Publications by authors named "Christine Sempoux"

100Publications

Incidence trends of lung and gastroenteropancreatic neuroendocrine neoplasms in Switzerland.

Cancer Med 2020 Dec 20;9(24):9454-9461. Epub 2020 Oct 20.

Vaud Cancer Registry, Centre for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.

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December 2020

Development of an optimized closed and semi-automatic protocol for Good Manufacturing Practice manufacturing of tumor-infiltrating lymphocytes in a hospital environment.

Cytotherapy 2020 Dec 14;22(12):780-791. Epub 2020 Oct 14.

Center of Experimental Therapeutics, Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland; Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland; Ludwig Institute for Cancer Research, Lausanne University Hospital, Lausanne, Switzerland. Electronic address:

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December 2020

Increasing incidence of microscopic colitis in a population-based cohort study in Switzerland.

Clin Gastroenterol Hepatol 2020 Oct 13. Epub 2020 Oct 13.

Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland. Electronic address:

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October 2020

Personalized Cytokine-Directed Therapy With Tocilizumab for Refractory Immune Checkpoint Inhibitor-Related Cholangiohepatitis.

J Thorac Oncol 2020 Sep 19. Epub 2020 Sep 19.

Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; University Hospital of Lausanne, Lausanne, Switzerland; Vaccine and Immunotherapy Center, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. Electronic address:

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September 2020

[Hepatocellular adenoma: update 2020].

Rev Med Suisse 2020 Sep;16(704):1554-1559

Institut universitaire de pathologie, CHUV et Université de Lausanne, 1011 Lausanne.

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September 2020

Prediction of tumour grade and survival outcome using pre-treatment PET- and MRI-derived imaging features in patients with resectable pancreatic ductal adenocarcinoma.

Eur Radiol 2021 Feb 26;31(2):992-1001. Epub 2020 Aug 26.

Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

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February 2021

Autoimmune hepatitis as a sequelae of oxcarbazepine-induced drug reaction with eosinophilia and systemic symptoms.

J Allergy Clin Immunol Pract 2021 Jan 10;9(1):580-581. Epub 2020 Aug 10.

Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland; Service of Immunology and Allergy, Lausanne University Hospital, Lausanne, Switzerland. Electronic address:

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January 2021

Histologic parameter score does not predict short-term survival in severe alcoholic hepatitis.

United European Gastroenterol J 2020 Nov 10;8(9):1003-1012. Epub 2020 Aug 10.

Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Université Libre de Bruxelles, Brussels, Belgium.

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November 2020

The histologic presentation of hepatitis E reflects patients' immune status and pre-existing liver condition.

Mod Pathol 2021 Jan 22;34(1):233-248. Epub 2020 Jun 22.

Department of Pathology and Molecular Pathology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.

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January 2021

Tumor response and outcome after reverse treatment for patients with synchronous colorectal liver metastasis: a cohort study.

BMC Surg 2020 Apr 19;20(1):78. Epub 2020 Apr 19.

Department of Visceral Surgery, Lausanne University Hospital (CHUV), University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland.

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April 2020

Molecular classification and therapeutic targets in extrahepatic cholangiocarcinoma.

J Hepatol 2020 Aug 12;73(2):315-327. Epub 2020 Mar 12.

Translational Research in Hepatic Oncology, Liver Unit, IDIBAPS, Hospital Clínic, University of Barcelona, Barcelona, Catalonia, Spain; Liver Cancer Program, Divisions of Liver Diseases, Pathology Department and RM Transplant Institute, Tisch Cancer Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain. Electronic address:

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August 2020

Updates in the diagnosis of combined hepatocellular-cholangiocarcinoma.

Hum Pathol 2020 02 10;96:48-55. Epub 2020 Jan 10.

Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital and University of Lausanne, 1011, Lausanne, Switzerland. Electronic address:

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February 2020

Donor-specific antibodies in liver transplantation.

Gastroenterol Hepatol 2020 Jan 4;43(1):34-45. Epub 2019 Dec 4.

Hospital Clinic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain.

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January 2020

Neutrophils suppress tumor-infiltrating T cells in colon cancer via matrix metalloproteinase-mediated activation of TGFβ.

EMBO Mol Med 2020 01 2;12(1):e10681. Epub 2019 Dec 2.

Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

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January 2020

[Alagille Syndrome].

Rev Med Suisse 2019 Aug;15(660):1506-1510

Service de gastroentérologie et d'hépatologie, CHUV, Université de Lausanne, 1011 Lausanne.

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August 2019

[Abecedary of colonic polyps].

Rev Med Suisse 2019 Aug;15(660):1483-1487

Service de gastroentérologie et d'hépatologie, CHUV et Université de Lausanne, 1011 Lausanne.

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August 2019

Invasive Ductular Reaction Operates Hepatobiliary Junctions upon Hepatocellular Injury in Rodents and Humans.

Am J Pathol 2019 08 18;189(8):1569-1581. Epub 2019 May 18.

Laboratory of Gastroenterology, Université Catholique de Louvain, Brussels, Belgium. Electronic address:

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August 2019

Reactive cholangiocytes differentiate into proliferative hepatocytes with efficient DNA repair in mice with chronic liver injury.

J Hepatol 2019 06 20;70(6):1180-1191. Epub 2019 Feb 20.

Laboratory of Hepato-gastroenterology, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium. Electronic address:

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June 2019

Correction to: CD73 expression in normal and pathological human hepatobiliopancreatic tissues.

Cancer Immunol Immunother 2019 03;68(3):529

Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, rue du Bugnon 25, 1011, Lausanne, Switzerland.

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March 2019

CD73 expression in normal and pathological human hepatobiliopancreatic tissues.

Cancer Immunol Immunother 2019 Mar 4;68(3):467-478. Epub 2019 Jan 4.

Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, rue du Bugnon 25, 1011, Lausanne, Switzerland.

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March 2019

Hepatic manifestations of Wilson's disease: 12-year experience in a Swiss tertiary referral centre.

Swiss Med Wkly 2018 12 21;148:w14699. Epub 2018 Dec 21.

Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland.

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December 2018

Tumoral response and tumoral phenotypic changes in a rat model of diethylnitrosamine-induced hepatocellular carcinoma after salirasib and sorafenib administration.

Onco Targets Ther 2018 17;11:7143-7153. Epub 2018 Oct 17.

Laboratory of Hepato-Gastroenterology, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium;

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October 2018

Snapshot summary of diagnosis and management of hepatocellular adenoma subtypes.

Clin Res Hepatol Gastroenterol 2019 02 10;43(1):12-19. Epub 2018 Sep 10.

Inserm, UMR1053 Bordeaux research in translational oncology, BaRITOn, université de Bordeaux, 33076 Bordeaux, France.

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February 2019

[Primary biliary cholangitis : an update].

Rev Med Suisse 2018 Aug;14(616):1489-1494

Service de gastroentérologie et d'hépatologie, CHUV, 1011 Lausanne.

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August 2018

β-Klotho deficiency shifts the gut-liver bile acid axis and induces hepatic alterations in mice.

Am J Physiol Endocrinol Metab 2018 11 26;315(5):E833-E847. Epub 2018 Jun 26.

Service of Endocrinology, Diabetology, and Metabolism, Department of Physiology, Faculty of Biology and Medicine, Lausanne University Hospital, University of Lausanne , Lausanne , Switzerland.

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November 2018

Hepatocellular nodules in vascular liver diseases.

Virchows Arch 2018 Jul 26;473(1):33-44. Epub 2018 May 26.

Inserm, UMR1053 Bordeaux Research In Translational Oncology, BaRITOn, F-33000 Bordeaux, Université de Bordeaux, 33076, Bordeaux, France.

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July 2018

Vascular liver lesions: contemporary views on long-recognized entities.

Virchows Arch 2018 07 14;473(1):1-2. Epub 2018 Mar 14.

Inserm, UMR1053 Bordeaux Research in Translational Oncology, BaRITOn, F-33000 Bordeaux, Université de Bordeaux, 33076, Bordeaux, France.

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July 2018

Local recurrence rate in patients with colorectal cancer liver metastasis after wedge resection or percutaneous radiofrequency ablation.

Int J Hyperthermia 2018 11 5;34(7):1020-1028. Epub 2018 Mar 5.

a Department of Radiology and Interventional Radiology , Lausanne University Hospital and University of Lausanne , Lausanne , Switzerland.

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November 2018

Quantification of hepatic perfusion and hepatocyte function with dynamic gadoxetic acid-enhanced MRI in patients with chronic liver disease.

Clin Sci (Lond) 2018 04 16;132(7):813-824. Epub 2018 Apr 16.

Laboratory of Imaging Biomarkers, Center of Research on Inflammation, UMR 1149 Inserm - University Paris Diderot, Sorbonne Paris Cité, Paris, France.

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April 2018

AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice.

Mol Metab 2017 12 20;6(12):1625-1633. Epub 2017 Oct 20.

Département de Physiologie, Université de Lausanne, 1005 Lausanne, Switzerland; Centre de Résonance Magnétique des Systèmes Biologiques, UMR5536 CNRS, LabEx TRAIL-IBIO, Université de Bordeaux, Bordeaux Cedex 33760, France. Electronic address:

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December 2017

[Benign focal liver lesions: a clinical, radiological and pathological review].

Rev Med Suisse 2017 Aug;13(572):1474-1479

Institut de pathologie, CHUV, Université de Lausanne, 1011 Lausanne.

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August 2017

[Eosinophilic gastrointestinal disorders].

Rev Med Suisse 2016 Aug;12(528):1430-1433

Service de gastroentérologie et d'hépatologie, CHUV, Université de Lausanne, 1011 Lausanne.

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August 2016

Hepatocellular Adenomas: Morphology and Genomics.

Gastroenterol Clin North Am 2017 06;46(2):253-272

Inserm U 1053, Université Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux, France.

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June 2017

Variant differentiation patterns in primary liver carcinoma.

Semin Diagn Pathol 2017 Mar 8;34(2):176-182. Epub 2017 Feb 8.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA. Electronic address:

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March 2017

Detection and Viability of Colorectal Liver Metastases After Neoadjuvant Chemotherapy: A Multiparametric PET/CT-MRI Study.

Clin Nucl Med 2017 Apr;42(4):258-263

From the Departments of *Diagnostic and Interventional Radiology, †Visceral Surgery, and ‡Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne; §Department of Radiology, Riviera and Chablais Hospitals, Vevey; and ∥Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.

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April 2017

Hepatocellular adenoma: Classification, variants and clinical relevance.

Semin Diagn Pathol 2017 Mar 20;34(2):112-125. Epub 2016 Dec 20.

Inserm U 1053, Université Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux, France. Electronic address:

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March 2017

Regorafenib induced severe toxic hepatitis: characterization and discussion.

Liver Int 2016 11 6;36(11):1590-1594. Epub 2016 Sep 6.

Service d'Oncologie médicale, Cliniques Universitaires Saint-Luc, Université catholique de Louvain (UCL), Brussels, Belgium.

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November 2016

Liver Failure, Hepatic Siderosis, and Membrane Attack Complexes: Neonatal Hemochromatosis and/or Galactosemia?: RETRACTED.

J Pediatr Gastroenterol Nutr 2016 Jul 11. Epub 2016 Jul 11.

*Service de Gastroentérologie et Hépatologie Pédiatrique †Service d'Anatomopathologie, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, Bruxelles, Belgium.

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July 2016

Expression of Molecular Differentiation Markers Does Not Correlate with Histological Differentiation Grade in Intrahepatic Cholangiocarcinoma.

PLoS One 2016 9;11(6):e0157140. Epub 2016 Jun 9.

de Duve Institute, Université catholique de Louvain, Avenue Hippocrate 75, B-1200 Brussels, Belgium.

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July 2017

Peritoneal sampling and histological assessment of therapeutic response in peritoneal metastasis: proposal of the Peritoneal Regression Grading Score (PRGS).

Pleura Peritoneum 2016 Jun 7;1(2):99-107. Epub 2016 Jun 7.

Department of Pathology, National Networks of Rare Periteoneal Tumors (RENAPE) and of digestive peritoneal carcinomatosis (BIG-REBNAPE), Institute du Cancer de Montpellier, Montpellier, France.

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June 2016

Oral valganciclovir for CMV gastritis.

Clin Res Hepatol Gastroenterol 2016 Sep 5;40(4):e50-1. Epub 2016 Apr 5.

Transplantation Center and Service of Immunology and Allergy, Lausanne University Hospital, 1011 Lausanne, Switzerland. Electronic address:

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September 2016

Impact of Intraoperative Pancreatoscopy with Intraductal Biopsies on Surgical Management of Intraductal Papillary Mucinous Neoplasm of the Pancreas.

J Am Coll Surg 2015 Nov 5;221(5):982-7. Epub 2015 Aug 5.

Unit of Hepato-biliary and Pancreatic Surgery, Department of Abdominal Surgery and Transplantation, Cliniques universitaires Saint-Luc, Université catholique de Louvain (UCL), Brussels, Belgium. Electronic address:

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November 2015

Intraductal biliary polypectomy performed with a nasogastroscope.

Endosc Int Open 2014 Jun 6;2(2):E124-5. Epub 2014 Jun 6.

Cliniques Universitaires St-Luc - Hepato-Gastroenterology, Brussels, Belgium.

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June 2014

Biphenotypic (hepatobiliary) primary liver carcinomas: the work in progress.

Hepat Oncol 2015 Jul 28;2(3):255-273. Epub 2015 Jul 28.

Departments of Pathology & Medicine, Mount Sinai Beth Israel Medical Center, Icahn School of Medicine at Mount Sinai, New York, NY 10002, USA.

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July 2015

Hepatocellular nodules expressing markers of hepatocellular adenomas in Budd-Chiari syndrome and other rare hepatic vascular disorders.

J Hepatol 2015 Nov 25;63(5):1173-80. Epub 2015 Jun 25.

Inserm, UMR 1053, Université de Bordeaux, Bordeaux F-33076, France; Department of Pathology, Pellegrin Hospital, Centre Hospitalier Universitaire Bordeaux, F-33076, France. Electronic address:

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November 2015

Human Insulinomas Show Distinct Patterns of Insulin Secretion In Vitro.

Diabetes 2015 Oct 26;64(10):3543-53. Epub 2015 Jun 26.

Department of Pathology, University Clinics Saint Luc, Faculty of Medicine, University of Louvain, Brussels, Belgium.

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October 2015

Living Donor Liver Transplantation in Children: Surgical and Immunological Results in 250 Recipients at Université Catholique de Louvain.

Ann Surg 2015 Dec;262(6):1141-9

*Pediatric Liver and Liver Transplantation Unit, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium †Internal Medicine Department, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium ‡Anesthesiology Department, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium §Pediatric Radiology Unit, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium ¶Adult Radiology Unit, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium ||Pediatric Intensive Care Unit, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium **Clinical Transplant Immunology Department, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium ††Pathology Department, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium ‡‡Abdominal Liver Transplant Unit, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium §§Adult Intensive Care Unit, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.

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December 2015

Hepatocellular adenoma management: call for shared guidelines and multidisciplinary approach.

Clin Res Hepatol Gastroenterol 2015 Apr 26;39(2):180-7. Epub 2014 Nov 26.

Inserm UMR 1053, université de Bordeaux, 146, rue Léo-Saignat, 33076 Bordeaux cedex, France. Electronic address:

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April 2015

Is minimal, [almost] steroid-free immunosuppression a safe approach in adult liver transplantation? Long-term outcome of a prospective, double blind, placebo-controlled, randomized, investigator-driven study.

Ann Surg 2014 Nov;260(5):886-91; discussion 891-2

*Starzl Unit of Abdominal Transplantation †Department of Pathology ‡Department Immunology, and §Department of Experimental Surgery, University Hospitals Saint-Luc, Université catholique Louvain (UCL), Brussels, Belgium ¶Department of Liver Transplantation, University of Sao Paulo (USP), Sao Paulo, Brazil ‖Department of Surgery, Section of Transplantation, Wake Forest School of Medicine, Winston-Salem, NC **Hepatobiliary Unit, Imbanaco Medical center, Cali, Colombia.

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November 2014

Extensive profiling of the expression of the indoleamine 2,3-dioxygenase 1 protein in normal and tumoral human tissues.

Cancer Immunol Res 2015 Feb 30;3(2):161-72. Epub 2014 Sep 30.

Ludwig Institute for Cancer Research, Brussels Branch, Brussels, Belgium. de Duve Institute, Université catholique de Louvain, Brussels, Belgium.

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February 2015

Malignant transformation of hepatocellular adenoma.

Hepat Oncol 2014 Oct 11;1(4):421-431. Epub 2014 Dec 11.

Institut National de la Santé et de la Recherche Médicale (Inserm) 1053, Université de Bordeaux, Bordeaux, France.

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October 2014

Pictures of focal nodular hyperplasia and hepatocellular adenomas.

World J Hepatol 2014 Aug;6(8):580-95

Christine Sempoux, Service d'Anatomie Pathologique, Cliniques universitaires Saint Luc, Université catholique de Louvain, 1200 Brussels, Belgium.

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August 2014

Is 18F-flutemetamol PET/CT able to reveal cardiac amyloidosis?

Clin Nucl Med 2014 Aug;39(8):747-9

From the Departments of *Nuclear Medicine, †Pathology, ‡Neurology, §Hematology, and ¶Cardiology, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, Brussels, Belgium.

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August 2014

Regulation of hepatic EAAT-2 glutamate transporter expression in human liver cholestasis.

World J Gastroenterol 2014 Feb;20(6):1554-64

Mustapha Najimi, Xavier Stéphenne, Etienne Sokal, Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique (IREC), Laboratory of Pediatric Hepatology and Cell Therapy, Brussels 1200, Belgium.

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February 2014

Immunohistochemical pitfalls in the diagnosis of focal nodular hyperplasia and inflammatory hepatocellular adenoma.

Clin Res Hepatol Gastroenterol 2014 Jun 10;38(3):245-9. Epub 2014 Feb 10.

Inserm U1053, Université Bordeaux Segalen, 33076 Bordeaux cedex, France.

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June 2014