Publications by authors named "Christine Pirker"

64Publications

Metal Drugs and the Anticancer Immune Response.

Chem Rev 2019 01 29;119(2):1519-1624. Epub 2018 Nov 29.

Institute of Cancer Research and Comprehensive Cancer Center, Department of Medicine I , Medical University of Vienna , Borschkegasse 8a , A-1090 Vienna , Austria.

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http://pubs.acs.org/doi/10.1021/acs.chemrev.8b00396
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http://dx.doi.org/10.1021/acs.chemrev.8b00396DOI Listing
January 2019

Dynamics of CRISPR/Cas9-mediated genomic editing of the locus in hepatocellular carcinoma cells.

Oncol Lett 2018 Feb 13;15(2):2441-2450. Epub 2017 Dec 13.

Department of Medicine I, Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, A-1090 Vienna, Austria.

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http://dx.doi.org/10.3892/ol.2017.7605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777348PMC
February 2018

Sensitivity towards the GRP78 inhibitor KP1339/IT-139 is characterized by apoptosis induction via caspase 8 upon disruption of ER homeostasis.

Cancer Lett 2017 09 14;404:79-88. Epub 2017 Jul 14.

Department of Medicine I, Institute of Cancer Research, Comprehensive Cancer Center of the Medical University, Medical University of Vienna, Borschkegasse 8a, A-1090, Vienna, Austria; Research Cluster "Translational Cancer Therapy Research", Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.07.009DOI Listing
September 2017

[C]Erlotinib PET cannot detect acquired erlotinib resistance in NSCLC tumor xenografts in mice.

Nucl Med Biol 2017 Sep 25;52:7-15. Epub 2017 May 25.

Biomedical Systems, Center for Health & Bioresources, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria; Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09698051173011
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http://dx.doi.org/10.1016/j.nucmedbio.2017.05.007DOI Listing
September 2017

Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling.

Oncotarget 2016 Dec;7(51):84556-84574

Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, A-1090 Vienna, Austria.

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http://dx.doi.org/10.18632/oncotarget.11821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356681PMC
December 2016

Trabectedin Is Active against Malignant Pleural Mesothelioma Cell and Xenograft Models and Synergizes with Chemotherapy and Bcl-2 Inhibition In Vitro.

Mol Cancer Ther 2016 10 10;15(10):2357-2369. Epub 2016 Aug 10.

Applied and Experimental Oncology, Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0846DOI Listing
October 2016

Anticancer metal drugs and immunogenic cell death.

J Inorg Biochem 2016 12 16;165:71-79. Epub 2016 Jun 16.

Research Platform "Translational Cancer Therapy Research", University of Vienna and Medical University of Vienna, Vienna, Austria; Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University Vienna, Borschkegasse 8a, A-1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jinorgbio.2016.06.021DOI Listing
December 2016

Opposing Roles of JNK and p38 in Lymphangiogenesis in Melanoma.

J Invest Dermatol 2016 05 30;136(5):967-977. Epub 2016 Jan 30.

Department of Dermatology, Skin and Endothelium Research Division (SERD), Medical University of Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.01.020DOI Listing
May 2016

EGFR is not a major driver for osteosarcoma cell growth in vitro but contributes to starvation and chemotherapy resistance.

J Exp Clin Cancer Res 2015 Nov 2;34:134. Epub 2015 Nov 2.

Institute of Cancer Research and Comprehensive Cancer Center, Department of Medicine I, Medical University Vienna, Borschkegasse 8a, 1090, Vienna, Austria.

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http://dx.doi.org/10.1186/s13046-015-0251-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630894PMC
November 2015

Prognostic quality of activating TERT promoter mutations in glioblastoma: interaction with the rs2853669 polymorphism and patient age at diagnosis.

Neuro Oncol 2015 Sep 13;17(9):1231-40. Epub 2015 Feb 13.

Department of Neurosurgery, Wagner-Jauregg Hospital, Linz, Austria (S.S.-K., M.L., A.O.); Institute of Pathology and Neuropathology, Wagner-Jauregg Hospital, Linz, Austria (S.W.); Department of Internal Medicine, Wagner-Jauregg Hospital, Linz, Austria (J.P.); Institute of Cancer Research and Comprehensive Cancer Center-Central Nervous System Tumors Unit, Department of Medicine I, Medical University of Vienna, Vienna, Austria (D.L., C.P., T.M., W.B.); Division of Thoracic Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria (B.G.); Laboratory of Molecular Biology and Tumorcytogenetics, Hospital Barmherzige Schwestern, Linz, Austria (G.W.).

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http://dx.doi.org/10.1093/neuonc/nov010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588753PMC
September 2015

The metastatic microenvironment: Claudin-1 suppresses the malignant phenotype of melanoma brain metastasis.

Int J Cancer 2015 Mar 8;136(6):1296-307. Epub 2014 Sep 8.

Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1002/ijc.29090DOI Listing
March 2015

Fibroblast growth factor receptor 4: a putative key driver for the aggressive phenotype of hepatocellular carcinoma.

Carcinogenesis 2014 Oct 16;35(10):2331-8. Epub 2014 Jul 16.

Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria and Institute of Clinical Pathology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria

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http://carcin.oxfordjournals.org/content/35/10/2331.full.pdf
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http://www.carcin.oxfordjournals.org/cgi/doi/10.1093/carcin/
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http://dx.doi.org/10.1093/carcin/bgu151DOI Listing
October 2014

New 5-Aryl-1H-imidazoles display in vitro antitumor activity against apoptosis-resistant cancer models, including melanomas, through mitochondrial targeting.

J Med Chem 2013 Sep 20;56(17):6626-37. Epub 2013 Aug 20.

Laboratoire de Toxicologie, Faculté de Pharmacie, Université Libre de Bruxelles (ULB) , Boulevard du Triomphe, CP205/1, B-1050 Brussels, Belgium.

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http://dx.doi.org/10.1021/jm400287vDOI Listing
September 2013

Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones.

Biochem Pharmacol 2012 Jun 15;83(12):1623-33. Epub 2012 Mar 15.

Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria.

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http://linkinghub.elsevier.com/retrieve/pii/S000629521200196
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http://dx.doi.org/10.1016/j.bcp.2012.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342514PMC
June 2012

DNA damage, somatic aneuploidy, and malignant sarcoma susceptibility in muscular dystrophies.

PLoS Genet 2011 Apr 14;7(4):e1002042. Epub 2011 Apr 14.

Neuromuscular Research Department, Center of Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1371/journal.pgen.1002042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077392PMC
April 2011

Overexpression of Aurora-A in primary cells interferes with S-phase entry by diminishing Cyclin D1 dependent activities.

Mol Cancer 2011 Mar 16;10:28. Epub 2011 Mar 16.

Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1186/1476-4598-10-28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068985PMC
March 2011

A human model of epithelial to mesenchymal transition to monitor drug efficacy in hepatocellular carcinoma progression.

Mol Cancer Ther 2011 May 1;10(5):850-60. Epub 2011 Mar 1.

Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria.

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http://dx.doi.org/10.1158/1535-7163.MCT-10-0917DOI Listing
May 2011

Response of experimental malignant melanoma models to the pan-Aurora kinase inhibitor VE-465.

Exp Dermatol 2010 Dec;19(12):1040-7

Institute of Cancer Research, Clinics for Medicine I, Medical University Vienna, Vienna, Austria.

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http://dx.doi.org/10.1111/j.1600-0625.2010.01182.xDOI Listing
December 2010

EGFR/KRAS/BRAF mutations in primary lung adenocarcinomas and corresponding locoregional lymph node metastases.

Clin Cancer Res 2009 Jul 7;15(14):4554-60. Epub 2009 Jul 7.

Clinical Institute of Pathology and Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, Vienna A-1090, Austria.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-0089DOI Listing
July 2009

Synergistic effect of Sorafenib and Sunitinib with Enzastaurin, a selective protein kinase C inhibitor in renal cell carcinoma cell lines.

Cancer Lett 2009 May 25;277(2):218-26. Epub 2009 Jan 25.

Clinical Division of Oncology, Department of Medicine I, Medical University Vienna, Waehringer Guertel 18-20, Vienna, Austria.

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http://linkinghub.elsevier.com/retrieve/pii/S030438350800945
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http://dx.doi.org/10.1016/j.canlet.2008.12.013DOI Listing
May 2009

The major vault protein is responsive to and interferes with interferon-gamma-mediated STAT1 signals.

J Cell Sci 2006 Feb 17;119(Pt 3):459-69. Epub 2006 Jan 17.

Department of Medicine I, Institute of Cancer Research, Medical University Vienna, Borschkegasse 8a, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1242/jcs.02773DOI Listing
February 2006

Seven novel and stable translocations associated with oncogenic gene expression in malignant melanoma.

Neoplasia 2005 Apr;7(4):303-11

Division of General Dermatology, Department of Dermatology, Center of Excellence and the Ludwig Boltzmann Institut for Clinical and Experimental Oncology, Medical University of Vienna, Vienna A-1090, Austria.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1501156PMC
http://dx.doi.org/10.1593/neo.04514DOI Listing
April 2005

SP-transcription factors are involved in basal MVP promoter activity and its stimulation by HDAC inhibitors.

Biochem Biophys Res Commun 2004 Apr;317(1):235-43

Division of Applied and Experimental Oncology, Institute of Cancer Research, Medical University Vienna, Borschkegasse 8a, A-1090 Vienna, Austria.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0400501
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http://dx.doi.org/10.1016/j.bbrc.2004.03.029DOI Listing
April 2004

Chromosomal imbalances in primary and metastatic melanomas: over-representation of essential telomerase genes.

Melanoma Res 2003 Oct;13(5):483-92

Institute of Cancer Research, Division of Applied and Experimental Oncology, and Division of Cell Biology, Borschkegasse 8a, Vienna University, Vienna, Austria.

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http://dx.doi.org/10.1097/00008390-200310000-00007DOI Listing
October 2003