Christine T N Pham

Division of Rheumatology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA; John Cochran VA Medical Center, Saint Louis, MO, USA. Electronic address:

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October 2019

Combined Experimental Approach and Finite Element Modeling of Small Molecule Transport Through Joint Synovium to Measure Effective Diffusivity.

Authors:

Young Guang Tom M McGrath Natalie Klug Robert Nims Chien-Cheng Shih Peter O Bayguinov Farshid Guilak Christine T N Pham James A J Fitzpatrick Lori A Setton

J Biomech Eng 2019 Sep 1. Epub 2019 Sep 1.

Department of Biomedical Engineering, Washington University in St. Louis, Whitaker Hall, 1 Brookings Dr., St. Louis, MO, 63130.

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September 2019

Applications of RNA interference in the treatment of arthritis.

Authors:

Muhammad Farooq Rai Hua Pan Huimin Yan Linda J Sandell Christine T N Pham Samuel A Wickline

Transl Res 2019 12 10;214:1-16. Epub 2019 Jul 10.

Department of Cardiovascular Sciences, University of South Florida Health Heart Institute, Morsani School of Medicine, Tampa, Florida.

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December 2019

Interleukin-12 and -23 blockade mitigates elastase-induced abdominal aortic aneurysm.

Authors:

Huimin Yan Ying Hu Antonina Akk Karen Ye John Bacon Christine T N Pham

Sci Rep 2019 07 18;9(1):10447. Epub 2019 Jul 18.

John Cochran VA Medical Center, Saint Louis, Missouri, USA.

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July 2019

Designer Stem Cells: Genome Engineering and the Next Generation of Cell-Based Therapies.

Authors:

Farshid Guilak Lara Pferdehirt Alison K Ross Yun-Rak Choi KelseyH Collins Robert J Nims Dakota B Katz Molly Klimak Suzanne Tabbaa Christine T N Pham

J Orthop Res 2019 06 2;37(6):1287-1293. Epub 2019 May 2.

Department of Medicine, Division of Rheumatology, Washington University, St. Louis, Missouri.

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June 2019

Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery.

Authors:

Huimin Yan Xin Duan Hua Pan Antonina Akk Linda J Sandell Samuel A Wickline Muhammad Farooq Rai Christine T N Pham

Sci Rep 2019 01 24;9(1):442. Epub 2019 Jan 24.

Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

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January 2019

Contribution of Adipose-Derived Factor D/Adipsin to Complement Alternative Pathway Activation: Lessons from Lipodystrophy.

Authors:

Xiaobo Wu Irina Hutson Antonina M Akk Smita Mascharak Christine T N Pham Dennis E Hourcade Rebecca Brown John P Atkinson Charles A Harris

J Immunol 2018 04 12;200(8):2786-2797. Epub 2018 Mar 12.

Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110;

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April 2018

Neutrophils and neutrophil serine proteases are increased in the spleens of estrogen-treated C57BL/6 mice and several strains of spontaneous lupus-prone mice.

Authors:

Rujuan Dai Catharine Cowan Bettina Heid Deena Khan Zhihong Liang Christine T N Pham S Ansar Ahmed

PLoS One 2017 13;12(2):e0172105. Epub 2017 Feb 13.

Infectious Disease Research Facility (IDRF), Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine (VMCVM), Virginia Tech, Blacksburg, Virginia, United States of America.

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August 2017

Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury.

Authors:

Huimin Yan Xin Duan Hua Pan Nilsson Holguin Muhammad Farooq Rai Antonina Akk Luke E Springer Samuel A Wickline Linda J Sandell Christine T N Pham

Proc Natl Acad Sci U S A 2016 10 28;113(41):E6199-E6208. Epub 2016 Sep 28.

Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110;

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October 2016

Neutrophil Extracellular Traps Enhance Early Inflammatory Response in Sendai Virus-Induced Asthma Phenotype.

Authors:

Antonina Akk Luke E Springer Christine T N Pham

Front Immunol 2016 26;7:325. Epub 2016 Aug 26.

Department of Medicine, Division of Rheumatology, Washington University School of Medicine , Saint Louis, MO , USA.

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September 2016

Neutrophil Proteases Promote Experimental Abdominal Aortic Aneurysm via Extracellular Trap Release and Plasmacytoid Dendritic Cell Activation.

Authors:

Huimin Yan Hui-Fang Zhou Antonina Akk Ying Hu Luke E Springer Terri L Ennis Christine T N Pham

Arterioscler Thromb Vasc Biol 2016 08 9;36(8):1660-1669. Epub 2016 Jun 9.

John Cochran VA Medical Center, Saint Louis, Missouri USA; the Department of Medicine, Division of Rheumatology and the Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, Saint Louis, Missouri, USA.

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August 2016

Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance.

Authors:

Erik J M Toonen Andreea-Manuela Mirea Cees J Tack Rinke Stienstra Dov B Ballak Janna A van Diepen Anneke Hijmans Triantafyllos Chavakis Wim H Dokter Christine T N Pham Mihai G Netea Charles A Dinarello Leo A B Joosten

Mol Med 2016 05 24;22. Epub 2016 May 24.

Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.

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May 2016

Anti-complement activity of the Ixodes scapularis salivary protein Salp20.

Authors:

Dennis E Hourcade Antonina M Akk Lynne M Mitchell Hui-fang Zhou Richard Hauhart Christine T N Pham

Mol Immunol 2016 Jan 8;69:62-9. Epub 2015 Dec 8.

Division of Rheumatology, Department of Medicine, Washington University, St. Louis, MO, USA. Electronic address:

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January 2016

Contact-facilitated drug delivery with Sn2 lipase labile prodrugs optimize targeted lipid nanoparticle drug delivery.

Authors:

Dipanjan Pan Christine T N Pham Katherine N Weilbaecher Michael H Tomasson Samuel A Wickline Gregory M Lanza

Wiley Interdiscip Rev Nanomed Nanobiotechnol 2016 Jan-Feb;8(1):85-106. Epub 2015 Aug 21.

Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

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September 2016

Peptide-siRNA nanotherapeutics in arthritis.

Authors:

Christine T N Pham Hua Pan Samuel A Wickline

Oncotarget 2015 Jun;6(17):14731-2

Washington University School of Medicine, Saint Louis, MO USA.

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June 2015

Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation.

Authors:

Huimin Yan Hui-Fang Zhou Ying Hu Christine T N Pham

J Rheum Dis Treat 2015 Feb;1(1)

Department of Medicine, Division of Rheumatology, Washington University School of Medicine, Saint Louis, Missouri.

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February 2015

Delivery of a Protease-Activated Cytolytic Peptide Prodrug by Perfluorocarbon Nanoparticles.

Authors:

Andrew P Jallouk Rohun U Palekar Jon N Marsh Hua Pan Christine T N Pham Paul H Schlesinger Samuel A Wickline

Bioconjug Chem 2015 Aug 2;26(8):1640-50. Epub 2015 Jul 2.

†Consortium for Translational Research in Advanced Imaging and Nanomedicine, Division of Cardiology, Department of Medicine, Washington University in St. Louis School of Medicine, St. Louis, Missouri 63108, United States.

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August 2015

Quantifying progression and regression of thrombotic risk in experimental atherosclerosis.

Authors:

Rohun U Palekar Andrew P Jallouk Matthew J Goette Junjie Chen Jacob W Myerson John S Allen Antonina Akk Lihua Yang Yizheng Tu Mark J Miller Christine T N Pham Samuel A Wickline Hua Pan

FASEB J 2015 Jul 9;29(7):3100-9. Epub 2015 Apr 9.

*Department of Biomedical Engineering and Department of Medicine, Washington University, St. Louis, Missouri, USA

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July 2015

Anti-mouse properdin TSR 5/6 monoclonal antibodies block complement alternative pathway-dependent pathogenesis.

Authors:

Paula Bertram Antonina M Akk Hui-fang Zhou Lynne M Mitchell Christine T N Pham Dennis E Hourcade

Monoclon Antib Immunodiagn Immunother 2015 Feb;34(1):1-6

Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine , St. Louis, Missouri.

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February 2015

Synergy between surface and core entrapped metals in a mixed manganese-gadolinium nanocolloid affords safer MR imaging of sparse biomarkers.

Authors:

Kezheng Wang Dipanjan Pan Anne H Schmieder Angana Senpan Dennis E Hourcade Christine T N Pham Lynne M Mitchell Shelton D Caruthers Grace Cui Samuel A Wickline Baozhong Shen Gregory M Lanza

Nanomedicine 2015 Apr 31;11(3):601-9. Epub 2015 Jan 31.

Division of Cardiology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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April 2015

Physicochemical signatures of nanoparticle-dependent complement activation.

Authors:

Dennis G Thomas Satish Chikkagoudar Alejandro Heredia-Langer Mark F Tardiff Zhixiang Xu Dennis E Hourcade Christine T N Pham Gregory M Lanza Kilian Q Weinberger Nathan A Baker

Comput Sci Discov 2014 Mar;7(1):015003

Knowledge Discovery and Informatics, Pacific Northwest National Laboratory, Richland, WA 99352, USA.

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March 2014

Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 suppress nascent experimental arthritis.

Authors:

Hui-fang Zhou Huimin Yan Hua Pan Kirk K Hou Antonina Akk Luke E Springer Ying Hu J Stacy Allen Samuel A Wickline Christine T N Pham

J Clin Invest 2014 Oct 26;124(10):4363-74. Epub 2014 Aug 26.

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October 2014

Fumagillin prodrug nanotherapy suppresses macrophage inflammatory response via endothelial nitric oxide.

Authors:

Hui-fang Zhou Huimin Yan Ying Hu Luke E Springer Xiaoxia Yang Samuel A Wickline Dipanjan Pan Gregory M Lanza Christine T N Pham

ACS Nano 2014 Jul 24;8(7):7305-17. Epub 2014 Jun 24.

Division of Rheumatology and ‡Division of Cardiology, Department of Medicine, Washington University School of Medicine , Saint Louis, Missouri, United States.

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July 2014

Application of a hemolysis assay for analysis of complement activation by perfluorocarbon nanoparticles.

Authors:

Christine T N Pham Dennis G Thomas Julia Beiser Lynne M Mitchell Jennifer L Huang Angana Senpan Grace Hu Mae Gordon Nathan A Baker Dipanjan Pan Gregory M Lanza Dennis E Hourcade

Nanomedicine 2014 Apr 8;10(3):651-60. Epub 2013 Nov 8.

Department of Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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April 2014

Fibrinogen-specific antibody induces abdominal aortic aneurysm in mice through complement lectin pathway activation.

Authors:

Hui-fang Zhou Huimin Yan Paula Bertram Ying Hu Luke E Springer Robert W Thompson John A Curci Dennis E Hourcade Christine T N Pham

Proc Natl Acad Sci U S A 2013 Nov 28;110(46):E4335-44. Epub 2013 Oct 28.

Division of Rheumatology, Department of Medicine, and Division of Vascular Surgery, Department of Surgery, Washington University in St. Louis, St. Louis, MO 63124.

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November 2013

CD43-mediated IFN-γ production by CD8+ T cells promotes abdominal aortic aneurysm in mice.

Authors:

Hui-fang Zhou Huimin Yan Judy L Cannon Luke E Springer Jonathan M Green Christine T N Pham

J Immunol 2013 May 12;190(10):5078-85. Epub 2013 Apr 12.

Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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May 2013

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