Publications by authors named "Christof Kramm"

82Publications

Spinal Deformities after Childhood Tumors.

Cancers (Basel) 2020 Nov 28;12(12). Epub 2020 Nov 28.

Pediatric Orthopedics, Department of Trauma, Orthopedic and Plastic Surgery, University Medical Center Göttingen; 37075 Göttingen, Germany.

View Article and Find Full Text PDF
November 2020

Combined treatment with CBP and BET inhibitors reverses inadvertent activation of detrimental super enhancer programs in DIPG cells.

Cell Death Dis 2020 08 21;11(8):673. Epub 2020 Aug 21.

Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Goettingen, Robert Koch Straße 40, Goettingen, Germany.

View Article and Find Full Text PDF
August 2020

Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes.

Authors:
Matthew Clarke Alan Mackay Britta Ismer Jessica C Pickles Ruth G Tatevossian Scott Newman Tejus A Bale Iris Stoler Elisa Izquierdo Sara Temelso Diana M Carvalho Valeria Molinari Anna Burford Louise Howell Alex Virasami Amy R Fairchild Aimee Avery Jane Chalker Mark Kristiansen Kelly Haupfear James D Dalton Wilda Orisme Ji Wen Michael Hubank Kathreena M Kurian Catherine Rowe Mellissa Maybury Stephen Crosier Jeffrey Knipstein Ulrich Schüller Uwe Kordes David E Kram Matija Snuderl Leslie Bridges Andrew J Martin Lawrence J Doey Safa Al-Sarraj Christopher Chandler Bassel Zebian Claire Cairns Rachael Natrajan Jessica K R Boult Simon P Robinson Martin Sill Ira J Dunkel Stephen W Gilheeney Marc K Rosenblum Debbie Hughes Paula Z Proszek Tobey J Macdonald Matthias Preusser Christine Haberler Irene Slavc Roger Packer Ho-Keung Ng Shani Caspi Mara Popović Barbara Faganel Kotnik Matthew D Wood Lissa Baird Monika Ashok Davare David A Solomon Thale Kristin Olsen Petter Brandal Michael Farrell Jane B Cryan Michael Capra Michael Karremann Jens Schittenhelm Martin U Schuhmann Martin Ebinger Winand N M Dinjens Kornelius Kerl Simone Hettmer Torsten Pietsch Felipe Andreiuolo Pablo Hernáiz Driever Andrey Korshunov Lotte Hiddingh Barbara C Worst Dominik Sturm Marc Zuckermann Olaf Witt Tabitha Bloom Clare Mitchell Evelina Miele Giovanna Stefania Colafati Francesca Diomedi-Camassei Simon Bailey Andrew S Moore Timothy E G Hassall Stephen P Lowis Maria Tsoli Mark J Cowley David S Ziegler Matthias A Karajannis Kristian Aquilina Darren R Hargrave Fernando Carceller Lynley V Marshall Andreas von Deimling Christof M Kramm Stefan M Pfister Felix Sahm Suzanne J Baker Angela Mastronuzzi Andrea Carai Maria Vinci David Capper Sergey Popov David W Ellison Thomas S Jacques David T W Jones Chris Jones

Cancer Discov 2020 Jul 1;10(7):942-963. Epub 2020 Apr 1.

Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.

View Article and Find Full Text PDF
July 2020

Musashi1 enhances chemotherapy resistance of pediatric glioblastoma cells in vitro.

Pediatr Res 2020 03 22;87(4):669-676. Epub 2019 Nov 22.

Department of Pediatric Hematology/Oncology, University Hospital, Halle (Saale), Germany.

View Article and Find Full Text PDF
March 2020

The German National Registry of Primary Immunodeficiencies (2012-2017).

Authors:
Sabine M El-Helou Anika-Kerstin Biegner Sebastian Bode Stephan R Ehl Maximilian Heeg Maria E Maccari Henrike Ritterbusch Carsten Speckmann Stephan Rusch Raphael Scheible Klaus Warnatz Faranaz Atschekzei Renata Beider Diana Ernst Stev Gerschmann Alexandra Jablonka Gudrun Mielke Reinhold E Schmidt Gesine Schürmann Georgios Sogkas Ulrich H Baumann Christian Klemann Dorothee Viemann Horst von Bernuth Renate Krüger Leif G Hanitsch Carmen M Scheibenbogen Kirsten Wittke Michael H Albert Anna Eichinger Fabian Hauck Christoph Klein Anita Rack-Hoch Franz M Sollinger Anne Avila Michael Borte Stephan Borte Maria Fasshauer Anja Hauenherm Nils Kellner Anna H Müller Anett Ülzen Peter Bader Shahrzad Bakhtiar Jae-Yun Lee Ursula Heß Ralf Schubert Sandra Wölke Stefan Zielen Sujal Ghosh Hans-Juergen Laws Jennifer Neubert Prasad T Oommen Manfred Hönig Ansgar Schulz Sandra Steinmann Klaus Schwarz Gregor Dückers Beate Lamers Vanessa Langemeyer Tim Niehues Sonu Shai Dagmar Graf Carmen Müglich Marc T Schmalzing Eva C Schwaneck Hans-Peter Tony Johannes Dirks Gabriele Haase Johannes G Liese Henner Morbach Dirk Foell Antje Hellige Helmut Wittkowski Katja Masjosthusmann Michael Mohr Linda Geberzahn Christian M Hedrich Christiane Müller Angela Rösen-Wolff Joachim Roesler Antje Zimmermann Uta Behrends Nikolaus Rieber Uwe Schauer Rupert Handgretinger Ursula Holzer Jörg Henes Lothar Kanz Christoph Boesecke Jürgen K Rockstroh Carolynne Schwarze-Zander Jan-Christian Wasmuth Dagmar Dilloo Brigitte Hülsmann Stefan Schönberger Stefan Schreiber Rainald Zeuner Tobias Ankermann Philipp von Bismarck Hans-Iko Huppertz Petra Kaiser-Labusch Johann Greil Donate Jakoby Andreas E Kulozik Markus Metzler Nora Naumann-Bartsch Bettina Sobik Norbert Graf Sabine Heine Robin Kobbe Kai Lehmberg Ingo Müller Friedrich Herrmann Gerd Horneff Ariane Klein Joachim Peitz Nadine Schmidt Stefan Bielack Ute Groß-Wieltsch Carl F Classen Jessica Klasen Peter Deutz Dirk Kamitz Lisa Lassay Klaus Tenbrock Norbert Wagner Benedikt Bernbeck Bastian Brummel Eusebia Lara-Villacanas Esther Münstermann Dominik T Schneider Nadine Tietsch Marco Westkemper Michael Weiß Christof Kramm Ingrid Kühnle Silke Kullmann Hermann Girschick Christof Specker Elisabeth Vinnemeier-Laubenthal Henriette Haenicke Claudia Schulz Lothar Schweigerer Thomas G Müller Martina Stiefel Bernd H Belohradsky Veronika Soetedjo Gerhard Kindle Bodo Grimbacher

Front Immunol 2019 19;10:1272. Epub 2019 Jul 19.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

View Article and Find Full Text PDF
October 2020

H3F3A-G34R mutant high grade neuroepithelial neoplasms with glial and dysplastic ganglion cell components.

Acta Neuropathol Commun 2019 05 20;7(1):78. Epub 2019 May 20.

Department of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Bonn, Germany.

View Article and Find Full Text PDF
May 2019

Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience.

Eur J Cancer 2019 06 22;114:27-35. Epub 2019 Apr 22.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

View Article and Find Full Text PDF
June 2019

Occurrence of high-grade glioma in Noonan syndrome: Report of two cases.

Pediatr Blood Cancer 2019 05 28;66(5):e27625. Epub 2019 Jan 28.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Hospital of Geneva, Geneva, Switzerland.

View Article and Find Full Text PDF
May 2019

The use of Do-Not-Resuscitate-Order equivalents in pediatric palliative care medicine in Germany.

Ann Palliat Med 2019 Apr 4;8(2):112-120. Epub 2018 Sep 4.

Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Göttingen, Göttingen, Germany.

View Article and Find Full Text PDF
April 2019

Author Correction: The landscape of genomic alterations across childhood cancers.

Nature 2018 07;559(7714):E10

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

View Article and Find Full Text PDF
July 2018

Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries.

J Clin Oncol 2018 07 10;36(19):1963-1972. Epub 2018 May 10.

Lindsey M. Hoffman and Nicholas K. Foreman, University of Colorado Denver; Lindsey M. Hoffman and Nicholas K. Foreman, Children's Hospital Colorado, Aurora, CO; Sophie E.M. Veldhuijzen van Zanten, Esther Hulleman, Gertjan J.L. Kaspers, Esther Sanchez, and Dannis G. van Vuurden, Vrije Universiteit University Medical Center, Amsterdam; William P. Vandertop, Academy of Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Niclas Colditz, Marion Hoffmann, Brigitte Bison, Monika Warmuth-Metz, and Christof M. Kramm, University Medical Center Goettingen, Goettingen; Torsten Pietsch and Gerrit H. Gielen, University of Bonn Medical Center, Bonn; David T.W. Jones, Dominik Sturm, Stefan M. Pfister, and Elke Pfaff, German Cancer Research Center, Hopp-Children's Cancer Center at the Nationale Centrum für Tumorerkrankungen Heidelberg, and German Consortium for Translational Cancer Research; Dominik Sturm, Stefan M. Pfister, and Elke Pfaff, Heidelberg University Hospital, Heidelberg, Germany; Joshua Baugh, Brooklyn Chaney, Adam Lane, Christine Fuller, Nancy Yanez Escorza, Renee Doughman, Rachid Drissi, James Leach, Blaise Jones, and Maryam Fouladi, Cincinnati Children's Hospital Medical Center, Cincinnati; Emmett Broxson, Wright State University and The Children's Medical Center, Dayton, OH; Lili Miles, Nemours Children's Hospital, Orlando, FL; Cynthia Hawkins, Ute Bartels, and Eric Bouffet, The Hospital for Sick Children, Toronto, Ontario; Anne Sophie Carret, Centre Hospitalier Universitaire Sainte-Justine; Nada Jabado, McGill University, Montreal, Quebec, Canada; Stewart Goldman, Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, IL; Sarah Leary, Seattle Children's Hospital, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA; Roger Packer, Children's National Health System; Javad Nazarian, Children's National Medical Center, Washington, DC; Katherine E. Warren, National Cancer Institute, Bethesda, MD; Alberto Broniscer, St Jude Children's Research Hospital, Memphis, TN; Mark W. Kieran, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA; Jane Minturn, Children's Hospital of Philadelphia and The Perelman School of Medicine at the University of Pennsylvania, Philadelphia; Melanie Comito, The Pennsylvania State University, Hershey, PA; Chie-Schin Shih, Indiana University, Indianapolis, IN; Soumen Khatua, The University of Texas MD Anderson Cancer Center; Murali Chintagumpala, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, TX; Timothy Hassall, Lady Cilento Children's Hospital, Brisbane, Queensland; David S. Ziegler, Kids Cancer Centre, Sydney Children's Hospital, Randwick; David S. Ziegler, University of New South Wales, Sydney, New South Wales; Nicholas Gottardo and Hetal Dholaria, Princess Margaret Hospital for Children, Perth, Western Australia, Australia; Martin Benesch, Medical University of Graz, Graz, Austria; Nathalie Boddaert. Stephanie Puget, and Raphaël Calmon, Hôpital Necker Enfants Malades; Pascale Varlet, Hôpital Sainte-Anne, Université Paris V Descartes, Sorbonne Paris Cité, Paris; Géraldine Giraud, David Castel, and Jacques Grill, Gustave Roussy, Université Paris-Sud, Université Paris-Saclay, Villejuif, France; Géraldine Giraud, Uppsala University, Uppsala, Sweden; Chris Jones, The Institute of Cancer Research, Sutton; Darren Hargrave, Great Ormond Street Hospital, London; Guirish A. Solanki, Birmingham Women's and Children's Hospital, Birmingham; Simon Bailey, Great North Children's Hospital, Victoria Wing, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom; Piergiorgio Modena and Marzia Giagnacovo, Sant' Anna Como General Hospital, Como; Manila Antonelli, Sapienza University of Rome, Rome; Veronica Biassoni and Maura Massimino, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, Milan, Italy; Nicolas U. Gerber and Michael A. Grotzer, University Children's Hospital of Zurich, Zurich; André O. von Bueren, University Hospital of Geneva and University of Geneva, Geneva, Switzerland; and Filip Jadrijevic Cvrlje and Gertjan J.L. Kaspers, Children's Hospital Zagreb, Zagreb, Croatia.

View Article and Find Full Text PDF
July 2018

Diffuse intrinsic pontine gliomas (DIPG) at recurrence: is there a window to test new therapies in some patients?

J Neurooncol 2018 Sep 17;139(2):501. Epub 2018 Apr 17.

Geneva University Hospitals, Geneva, Switzerland.

View Article and Find Full Text PDF
September 2018

DNA methylation-based classification of central nervous system tumours.

Authors:
David Capper David T W Jones Martin Sill Volker Hovestadt Daniel Schrimpf Dominik Sturm Christian Koelsche Felix Sahm Lukas Chavez David E Reuss Annekathrin Kratz Annika K Wefers Kristin Huang Kristian W Pajtler Leonille Schweizer Damian Stichel Adriana Olar Nils W Engel Kerstin Lindenberg Patrick N Harter Anne K Braczynski Karl H Plate Hildegard Dohmen Boyan K Garvalov Roland Coras Annett Hölsken Ekkehard Hewer Melanie Bewerunge-Hudler Matthias Schick Roger Fischer Rudi Beschorner Jens Schittenhelm Ori Staszewski Khalida Wani Pascale Varlet Melanie Pages Petra Temming Dietmar Lohmann Florian Selt Hendrik Witt Till Milde Olaf Witt Eleonora Aronica Felice Giangaspero Elisabeth Rushing Wolfram Scheurlen Christoph Geisenberger Fausto J Rodriguez Albert Becker Matthias Preusser Christine Haberler Rolf Bjerkvig Jane Cryan Michael Farrell Martina Deckert Jürgen Hench Stephan Frank Jonathan Serrano Kasthuri Kannan Aristotelis Tsirigos Wolfgang Brück Silvia Hofer Stefanie Brehmer Marcel Seiz-Rosenhagen Daniel Hänggi Volkmar Hans Stephanie Rozsnoki Jordan R Hansford Patricia Kohlhof Bjarne W Kristensen Matt Lechner Beatriz Lopes Christian Mawrin Ralf Ketter Andreas Kulozik Ziad Khatib Frank Heppner Arend Koch Anne Jouvet Catherine Keohane Helmut Mühleisen Wolf Mueller Ute Pohl Marco Prinz Axel Benner Marc Zapatka Nicholas G Gottardo Pablo Hernáiz Driever Christof M Kramm Hermann L Müller Stefan Rutkowski Katja von Hoff Michael C Frühwald Astrid Gnekow Gudrun Fleischhack Stephan Tippelt Gabriele Calaminus Camelia-Maria Monoranu Arie Perry Chris Jones Thomas S Jacques Bernhard Radlwimmer Marco Gessi Torsten Pietsch Johannes Schramm Gabriele Schackert Manfred Westphal Guido Reifenberger Pieter Wesseling Michael Weller Vincent Peter Collins Ingmar Blümcke Martin Bendszus Jürgen Debus Annie Huang Nada Jabado Paul A Northcott Werner Paulus Amar Gajjar Giles W Robinson Michael D Taylor Zane Jaunmuktane Marina Ryzhova Michael Platten Andreas Unterberg Wolfgang Wick Matthias A Karajannis Michel Mittelbronn Till Acker Christian Hartmann Kenneth Aldape Ulrich Schüller Rolf Buslei Peter Lichter Marcel Kool Christel Herold-Mende David W Ellison Martin Hasselblatt Matija Snuderl Sebastian Brandner Andrey Korshunov Andreas von Deimling Stefan M Pfister

Nature 2018 03 14;555(7697):469-474. Epub 2018 Mar 14.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

View Article and Find Full Text PDF
March 2018

The landscape of genomic alterations across childhood cancers.

Nature 2018 03 28;555(7696):321-327. Epub 2018 Feb 28.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

View Article and Find Full Text PDF
March 2018

High-grade glioma in very young children: a rare and particular patient population.

Oncotarget 2017 Sep 14;8(38):64564-64578. Epub 2017 Jun 14.

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Hospital of Geneva, Geneva, Switzerland.

View Article and Find Full Text PDF
September 2017

Snail homolog 1 is involved in epithelial-mesenchymal transition-like processes in human glioblastoma cells.

Oncol Lett 2017 May 17;13(5):3882-3888. Epub 2017 Mar 17.

Department of Pediatrics, University Clinic and Polyclinic for Child and Adolescent Medicine I, Martin Luther University Halle-Wittenberg, D-06120 Halle, Germany.

View Article and Find Full Text PDF
May 2017

The β-catenin/CBP-antagonist ICG-001 inhibits pediatric glioma tumorigenicity in a Wnt-independent manner.

Oncotarget 2017 Apr;8(16):27300-27313

Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Goettingen, Goettingen, Germany.

View Article and Find Full Text PDF
April 2017

Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology.

Am J Med Genet A 2017 Apr 7;173(4):1017-1037. Epub 2017 Feb 7.

Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

View Article and Find Full Text PDF
April 2017

Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease.

J Neurooncol 2017 04 21;132(2):255-266. Epub 2017 Jan 21.

Department of Paediatrics, Division of Oncology/Haematology, VU University Medical Center, Amsterdam, The Netherlands.

View Article and Find Full Text PDF
April 2017

Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study.

Eur J Cancer 2016 09 29;65:91-101. Epub 2016 Jul 29.

Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg, 69120, Germany; German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany. Electronic address:

View Article and Find Full Text PDF
September 2016

Commentary on "Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes".

Acta Neuropathol 2016 May 30;131(5):793-4. Epub 2016 Mar 30.

Department of Pediatrics, Pediatric Oncology and Hematology, VU University Medical Center, Room PK 4x027, De Boelelaan 1118, 1081 HZ, Amsterdam, The Netherlands.

View Article and Find Full Text PDF
May 2016

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.

Authors:
Dominik Sturm Brent A Orr Umut H Toprak Volker Hovestadt David T W Jones David Capper Martin Sill Ivo Buchhalter Paul A Northcott Irina Leis Marina Ryzhova Christian Koelsche Elke Pfaff Sariah J Allen Gnanaprakash Balasubramanian Barbara C Worst Kristian W Pajtler Sebastian Brabetz Pascal D Johann Felix Sahm Jüri Reimand Alan Mackay Diana M Carvalho Marc Remke Joanna J Phillips Arie Perry Cynthia Cowdrey Rachid Drissi Maryam Fouladi Felice Giangaspero Maria Łastowska Wiesława Grajkowska Wolfram Scheurlen Torsten Pietsch Christian Hagel Johannes Gojo Daniela Lötsch Walter Berger Irene Slavc Christine Haberler Anne Jouvet Stefan Holm Silvia Hofer Marco Prinz Catherine Keohane Iris Fried Christian Mawrin David Scheie Bret C Mobley Matthew J Schniederjan Mariarita Santi Anna M Buccoliero Sonika Dahiya Christof M Kramm André O von Bueren Katja von Hoff Stefan Rutkowski Christel Herold-Mende Michael C Frühwald Till Milde Martin Hasselblatt Pieter Wesseling Jochen Rößler Ulrich Schüller Martin Ebinger Jens Schittenhelm Stephan Frank Rainer Grobholz Istvan Vajtai Volkmar Hans Reinhard Schneppenheim Karel Zitterbart V Peter Collins Eleonora Aronica Pascale Varlet Stephanie Puget Christelle Dufour Jacques Grill Dominique Figarella-Branger Marietta Wolter Martin U Schuhmann Tarek Shalaby Michael Grotzer Timothy van Meter Camelia-Maria Monoranu Jörg Felsberg Guido Reifenberger Matija Snuderl Lynn Ann Forrester Jan Koster Rogier Versteeg Richard Volckmann Peter van Sluis Stephan Wolf Tom Mikkelsen Amar Gajjar Kenneth Aldape Andrew S Moore Michael D Taylor Chris Jones Nada Jabado Matthias A Karajannis Roland Eils Matthias Schlesner Peter Lichter Andreas von Deimling Stefan M Pfister David W Ellison Andrey Korshunov Marcel Kool

Cell 2016 Feb;164(5):1060-1072

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.

View Article and Find Full Text PDF
February 2016

Lenalidomide in an in vitro Dendritic Cell Model for Malignant Gliomas.

Anticancer Agents Med Chem 2016 ;16(11):1468-1473

Department of Pediatrics, Medical Faculty, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

View Article and Find Full Text PDF
June 2017

Characterization of an Additional Splice Acceptor Site Introduced into CYP4B1 in Hominoidae during Evolution.

PLoS One 2015 10;10(9):e0137110. Epub 2015 Sep 10.

Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich Heine University, 40225 Düsseldorf, Germany; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, United States of America; Department of Pediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany.

View Article and Find Full Text PDF
May 2016

Secondary Solid Malignancies After High-Grade Glioma Treatment in Pediatric Patients.

Pediatr Hematol Oncol 2015 3;32(7):467-73. Epub 2015 Aug 3.

b Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health , University Medical Center Göttingen , Göttingen, Germany.

View Article and Find Full Text PDF
September 2016

External validation of a prognostic model estimating the survival of patients with recurrent high-grade gliomas after reirradiation.

Pract Radiat Oncol 2015 May-Jun;5(3):e143-e150. Epub 2014 Nov 18.

Department of Radiation Oncology (MAASTRO), GROW (School for Oncology & Developmental Biology), Maastricht University Medical Centre, Maastricht, The Netherlands; Department of Radiation Oncology, MediClin Robert Janker Clinic & University of Bonn Med Centre, Clinical Cooperation Unit Neurooncology, Bonn, Germany.

View Article and Find Full Text PDF
April 2016

Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol.

Biochem J 2015 Jan;465(1):103-14

*Department of Otorhinolaryngology, Head and Neck Surgery, Children's Hospital, Heinrich Heine University, Moorenstrasse 5, D-40225, Düsseldorf, Germany.

View Article and Find Full Text PDF
January 2015

Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria.

Neuro Oncol 2015 Jan 5;17(1):160-6. Epub 2014 Jun 5.

Department of Pediatric Oncology and Hematology, VU University Medical Center, Amsterdam, Netherlands (M.H.A.J., S.E.M.V.v.Z., E.J.v.d.H., G.J.L.K., D.G.v.V.); Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, Netherlands (E.S.A., F.B.); Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands (M.W.H.); Department of Neuroradiology, Reference Center for Neuroradiology, Uniklinikum Wurzburg, University of Würzburg, Wurzburg, Germany (M.W-M.); Department of Oncology, Great Ormond Street Hospital London, London, UK (D.H.); Department of Pediatric Oncology and Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (C.E.G.); Department of Pediatric Oncology and Hematology, University Medical Center Groningen, Groningen, Netherlands (E.S.J.M.d.B.); Department of Radiology, University Medical Center Groningen, Groningen, Netherlands (O.S.E.); Department of Pediatric Oncology and Hematology, Erasmus Medical Centre Rotterdam, Rotterdam, Netherlands (R.R.); Department of Pediatric Neurology, Leiden University Medical Center Rotterdam, Leiden, Netherlands (C.M.P.C.D.P.); Department of Pediatric Oncology and Hematology, Academic Medical Center Amsterdam, Emma Children's Hospital AMC, Amsterdam, Netherlands (A.Y.N.S-v.M.); Department of Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands (R.H.J.G.); Department of Pediatric Oncology and Hematology, University Hospital Maastricht, Maastricht, Netherlands (B.G.); Department of Radiotherapy, Isala Clinics Zwolle, Zwolle, Netherlands (G.M.R.N.P.); Department of Radiation Oncology (874), Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands (G.O.J.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands (D.P.N., W.P.V.); University Children's Hospital, Halle, Germany (C.M.K.); Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medi

View Article and Find Full Text PDF
January 2015

Impact of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and MGMT expression on dacarbazine resistance of Hodgkin's lymphoma cells.

Leuk Res 2014 Jan 13;38(1):138-43. Epub 2013 Nov 13.

Department of Pediatrics, Martin-Luther-University Halle-Wittenberg, Halle, Germany. Electronic address:

View Article and Find Full Text PDF
January 2014

CD137 stimulation and p38 MAPK inhibition improve reactivity in an in vitro model of glioblastoma immunotherapy.

Cancer Immunol Immunother 2013 Dec 16;62(12):1797-809. Epub 2013 Oct 16.

Department of Pediatrics, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle, Germany.

View Article and Find Full Text PDF
December 2013

H3F3A K27M mutation in pediatric CNS tumors: a marker for diffuse high-grade astrocytomas.

Am J Clin Pathol 2013 Mar;139(3):345-9

Institute of Neuropathology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, D-53105 Bonn, Germany.

View Article and Find Full Text PDF
March 2013

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.

Cancer Cell 2012 Oct;22(4):425-37

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany.

View Article and Find Full Text PDF
October 2012

Thalamic high-grade gliomas in children: a distinct clinical subset?

Neuro Oncol 2011 Jun;13(6):680-9

University Children's Hospital, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Str. 40, 06120 Halle, Germany.

View Article and Find Full Text PDF
June 2011

Tumor vaccination for high-grade glioma.

Pediatr Blood Cancer 2010 Dec 16;55(7):1437. Epub 2010 Sep 16.

View Article and Find Full Text PDF
December 2010

Clinical and epidemiological characteristics of pediatric gliosarcomas.

J Neurooncol 2010 Apr 6;97(2):257-65. Epub 2009 Oct 6.

Department of Pediatrics and Adolescence Medicine, Martin Luther University Halle-Wittenberg, Halle, Germany.

View Article and Find Full Text PDF
April 2010

Critical illness polyneuropathy: a rare but serious adverse event in pediatric oncology.

Pediatr Blood Cancer 2010 Jan;54(1):161-5

University Children's Hospital, University Medical Center, Martin-Luther University Halle-Wittenberg, Halle, Germany.

View Article and Find Full Text PDF
January 2010

Pediatric giant cell glioblastoma: New insights into a rare tumor entity.

Neuro Oncol 2009 Jun 2;11(3):323-9. Epub 2008 Dec 2.

Department of Pediatrics and Adolescent Medicine, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06120 Halle, Germany.

View Article and Find Full Text PDF
June 2009

Anaplastic ganglioglioma in children.

J Neurooncol 2009 Apr 29;92(2):157-63. Epub 2008 Nov 29.

Department of Pediatrics and Adolescence Medicine, Martin-Luther-University Halle-Wittenberg, Halle, Germany.

View Article and Find Full Text PDF
April 2009

Valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma.

J Neurooncol 2008 Dec 5;90(3):309-14. Epub 2008 Aug 5.

Children's Cancer Hospital, Department of Pediatrics, Unit 87, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, USA.

View Article and Find Full Text PDF
December 2008

Subpopulations of malignant gliomas in pediatric patients: analysis of the HIT-GBM database.

J Neurooncol 2008 Apr 22;87(2):155-64. Epub 2008 Jan 22.

Department of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

View Article and Find Full Text PDF
April 2008

Value of surrogate tests to predict exercise-induced bronchoconstriction in atopic childhood asthma.

Pediatr Pulmonol 2007 Mar;42(3):225-30

Department of Paediatric Cardiology and Pulmonology, Heinrich-Heine-University, Düsseldorf, Germany.

View Article and Find Full Text PDF
March 2007

Improved survival after gross total resection of malignant gliomas in pediatric patients from the HIT-GBM studies.

Anticancer Res 2006 Sep-Oct;26(5B):3773-9

Department of Pediatric Oncology, Hematology & Immunology, University Children's Hospital, Duesseldorf, Germany.

View Article and Find Full Text PDF
December 2006

Transduction of human glial and neuronal tumor cells with different lentivirus vector pseudotypes.

J Neurooncol 2004 Dec;70(3):281-8

Surgery Department, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

View Article and Find Full Text PDF
December 2004

Transduction of human glial and neuronal tumor cells with different lentivirus vector pseudotypes.

J Neurooncol 2004 Dec;70(3):281-8

Surgery Department, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

View Article and Find Full Text PDF
December 2004

Hypercalcemia with nephrocalcinosis and impaired renal function due to increased Parathyroid hormone secretion at onset of childhood acute lymphoblastic leukemia.

Leuk Lymphoma 2004 Aug;45(8):1695-7

Department of Pediatric Hematology, Oncology, and Immunology, Center of Pediatric and Adolescent Medicine, University Hospital Düsseldorf, Düsseldorf, Germany.

View Article and Find Full Text PDF
August 2004

Recurrent atrial ectopic tachycardia following chemotherapy with ifosfamide.

Pediatr Hematol Oncol 2004 Jun;21(4):307-11

Department of Pediatric Hematology, Oncology and Immunology, University Medical Center, Heinrich-Heine-University, Düsseldorf, Germany.

View Article and Find Full Text PDF
June 2004

Recurrent atrial ectopic tachycardia following chemotherapy with ifosfamide.

Pediatr Hematol Oncol 2004 Jun;21(4):307-11

Department of Pediatric Hematology, Oncology and Immunology, University Medical Center, Heinrich-Heine-University, Düsseldorf, Germany.

View Article and Find Full Text PDF
June 2004

Treatment of vincristine-induced bilateral ptosis with pyridoxine and pyridostigmine.

Pediatr Blood Cancer 2004 Mar;42(3):287-8

Department of Pediatric Hematology and Oncology, University Medical Center, Heinrich-Heine-University, Düsseldorf, Germany.

View Article and Find Full Text PDF
March 2004

Treatment of vincristine-induced bilateral ptosis with pyridoxine and pyridostigmine.

Pediatr Blood Cancer 2004 Mar;42(3):287-8

Department of Pediatric Hematology and Oncology, University Medical Center, Heinrich-Heine-University, Düsseldorf, Germany.

View Article and Find Full Text PDF
March 2004

Recombinant retrovirus vectors for treatment of malignant brain tumors.

Int Rev Neurobiol 2003 ;55:185-203

Department of Neurological Science, University of Liverpool, Walton Centre for Neurology and Neurosurgery NHS Trust, Liverpool L9 7LJ, United Kingdom.

View Article and Find Full Text PDF
October 2003

Stable transgenic expression of IL-2 and HSV1-tk by single and fusion tumor cell lines bearing EWS/FLI-1 chimeric genes.

Pediatr Hematol Oncol 2003 Mar;20(2):119-40

Children's Cancer Research Center, Department of Pediatrics and BioCenter, Martin-Luther University Halle-Wittenberg, Halle/Saale, Germany.

View Article and Find Full Text PDF
March 2003

Stable transgenic expression of IL-2 and HSV1-tk by single and fusion tumor cell lines bearing EWS/FLI-1 chimeric genes.

Pediatr Hematol Oncol 2003 Mar;20(2):119-40

Children's Cancer Research Center, Department of Pediatrics and BioCenter, Martin-Luther University Halle-Wittenberg, Halle/Saale, Germany.

View Article and Find Full Text PDF
March 2003

Pre-eruptive varicella zoster virus encephalitis in two children after haematopoietic stem cell transplantation.

Med Pediatr Oncol 2002 Apr;38(4):288-9

Department of Pediatric Hematology and Oncology, University Children's Hospital, Heinrich-Heine-University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany.

View Article and Find Full Text PDF
April 2002

Differential cytotoxicity and bystander effect of the rabbit cytochrome P450 4B1 enzyme gene by two different prodrugs: implications for pharmacogene therapy.

Cancer Gene Ther 2002 Feb;9(2):178-88

Department of Pediatric Hematology and Oncology, University Children's Hospital, Heinrich Heine University, Duesseldorf, Germany.

View Article and Find Full Text PDF
February 2002