Publications by authors named "Christof R Hauck"

66Publications

PPM1F controls integrin activity via a conserved phospho-switch.

J Cell Biol 2020 Dec;219(12)

Lehrstuhl Zellbiologie, Fachbereich Biologie, Universität Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.1083/jcb.202001057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604772PMC
December 2020

Neisseria gonorrhoeae Blocks Epithelial Exfoliation by Nitric-Oxide-Mediated Metabolic Cross Talk to Promote Colonization in Mice.

Cell Host Microbe 2020 05 13;27(5):793-808.e5. Epub 2020 Apr 13.

Lehrstuhl Für Zellbiologie, Fachbereich Biologie, Universität Konstanz, 78457 Konstanz, Germany; Konstanz Research School Chemical Biology, Universität Konstanz, 78457 Konstanz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2020.03.010DOI Listing
May 2020

CEACAM3-A Prim(at)e Invention for Opsonin-Independent Phagocytosis of Bacteria.

Front Immunol 2019 11;10:3160. Epub 2020 Feb 11.

Lehrstuhl Zellbiologie, Fachbereich Biologie, Universität Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.03160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026191PMC
November 2020

A thiochromenone antibiotic derived from the quinolone signal selectively targets the Gram-negative pathogen .

Chem Sci 2019 Jul 23;10(27):6624-6628. Epub 2019 May 23.

Department of Chemistry , Konstanz Research School Chemical Biology , Zukunftskolleg , University of Konstanz , 78457 Konstanz , Germany . Email:

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http://dx.doi.org/10.1039/c9sc01090dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624978PMC
July 2019

Adaptation to Host-Specific Bacterial Pathogens Drives Rapid Evolution of a Human Innate Immune Receptor.

Curr Biol 2019 02 7;29(4):616-630.e5. Epub 2019 Feb 7.

Lehrstuhl für Zellbiologie, Fachbereich Biologie, Universität Konstanz, Universitätsstraße 10, 78457 Konstanz, Germany; Konstanz Research School-Chemical Biology, Universität Konstanz, Universitätsstraße 10, 78457 Konstanz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2019.01.058DOI Listing
February 2019

Different Enzymatic Processing of γ-Phosphoramidate and γ-Phosphoester-Modified ATP Analogues.

Chembiochem 2017 02 10;18(4):378-381. Epub 2017 Jan 10.

Department of Chemistry, Konstanz Research School Chemical Biology, University of Konstanz, Universitätsstrasse 10, 78457, Konstanz, Germany.

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http://dx.doi.org/10.1002/cbic.201600590DOI Listing
February 2017

Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA.

Nat Microbiol 2016 10 17;2:16188. Epub 2016 Oct 17.

Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Ludwig-Maximilians-Universität, Pettenkoferstraße 9a, München D-80336, Germany.

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http://dx.doi.org/10.1038/nmicrobiol.2016.188DOI Listing
October 2016

Synthetic Glycosphingolipids for Live-Cell Labeling.

Bioconjug Chem 2016 Jul 22;27(7):1624-37. Epub 2016 Jun 22.

Department of Chemistry and ‡Department of Biology, Konstanz Research School Chemical Biology (KoRS-CB), University of Konstanz , 78457 Konstanz, Germany.

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http://dx.doi.org/10.1021/acs.bioconjchem.6b00177DOI Listing
July 2016

Uropathogenic E. coli Exploit CEA to Promote Colonization of the Urogenital Tract Mucosa.

PLoS Pathog 2016 05 12;12(5):e1005608. Epub 2016 May 12.

Lehrstuhl Zellbiologie, Fachbereich Biologie, Universität Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1005608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865239PMC
May 2016

Inflammation-Induced CCR7 Oligomers Form Scaffolds to Integrate Distinct Signaling Pathways for Efficient Cell Migration.

Immunity 2016 Jan;44(1):59-72

Biotechnology Institute Thurgau (BITg) at the University of Konstanz, 8280 Kreuzlingen, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.12.010DOI Listing
January 2016

Visualization of Protein-Specific Glycosylation inside Living Cells.

Angew Chem Int Ed Engl 2016 Feb 12;55(6):2262-6. Epub 2016 Jan 12.

Department of Chemistry and Konstanz Research School, Chemical Biology (KoRS-CB), University of Konstanz, Universitätsstraße 10, 78457, Konstanz, Germany.

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http://dx.doi.org/10.1002/anie.201503183DOI Listing
February 2016

Outer membrane protein P1 is the CEACAM-binding adhesin of Haemophilus influenzae.

Mol Microbiol 2015 Oct 18;98(3):440-55. Epub 2015 Aug 18.

Lehrstuhl für Zellbiologie, Universität Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.1111/mmi.13134DOI Listing
October 2015

The granulocyte orphan receptor CEACAM4 is able to trigger phagocytosis of bacteria.

J Leukoc Biol 2015 Mar 7;97(3):521-31. Epub 2015 Jan 7.

*Lehrstuhl für Zellbiologie and Konstanz Research School Chemical Biology, Universität Konstanz, Germany; and Division of Experimental Pathology, Institute of Pathology, University of Bern, Switzerland

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http://dx.doi.org/10.1189/jlb.2AB0813-449RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477890PMC
March 2015

Signaling by epithelial members of the CEACAM family - mucosal docking sites for pathogenic bacteria.

Cell Commun Signal 2014 Apr 15;12:27. Epub 2014 Apr 15.

Lehrstuhl für Zellbiologie, Universität Konstanz, 78457 Konstanz, Germany.

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http://dx.doi.org/10.1186/1478-811X-12-27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057559PMC
April 2014

Integrin-mediated internalization of Staphylococcus aureus does not require vinculin.

BMC Cell Biol 2013 Jan 7;14. Epub 2013 Jan 7.

Lehrstuhl Zellbiologie, Universität Konstanz, Postfach X908, 78457 Konstanz, Germany.

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http://dx.doi.org/10.1186/1471-2121-14-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562162PMC
January 2013

Grb14 is a negative regulator of CEACAM3-mediated phagocytosis of pathogenic bacteria.

J Biol Chem 2012 Nov 4;287(46):39158-70. Epub 2012 Sep 4.

Lehrstuhl Zellbiologie, Universität Konstanz, 78457 Konstanz, Germany.

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http://dx.doi.org/10.1074/jbc.M112.395228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493956PMC
November 2012

Exploitation of integrin function by pathogenic microbes.

Curr Opin Cell Biol 2012 Oct 8;24(5):637-44. Epub 2012 Aug 8.

Lehrstuhl Zellbiologie, Fachbereich Biologie, Universität Konstanz, Germany.

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http://dx.doi.org/10.1016/j.ceb.2012.07.004DOI Listing
October 2012

HemITAM signaling by CEACAM3, a human granulocyte receptor recognizing bacterial pathogens.

Arch Biochem Biophys 2012 Aug 24;524(1):77-83. Epub 2012 Mar 24.

Lehrstuhl für Zellbiologie, Universität Konstanz, Germany.

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http://dx.doi.org/10.1016/j.abb.2012.03.020DOI Listing
August 2012

Integrin-mediated uptake of fibronectin-binding bacteria.

Eur J Cell Biol 2011 Nov 10;90(11):891-6. Epub 2011 May 10.

Lehrstuhl Zellbiologie, Universität Konstanz, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S01719335110005
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http://dx.doi.org/10.1016/j.ejcb.2011.03.001DOI Listing
November 2011

Neisseria meningitidis has two independent modes of recognizing its human receptor CEACAM1.

PLoS One 2011 Jan 27;6(1):e14609. Epub 2011 Jan 27.

Lehrstuhl für Zellbiologie, Universität Konstanz, Konstanz, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014609PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029278PMC
January 2011

Caveolin limits membrane microdomain mobility and integrin-mediated uptake of fibronectin-binding pathogens.

J Cell Sci 2010 Dec 23;123(Pt 24):4280-91. Epub 2010 Nov 23.

Lehrstuhl Zellbiologie X908, Universität Konstanz, Universitätsstr. 10, 78457 Konstanz, Germany.

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http://dx.doi.org/10.1242/jcs.064006DOI Listing
December 2010

Polymeric immunoglobulin receptor-mediated invasion of Streptococcus pneumoniae into host cells requires a coordinate signaling of SRC family of protein-tyrosine kinases, ERK, and c-Jun N-terminal kinase.

J Biol Chem 2010 Nov 9;285(46):35615-23. Epub 2010 Sep 9.

Department Genetics of Microorganisms, Interfaculty Institute for Genetics and Functional Genomics, Ernst Moritz Arndt Universität Greifswald, Friedrich-Ludwig-Jahn-Strasse 15a, D-17487 Greifswald.

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http://dx.doi.org/10.1074/jbc.M110.172999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975186PMC
November 2010

Human-restricted bacterial pathogens block shedding of epithelial cells by stimulating integrin activation.

Science 2010 Sep;329(5996):1197-201

Lehrstuhl Zellbiologie, Fachbereich Biologie, Universität Konstanz, 78457 Konstanz, Germany.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1190892
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http://dx.doi.org/10.1126/science.1190892DOI Listing
September 2010

CEACAM1 recognition by bacterial pathogens is species-specific.

BMC Microbiol 2010 Apr 20;10:117. Epub 2010 Apr 20.

Lehrstuhl für Zellbiologie, Universität Konstanz, Mailbox X908, 78457 Konstanz, Germany.

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http://dx.doi.org/10.1186/1471-2180-10-117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871271PMC
April 2010

Entry of Neisseria meningitidis into mammalian cells requires the Src family protein tyrosine kinases.

Infect Immun 2010 May 22;78(5):1905-14. Epub 2010 Feb 22.

Institute of Hygiene and Microbiology, University of Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany.

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http://dx.doi.org/10.1128/IAI.01267-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863495PMC
May 2010

Characterizing host receptor recognition by individual bacterial pathogens.

Methods Mol Biol 2009 ;470:57-65

Department of Biology, University of Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.1007/978-1-59745-204-5_5DOI Listing
February 2009

Introduction: bacterial pathogens.

Authors:
Christof R Hauck

Methods Mol Biol 2009 ;470:3-4

Department of Cell Biology, University of Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.1007/978-1-59745-204-5_1DOI Listing
February 2009

CEACAM3: an innate immune receptor directed against human-restricted bacterial pathogens.

Int J Med Microbiol 2008 Oct 7;298(7-8):553-60. Epub 2008 Jul 7.

Lehrstuhl Zellbiologie, Fachbereich Biologie X908, Universität Konstanz, Universitätsstrasse 10, 78457 Konstanz, Germany.

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http://dx.doi.org/10.1016/j.ijmm.2008.04.005DOI Listing
October 2008

The CEACAM1 transmembrane domain, but not the cytoplasmic domain, directs internalization of human pathogens via membrane microdomains.

Cell Microbiol 2008 May 7;10(5):1074-92. Epub 2007 Dec 7.

Lehrstuhl für Zellbiologie, Universität Konstanz, Postfach X908, D-78457 Konstanz, Germany.

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http://dx.doi.org/10.1111/j.1462-5822.2007.01106.xDOI Listing
May 2008

Microbiology: preparing the shot.

Authors:
Christof R Hauck

Nature 2007 Oct;449(7164):798-9

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http://dx.doi.org/10.1038/449798aDOI Listing
October 2007

Profiling of bacterial adhesin--host receptor recognition by soluble immunoglobulin superfamily domains.

J Microbiol Methods 2007 Mar 28;68(3):478-85. Epub 2006 Nov 28.

Lehrstuhl für Zellbiologie, Fachbereich Biologie X908, Universitätsstr.10, Universität Konstanz, 78457 Konstanz, Germany.

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http://dx.doi.org/10.1016/j.mimet.2006.10.003DOI Listing
March 2007

CEACAMs: their role in physiology and pathophysiology.

Curr Opin Cell Biol 2006 Oct 17;18(5):565-71. Epub 2006 Aug 17.

Lehrstuhl Zellbiologie, Fachbereich Biologie X908, Universität Konstanz, Universitätsstrasse 10, 78457 Konstanz, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S095506740600118
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http://dx.doi.org/10.1016/j.ceb.2006.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127089PMC
October 2006

Cellular adhesion molecules as targets for bacterial infection.

Eur J Cell Biol 2006 Apr 12;85(3-4):235-42. Epub 2005 Sep 12.

Zentrum für Infektionsforschung, Universität Würzburg, Röntgenring 11, D-97070 Würzburg, Germany.

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http://dx.doi.org/10.1016/j.ejcb.2005.08.002DOI Listing
April 2006

Fibroblast migration after myocardial infarction is regulated by transient SPARC expression.

J Mol Med (Berl) 2006 Mar 17;84(3):241-52. Epub 2006 Jan 17.

Department of Medicine I, Center for Cardiovascular Medicine, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.

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http://link.springer.com/10.1007/s00109-005-0026-0
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http://dx.doi.org/10.1007/s00109-005-0026-0DOI Listing
March 2006

Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus.

Curr Opin Microbiol 2006 Feb 6;9(1):5-11. Epub 2006 Jan 6.

Zentrum für Infektionsforschung and Institut für Molekulare Infektionsbiologie, Universität Würzburg, Röntgenring 11, 97070 Würzburg, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S136952740500196
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http://dx.doi.org/10.1016/j.mib.2005.12.002DOI Listing
February 2006

Quantification of bacterial invasion into adherent cells by flow cytometry.

J Microbiol Methods 2006 May 26;65(2):301-10. Epub 2005 Sep 26.

Zentrum für Infektionsforschung, Universität Würzburg, Röntgenring 11, 97070 Würzburg, Germany.

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http://dx.doi.org/10.1016/j.mimet.2005.08.013DOI Listing
May 2006

CEACAM engagement by human pathogens enhances cell adhesion and counteracts bacteria-induced detachment of epithelial cells.

J Cell Biol 2005 Aug 22;170(5):825-36. Epub 2005 Aug 22.

Zentrum für Infektionsforschung, Universität Würzburg, 97070 Würzburg, Germany.

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http://dx.doi.org/10.1083/jcb.200412151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171332PMC
August 2005

Migration of human melanoma cells depends on extracellular pH and Na+/H+ exchange.

J Physiol 2005 Aug 9;567(Pt 1):225-38. Epub 2005 Jun 9.

Institute of Physiology II, University of Münster, Robert-Koch-Str.27b, D-48149 Münster, Germany.

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http://dx.doi.org/10.1113/jphysiol.2005.088344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474168PMC
August 2005

Cellular invasion by Staphylococcus aureus reveals a functional link between focal adhesion kinase and cortactin in integrin-mediated internalisation.

J Cell Sci 2005 May 26;118(Pt 10):2189-200. Epub 2005 Apr 26.

Zentrum für Infektionsforschung, Universität Würzburg, Röntgenring 11, 97070 Würzburg, Germany.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.02328
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http://dx.doi.org/10.1242/jcs.02328DOI Listing
May 2005

Targeting of alpha(v) integrins interferes with FAK activation and smooth muscle cell migration and invasion.

Biochem Biophys Res Commun 2005 Jun;331(2):404-12

ZINF, Universität Würzburg, Röntgenring 11, 97070 Würzburg, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2005.03.175DOI Listing
June 2005

Microscopic quantification of bacterial invasion by a novel antibody-independent staining method.

J Microbiol Methods 2004 Oct;59(1):23-32

Zentrum für Infektionsforschung, Universität Würzburg, Röntgenring 11, 97070 Würzburg, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S016770120400148
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http://dx.doi.org/10.1016/j.mimet.2004.05.008DOI Listing
October 2004

Integrin-mediated invasion of Staphylococcus aureus into human cells requires Src family protein-tyrosine kinases.

J Biol Chem 2003 Oct 31;278(43):42524-31. Epub 2003 Jul 31.

Zentrum für Infektionsforschung, Universität Würzburg, Röntgenring 11, 97070 Würzburg, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M302096200
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http://dx.doi.org/10.1074/jbc.M302096200DOI Listing
October 2003

'Small' talk: Opa proteins as mediators of Neisseria-host-cell communication.

Curr Opin Microbiol 2003 Feb;6(1):43-9

Zentrum für Infektionsforschung, Universität Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1016/s1369-5274(03)00004-3DOI Listing
February 2003

The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation.

EMBO J 2003 Feb;22(3):515-28

Max-Planck-Institut für Infektionsbiologie, Abt. Molekulare Biologie, Schumannstrasse 20/21, D-10117 Berlin, Germany.

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http://dx.doi.org/10.1093/emboj/cdg050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC140734PMC
February 2003

FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth.

EMBO J 2002 Dec;21(23):6289-302

Department of Immunology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC136935PMC
http://dx.doi.org/10.1093/emboj/cdf631DOI Listing
December 2002

Cell adhesion receptors - signaling capacity and exploitation by bacterial pathogens.

Authors:
Christof R Hauck

Med Microbiol Immunol 2002 Oct 11;191(2):55-62. Epub 2002 Sep 11.

Research Center for Infectious Diseases, University of Würzburg, Röntgenring 11, Germany.

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http://dx.doi.org/10.1007/s00430-002-0119-0DOI Listing
October 2002

The focal adhesion kinase--a regulator of cell migration and invasion.

IUBMB Life 2002 Feb;53(2):115-9

Research Center for Infectious Diseases, Würzburg, Germany.

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http://dx.doi.org/10.1080/15216540211470DOI Listing
February 2002

v-Src SH3-enhanced interaction with focal adhesion kinase at beta 1 integrin-containing invadopodia promotes cell invasion.

J Biol Chem 2002 Apr 11;277(15):12487-90. Epub 2002 Feb 11.

Department of Immunology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1074/jbc.C100760200DOI Listing
April 2002

Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo.

J Biol Chem 2002 Mar 11;277(9):6775-8. Epub 2002 Jan 11.

Max-Planck-Institut für Infektionsbiologie, Abt. Molekulare Biologie, Schumannstrasse 20/21, D-10117 Berlin, Germany.

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http://dx.doi.org/10.1074/jbc.C100754200DOI Listing
March 2002