Publications by authors named "Christine Mummery"

100Publications

Reprogramming Urine-Derived Cells using Commercially Available Self-Replicative RNA and a Single Electroporation.

Curr Protoc Stem Cell Biol 2020 Dec;55(1):e124

LUMC hiPSC Hotel, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/cpsc.124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540473PMC
December 2020

Organs-on-chips: into the next decade.

Nat Rev Drug Discov 2020 Sep 10. Epub 2020 Sep 10.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41573-020-0079-3DOI Listing
September 2020

Human Organs-on-Chips for Virology.

Trends Microbiol 2020 11 13;28(11):934-946. Epub 2020 Jul 13.

Medical Systems Biophysics and Bioengineering, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tim.2020.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357975PMC
November 2020

Generation and genetic repair of 2 iPSC clones from a patient bearing a heterozygous c.1120del18 mutation in the ACVRL1 gene leading to Hereditary Hemorrhagic Telangiectasia (HHT) type 2.

Stem Cell Res 2020 07 28;46:101786. Epub 2020 May 28.

LUMC hiPSC Hotel, Leiden University Medical Center, Leiden, 2333 ZC, The Netherlands; Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, 2333 ZC, The Netherlands.

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http://dx.doi.org/10.1016/j.scr.2020.101786DOI Listing
July 2020

Fibronectin Patches as Anchoring Points for Force Sensing and Transmission in Human Induced Pluripotent Stem Cell-Derived Pericytes.

Stem Cell Reports 2020 06 28;14(6):1107-1122. Epub 2020 May 28.

Physics of Life Processes, Leiden Institute of Physics, Leiden University, Einsteinweg 55, Leiden, South Holland 2333 CC, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2020.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355144PMC
June 2020

A cardiomyocyte show of force: A fluorescent alpha-actinin reporter line sheds light on human cardiomyocyte contractility versus substrate stiffness.

J Mol Cell Cardiol 2020 04 20;141:54-64. Epub 2020 Mar 20.

Department of Applied Stem Cell Technologies, TechMed Centre, University of Twente, Drienerlolaan 5, 7500AE Enschede, the Netherlands; Department of Anatomy and Embryology, Leiden University Medical Centre, PO Box 9600, 2300, RC, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2020.03.008DOI Listing
April 2020

Generation and Functional Characterization of Monocytes and Macrophages Derived from Human Induced Pluripotent Stem Cells.

Curr Protoc Stem Cell Biol 2020 03;52(1):e108

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/cpsc.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154707PMC
March 2020

Cryopreservation of human pluripotent stem cell-derived cardiomyocytes is not detrimental to their molecular and functional properties.

Stem Cell Res 2020 03 7;43:101698. Epub 2020 Jan 7.

Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2300 RC Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2019.101698DOI Listing
March 2020

Lymphoblast-derived hiPS cell lines generated from four individuals of a family of genetically unrelated parents and their female monozygotic twins.

Stem Cell Res 2019 12 8;41:101654. Epub 2019 Nov 8.

LUMC human iPSC Hotel, Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, 2333 ZC, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2019.101654DOI Listing
December 2019

Closing the Mitochondrial Permeability Transition Pore in hiPSC-Derived Endothelial Cells Induces Glycocalyx Formation and Functional Maturation.

Stem Cell Reports 2019 11 31;13(5):803-816. Epub 2019 Oct 31.

The Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Division of Nephrology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895683PMC
November 2019

Inherited cardiac diseases, pluripotent stem cells, and genome editing combined-the past, present, and future.

Stem Cells 2020 02 16;38(2):174-186. Epub 2019 Dec 16.

Department of Anatomy and Embryology, Leiden University Medical Center, RC Leiden, The Netherlands.

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http://dx.doi.org/10.1002/stem.3110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027796PMC
February 2020

Scalable microphysiological system to model three-dimensional blood vessels.

APL Bioeng 2019 Jun 21;3(2):026105. Epub 2019 Jun 21.

Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands.

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http://dx.doi.org/10.1063/1.5090986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588522PMC
June 2019

Transforming youth mental health services in a large urban centre: ACCESS Open Minds Edmonton.

Early Interv Psychiatry 2019 06;13 Suppl 1:14-19

ACCESS Open Minds (Pan-Canadian Youth Mental Health Services Research Network), Douglas Mental Health University Institute, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1111/eip.12813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771682PMC
June 2019

Differentiation and Functional Comparison of Monocytes and Macrophages from hiPSCs with Peripheral Blood Derivatives.

Stem Cell Reports 2019 06;12(6):1282-1297

Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565887PMC
June 2019

Quantifying Ca signaling and contraction in vascular pericytes and smooth muscle cells.

Biochem Biophys Res Commun 2019 05 30;513(1):112-118. Epub 2019 Mar 30.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, 2333 ZC, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.03.143DOI Listing
May 2019

Quantitative Analysis of Intracellular Ca Release and Contraction in hiPSC-Derived Vascular Smooth Muscle Cells.

Stem Cell Reports 2019 04 7;12(4):647-656. Epub 2019 Mar 7.

Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449838PMC
April 2019

Perspectives on the Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Biomedical Research.

Stem Cell Reports 2018 12;11(6):1306-1311

Department of Anatomy and Embryology, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294284PMC
December 2018

The Next Chapter for Stem Cell Reports.

Stem Cell Reports 2018 12;11(6):1303-1304

Editor-in-Chief, Stem Cell Reports.

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http://dx.doi.org/10.1016/j.stemcr.2018.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294170PMC
December 2018

Microfluidic Assay for the Assessment of Leukocyte Adhesion to Human Induced Pluripotent Stem Cell-derived Endothelial Cells (hiPSC-ECs).

J Vis Exp 2018 11 26(141). Epub 2018 Nov 26.

Department of Anatomy and Embryology, Leiden University Medical Center;

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http://dx.doi.org/10.3791/58678DOI Listing
November 2018

Quantification of Muscle Contraction In Vitro and In Vivo Using MUSCLEMOTION Software: From Stem Cell-Derived Cardiomyocytes to Zebrafish and Human Hearts.

Curr Protoc Hum Genet 2018 10 25;99(1):e67. Epub 2018 Sep 25.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands.

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http://doi.wiley.com/10.1002/cphg.67
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http://dx.doi.org/10.1002/cphg.67DOI Listing
October 2018

Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology.

Adv Drug Deliv Rev 2019 02 23;140:68-77. Epub 2018 Jun 23.

Applied Stem Cell Technologies group, University of Twente, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0169409X183014
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http://dx.doi.org/10.1016/j.addr.2018.06.007DOI Listing
February 2019

Inflammatory Responses and Barrier Function of Endothelial Cells Derived from Human Induced Pluripotent Stem Cells.

Stem Cell Reports 2018 05 12;10(5):1642-1656. Epub 2018 Apr 12.

Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2333ZC Leiden, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22136711183013
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http://dx.doi.org/10.1016/j.stemcr.2018.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995303PMC
May 2018

Squaramide-Based Supramolecular Materials for Three-Dimensional Cell Culture of Human Induced Pluripotent Stem Cells and Their Derivatives.

Biomacromolecules 2018 04 12;19(4):1091-1099. Epub 2018 Mar 12.

Department of Supramolecular and Biomaterials Chemistry, Leiden Institute of Chemistry , Leiden University , P.O. Box 9502, 2300 RA , Leiden , The Netherlands.

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http://pubs.acs.org/doi/10.1021/acs.biomac.7b01614
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http://dx.doi.org/10.1021/acs.biomac.7b01614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894061PMC
April 2018

Regenerative medicine funding policies in Europe and The Netherlands.

NPJ Regen Med 2017 5;2. Epub 2017 Jan 5.

Chair Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/s41536-016-0006-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677946PMC
January 2017

MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo.

Circ Res 2018 02 27;122(3):e5-e16. Epub 2017 Dec 27.

From the Department of Anatomy and Embryology, Leiden University Medical Center, The Netherlands (L.S., B.J.v.M., L.G.J.T., M.B., R.P.D., M.A.E.D., E.G., C.G., M.R.M.J., M.P.H.M., V.V.O., R.P., C.L.M.); Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary, and Life Science, University of Glasgow, United Kingdom (Q.L., G.L.S., F.L.B.); Hubrecht Institute - Royal Netherlands Academy of Arts and Sciences, Utrecht, The Netherlands (J.B., S.M.K., C.D.K.); Department of Stem Cell Biology, University of Nottingham, University Park, Nottingham, United Kingdom (C.D., D.M.); Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Germany (T.E., A.H., I.M., U.S.); DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck (T.E., A.H., I.M., U.S.); Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Hamburg, Germany (U.S.); Hart Long Centrum, Leiden University Medical Center, The Netherlands (E.R.H., M.R.M.J.); Department of Applied Stem Cell Technologies, University of Twente, Enschede, The Netherlands (R.P., M.C.R., C.L.M.).; Division of Heart and Lungs, Department of Medical Physiology, University Medical Center Utrecht, The Netherlands (J.B., S.M.K., C.D.K.); and Clyde Biosciences, Ltd, BioCity Scotland, United Kingdom (G.L.S., F.L.B.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.312067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805275PMC
February 2018

Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells.

Stem Cell Reports 2017 12 22;9(6):1754-1764. Epub 2017 Nov 22.

Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, the Netherlands; Department of Applied Stem Cell Technologies, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Building Zuidhorst, 7500 AE Enschede, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785703PMC
December 2017

A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes.

Stem Cell Reports 2017 12 22;9(6):1765-1779. Epub 2017 Nov 22.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands; Department of Applied Stem Cell Technologies, MIRA Institute, University of Twente, Twente, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22136711173047
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http://dx.doi.org/10.1016/j.stemcr.2017.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785710PMC
December 2017

Executive summary of the 12th HHT international scientific conference.

Angiogenesis 2018 02;21(1):169-181

Department of Pulmonology, St. Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands.

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http://dx.doi.org/10.1007/s10456-017-9585-2DOI Listing
February 2018

Co-Differentiation of Human Pluripotent Stem Cells-Derived Cardiomyocytes and Endothelial Cells from Cardiac Mesoderm Provides a Three-Dimensional Model of Cardiac Microtissue.

Curr Protoc Hum Genet 2017 10 18;95:21.9.1-21.9.22. Epub 2017 Oct 18.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/cphg.46DOI Listing
October 2017

Human pluripotent stem cell models of cardiac disease: from mechanisms to therapies.

Dis Model Mech 2017 09;10(9):1039-1059

Department of Anatomy and Embryology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands

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http://dx.doi.org/10.1242/dmm.030320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611968PMC
September 2017

FANTOM5 CAGE profiles of human and mouse samples.

Authors:
Shuhei Noguchi Takahiro Arakawa Shiro Fukuda Masaaki Furuno Akira Hasegawa Fumi Hori Sachi Ishikawa-Kato Kaoru Kaida Ai Kaiho Mutsumi Kanamori-Katayama Tsugumi Kawashima Miki Kojima Atsutaka Kubosaki Ri-Ichiroh Manabe Mitsuyoshi Murata Sayaka Nagao-Sato Kenichi Nakazato Noriko Ninomiya Hiromi Nishiyori-Sueki Shohei Noma Eri Saijyo Akiko Saka Mizuho Sakai Christophe Simon Naoko Suzuki Michihira Tagami Shoko Watanabe Shigehiro Yoshida Peter Arner Richard A Axton Magda Babina J Kenneth Baillie Timothy C Barnett Anthony G Beckhouse Antje Blumenthal Beatrice Bodega Alessandro Bonetti James Briggs Frank Brombacher Ailsa J Carlisle Hans C Clevers Carrie A Davis Michael Detmar Taeko Dohi Albert S B Edge Matthias Edinger Anna Ehrlund Karl Ekwall Mitsuhiro Endoh Hideki Enomoto Afsaneh Eslami Michela Fagiolini Lynsey Fairbairn Mary C Farach-Carson Geoffrey J Faulkner Carmelo Ferrai Malcolm E Fisher Lesley M Forrester Rie Fujita Jun-Ichi Furusawa Teunis B Geijtenbeek Thomas Gingeras Daniel Goldowitz Sven Guhl Reto Guler Stefano Gustincich Thomas J Ha Masahide Hamaguchi Mitsuko Hara Yuki Hasegawa Meenhard Herlyn Peter Heutink Kelly J Hitchens David A Hume Tomokatsu Ikawa Yuri Ishizu Chieko Kai Hiroshi Kawamoto Yuki I Kawamura Judith S Kempfle Tony J Kenna Juha Kere Levon M Khachigian Toshio Kitamura Sarah Klein S Peter Klinken Alan J Knox Soichi Kojima Haruhiko Koseki Shigeo Koyasu Weonju Lee Andreas Lennartsson Alan Mackay-Sim Niklas Mejhert Yosuke Mizuno Hiromasa Morikawa Mitsuru Morimoto Kazuyo Moro Kelly J Morris Hozumi Motohashi Christine L Mummery Yutaka Nakachi Fumio Nakahara Toshiyuki Nakamura Yukio Nakamura Tadasuke Nozaki Soichi Ogishima Naganari Ohkura Hiroshi Ohno Mitsuhiro Ohshima Mariko Okada-Hatakeyama Yasushi Okazaki Valerio Orlando Dmitry A Ovchinnikov Robert Passier Margaret Patrikakis Ana Pombo Swati Pradhan-Bhatt Xian-Yang Qin Michael Rehli Patrizia Rizzu Sugata Roy Antti Sajantila Shimon Sakaguchi Hiroki Sato Hironori Satoh Suzana Savvi Alka Saxena Christian Schmidl Claudio Schneider Gundula G Schulze-Tanzil Anita Schwegmann Guojun Sheng Jay W Shin Daisuke Sugiyama Takaaki Sugiyama Kim M Summers Naoko Takahashi Jun Takai Hiroshi Tanaka Hideki Tatsukawa Andru Tomoiu Hiroo Toyoda Marc van de Wetering Linda M van den Berg Roberto Verardo Dipti Vijayan Christine A Wells Louise N Winteringham Ernst Wolvetang Yoko Yamaguchi Masayuki Yamamoto Chiyo Yanagi-Mizuochi Misako Yoneda Yohei Yonekura Peter G Zhang Silvia Zucchelli Imad Abugessaisa Erik Arner Jayson Harshbarger Atsushi Kondo Timo Lassmann Marina Lizio Serkan Sahin Thierry Sengstag Jessica Severin Hisashi Shimoji Masanori Suzuki Harukazu Suzuki Jun Kawai Naoto Kondo Masayoshi Itoh Carsten O Daub Takeya Kasukawa Hideya Kawaji Piero Carninci Alistair R R Forrest Yoshihide Hayashizaki

Sci Data 2017 08 29;4:170112. Epub 2017 Aug 29.

RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1038/sdata.2017.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574368PMC
August 2017

Differentiation-Defective Human Induced Pluripotent Stem Cells Reveal Strengths and Limitations of the Teratoma Assay and In Vitro Pluripotency Assays.

Stem Cell Reports 2017 05;8(5):1340-1353

Department of Anatomy & Embryology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425621PMC
May 2017

Readthrough-Promoting Drugs Gentamicin and PTC124 Fail to Rescue Nav1.5 Function of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Carrying Nonsense Mutations in the Sodium Channel Gene SCN5A.

Circ Arrhythm Electrophysiol 2016 11;9(11)

From the Department of Anatomy and Embryology, Leiden University Medical Center, Leiden (G.K., S.C., S.v.d.P., M.B., C.L.M.); and Heart Center, Department of Experimental and Clinical Cardiology (C.C.V., A.A.M.W., C.R.B.) and Department of Anatomy and Embryology, Academic Medical Center (A.O.V.), Amsterdam, The Netherlands.

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http://dx.doi.org/10.1161/CIRCEP.116.004227DOI Listing
November 2016

CCN2 reduction mediates protective effects of BMP7 treatment in obstructive nephropathy.

J Cell Commun Signal 2017 Mar 20;11(1):39-48. Epub 2016 Oct 20.

Department of Pathology, Kidney Group, University Medical Centre Utrecht, H04.312, Heidelberglaan 100, 3584, CX, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s12079-016-0358-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362571PMC
March 2017

Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come?

Br J Pharmacol 2017 Nov 20;174(21):3749-3765. Epub 2016 Sep 20.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, ZA, The Netherlands.

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http://dx.doi.org/10.1111/bph.13577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647193PMC
November 2017

Cytostretch, an Organ-on-Chip Platform.

Micromachines (Basel) 2016 Jul 14;7(7). Epub 2016 Jul 14.

Laboratory of Electronic Components, Technology & Materials (ECTM), DIMES, Delft University of Technology, 2628 CD Delft, The Netherlands.

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http://dx.doi.org/10.3390/mi7070120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189941PMC
July 2016

Inherited heart disease - what can we expect from the second decade of human iPS cell research?

FEBS Lett 2016 08 22;590(15):2482-93. Epub 2016 Jul 22.

Department of Anatomy and Embryology, Leiden University Medical Center, The Netherlands.

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http://dx.doi.org/10.1002/1873-3468.12285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113704PMC
August 2016

Concise Review: Measuring Physiological Responses of Human Pluripotent Stem Cell Derived Cardiomyocytes to Drugs and Disease.

Stem Cells 2016 08 30;34(8):2008-15. Epub 2016 Jun 30.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/stem.2403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113667PMC
August 2016

Stem cells: The cancer's gone, but did chemotherapy damage your heart?

Nat Rev Cardiol 2016 07 26;13(7):383-4. Epub 2016 May 26.

Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, Netherlands.

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http://dx.doi.org/10.1038/nrcardio.2016.88DOI Listing
July 2016

SnapShot: Key Advances in hiPSC Disease Modeling.

Cell Stem Cell 2016 Mar;18(3):422

Department of Anatomy and Embryology, Leiden University Medical Centre, Einthovenweg 20, 2333ZC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.stem.2016.02.013DOI Listing
March 2016

Complex Tissue and Disease Modeling using hiPSCs.

Cell Stem Cell 2016 Mar;18(3):309-21

Department of Anatomy and Embryology, Leiden University Medical Centre, Einthovenweg 20, 2333ZC Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.02.011DOI Listing
March 2016

BMP and Hedgehog Regulate Distinct AGM Hematopoietic Stem Cells Ex Vivo.

Stem Cell Reports 2016 Mar 25;6(3):383-95. Epub 2016 Feb 25.

Department of Cell Biology, Erasmus Medical Center, Erasmus MC Stem Cell Institute, 3000 CA Rotterdam, the Netherlands; Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788785PMC
March 2016

The avian embryo to study development of the cardiac conduction system.

Differentiation 2016 Apr-Jun;91(4-5):90-103. Epub 2016 Feb 5.

Anatomy & Embryology, Leiden University Medical Center, The Netherlands; Cardiology, Leiden University Medical Center, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.diff.2016.01.006DOI Listing
September 2017

Interaction Between ALK1 Signaling and Connexin40 in the Development of Arteriovenous Malformations.

Arterioscler Thromb Vasc Biol 2016 Apr 28;36(4):707-17. Epub 2016 Jan 28.

From the Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands (K.G., C.L.M.); CNRS Unité mixte de recherche 7241/INSERM U1050, Center for Interdisciplinary Research in Biology, Collège de France, Paris cedex 05, France (J.T., D.D.-S.-L., S.M., N.L., F.L.); MEMOLIFE Laboratory of Excellence, Paris Sciences et Lettres Research University, Paris, France (J.T., D.D.-S.-L., S.M., N.L., F.L.); Department of Radiology, AP-HP, Tenon Hospital, Paris, France (M.F.C.); Sorbonne Universités, UPMC University, Paris, France (M.F.C.); St. Antonius Hospital, Nieuwegein, The Netherlands (F.D., R.J.S., C.J.W., J.J.M.); Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville (S.P.O.); Aix Marseille Université, CNRS IBDM UMR 7288, Marseille cedex 09, France (L.M.); and Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom (H.M.A.).

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http://dx.doi.org/10.1161/ATVBAHA.115.306719DOI Listing
April 2016

Advantages of the avian model for human ovarian cancer.

Mol Clin Oncol 2015 Nov 11;3(6):1191-1198. Epub 2015 Aug 11.

Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands.

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http://dx.doi.org/10.3892/mco.2015.619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665342PMC
November 2015

A comprehensive gene expression analysis at sequential stages of in vitro cardiac differentiation from isolated MESP1-expressing-mesoderm progenitors.

Sci Rep 2016 Jan 19;6:19386. Epub 2016 Jan 19.

Department of Anatomy and Embryology, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/srep19386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726039PMC
January 2016

BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells.

Stem Cell Reports 2016 Jan 17;6(1):85-94. Epub 2015 Dec 17.

Department Anatomy and Embryology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands; Department Reproductive Medicine, Ghent University Hospital, Ghent 9000, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720007PMC
January 2016

Induced Pluripotent Stem Cells to Model Human Fibrodysplasia Ossificans Progressiva.

Stem Cell Reports 2015 Dec 26;5(6):963-970. Epub 2015 Nov 26.

Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Leiden University Medical Center, Leiden 2300, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682290PMC
December 2015

Altered calcium handling and increased contraction force in human embryonic stem cell derived cardiomyocytes following short term dexamethasone exposure.

Biochem Biophys Res Commun 2015 Nov 9;467(4):998-1005. Epub 2015 Oct 9.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.10.026DOI Listing
November 2015

What if stem cells turn into embryos in a dish?

Nat Methods 2015 Oct;12(10):917-9

Embryology Unit, Children's Medical Research Institute, Westmead, New South Wales, Australia.

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http://dx.doi.org/10.1038/nmeth.3586DOI Listing
October 2015

BMP signalling differentially regulates distinct haematopoietic stem cell types.

Nat Commun 2015 Aug 18;6:8040. Epub 2015 Aug 18.

1] Department of Cell Biology, Erasmus MC Stem Cell Institute, Erasmus Medical Center, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands [2] University of Edinburgh, Centre for Inflammation Research, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

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http://dx.doi.org/10.1038/ncomms9040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557333PMC
August 2015

Transcriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells.

Development 2015 Sep 24;142(18):3231-8. Epub 2015 Jul 24.

Dept. of Anatomy & Embryology, Leiden University Medical Center, Einthovenweg 20, Leiden 2333 ZC, The Netherlands

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http://dx.doi.org/10.1242/dev.123810DOI Listing
September 2015

KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas.

Stem Cell Reports 2015 Jun 28;4(6):1112-24. Epub 2015 May 28.

Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, the Netherlands; Department for Reproductive Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472038PMC
June 2015

What Endothelial Cells from Patient iPSCs Can Tell Us about Aortic Valve Disease.

Cell Stem Cell 2015 May;16(5):455-7

Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909150016
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http://dx.doi.org/10.1016/j.stem.2015.04.006DOI Listing
May 2015

Reply to Christ et al.: LQT1 and JLNS phenotypes in hiPSC-derived cardiomyocytes are due to KCNQ1 mutations.

Proc Natl Acad Sci U S A 2015 Apr 20;112(16):E1969. Epub 2015 Mar 20.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands

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http://dx.doi.org/10.1073/pnas.1503762112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413298PMC
April 2015

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells.

Authors:
Erik Arner Carsten O Daub Kristoffer Vitting-Seerup Robin Andersson Berit Lilje Finn Drabløs Andreas Lennartsson Michelle Rönnerblad Olga Hrydziuszko Morana Vitezic Tom C Freeman Ahmad M N Alhendi Peter Arner Richard Axton J Kenneth Baillie Anthony Beckhouse Beatrice Bodega James Briggs Frank Brombacher Margaret Davis Michael Detmar Anna Ehrlund Mitsuhiro Endoh Afsaneh Eslami Michela Fagiolini Lynsey Fairbairn Geoffrey J Faulkner Carmelo Ferrai Malcolm E Fisher Lesley Forrester Daniel Goldowitz Reto Guler Thomas Ha Mitsuko Hara Meenhard Herlyn Tomokatsu Ikawa Chieko Kai Hiroshi Kawamoto Levon M Khachigian S Peter Klinken Soichi Kojima Haruhiko Koseki Sarah Klein Niklas Mejhert Ken Miyaguchi Yosuke Mizuno Mitsuru Morimoto Kelly J Morris Christine Mummery Yutaka Nakachi Soichi Ogishima Mariko Okada-Hatakeyama Yasushi Okazaki Valerio Orlando Dmitry Ovchinnikov Robert Passier Margaret Patrikakis Ana Pombo Xian-Yang Qin Sugata Roy Hiroki Sato Suzana Savvi Alka Saxena Anita Schwegmann Daisuke Sugiyama Rolf Swoboda Hiroshi Tanaka Andru Tomoiu Louise N Winteringham Ernst Wolvetang Chiyo Yanagi-Mizuochi Misako Yoneda Susan Zabierowski Peter Zhang Imad Abugessaisa Nicolas Bertin Alexander D Diehl Shiro Fukuda Masaaki Furuno Jayson Harshbarger Akira Hasegawa Fumi Hori Sachi Ishikawa-Kato Yuri Ishizu Masayoshi Itoh Tsugumi Kawashima Miki Kojima Naoto Kondo Marina Lizio Terrence F Meehan Christopher J Mungall Mitsuyoshi Murata Hiromi Nishiyori-Sueki Serkan Sahin Sayaka Nagao-Sato Jessica Severin Michiel J L de Hoon Jun Kawai Takeya Kasukawa Timo Lassmann Harukazu Suzuki Hideya Kawaji Kim M Summers Christine Wells David A Hume Alistair R R Forrest Albin Sandelin Piero Carninci Yoshihide Hayashizaki

Science 2015 Feb 12;347(6225):1010-4. Epub 2015 Feb 12.

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http://dx.doi.org/10.1126/science.1259418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681433PMC
February 2015

Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes Under Defined Conditions.

Methods Mol Biol 2016 ;1353:163-80

Department of Anatomy & Embryology, Leiden University Medical Center, Einthovenweg 20, Leiden, 2333 ZC, The Netherlands.

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http://link.springer.com/10.1007/7651_2014_178
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http://dx.doi.org/10.1007/7651_2014_178DOI Listing
August 2016

Pluripotent stem cell derived cardiovascular progenitors--a developmental perspective.

Dev Biol 2015 Apr 24;400(2):169-79. Epub 2015 Jan 24.

Leiden University Medical Center, 2300 RC Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2015.01.012DOI Listing
April 2015

Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes.

Cardiovasc Res 2015 Apr 24;105(4):424-38. Epub 2015 Jan 24.

Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, 2215 Garland Ave, Nashville, TN 37232, USA

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http://dx.doi.org/10.1093/cvr/cvv017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349163PMC
April 2015

Immaturity of human stem-cell-derived cardiomyocytes in culture: fatal flaw or soluble problem?

Stem Cells Dev 2015 May 25;24(9):1035-52. Epub 2015 Feb 25.

1 Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam , Amsterdam, the Netherlands .

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http://dx.doi.org/10.1089/scd.2014.0533DOI Listing
May 2015

International coordination of large-scale human induced pluripotent stem cell initiatives: Wellcome Trust and ISSCR workshops white paper.

Stem Cell Reports 2014 Dec;3(6):931-9

Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, Anne McLaren Laboratory for Regenerative Medicine and Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2014.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263998PMC
December 2014

A case for crowd sourcing in stem cell research.

Stem Cells Transl Med 2014 Nov 17;3(11):1259-61. Epub 2014 Sep 17.

Medicine, and.

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http://dx.doi.org/10.5966/sctm.2014-0125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214850PMC
November 2014

Dual reporter MESP1 mCherry/w-NKX2-5 eGFP/w hESCs enable studying early human cardiac differentiation.

Stem Cells 2015 Jan;33(1):56-67

Department of Anatomy and Embryology, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/stem.1842DOI Listing
January 2015

Assessment of functional competence of endothelial cells from human pluripotent stem cells in zebrafish embryos.

Methods Mol Biol 2014 ;1213:107-19

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden Einthovenweg 20, 2333, ZC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/978-1-4939-1453-1_10DOI Listing
May 2015

Cell replacement therapies: is it time to reprogram?

Hum Gene Ther 2014 Oct 17;25(10):866-74. Epub 2014 Sep 17.

1 Department of Molecular Cell Biology, Leiden University Medical Center , 2300RC Leiden, The Netherlands .

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http://dx.doi.org/10.1089/hum.2014.097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180125PMC
October 2014

Serum supplemented culture medium masks hypertrophic phenotypes in human pluripotent stem cell derived cardiomyocytes.

J Cell Mol Med 2014 Aug 1;18(8):1509-18. Epub 2014 Jul 1.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.

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http://doi.wiley.com/10.1111/jcmm.12356
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http://dx.doi.org/10.1111/jcmm.12356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190898PMC
August 2014

SIRPA, VCAM1 and CD34 identify discrete lineages during early human cardiovascular development.

Stem Cell Res 2014 Jul 4;13(1):172-9. Epub 2014 May 4.

Murdoch Childrens Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia; Australian Regenerative Medicine Institute, Monash University, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2014.04.016DOI Listing
July 2014

Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells.

Nat Protoc 2014 29;9(6):1514-31. Epub 2014 May 29.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands.

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http://www.nature.com/articles/nprot.2014.102
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http://dx.doi.org/10.1038/nprot.2014.102DOI Listing
December 2014