Publications by authors named "Christof Niehrs"

100Publications

R-spondins are BMP receptor antagonists in Xenopus early embryonic development.

Nat Commun 2020 11 4;11(1):5570. Epub 2020 Nov 4.

Division of Molecular Embryology, DKFZ-ZMBH Alliance, Deutsches Krebsforschungszentrum (DKFZ), 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41467-020-19373-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642414PMC
November 2020

Fgf and Wnt signaling interaction in the mesenchymal niche regulates the murine hair cycle clock.

Nat Commun 2020 10 9;11(1):5114. Epub 2020 Oct 9.

The Laboratory of Developmental Biology, The Azrieli Faculty of Medicine, Bar-Ilan university, Safed, Israel.

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http://dx.doi.org/10.1038/s41467-020-18643-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547083PMC
October 2020

Eddy De Robertis - Lessons from the Organizer - An Interview with Prof. Edward M. (Eddy) De Robertis.

Authors:
Christof Niehrs

Int J Dev Biol 2020 Aug 5. Epub 2020 Aug 5.

Institute of Molecular Biology (IMB), 55128 Mainz, Germany. Division of Molecular Embryology, DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1387/ijdb.190298cnDOI Listing
August 2020

The origin of genomic N-methyl-deoxyadenosine in mammalian cells.

Nat Chem Biol 2020 06 23;16(6):630-634. Epub 2020 Mar 23.

Institute of Molecular Biology gGmbH, Mainz, Germany.

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http://dx.doi.org/10.1038/s41589-020-0504-2DOI Listing
June 2020

Regulatory R-loops as facilitators of gene expression and genome stability.

Nat Rev Mol Cell Biol 2020 03 31;21(3):167-178. Epub 2020 Jan 31.

Institute of Molecular Biology (IMB), Mainz, Germany.

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http://dx.doi.org/10.1038/s41580-019-0206-3DOI Listing
March 2020

The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer.

Elife 2020 Jan 14;9. Epub 2020 Jan 14.

Division of Molecular Embryology, DKFZ-ZMBH Alliance, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.7554/eLife.51248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996932PMC
January 2020

Emerging Role of C/EBPβ and Epigenetic DNA Methylation in Ageing.

Trends Genet 2020 02 7;36(2):71-80. Epub 2019 Dec 7.

European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, University of Groningen, 9700 AD Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.tig.2019.11.005DOI Listing
February 2020

Osteogenic Dkk1 Mediates Glucocorticoid-Induced but Not Arthritis-Induced Bone Loss.

J Bone Miner Res 2019 07 7;34(7):1314-1323. Epub 2019 Mar 7.

Department of Medicine III, Technische Universität Dresden, Dresden, Germany.

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http://doi.wiley.com/10.1002/jbmr.3702
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http://dx.doi.org/10.1002/jbmr.3702DOI Listing
July 2019

The Role of Dickkopf-1 in Thyroid Hormone-Induced Changes of Bone Remodeling in Male Mice.

Endocrinology 2019 03;160(3):664-674

Department of Medicine III, Technische Universität Dresden Medical Center, Dresden, Germany.

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http://dx.doi.org/10.1210/en.2018-00998DOI Listing
March 2019

Health-Relevant Phenotypes in the Offspring of Mice Given CAR Activators Prior to Pregnancy.

Drug Metab Dispos 2018 11 28;46(11):1827-1835. Epub 2018 Aug 28.

Department of Pharmacology (K.D., L.R., U.G.-A., P.M., T.G., L.W., M.Ma.) and Institute of Medical Biostatistics, Epidemiology and Informatics (F.M.), University Medical Center Mainz, Mainz, Germany; Translational Animal Research Center (J.B., L.E.), University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany; Institute of Experimental Biomedicine II, University Hospital Würzburg, Würzburg, Germany (E.B.); Institute of Molecular Biology, Mainz, Germany (M.Mu., C.N.); and Division of Molecular Embryology, German Cancer Research Center (DKFZ-ZMBH Alliance), Heidelberg, Germany (C.N.)

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http://dx.doi.org/10.1124/dmd.118.082925DOI Listing
November 2018

Postnatal Skeletal Deletion of Dickkopf-1 Increases Bone Formation and Bone Volume in Male and Female Mice, Despite Increased Sclerostin Expression.

J Bone Miner Res 2018 09 12;33(9):1698-1707. Epub 2018 Jun 12.

Department of Medicine III, Technische Universität Dresden, Dresden, Germany.

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http://dx.doi.org/10.1002/jbmr.3463DOI Listing
September 2018

DKK3 (Dickkopf 3) Alters Atherosclerotic Plaque Phenotype Involving Vascular Progenitor and Fibroblast Differentiation Into Smooth Muscle Cells.

Arterioscler Thromb Vasc Biol 2018 02 28;38(2):425-437. Epub 2017 Dec 28.

From the School of Cardiovascular Medicine & Sciences, King's College London BHF Centre, United Kingdom (E.K., B.Y., C.M.F.P., M.M.W., R.M.L.S., Z.Z., X.W., Y.H., Q.X.); The Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University, Jinan, China (C. Zhai, L.Q., Y.Z., C. Zhang); State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials of Ministry of Education, Nankai University, Tianjin, China (Z.W., D.K., Q.Z.); Division of Molecular Embryology, DKFZ-ZMBH Alliance, Heidelberg, Germany (I.d.B.B., C.N.); and Institute of Molecular Biology (IMB), Mainz, Germany (C.N.).

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http://dx.doi.org/10.1161/ATVBAHA.117.310079DOI Listing
February 2018

Stk33 is required for spermatid differentiation and male fertility in mice.

Dev Biol 2018 01 16;433(1):84-93. Epub 2017 Nov 16.

Division of Applied Functional Genomics, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2017.11.007DOI Listing
January 2018

Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover.

Dev Cell 2017 10;43(1):71-82.e6

Division of Molecular Embryology, DKFZ-ZMBH Alliance, Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany; Institute of Molecular Biology (IMB), 55128 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.09.011DOI Listing
October 2017

Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes.

DNA Repair (Amst) 2017 10 12;58:13-20. Epub 2017 Aug 12.

Institute of Pharmacy and Biochemistry, University of Mainz, Staudingerweg 5, D-55099 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2017.08.005DOI Listing
October 2017

A Cytokine-Like Protein Dickkopf-Related Protein 3 Is Atheroprotective.

Circulation 2017 Sep 3;136(11):1022-1036. Epub 2017 Jul 3.

From Cardiovascular Division, King's College London British Heart Foundation Centre, London, United Kingdom (B.Y., X.W., A.L.B., E.K., Z.Z., Y.H., Q.X.); Department of Neurology, Medical University of Innsbruck, Austria (S.K., J.W.); Department of Physiology and Pathophysiology, Capital Medical University, Beijing, China (D.Q., Y.S., A.Q.); Department of Internal and Laboratory Medicine, Bruneck Hospital, Italy (S.W., A.M.); Division of Molecular Embryology, German Cancer Research Center (DKFZ) Heidelberg Germany and Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) Alliance, Heidelberg, Germany (I.d.B.B., C.N.); Institute of Molecular Biology, Mainz, Germany (C.N.); Department of Internal Medicine, Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg, Germany (G.S.); The Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University, Jinan, China (Y.H., Q.X.); and Institute of Bioengineering, Queen Mary University of London, United Kingdom (W.W.)

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.027690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598907PMC
September 2017

RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding.

Nat Struct Mol Biol 2017 Jul 5;24(7):561-569. Epub 2017 Jun 5.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://dx.doi.org/10.1038/nsmb.3419DOI Listing
July 2017

Parkinson's disease-associated receptor GPR37 is an ER chaperone for LRP6.

EMBO Rep 2017 05 24;18(5):712-725. Epub 2017 Mar 24.

Division of Molecular Embryology, DKFZ-ZMBH Alliance, Heidelberg, Germany

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http://dx.doi.org/10.15252/embr.201643585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412897PMC
May 2017

Overcoming drug resistance by cell-penetrating peptide-mediated delivery of a doxorubicin dimer with high DNA-binding affinity.

Eur J Med Chem 2017 Apr 27;130:336-345. Epub 2017 Feb 27.

Institute of Organic Chemistry and Macromolecular Chemistry, Jena Center of Soft Matter, Friedrich Schiller University Jena, Lessingstr. 8, 07743, Jena, Germany; Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.02.056DOI Listing
April 2017

DNA repair and erasure of 5-methylcytosine in vertebrates.

Bioessays 2017 03 18;39(3). Epub 2017 Jan 18.

Institute of Molecular Biology (IMB), Mainz, Germany.

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http://dx.doi.org/10.1002/bies.201600218DOI Listing
March 2017

β-Catenin-Independent Roles of Wnt/LRP6 Signaling.

Trends Cell Biol 2016 12 24;26(12):956-967. Epub 2016 Aug 24.

Division of Molecular Embryology, Deutsches Krebsforschungszentrum (DKFZ)-Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) Alliance, 69120 Heidelberg, Germany; Institute of Molecular Biology, 55128 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2016.07.009DOI Listing
December 2016

Sticking Around: Short-Range Activity of Wnt Ligands.

Dev Cell 2016 Mar;36(5):485-6

Division of Molecular Embryology, German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany; Institute of Molecular Biology (IMB), 55128 Mainz, Germany.

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http://dx.doi.org/10.1016/j.devcel.2016.02.018DOI Listing
March 2016

Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca(2+)/NFAT Signaling.

Dev Cell 2016 Jan;36(1):79-93

Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Department of Vascular Biology and Tumor Angiogenesis (CBTM), Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Straße 13-17, 68167 Mannheim, Germany; German Cancer Consortium, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address:

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http://www.cell.com/developmental-cell/pdf/S1534-5807(15)008
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http://www.cell.com/cms/attachment/2056136664/2061267138/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S153458071500800
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http://dx.doi.org/10.1016/j.devcel.2015.12.015DOI Listing
January 2016

Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation.

Nat Struct Mol Biol 2016 Feb 11;23(2):116-124. Epub 2016 Jan 11.

Institute of Molecular Biology (IMB), Mainz, Germany.

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http://dx.doi.org/10.1038/nsmb.3151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894546PMC
February 2016

Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation.

Cell 2015 Nov;163(5):1225-1236

Division of Molecular Embryology, DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany; Institute of Molecular Biology (IMB), 55128 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.10.029DOI Listing
November 2015

GADD45a physically and functionally interacts with TET1.

Differentiation 2015 Jul-Oct;90(1-3):59-68. Epub 2015 Nov 3.

Institute of Molecular Biology, 55128 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.diff.2015.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673086PMC
June 2016

Octreotide-Mediated Tumor-Targeted Drug Delivery via a Cleavable Doxorubicin-Peptide Conjugate.

Mol Pharm 2015 Dec 17;12(12):4290-300. Epub 2015 Nov 17.

Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.

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http://dx.doi.org/10.1021/acs.molpharmaceut.5b00487DOI Listing
December 2015

Morpholinos: Antisense and Sensibility.

Dev Cell 2015 Oct;35(2):145-9

Institute of Molecular Biology, 55128 Mainz, Germany; DKFZ-ZMBH Alliance, Division of Molecular Embryology, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2015.09.017DOI Listing
October 2015

Fate Specification of Neural Plate Border by Canonical Wnt Signaling and Grhl3 is Crucial for Neural Tube Closure.

EBioMedicine 2015 Jun 18;2(6):513-27. Epub 2015 Apr 18.

Department of Molecular Embryology, Osaka Medical Center, Research Institute for Maternal and Child Health, Osaka Prefectural Hospital Organization, 840 Murodo-cho, Izumi, Osaka 594-1101, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S23523964150010
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http://dx.doi.org/10.1016/j.ebiom.2015.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535158PMC
June 2015

DAZL regulates Tet1 translation in murine embryonic stem cells.

EMBO Rep 2015 Jul 15;16(7):791-802. Epub 2015 Jun 15.

Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands Department of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

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http://dx.doi.org/10.15252/embr.201540538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515119PMC
July 2015

Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis.

Proc Natl Acad Sci U S A 2015 May 21;112(18):5732-7. Epub 2015 Apr 21.

Division of Molecular Embryology, German Cancer Research Center-Zentrum für Molekulare Biologie der Universität Heidelberg (DKFZ-ZMBH) Alliance, D-69120 Heidelberg, Germany; and Institute of Molecular Biology, D-55128 Mainz, Germany

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http://dx.doi.org/10.1073/pnas.1423533112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426427PMC
May 2015

Herbert Steinbeisser: a life with the Xenopus embryo.

Int J Dev Biol 2014 ;58(5):299-302

Howard Hughes Medical Institute, University of California, Los Angeles, USA.

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http://www.intjdevbiol.com/paper.php?doi=140117ed
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http://dx.doi.org/10.1387/ijdb.140117edDOI Listing
July 2015

Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A.

Mol Cell 2014 Aug 31;55(4):604-14. Epub 2014 Jul 31.

Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; The German Cancer Consortium, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.06.031DOI Listing
August 2014

Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways.

Neuron 2014 Jul;83(1):104-21

Institute for Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany; Molecular Medicine Partnership Unit, Otto Meyerhof Center, Im Neuenheimer Feld, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.05.037DOI Listing
July 2014

Mitotic wnt signaling promotes protein stabilization and regulates cell size.

Mol Cell 2014 May 15;54(4):663-74. Epub 2014 May 15.

DKFZ-ZMBH Alliance, Division of Molecular Embryology, DKFZ, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany; Institute of Molecular Biology, Ackermannweg 4, D-55128 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.04.014DOI Listing
May 2014

Polarized Wnt signaling regulates ectodermal cell fate in Xenopus.

Dev Cell 2014 Apr;29(2):250-7

Division of Molecular Embryology, DKFZ-ZMBH Alliance, Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany; Institute of Molecular Biology, 55128 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.03.015DOI Listing
April 2014

RAB8B is required for activity and caveolar endocytosis of LRP6.

Cell Rep 2013 Sep 12;4(6):1224-34. Epub 2013 Sep 12.

German Cancer Research Center (DKFZ), Division of Signaling and Functional Genomics, Heidelberg University, Department of Cell and Molecular Biology, Medical Faculty Mannheim, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.celrep.2013.08.008DOI Listing
September 2013

Downregulation of Dickkopf-3 disrupts prostate acinar morphogenesis through TGF-β/Smad signalling.

J Cell Sci 2013 Apr 26;126(Pt 8):1858-67. Epub 2013 Feb 26.

Department of Surgery and Cancer, Imperial College London, London, W12 0NN, UK.

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http://dx.doi.org/10.1242/jcs.119388DOI Listing
April 2013

RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling.

Science 2013 Mar 14;339(6126):1436-41. Epub 2013 Feb 14.

Division of Molecular Embryology, DKFZ-ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1126/science.1231499DOI Listing
March 2013

Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline.

Cell Stem Cell 2013 Feb;12(2):204-14

Division of Molecular Neurobiology, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.stem.2012.11.010DOI Listing
February 2013

The complex world of WNT receptor signalling.

Authors:
Christof Niehrs

Nat Rev Mol Cell Biol 2012 Dec 15;13(12):767-79. Epub 2012 Nov 15.

Division of Molecular Embryology, DKFZ-ZMBH Alliance, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/nrm3470DOI Listing
December 2012

GADD45G functions in male sex determination by promoting p38 signaling and Sry expression.

Dev Cell 2012 Nov 25;23(5):1032-42. Epub 2012 Oct 25.

Institute of Molecular Biology, 55128 Mainz, Germany.

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http://dx.doi.org/10.1016/j.devcel.2012.09.014DOI Listing
November 2012

Secreted and transmembrane wnt inhibitors and activators.

Cold Spring Harb Perspect Biol 2013 Mar 1;5(3):a015081. Epub 2013 Mar 1.

Division of Molecular Embryology, DKFZ-ZMBH Alliance, DKFZ, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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http://cshperspectives.cshlp.org/lookup/doi/10.1101/cshpersp
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http://dx.doi.org/10.1101/cshperspect.a015081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578365PMC
March 2013

Dkk3 is a component of the genetic circuitry regulating aldosterone biosynthesis in the adrenal cortex.

Hum Mol Genet 2012 Nov 23;21(22):4922-9. Epub 2012 Aug 23.

Institut de Pharmacologie Moléculaire et Cellulaire CNRS, Valbonne, France.

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http://dx.doi.org/10.1093/hmg/dds333DOI Listing
November 2012

Identification of RARRES1 as a core regulator in liver fibrosis.

J Mol Med (Berl) 2012 Dec 6;90(12):1439-47. Epub 2012 Jun 6.

Department of Medicine I, Johannes Gutenberg University, Building 605, Langenbeckstr. 1, 55101 Mainz, Germany.

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http://dx.doi.org/10.1007/s00109-012-0919-7DOI Listing
December 2012

Mitotic and mitogenic Wnt signalling.

EMBO J 2012 Jun 22;31(12):2705-13. Epub 2012 May 22.

Division of Molecular Embryology, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany.

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http://dx.doi.org/10.1038/emboj.2012.124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380213PMC
June 2012

Active DNA demethylation by Gadd45 and DNA repair.

Trends Cell Biol 2012 Apr 15;22(4):220-7. Epub 2012 Feb 15.

Institute of Molecular Biology, 55128 Mainz, Germany.

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http://dx.doi.org/10.1016/j.tcb.2012.01.002DOI Listing
April 2012

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.

EMBO Rep 2011 Sep 30;12(10):1055-61. Epub 2011 Sep 30.

Division of Molecular Embryology, DKFZ-ZMBH Alliance, DKFZ, Im Neuenheimer Feld 580, Heidelberg D-69120, Germany.

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http://dx.doi.org/10.1038/embor.2011.175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185347PMC
September 2011

Gadd45a and Gadd45g regulate neural development and exit from pluripotency in Xenopus.

Mech Dev 2011 Sep-Dec;128(7-10):401-11. Epub 2011 Aug 10.

Division of Molecular Embryology, DKFZ-ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 581, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.mod.2011.08.002DOI Listing
March 2012

Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development.

Gene Expr Patterns 2011 Dec 6;11(8):465-70. Epub 2011 Aug 6.

Division of Molecular Embryology, DKFZ-ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.gep.2011.07.005DOI Listing
December 2011

Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development.

Proc Natl Acad Sci U S A 2011 Jun 1;108(25):10202-7. Epub 2011 Jun 1.

Division of Molecular Embryology and Department of Theoretical Bioinformatics, Deutsches Krebsforschungszentrum, D-69120 Heidelberg, Germany.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1100179108
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http://dx.doi.org/10.1073/pnas.1100179108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121836PMC
June 2011

Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation.

Mol Cell Biol 2011 Jul 2;31(13):2577-90. Epub 2011 May 2.

Protein Science Laboratory of the Ministry of Education, School of Life Sciences, Tsinghua University, Beijing 100084, People's Republic of China.

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http://dx.doi.org/10.1128/MCB.05103-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133378PMC
July 2011

Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis.

Dev Cell 2011 Mar;20(3):303-14

Division of Molecular Embryology, DKFZ-ZMBH Alliance, German Cancer Research Center, Im Neuenheimer Feld 581, Heidelberg, Germany.

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http://www.cell.com/cms/attachment/614054/4941062/mmc1.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S153458071100034
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http://dx.doi.org/10.1016/j.devcel.2011.01.006DOI Listing
March 2011

Negative autoregulation of Oct3/4 through Cdx1 promotes the onset of gastrulation.

Dev Dyn 2011 Apr 28;240(4):796-807. Epub 2011 Feb 28.

Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University, Jerusalem, Israel.

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http://doi.wiley.com/10.1002/dvdy.22588
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April 2011

Secreted Wnt antagonist Dickkopf-1 controls kidney papilla development coordinated by Wnt-7b signalling.

Dev Biol 2011 May 24;353(1):50-60. Epub 2011 Feb 24.

Oulu Center for Cell-Matrix Research, Biocenter Oulu, Laboratory of Developmental Biology and Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine, University of Oulu, Finland.

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http://dx.doi.org/10.1016/j.ydbio.2011.02.019DOI Listing
May 2011

Dkk1 regulates ventral midbrain dopaminergic differentiation and morphogenesis.

PLoS One 2011 Feb 11;6(2):e15786. Epub 2011 Feb 11.

Section of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015786PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037958PMC
February 2011

Dialectics, systems biology and embryonic induction.

Authors:
Christof Niehrs

Differentiation 2011 Apr;81(4):209-16

Division of Molecular Embryology, DKFZ-ZMBH Alliance, German Cancer Research Center, Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.diff.2010.10.004DOI Listing
April 2011

Gadd45a is an RNA binding protein and is localized in nuclear speckles.

PLoS One 2011 Jan 7;6(1):e14500. Epub 2011 Jan 7.

Division of Molecular Embryology, DKFZ-ZMBH Alliance, Krebsforschungszentrum, Heidelberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014500PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017548PMC
January 2011

Wnt signaling: multivesicular bodies hold GSK3 captive.

Cell 2010 Dec;143(7):1044-6

German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Division of Molecular Embryology, Im Neuenheimer Feld 581, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.cell.2010.12.003DOI Listing
December 2010

An ATF2-based luciferase reporter to monitor non-canonical Wnt signaling in Xenopus embryos.

Dev Dyn 2011 Jan;240(1):188-94

Division of Molecular Embryology, DKFZ-ZMBH Alliance, Deutsches Krebsforschungszentrum, Heidelberg, Germany.

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http://dx.doi.org/10.1002/dvdy.22500DOI Listing
January 2011

Gemcitabine functions epigenetically by inhibiting repair mediated DNA demethylation.

PLoS One 2010 Nov 19;5(11):e14060. Epub 2010 Nov 19.

Division of Molecular Embryology, DKFZ-ZMBH Alliance, Deutsches Krebsforschungszentrum, Heidelberg, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988820PMC
November 2010

Trafficking, acidification, and growth factor signaling.

Sci Signal 2010 Aug 10;3(134):pe26. Epub 2010 Aug 10.

1German Cancer Research Center (DKFZ), DKFZ-Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) Alliance, Division of Molecular Embryology, Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1126/scisignal.3134pe26DOI Listing
August 2010

Emerging links between CDK cell cycle regulators and Wnt signaling.

Trends Cell Biol 2010 Aug 4;20(8):453-60. Epub 2010 Jun 4.

Karlsruhe Institute of Technology (KIT), Institute of Toxicology and Genetics, H. v. Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen, Germany.

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http://dx.doi.org/10.1016/j.tcb.2010.05.002DOI Listing
August 2010

Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor.

Curr Biol 2010 Jul 24;20(14):1263-8. Epub 2010 Jun 24.

Division of Signaling and Functional Genomics, German Cancer Research Center (DKFZ), and Department of Cell and Molecular Biology, Faculty of Medicine Mannheim, University of Heidelberg, Im Neuenheimer Feld 580, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.cub.2010.05.028DOI Listing
July 2010

Regulation of Lrp6 phosphorylation.

Cell Mol Life Sci 2010 Aug 14;67(15):2551-62. Epub 2010 Mar 14.

Division of Molecular Embryology, DKFZ-ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 581, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00018-010-0329-3DOI Listing
August 2010

On growth and form: a Cartesian coordinate system of Wnt and BMP signaling specifies bilaterian body axes.

Authors:
Christof Niehrs

Development 2010 Mar;137(6):845-57

Division of Molecular Embryology, DKFZ-ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1242/dev.039651DOI Listing
March 2010

Xenopus skip modulates Wnt/beta-catenin signaling and functions in neural crest induction.

J Biol Chem 2010 Apr 26;285(14):10890-901. Epub 2010 Jan 26.

School of Life Sciences, Protein Science Laboratory of the Ministry of Education, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1074/jbc.M109.058347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856295PMC
April 2010

Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling.

Science 2010 Jan;327(5964):459-63

Division of Molecular Embryology, DKFZ-ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1179802
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January 2010

Cell cycle control of wnt receptor activation.

Dev Cell 2009 Dec;17(6):788-99

Division of Molecular Embryology, Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Hermann von Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany.

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http://dx.doi.org/10.1016/j.devcel.2009.11.006DOI Listing
December 2009

Unc5B interacts with FLRT3 and Rnd1 to modulate cell adhesion in Xenopus embryos.

PLoS One 2009 May 29;4(5):e5742. Epub 2009 May 29.

Division of Molecular Embryology, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005742PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683942PMC
May 2009

Active DNA demethylation and DNA repair.

Authors:
Christof Niehrs

Differentiation 2009 Jan 25;77(1):1-11. Epub 2008 Oct 25.

Division of Molecular Embryology, DKFZ-ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.diff.2008.09.004DOI Listing
January 2009

The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development.

Development 2008 Nov 8;135(22):3655-64. Epub 2008 Oct 8.

Division of Molecular Embryology, German Cancer Research Center, Im Neuenheimer Feld 581, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1242/dev.027284DOI Listing
November 2008

Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density.

Mol Cell Biol 2008 Aug 27;28(15):4875-82. Epub 2008 May 27.

Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1128/MCB.00222-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493355PMC
August 2008

Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling.

Development 2007 Dec 31;134(23):4255-63. Epub 2007 Oct 31.

Department of Molecular Embryology, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1242/dev.005942DOI Listing
December 2007

TGF-beta signaling-mediated morphogenesis: modulation of cell adhesion via cadherin endocytosis.

Genes Dev 2007 Jul;21(14):1817-31

Department of Developmental and Cell Biology, Developmental Biology Center, University of California at Irvine, Irvine, California 92697, USA.

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http://dx.doi.org/10.1101/gad.1541807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920175PMC
July 2007

Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation.

Science 2007 Jun;316(5831):1619-22

Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1126/science.1137065DOI Listing
June 2007

Dkk3 is required for TGF-beta signaling during Xenopus mesoderm induction.

Differentiation 2007 Dec 9;75(10):957-67. Epub 2007 May 9.

Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S030146810960188
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http://dx.doi.org/10.1111/j.1432-0436.2007.00185.xDOI Listing
December 2007

Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.

Nature 2007 Feb 31;445(7128):671-5. Epub 2007 Jan 31.

Division of Molecular Embryology, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature05515DOI Listing
February 2007

The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition.

J Biol Chem 2006 May 10;281(18):12986-93. Epub 2006 Mar 10.

Department of Molecular Embryology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1074/jbc.M511872200DOI Listing
May 2006

An ancient Wnt-Dickkopf antagonism in Hydra.

Development 2006 Mar 1;133(5):901-11. Epub 2006 Feb 1.

Molecular Evolution and Genomics, Heidelberg University, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany.

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http://dev.biologists.org/content/develop/133/5/901.full.pdf
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http://dev.biologists.org/cgi/doi/10.1242/dev.02265
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March 2006

A role for fibronectin-leucine-rich transmembrane cell-surface proteins in homotypic cell adhesion.

EMBO Rep 2006 Mar 20;7(3):283-90. Epub 2006 Jan 20.

Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/sj.embor.7400614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456895PMC
March 2006