Christof Fellmann

Christof Fellmann

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Christof Fellmann

Christof Fellmann

Publications by authors named "Christof Fellmann"

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Author Correction: Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors.

Nat Biotechnol 2019 Jul;37(7):820

Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41587-019-0168-1DOI Listing
July 2019

Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors.

Nat Biotechnol 2019 06 20;37(6):626-631. Epub 2019 May 20.

Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41587-019-0134-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551276PMC
June 2019

MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival.

Proc Natl Acad Sci U S A 2019 Mar 1;116(10):4508-4517. Epub 2019 Feb 1.

Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892;

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http://dx.doi.org/10.1073/pnas.1817494116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410784PMC
March 2019

Systematic discovery of natural CRISPR-Cas12a inhibitors.

Science 2018 10 6;362(6411):236-239. Epub 2018 Sep 6.

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1126/science.aau5138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6185749PMC
October 2018

Differential Effector Engagement by Oncogenic KRAS.

Cell Rep 2018 02;22(7):1889-1902

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 1450 3rd Street, San Francisco, CA 94158, USA; Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., P.O. Box B, Frederick, MD 21702, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.01.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343826PMC
February 2018

Cornerstones of CRISPR-Cas in drug discovery and therapy.

Nat Rev Drug Discov 2017 02 23;16(2):89-100. Epub 2016 Dec 23.

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1038/nrd.2016.238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459481PMC
February 2017

Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch.

Nat Biotechnol 2016 06 2;34(6):646-51. Epub 2016 May 2.

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.

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http://dx.doi.org/10.1038/nbt.3528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900928PMC
June 2016

A computational algorithm to predict shRNA potency.

Mol Cell 2014 Dec 26;56(6):796-807. Epub 2014 Nov 26.

Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.

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http://dx.doi.org/10.1016/j.molcel.2014.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272634PMC
December 2014

Translation initiation factor eIF4F modifies the dexamethasone response in multiple myeloma.

Proc Natl Acad Sci U S A 2014 Sep 2;111(37):13421-6. Epub 2014 Sep 2.

Departments of Biochemistry, The Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, QC, Canada H3G 1Y6; Oncology, and

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http://dx.doi.org/10.1073/pnas.1402650111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169926PMC
September 2014

Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors.

Cancer Cell 2014 May 17;25(5):697-710. Epub 2014 Apr 17.

Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049532PMC
May 2014

Stable RNA interference rules for silencing.

Nat Cell Biol 2014 Jan;16(1):10-8

Howard Hughes Medical Institute and Memorial Sloan-Kettering Cancer Center, 415 East 68th Street, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/ncb2895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001088PMC
January 2014

An optimized microRNA backbone for effective single-copy RNAi.

Cell Rep 2013 Dec 12;5(6):1704-13. Epub 2013 Dec 12.

Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, 1030 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2013.11.020DOI Listing
December 2013

Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy.

Proc Natl Acad Sci U S A 2012 Jan 4;109(3):869-74. Epub 2012 Jan 4.

Department of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1119873109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271875PMC
January 2012

HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase.

Nature 2010 Jun;465(7298):577-83

Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.

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http://dx.doi.org/10.1038/nature09141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328299PMC
June 2010