):290-5. Epub 2009 May 20.

Department of Thoracic Surgery, Albert-Ludwigs University Freiburg, 79106 Freiburg, Germany.

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http://dx.doi.org/10.1016/j.lungcan.2009.04.012DOI Listing
March 2010

Genetic disparity between primary tumours, disseminated tumour cells, and manifest metastasis.

Int J Cancer 2010 Feb;126(3):589-98

Department of General, Visceral, and Pediatric Surgery, Heinrich-Heine-University and University Hospital Düsseldorf, D-40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1002/ijc.24916DOI Listing
February 2010

Genomic instability of micronucleated cells revealed by single-cell comparative genomic hybridization.

Cytometry A 2009 Jul;75(7):562-8

Rudolf Virchow Center for Experimental Biomedicine, Department of Dermatology, Universtiy Würzburg, Germany.

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http://dx.doi.org/10.1002/cyto.a.20733DOI Listing
July 2009

Lessons from an aggressive cancer: evolutionary dynamics in esophageal carcinoma.

Cancer Res 2009 Jul 23;69(13):5285-8. Epub 2009 Jun 23.

Department of Pathology, Division of Oncogenomics, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-4586DOI Listing
July 2009

Perioperative activation of disseminated tumor cells in bone marrow of patients with prostate cancer.

J Clin Oncol 2009 Apr 23;27(10):1549-56. Epub 2009 Feb 23.

Department of Urology and Hematology and Oncology, Institute for Pathology, Klinikum Augsburg, Augsburg, Germany.

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http://ascopubs.org/doi/10.1200/JCO.2008.17.0563
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http://dx.doi.org/10.1200/JCO.2008.17.0563DOI Listing
April 2009

Parallel progression of primary tumours and metastases.

Nat Rev Cancer 2009 04;9(4):302-12

Division of Oncogenomics, Department of Pathology, University of Regensburg, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1038/nrc2627DOI Listing
April 2009

The analysis of metastasis in transgenic mouse models.

Transgenic Res 2009 Feb 11;18(1):1-5. Epub 2008 Nov 11.

Department of Pathology, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.

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http://dx.doi.org/10.1007/s11248-008-9225-0DOI Listing
February 2009

On the abundance of EpCAM on cancer stem cells.

Nat Rev Cancer 2009 Feb 9;9(2):143; author reply 143. Epub 2009 Jan 9.

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http://dx.doi.org/10.1038/nrc2499-c1DOI Listing
February 2009

The direct molecular analysis of metastatic precursor cells in breast cancer: a chance for a better understanding of metastasis and for personalised medicine.

Eur J Cancer 2008 Dec 18;44(18):2721-5. Epub 2008 Nov 18.

Division of Oncogenomics, Department of Pathology, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1016/j.ejca.2008.09.035DOI Listing
December 2008

Clinicopathological characterization and genomic aberrations in subcutaneous panniculitis-like T-cell lymphoma.

J Invest Dermatol 2008 Sep 13;128(9):2304-9. Epub 2008 Mar 13.

Department of Dermatology and Allergology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1038/jid.2008.6DOI Listing
September 2008

Cancer. The metastasis cascade.

Science 2008 Sep;321(5897):1785-7

Division of Oncogenomics, Department of Pathology, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1126/science.1164853DOI Listing
September 2008

High-resolution array comparative genomic hybridization of single micrometastatic tumor cells.

Nucleic Acids Res 2008 Apr 15;36(7):e39. Epub 2008 Mar 15.

Division of Oncogenomics, Department of Pathology, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1093/nar/gkn101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367728PMC
April 2008

Systemic spread is an early step in breast cancer.

Cancer Cell 2008 Jan;13(1):58-68

Department of Pathology, Division of Oncogenomics, University of Regensburg, Regensburg 93053, Germany.

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http://dx.doi.org/10.1016/j.ccr.2007.12.003DOI Listing
January 2008

Gene expression profiling of single cells on large-scale oligonucleotide arrays.

Nucleic Acids Res 2006 27;34(21):e143. Epub 2006 Oct 27.

Institut für Immunologie, Ludwig-Maximilians Universität, Goethestr. 31, 80336 München, Germany.

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http://dx.doi.org/10.1093/nar/gkl740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635316PMC
January 2007

Random mutations, selected mutations: A PIN opens the door to new genetic landscapes.

Proc Natl Acad Sci U S A 2006 Nov 20;103(48):18033-4. Epub 2006 Nov 20.

Department of Pathology, Division of Oncogenomics, University of Regensburg, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1073/pnas.0609000103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838701PMC
November 2006

Systemic cancer progression and tumor dormancy: mathematical models meet single cell genomics.

Cell Cycle 2006 Aug 15;5(16):1788-98. Epub 2006 Aug 15.

Institut für Immunologie, Ludwig-Maximilians-Universität, München, Germany.

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http://dx.doi.org/10.4161/cc.5.16.3097DOI Listing
August 2006

Detection of disseminated tumor cells in mediastinoscopic lymph node biopsies and lymphadenectomy specimens of patients with NSCLC by quantitative RT-PCR.

Eur J Cardiothorac Surg 2005 Jul;28(1):26-32

Department of Thoracic Surgery, Albert-Ludwigs-University Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany.

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http://dx.doi.org/10.1016/j.ejcts.2005.03.029DOI Listing
July 2005

Gene expression analysis of a single or few cells.

Curr Protoc Hum Genet 2005 Feb;Chapter 11:Unit 11.8

Ludwig-Maximilians-University of Munich, Munich, Germany.

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http://dx.doi.org/10.1002/0471142905.hg1108s44DOI Listing
February 2005

Single cell amplification methods for the study of cancer and cellular ageing.

Mech Ageing Dev 2005 Jan;126(1):147-51

Institut für Immunologie der Ludwigs-Maximilian Universität München, München 80336, Germany.

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http://dx.doi.org/10.1016/j.mad.2004.09.014DOI Listing
January 2005

Gene expression sigantures, cancer cell evolution and metastatic progression.

Cell Cycle 2004 Jan;3(1):29-31

Institut für Immunologie, Ludwig-Maximilians Universität Munchen; Goethestr. 31, 80336 Munchen, Germany.

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January 2004

Immunomagnetic enrichment, genomic characterization, and prognostic impact of circulating melanoma cells.

Clin Cancer Res 2004 Jan;10(2):531-7

Universitäts-Hautklinik, Eberhard-Karls-Universität, Tübingen, Germany.

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January 2004

The systemic progression of human cancer: a focus on the individual disseminated cancer cell--the unit of selection.

Adv Cancer Res 2003 ;89:35-67

Institut für Immunologie, Ludwig-Maximilians Universität München, Goethestr 31, 80336 München, Germany.

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December 2003

Gene expression analysis of a single or few cells.

Curr Protoc Mol Biol 2003 Feb;Chapter 25:Unit 25B.8

Ludwig-Maximilians-University of Munich, Munich, Germany.

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http://dx.doi.org/10.1002/0471142727.mb25b08s61DOI Listing
February 2003