Christine Seidman

Christine Seidman

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Christine Seidman

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Yin Yang 1 Suppresses Dilated Cardiomyopathy and Cardiac Fibrosis Through Regulation of and .

Circ Res 2019 Oct 9;125(9):834-846. Epub 2019 Sep 9.

From the Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (C.Y.T., J.X.W., P.S.C., H.T., D.L., W.C., J.J.).

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http://dx.doi.org/10.1161/CIRCRESAHA.119.314794DOI Listing
October 2019

Advances in the Genetic Basis and Pathogenesis of Sarcomere Cardiomyopathies.

Annu Rev Genomics Hum Genet 2019 Aug 12;20:129-153. Epub 2019 Apr 12.

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA; email:

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https://www.annualreviews.org/doi/10.1146/annurev-genom-0831
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http://dx.doi.org/10.1146/annurev-genom-083118-015306DOI Listing
August 2019

The Translational Landscape of the Human Heart.

Cell 2019 Jun 30;178(1):242-260.e29. Epub 2019 May 30.

Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 13347 Berlin, Germany; Berlin Institute of Health (BIH), 10178 Berlin, Germany; Charité-Universitätsmedizin, 10117 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.05.010DOI Listing
June 2019

Response to Brodehl et al.

Genet Med 2019 05 28;21(5):1248-1249. Epub 2018 Sep 28.

Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, Sydney, NSW, Australia.

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http://www.nature.com/articles/s41436-018-0292-1
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http://dx.doi.org/10.1038/s41436-018-0292-1DOI Listing
May 2019

Novel Therapies for Prevention and Early Treatment of Cardiomyopathies.

Circ Res 2019 May;124(11):1536-1550

From the Department of Genetics, Harvard Medical School, Boston, MA (G.G.R., C.N.T., J.G.S., C.E.S.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.119.31356
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http://dx.doi.org/10.1161/CIRCRESAHA.119.313569DOI Listing
May 2019

SarcTrack.

Circ Res 2019 Apr;124(8):1172-1183

From the Department of Genetics (C.N.T., A.S., A.C.G., M.N., J.A.L.W., R.A., M.S., J.R., O.P., J.G.S., C.E.S.), Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.314505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485312PMC
April 2019

Genetic Testing and Counseling for Hypertrophic Cardiomyopathy.

Cardiol Clin 2019 Feb 29;37(1):35-43. Epub 2018 Oct 29.

Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07338651183086
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http://dx.doi.org/10.1016/j.ccl.2018.08.003DOI Listing
February 2019

The Transcriptional Signature of Growth in Human Fetal Aortic Valve Development.

Ann Thorac Surg 2018 12 30;106(6):1834-1840. Epub 2018 Jul 30.

Department of Genetics, Harvard University, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.athoracsur.2018.06.034DOI Listing
December 2018

Molecular Genetics of Lidocaine-Containing Cardioplegia in the Human Heart During Cardiac Surgery.

Ann Thorac Surg 2018 11 17;106(5):1379-1387. Epub 2018 Jul 17.

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00034975183099
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http://dx.doi.org/10.1016/j.athoracsur.2018.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203633PMC
November 2018

Multilayer Myocardial Mechanics in Genotype-Positive Left Ventricular Hypertrophy-Negative Patients With Hypertrophic Cardiomyopathy.

Am J Cardiol 2018 11 21;122(10):1754-1760. Epub 2018 Aug 21.

Department of Cardiology, B Padeh Medical Center, Poriya and Bar-Ilan University, Israel.

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http://dx.doi.org/10.1016/j.amjcard.2018.08.008DOI Listing
November 2018

Telomere shortening is a hallmark of genetic cardiomyopathies.

Proc Natl Acad Sci U S A 2018 09 27;115(37):9276-9281. Epub 2018 Aug 27.

Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1714538115
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http://dx.doi.org/10.1073/pnas.1714538115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140486PMC
September 2018

Genetic Pathogenesis of Hypertrophic and Dilated Cardiomyopathy.

Heart Fail Clin 2018 Apr;14(2):139-146

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA; Department of Genetics, Brigham and Women's Hospital, Harvard Medical School, New Research Building Room 256, 77 Avenue Louis Pasteur, Boston, MA 02115, USA; Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15517136173012
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http://dx.doi.org/10.1016/j.hfc.2017.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851453PMC
April 2018

Human Induced Pluripotent Stem Cell Production and Expansion from Blood using a Non-Integrating Viral Reprogramming Vector.

Curr Protoc Mol Biol 2018 04;122(1):e58

Department of Genetics, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cpmb.58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986089PMC
April 2018

In vivo and In vitro methods to identify DNA sequence variants that alter RNA Splicing.

Curr Protoc Hum Genet 2018 04 26;97(1). Epub 2018 Apr 26.

Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115 and Howard Hughes Medical Institute, Boston, MA 02115.

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http://dx.doi.org/10.1002/cphg.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054316PMC
April 2018

ViroFind: A novel target-enrichment deep-sequencing platform reveals a complex JC virus population in the brain of PML patients.

PLoS One 2018 23;13(1):e0186945. Epub 2018 Jan 23.

Division of NeuroImmunology, Center for Virology and Vaccine Research, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186945PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779639PMC
February 2018

Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions.

Dev Cell 2018 01 8;44(1):87-96.e5. Epub 2018 Jan 8.

Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA; The Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421364PMC
January 2018

CRISPR/Cas9-Mediated Fluorescent Tagging of Endogenous Proteins in Human Pluripotent Stem Cells.

Curr Protoc Hum Genet 2018 01 24;96:21.11.1-21.11.20. Epub 2018 Jan 24.

Department of Genetics, Harvard Medical School, Boston, Massachusetts.

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http://doi.wiley.com/10.1002/cphg.52
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http://dx.doi.org/10.1002/cphg.52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785097PMC
January 2018

Differentiation and Contractile Analysis of GFP-Sarcomere Reporter hiPSC-Cardiomyocytes.

Curr Protoc Hum Genet 2018 01 24;96:21.12.1-21.12.12. Epub 2018 Jan 24.

Department of Genetics, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cphg.53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786381PMC
January 2018

A Comparison of Whole Genome Sequencing to Multigene Panel Testing in Hypertrophic Cardiomyopathy Patients.

Circ Cardiovasc Genet 2017 Oct;10(5)

From the Cardiovascular Division (A.L.C., N.K.L., B.M., D.A., M.W., P.O., C.A.M., C.E.S., C.Y.H.), Department of Pathology (H.L.R.), and Division of Genetics (C.B., R.C.G., C.A.M.), Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA (N.K.L., B.M., D.A., M.W., P.O., H.L.R., R.C.G., C.A.M., C.E.S., C.Y.H.); Albany Medical College, NY (L.C.); Broad Institute of Harvard and MIT, Cambridge, MA (H.L.R., R.C.G., C.A.M.); Laboratory for Molecular Medicine (H.L.R., K.M., M.L.), Leadership Team (R.C.G.), Partners HealthCare Personalized Medicine, Cambridge, MA; and Howard Hughes Medical Institute, Chevy Chase, MD (C.E.S.).

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http://dx.doi.org/10.1161/CIRCGENETICS.117.001768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683423PMC
October 2017

Closing the Genotype-Phenotype Loop for Precision Medicine.

Circulation 2017 10;136(16):1492-1494

From Cardiovascular Medicine Division, Brigham and Women's Hospital, Departments of Medicine (C.A.M., C.E.S.) and Genetics (C.E.S.), Harvard Medical School, Boston, MA; and Howard Hughes Medical Institute, Chevy Chase, MD (C.E.S.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.030831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540750PMC
October 2017

Fabry Disease in Families With Hypertrophic Cardiomyopathy: Clinical Manifestations in the Classic and Later-Onset Phenotypes.

Circ Cardiovasc Genet 2017 Aug;10(4)

From the Faculty of Medicine, University of Iceland, Reykjavik, Iceland (B.A., R.P., R.A., G.T.G.); Division of Cardiology (B.A., R.D.), Department of Genetics (R.A.), Division of Nephrology (R.P.), and Department of Radiology (M.G.), Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland; Department of Cardiology, Haukeland University Hospital, Bergen, Norway (B.A.); Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY (R.J.D., B.C., S.P.); Department of Genetics, Harvard Medical School, Boston, MA (P.T., M.A.B., J.G.S., C.E.S.); Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (E.A., U.N.); Division of Cardiology, Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, MA (M.M., B.J.M.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (M.A.B., C.E.S.); Division of Cardiology, Emory University School of Medicine, Atlanta, GA (M.A.B.); Department of Medical Endocrinology, Rigshospitalet and University of Copenhagen, Denmark (C.V.M., U.F.-R.); Howard Hughes Medical Institute, Boston, MA (C.E.S.); and Department of Medicine, Akureyri Hospital, Iceland (G.T.G.).

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001639DOI Listing
August 2017

Joint analysis of left ventricular expression and circulating plasma levels of Omentin after myocardial ischemia.

Cardiovasc Diabetol 2017 07 7;16(1):87. Epub 2017 Jul 7.

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, CWN L1, 75 Francis Street, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1186/s12933-017-0567-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501278PMC
July 2017

Early remodeling of repolarizing K currents in the αMHC mouse model of familial hypertrophic cardiomyopathy.

J Mol Cell Cardiol 2017 02 13;103:93-101. Epub 2017 Jan 13.

Department of Developmental Biology, Washington University Medical School, St. Louis, MO 63110-1093, USA; Department of Medicine, Washington University Medical School, St. Louis, MO 63110-1093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2017.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398411PMC
February 2017

The Long Noncoding RNA Landscape of the Ischemic Human Left Ventricle.

Circ Cardiovasc Genet 2017 Jan;10(1)

From the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital (L.A.S., M.I.S., T.-W.C., M.H., S.K.S., S.C.B., J.D.M.), Division of Cardiac Surgery, Department of Surgery, Brigham and Women's Hospital (S.F.A.), and Department of Genetics (E.M., C.E.S., J.G.S.), Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302288PMC
January 2017

THSD1 (Thrombospondin Type 1 Domain Containing Protein 1) Mutation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage.

Stroke 2016 12 15;47(12):3005-3013. Epub 2016 Nov 15.

From the Department of Neurosurgery (T.S.-S., X.F., G.W.H., K.J.P., S.M.C., K.J.Q., J.P.H., D.H.K.) and Division of Medical Genetics, Department of Internal Medicine (D.M.M.), The University of Texas Medical School at Houston; Department of Genetics, Harvard Medical School, Boston, MA (M.L.H., S.V.N., S.R.D., S.C.G., B.M., S.M.D., C.E.S., J.G.S.); Department of Neurosurgery (S.V.N.), Department of Medicine (M.S.L., C.A.M.), and Cardiovascular Division (C.E.S.), Brigham and Women's Hospital, Boston, MA; and Howard Hughes Medical Institute, Chevy Chase, MD (C.E.S.).

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http://dx.doi.org/10.1161/STROKEAHA.116.014161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134902PMC
December 2016

Clinical and Mechanistic Insights Into the Genetics of Cardiomyopathy.

J Am Coll Cardiol 2016 Dec;68(25):2871-2886

Department of Genetics, Harvard Medical School, Boston, Massachusetts; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Howard Hughes Medical Institute, Chevy Chase, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2016.08.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843375PMC
December 2016

Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis.

Cell Rep 2016 12;17(12):3292-3304

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.11.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193246PMC
December 2016

Preparation of rAAV9 to Overexpress or Knockdown Genes in Mouse Hearts.

J Vis Exp 2016 12 17(118). Epub 2016 Dec 17.

Department of Cardiology, Boston Children's Hospital; Department of Pediatrics, Harvard Medical School;

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http://dx.doi.org/10.3791/54787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5226409PMC
December 2016

Fulminant Myocarditis with Combination Immune Checkpoint Blockade.

N Engl J Med 2016 Nov;375(18):1749-1755

From the Departments of Medicine (D.B.J., J.M.B., M.H., I.P., M.R.A., T.L.B., J.R.B., D.A.S., E.J.P., M.A.P., D.M.R., J.A.S., J.J.M.), Cancer Biology (J.M.B., J.J.M.), Pathology, Microbiology, and Immunology (M.L.C., L.C.-O., R.D.H.), Biostatistics (Y.X.), Pharmacology (D.M.R.), and Biomedical Informatics (Y.X., D.M.R.), the Cardio-oncology Program (D.A.S., J.J.M.), the Breast Cancer Research Program (J.M.B.), and the Center for Quantitative Sciences (Y.X.), Vanderbilt University Medical Center, Nashville; the Department of Medicine (S.C.) and the Division of Neuroimmunology (S.C., I.J.K.), Beth Israel Deaconess Medical Center, the Departments of Medicine (B.A.O., C.E.S., J.G.S.) and Pathology (A.H.L.), Brigham and Women's Hospital, the Department of Genetics, Harvard Medical School (J.G., C.E.S., J.G.S.) - all in Boston; Howard Hughes Medical Institute, Chevy Chase, MD (C.E.S.); Bristol-Myers Squibb, New York (N.K., G.P., D.S.R., J.S.D.); Neon Therapeutics, Cambridge, MA (R.P.D.); and the Departments of Pathology (J.M.T., R.A.A.), Dermatology (J.M.T.), and Oncology (L.A.D.), Johns Hopkins University, Baltimore.

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http://dx.doi.org/10.1056/NEJMoa1609214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247797PMC
November 2016

Single-Cell Resolution of Temporal Gene Expression during Heart Development.

Dev Cell 2016 11 10;39(4):480-490. Epub 2016 Nov 10.

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Cardiovascular Division, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2016.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198784PMC
November 2016

Detection of Cell Proliferation Markers by Immunofluorescence Staining and Microscopy Imaging in Paraffin-Embedded Tissue Sections.

Curr Protoc Mol Biol 2016 07 1;115:14.25.1-14.25.14. Epub 2016 Jul 1.

Department of Genetics, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cpmb.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349766PMC
July 2016

A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy.

Cell 2016 May 21;165(5):1147-1159. Epub 2016 Apr 21.

Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati 45247, OH, USA; Cincinnati Children's Hospital Medical Center, Howard Hughes Medical Institute, Cincinnati 45247, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874838PMC
May 2016

Molecular profiling of dilated cardiomyopathy that progresses to heart failure.

JCI Insight 2016 May;1(6)

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/jci.insight.86898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882118PMC
May 2016

The Muscle-Bound Heart.

Card Electrophysiol Clin 2016 Mar;8(1):223-31

Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon.

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http://dx.doi.org/10.1016/j.ccep.2015.10.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599619PMC
March 2016

A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice.

Science 2016 Feb;351(6273):617-21

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

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http://dx.doi.org/10.1126/science.aad3456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784435PMC
February 2016

Mutation analysis of the phospholamban gene in 315 South Africans with dilated, hypertrophic, peripartum and arrhythmogenic right ventricular cardiomyopathies.

Sci Rep 2016 Feb 26;6:22235. Epub 2016 Feb 26.

Cardiovascular Genetics Laboratory, Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Old Groote Schuur Hospital, Groote Schuur Drive, Observatory, 7925, Cape Town, South Africa.

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http://dx.doi.org/10.1038/srep22235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808831PMC
February 2016

Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies.

N Engl J Med 2016 Jan 6;374(3):233-41. Epub 2016 Jan 6.

From the Department of Genetics, Harvard Medical School (J.S.W., E.M., C.M.Y., C.E.S., J.G.S.), the Howard Hughes Medical Institute (C.E.S.), and the Cardiovascular Division, Brigham and Women's Hospital (J.S.W., E.M., C.E.S., J.G.S.) - all in Boston; the Cardiovascular Institute and the Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (J.L., T.D., T.P.C., Z.A.), the Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh (I.H., J.P., K.H.-Y., J.G., D.M.M.), and Penn State Hershey Medical Center, Hershey (J.B.) - all in Pennsylvania; the National Institute for Health Research Royal Brompton Cardiovascular Biomedical Research Unit (J.S.W., F.M., S.K.P.) and the National Heart and Lung Institute (J.S.W., F.M., S.A.C., S.K.P.), Imperial College London, London; the Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York (E.J.T.), and the University of Rochester, Rochester (J.A.) - both in New York; the Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany (D.H.-K.); the Department of Perinatology and Gynecology, the National Cerebral and Cardiovascular Center, Osaka, Japan (C.A.K.); the National Heart Center and Duke-National University of Singapore, Singapore (S.A.C.); the Intermountain Medical Center, Murray, Utah (R.A.); Vanderbilt University, Nashville (J.D.); Cleveland Clinic, Cleveland (E.H.); University of Southern California, Los Angeles (U.E.); McGill University and Jewish General Hospital, Montreal (R.S.), University of Calgary, Calgary, AB (A.K.), and University of Toronto, Toronto (P.L.) - all in Canada; University of Maryland, College Park (G.R.), and Johns Hopkins Hospital, Baltimore (I.S.W.) - both in Maryland; Morristown Hospital, Morristown (J.S.), and Newark Beth Israel Medical Center, Newark (M.J.Z.) - both in New Jersey; Truman Medical Center, University of Missouri, Kansas City (D.F.P.); and Wa

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http://dx.doi.org/10.1056/NEJMoa1505517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797319PMC
January 2016

HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.

Science 2015 Aug;349(6251):982-6

Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

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http://dx.doi.org/10.1126/science.aaa5458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618316PMC
August 2015

Phenotype and prognostic correlations of the converter region mutations affecting the β myosin heavy chain.

Heart 2015 Jul 2;101(13):1047-53. Epub 2015 May 2.

Health in Code, A Coruña, Spain Inherited Cardiovascular Disease Unit, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas Universidade da Coruña (UDC), A Coruña, Spain.

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http://dx.doi.org/10.1136/heartjnl-2014-307205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484257PMC
July 2015

Cardiac myosin binding protein C regulates postnatal myocyte cytokinesis.

Proc Natl Acad Sci U S A 2015 Jul 7;112(29):9046-51. Epub 2015 Jul 7.

Department of Genetics, Harvard Medical School, Boston, MA 02115; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1511004112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517252PMC
July 2015

Using next-generation RNA sequencing to examine ischemic changes induced by cold blood cardioplegia on the human left ventricular myocardium transcriptome.

Anesthesiology 2015 Mar;122(3):537-50

From the Brigham and Women's Hospital, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Boston, Massachusetts (J.D.M., M.H., S.K.S., S.C.B.); Department of Genetics, Harvard Medical School, Boston, Massachusetts (D.C.C., D.M., J.G., E.M., S.R.D., J.G.S.); Harvard Medical School, Boston, Massachusetts (G.L.); Northwest Anesthesia, Abbott Northwestern Hospital and Minneapolis Heart Institute, Minneapolis, Minnesota (T.E.P.); Department of Anesthesiology, University of Texas Southwestern Medical Center, Dallas, Texas (A.A.F.); Howard Hughes Medical Institute, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts (C.E.S.); and Brigham and Women's Hospital, Division of Cardiac Surgery, Department of Surgery, Harvard Medical School, Boston, Massachusetts (S.F.A.).

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http://dx.doi.org/10.1097/ALN.0000000000000582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333028PMC
March 2015

Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice.

J Mol Cell Cardiol 2015 Feb 25;79:234-43. Epub 2014 Nov 25.

Department of Cell and Molecular Physiology, Health Sciences Division, Loyola University Chicago, Maywood, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2014.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642280PMC
February 2015

Prediction of sarcomere mutations in subclinical hypertrophic cardiomyopathy.

Circ Cardiovasc Imaging 2014 Nov 16;7(6):863-71. Epub 2014 Sep 16.

From the Department of Cardiovascular Science (G.C., L.R.L., V.P., V.M., W.J.M., P.M.E., J.C.M.) and Biostatistics Joint Research Office (P.B.), University College London, London, United Kingdom; Department of Inherited Cardiovascular Diseases (G.C., L.R.L., V.P., M.T.E., W.J.M., P.M.E., J.C.M.) and Cardiac Imaging Department (G.C., G.F., M.T.E., W.J.M., J.C.M.), Barts Heart Centre, London, United Kingdom; Department of Developmental Biology, MRC National Institutes for Medical Research, Mill Hill, United Kingdom (T.J.M.); Department of Radiology, University of Pennsylvania, Philadelphia (C.L.); Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford Center for Clinical Magnetic Resonance Research (OCMR), Oxford, United Kingdom (V.M.F.); UCL Department for Cardiovascular Imaging, Great Ormond Street Hospital for Children, London, United Kingdom (V.M.); Department of Cardiology, Mount Sinai Roosevelt Hospital, Icahn School of Medicine at Mount Sinai, New York, NY (M.V.S.); Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor (S.M.D.); Pediatric Cardiology Department, Washington University School of Medicine, St Louis, MO (C.E.C.); Department of Genetics, Harvard Medical School, Boston, MA (C.E.S.); Radiology and Imaging Sciences Department, National Institutes of Health/Clinical Center, Bethesda, MD (D.A.B.); and Cardiovascular Department, Brigham and Women's Hospital, Boston, MA (C.Y.H.).

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http://dx.doi.org/10.1161/CIRCIMAGING.114.002411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237712PMC
November 2014

Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells.

Nat Commun 2014 Nov 26;5:5507. Epub 2014 Nov 26.

1] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncomms6507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352754PMC
November 2014

Tbx5 is required for avian and Mammalian epicardial formation and coronary vasculogenesis.

Circ Res 2014 Oct 22;115(10):834-44. Epub 2014 Sep 22.

From the Center for Molecular Cardiology, Greenberg Division of Cardiology (N.Y.S.-G.D., G.B., B.P.T.K., C.T.B., C.J.H.) and Department of Physiology and Biophysics (O.E.), Weill Cornell Medical College, New York, NY; Department of Genetics, Harvard Medical School, Boston, MA (J.G.S., C.E.S.); and Department of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine, PA (C.J.H.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.304379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727243PMC
October 2014