Christine L Mummery

Christine L Mummery

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Christine L Mummery

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Differentiation and Functional Comparison of Monocytes and Macrophages from hiPSCs with Peripheral Blood Derivatives.

Stem Cell Reports 2019 Jun;12(6):1282-1297

Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565887PMC
June 2019

Scalable microphysiological system to model three-dimensional blood vessels.

APL Bioeng 2019 Jun 21;3(2):026105. Epub 2019 Jun 21.

Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands.

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http://dx.doi.org/10.1063/1.5090986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588522PMC
June 2019

Quantifying Ca signaling and contraction in vascular pericytes and smooth muscle cells.

Biochem Biophys Res Commun 2019 May 30;513(1):112-118. Epub 2019 Mar 30.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, 2333 ZC, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.03.143DOI Listing
May 2019

Quantitative Analysis of Intracellular Ca Release and Contraction in hiPSC-Derived Vascular Smooth Muscle Cells.

Stem Cell Reports 2019 Apr 7;12(4):647-656. Epub 2019 Mar 7.

Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449838PMC
April 2019

Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology.

Adv Drug Deliv Rev 2019 Feb 23;140:68-77. Epub 2018 Jun 23.

Applied Stem Cell Technologies group, University of Twente, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0169409X183014
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http://dx.doi.org/10.1016/j.addr.2018.06.007DOI Listing
February 2019

Perspectives on the Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Biomedical Research.

Stem Cell Reports 2018 12;11(6):1306-1311

Department of Anatomy and Embryology, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294284PMC
December 2018

Microfluidic Assay for the Assessment of Leukocyte Adhesion to Human Induced Pluripotent Stem Cell-derived Endothelial Cells (hiPSC-ECs).

J Vis Exp 2018 11 26(141). Epub 2018 Nov 26.

Department of Anatomy and Embryology, Leiden University Medical Center;

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http://dx.doi.org/10.3791/58678DOI Listing
November 2018

Quantification of Muscle Contraction In Vitro and In Vivo Using MUSCLEMOTION Software: From Stem Cell-Derived Cardiomyocytes to Zebrafish and Human Hearts.

Curr Protoc Hum Genet 2018 10 25;99(1):e67. Epub 2018 Sep 25.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands.

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http://doi.wiley.com/10.1002/cphg.67
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http://dx.doi.org/10.1002/cphg.67DOI Listing
October 2018

Inflammatory Responses and Barrier Function of Endothelial Cells Derived from Human Induced Pluripotent Stem Cells.

Stem Cell Reports 2018 05 12;10(5):1642-1656. Epub 2018 Apr 12.

Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2333ZC Leiden, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22136711183013
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http://dx.doi.org/10.1016/j.stemcr.2018.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995303PMC
May 2018

Squaramide-Based Supramolecular Materials for Three-Dimensional Cell Culture of Human Induced Pluripotent Stem Cells and Their Derivatives.

Biomacromolecules 2018 04 12;19(4):1091-1099. Epub 2018 Mar 12.

Department of Supramolecular and Biomaterials Chemistry, Leiden Institute of Chemistry , Leiden University , P.O. Box 9502, 2300 RA , Leiden , The Netherlands.

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http://pubs.acs.org/doi/10.1021/acs.biomac.7b01614
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http://dx.doi.org/10.1021/acs.biomac.7b01614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894061PMC
April 2018

Executive summary of the 12th HHT international scientific conference.

Angiogenesis 2018 02;21(1):169-181

Department of Pulmonology, St. Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands.

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http://dx.doi.org/10.1007/s10456-017-9585-2DOI Listing
February 2018

MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo.

Circ Res 2018 02 27;122(3):e5-e16. Epub 2017 Dec 27.

From the Department of Anatomy and Embryology, Leiden University Medical Center, The Netherlands (L.S., B.J.v.M., L.G.J.T., M.B., R.P.D., M.A.E.D., E.G., C.G., M.R.M.J., M.P.H.M., V.V.O., R.P., C.L.M.); Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary, and Life Science, University of Glasgow, United Kingdom (Q.L., G.L.S., F.L.B.); Hubrecht Institute - Royal Netherlands Academy of Arts and Sciences, Utrecht, The Netherlands (J.B., S.M.K., C.D.K.); Department of Stem Cell Biology, University of Nottingham, University Park, Nottingham, United Kingdom (C.D., D.M.); Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Germany (T.E., A.H., I.M., U.S.); DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck (T.E., A.H., I.M., U.S.); Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Hamburg, Germany (U.S.); Hart Long Centrum, Leiden University Medical Center, The Netherlands (E.R.H., M.R.M.J.); Department of Applied Stem Cell Technologies, University of Twente, Enschede, The Netherlands (R.P., M.C.R., C.L.M.).; Division of Heart and Lungs, Department of Medical Physiology, University Medical Center Utrecht, The Netherlands (J.B., S.M.K., C.D.K.); and Clyde Biosciences, Ltd, BioCity Scotland, United Kingdom (G.L.S., F.L.B.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.312067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805275PMC
February 2018

A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes.

Stem Cell Reports 2017 12 22;9(6):1765-1779. Epub 2017 Nov 22.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, the Netherlands; Department of Applied Stem Cell Technologies, MIRA Institute, University of Twente, Twente, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22136711173047
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http://dx.doi.org/10.1016/j.stemcr.2017.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785710PMC
December 2017

Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells.

Stem Cell Reports 2017 12 22;9(6):1754-1764. Epub 2017 Nov 22.

Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, the Netherlands; Department of Applied Stem Cell Technologies, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Building Zuidhorst, 7500 AE Enschede, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785703PMC
December 2017

Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come?

Br J Pharmacol 2017 Nov 20;174(21):3749-3765. Epub 2016 Sep 20.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, ZA, The Netherlands.

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http://dx.doi.org/10.1111/bph.13577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647193PMC
November 2017

Co-Differentiation of Human Pluripotent Stem Cells-Derived Cardiomyocytes and Endothelial Cells from Cardiac Mesoderm Provides a Three-Dimensional Model of Cardiac Microtissue.

Curr Protoc Hum Genet 2017 10 18;95:21.9.1-21.9.22. Epub 2017 Oct 18.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/cphg.46DOI Listing
October 2017

The avian embryo to study development of the cardiac conduction system.

Differentiation 2016 Apr-Jun;91(4-5):90-103. Epub 2016 Feb 5.

Anatomy & Embryology, Leiden University Medical Center, The Netherlands; Cardiology, Leiden University Medical Center, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.diff.2016.01.006DOI Listing
September 2017

Human pluripotent stem cell models of cardiac disease: from mechanisms to therapies.

Dis Model Mech 2017 09;10(9):1039-1059

Department of Anatomy and Embryology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands

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http://dx.doi.org/10.1242/dmm.030320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611968PMC
September 2017

FANTOM5 CAGE profiles of human and mouse samples.

Authors:
Shuhei Noguchi Takahiro Arakawa Shiro Fukuda Masaaki Furuno Akira Hasegawa Fumi Hori Sachi Ishikawa-Kato Kaoru Kaida Ai Kaiho Mutsumi Kanamori-Katayama Tsugumi Kawashima Miki Kojima Atsutaka Kubosaki Ri-Ichiroh Manabe Mitsuyoshi Murata Sayaka Nagao-Sato Kenichi Nakazato Noriko Ninomiya Hiromi Nishiyori-Sueki Shohei Noma Eri Saijyo Akiko Saka Mizuho Sakai Christophe Simon Naoko Suzuki Michihira Tagami Shoko Watanabe Shigehiro Yoshida Peter Arner Richard A Axton Magda Babina J Kenneth Baillie Timothy C Barnett Anthony G Beckhouse Antje Blumenthal Beatrice Bodega Alessandro Bonetti James Briggs Frank Brombacher Ailsa J Carlisle Hans C Clevers Carrie A Davis Michael Detmar Taeko Dohi Albert S B Edge Matthias Edinger Anna Ehrlund Karl Ekwall Mitsuhiro Endoh Hideki Enomoto Afsaneh Eslami Michela Fagiolini Lynsey Fairbairn Mary C Farach-Carson Geoffrey J Faulkner Carmelo Ferrai Malcolm E Fisher Lesley M Forrester Rie Fujita Jun-Ichi Furusawa Teunis B Geijtenbeek Thomas Gingeras Daniel Goldowitz Sven Guhl Reto Guler Stefano Gustincich Thomas J Ha Masahide Hamaguchi Mitsuko Hara Yuki Hasegawa Meenhard Herlyn Peter Heutink Kelly J Hitchens David A Hume Tomokatsu Ikawa Yuri Ishizu Chieko Kai Hiroshi Kawamoto Yuki I Kawamura Judith S Kempfle Tony J Kenna Juha Kere Levon M Khachigian Toshio Kitamura Sarah Klein S Peter Klinken Alan J Knox Soichi Kojima Haruhiko Koseki Shigeo Koyasu Weonju Lee Andreas Lennartsson Alan Mackay-Sim Niklas Mejhert Yosuke Mizuno Hiromasa Morikawa Mitsuru Morimoto Kazuyo Moro Kelly J Morris Hozumi Motohashi Christine L Mummery Yutaka Nakachi Fumio Nakahara Toshiyuki Nakamura Yukio Nakamura Tadasuke Nozaki Soichi Ogishima Naganari Ohkura Hiroshi Ohno Mitsuhiro Ohshima Mariko Okada-Hatakeyama Yasushi Okazaki Valerio Orlando Dmitry A Ovchinnikov Robert Passier Margaret Patrikakis Ana Pombo Swati Pradhan-Bhatt Xian-Yang Qin Michael Rehli Patrizia Rizzu Sugata Roy Antti Sajantila Shimon Sakaguchi Hiroki Sato Hironori Satoh Suzana Savvi Alka Saxena Christian Schmidl Claudio Schneider Gundula G Schulze-Tanzil Anita Schwegmann Guojun Sheng Jay W Shin Daisuke Sugiyama Takaaki Sugiyama Kim M Summers Naoko Takahashi Jun Takai Hiroshi Tanaka Hideki Tatsukawa Andru Tomoiu Hiroo Toyoda Marc van de Wetering Linda M van den Berg Roberto Verardo Dipti Vijayan Christine A Wells Louise N Winteringham Ernst Wolvetang Yoko Yamaguchi Masayuki Yamamoto Chiyo Yanagi-Mizuochi Misako Yoneda Yohei Yonekura Peter G Zhang Silvia Zucchelli Imad Abugessaisa Erik Arner Jayson Harshbarger Atsushi Kondo Timo Lassmann Marina Lizio Serkan Sahin Thierry Sengstag Jessica Severin Hisashi Shimoji Masanori Suzuki Harukazu Suzuki Jun Kawai Naoto Kondo Masayoshi Itoh Carsten O Daub Takeya Kasukawa Hideya Kawaji Piero Carninci Alistair R R Forrest Yoshihide Hayashizaki

Sci Data 2017 08 29;4:170112. Epub 2017 Aug 29.

RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1038/sdata.2017.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574368PMC
August 2017

Differentiation-Defective Human Induced Pluripotent Stem Cells Reveal Strengths and Limitations of the Teratoma Assay and In Vitro Pluripotency Assays.

Stem Cell Reports 2017 05;8(5):1340-1353

Department of Anatomy & Embryology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425621PMC
May 2017

CCN2 reduction mediates protective effects of BMP7 treatment in obstructive nephropathy.

J Cell Commun Signal 2017 Mar 20;11(1):39-48. Epub 2016 Oct 20.

Department of Pathology, Kidney Group, University Medical Centre Utrecht, H04.312, Heidelberglaan 100, 3584, CX, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s12079-016-0358-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362571PMC
March 2017

Readthrough-Promoting Drugs Gentamicin and PTC124 Fail to Rescue Nav1.5 Function of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Carrying Nonsense Mutations in the Sodium Channel Gene SCN5A.

Circ Arrhythm Electrophysiol 2016 11;9(11)

From the Department of Anatomy and Embryology, Leiden University Medical Center, Leiden (G.K., S.C., S.v.d.P., M.B., C.L.M.); and Heart Center, Department of Experimental and Clinical Cardiology (C.C.V., A.A.M.W., C.R.B.) and Department of Anatomy and Embryology, Academic Medical Center (A.O.V.), Amsterdam, The Netherlands.

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http://dx.doi.org/10.1161/CIRCEP.116.004227DOI Listing
November 2016

Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes Under Defined Conditions.

Methods Mol Biol 2016 ;1353:163-80

Department of Anatomy & Embryology, Leiden University Medical Center, Einthovenweg 20, Leiden, 2333 ZC, The Netherlands.

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http://link.springer.com/10.1007/7651_2014_178
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http://dx.doi.org/10.1007/7651_2014_178DOI Listing
August 2016

Concise Review: Measuring Physiological Responses of Human Pluripotent Stem Cell Derived Cardiomyocytes to Drugs and Disease.

Stem Cells 2016 08 30;34(8):2008-15. Epub 2016 Jun 30.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/stem.2403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113667PMC
August 2016

Inherited heart disease - what can we expect from the second decade of human iPS cell research?

FEBS Lett 2016 08 22;590(15):2482-93. Epub 2016 Jul 22.

Department of Anatomy and Embryology, Leiden University Medical Center, The Netherlands.

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http://dx.doi.org/10.1002/1873-3468.12285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113704PMC
August 2016

Stem cells: The cancer's gone, but did chemotherapy damage your heart?

Nat Rev Cardiol 2016 07 26;13(7):383-4. Epub 2016 May 26.

Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, Netherlands.

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http://dx.doi.org/10.1038/nrcardio.2016.88DOI Listing
July 2016

Interaction Between ALK1 Signaling and Connexin40 in the Development of Arteriovenous Malformations.

Arterioscler Thromb Vasc Biol 2016 Apr 28;36(4):707-17. Epub 2016 Jan 28.

From the Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands (K.G., C.L.M.); CNRS Unité mixte de recherche 7241/INSERM U1050, Center for Interdisciplinary Research in Biology, Collège de France, Paris cedex 05, France (J.T., D.D.-S.-L., S.M., N.L., F.L.); MEMOLIFE Laboratory of Excellence, Paris Sciences et Lettres Research University, Paris, France (J.T., D.D.-S.-L., S.M., N.L., F.L.); Department of Radiology, AP-HP, Tenon Hospital, Paris, France (M.F.C.); Sorbonne Universités, UPMC University, Paris, France (M.F.C.); St. Antonius Hospital, Nieuwegein, The Netherlands (F.D., R.J.S., C.J.W., J.J.M.); Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville (S.P.O.); Aix Marseille Université, CNRS IBDM UMR 7288, Marseille cedex 09, France (L.M.); and Institute of Genetic Medicine, Newcastle University, Newcastle, United Kingdom (H.M.A.).

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http://dx.doi.org/10.1161/ATVBAHA.115.306719DOI Listing
April 2016

A comprehensive gene expression analysis at sequential stages of in vitro cardiac differentiation from isolated MESP1-expressing-mesoderm progenitors.

Sci Rep 2016 Jan 19;6:19386. Epub 2016 Jan 19.

Department of Anatomy and Embryology, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/srep19386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726039PMC
January 2016

Induced Pluripotent Stem Cells to Model Human Fibrodysplasia Ossificans Progressiva.

Stem Cell Reports 2015 Dec 26;5(6):963-970. Epub 2015 Nov 26.

Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Leiden University Medical Center, Leiden 2300, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682290PMC
December 2015

Altered calcium handling and increased contraction force in human embryonic stem cell derived cardiomyocytes following short term dexamethasone exposure.

Biochem Biophys Res Commun 2015 Nov 9;467(4):998-1005. Epub 2015 Oct 9.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.10.026DOI Listing
November 2015

Advantages of the avian model for human ovarian cancer.

Mol Clin Oncol 2015 Nov 11;3(6):1191-1198. Epub 2015 Aug 11.

Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands.

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http://dx.doi.org/10.3892/mco.2015.619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665342PMC
November 2015

What if stem cells turn into embryos in a dish?

Nat Methods 2015 Oct;12(10):917-9

Embryology Unit, Children's Medical Research Institute, Westmead, New South Wales, Australia.

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http://dx.doi.org/10.1038/nmeth.3586DOI Listing
October 2015

Transcriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells.

Development 2015 Sep 24;142(18):3231-8. Epub 2015 Jul 24.

Dept. of Anatomy & Embryology, Leiden University Medical Center, Einthovenweg 20, Leiden 2333 ZC, The Netherlands

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http://dx.doi.org/10.1242/dev.123810DOI Listing
September 2015

KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas.

Stem Cell Reports 2015 Jun 28;4(6):1112-24. Epub 2015 May 28.

Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, the Netherlands; Department for Reproductive Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472038PMC
June 2015

Assessment of functional competence of endothelial cells from human pluripotent stem cells in zebrafish embryos.

Methods Mol Biol 2014 ;1213:107-19

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden Einthovenweg 20, 2333, ZC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/978-1-4939-1453-1_10DOI Listing
May 2015

Immaturity of human stem-cell-derived cardiomyocytes in culture: fatal flaw or soluble problem?

Stem Cells Dev 2015 May 25;24(9):1035-52. Epub 2015 Feb 25.

1 Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam , Amsterdam, the Netherlands .

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http://dx.doi.org/10.1089/scd.2014.0533DOI Listing
May 2015

What Endothelial Cells from Patient iPSCs Can Tell Us about Aortic Valve Disease.

Cell Stem Cell 2015 May;16(5):455-7

Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909150016
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http://dx.doi.org/10.1016/j.stem.2015.04.006DOI Listing
May 2015

Pluripotent stem cell derived cardiovascular progenitors--a developmental perspective.

Dev Biol 2015 Apr 24;400(2):169-79. Epub 2015 Jan 24.

Leiden University Medical Center, 2300 RC Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2015.01.012DOI Listing
April 2015

Reply to Christ et al.: LQT1 and JLNS phenotypes in hiPSC-derived cardiomyocytes are due to KCNQ1 mutations.

Proc Natl Acad Sci U S A 2015 Apr 20;112(16):E1969. Epub 2015 Mar 20.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands

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http://dx.doi.org/10.1073/pnas.1503762112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413298PMC
April 2015

Lymphangiogenesis and angiogenesis during human fetal pancreas development.

Vasc Cell 2014 1;6:22. Epub 2014 Nov 1.

Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands ; Department for Reproductive Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium.

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http://dx.doi.org/10.1186/2045-824X-6-22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362646PMC
March 2015

Dual reporter MESP1 mCherry/w-NKX2-5 eGFP/w hESCs enable studying early human cardiac differentiation.

Stem Cells 2015 Jan;33(1):56-67

Department of Anatomy and Embryology, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/stem.1842DOI Listing
January 2015

Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells.

Nat Protoc 2014 29;9(6):1514-31. Epub 2014 May 29.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands.

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http://www.nature.com/articles/nprot.2014.102
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http://dx.doi.org/10.1038/nprot.2014.102DOI Listing
December 2014

A case for crowd sourcing in stem cell research.

Stem Cells Transl Med 2014 Nov 17;3(11):1259-61. Epub 2014 Sep 17.

Medicine, and.

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http://dx.doi.org/10.5966/sctm.2014-0125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214850PMC
November 2014

Strategies for rapidly mapping proviral integration sites and assessing cardiogenic potential of nascent human induced pluripotent stem cell clones.

Exp Cell Res 2014 Oct 13;327(2):297-306. Epub 2014 May 13.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands; Netherlands Proteomics Institute, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2014.05.001DOI Listing
October 2014

Cell replacement therapies: is it time to reprogram?

Hum Gene Ther 2014 Oct 17;25(10):866-74. Epub 2014 Sep 17.

1 Department of Molecular Cell Biology, Leiden University Medical Center , 2300RC Leiden, The Netherlands .

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http://dx.doi.org/10.1089/hum.2014.097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180125PMC
October 2014

Serum supplemented culture medium masks hypertrophic phenotypes in human pluripotent stem cell derived cardiomyocytes.

J Cell Mol Med 2014 Aug 1;18(8):1509-18. Epub 2014 Jul 1.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.

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http://doi.wiley.com/10.1111/jcmm.12356
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http://dx.doi.org/10.1111/jcmm.12356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190898PMC
August 2014

SIRPA, VCAM1 and CD34 identify discrete lineages during early human cardiovascular development.

Stem Cell Res 2014 Jul 4;13(1):172-9. Epub 2014 May 4.

Murdoch Childrens Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia; Australian Regenerative Medicine Institute, Monash University, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2014.04.016DOI Listing
July 2014

Generation of induced pluripotent stem cells from human foetal fibroblasts using the Sleeping Beauty transposon gene delivery system.

Differentiation 2013 Jul-Sep;86(1-2):30-7. Epub 2013 Aug 7.

Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands; Netherlands Proteomics Institute, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.diff.2013.06.002DOI Listing
April 2014

A promoter-level mammalian expression atlas.

Authors:
Alistair R R Forrest Hideya Kawaji Michael Rehli J Kenneth Baillie Michiel J L de Hoon Vanja Haberle Timo Lassmann Ivan V Kulakovskiy Marina Lizio Masayoshi Itoh Robin Andersson Christopher J Mungall Terrence F Meehan Sebastian Schmeier Nicolas Bertin Mette Jørgensen Emmanuel Dimont Erik Arner Christian Schmidl Ulf Schaefer Yulia A Medvedeva Charles Plessy Morana Vitezic Jessica Severin Colin A Semple Yuri Ishizu Robert S Young Margherita Francescatto Intikhab Alam Davide Albanese Gabriel M Altschuler Takahiro Arakawa John A C Archer Peter Arner Magda Babina Sarah Rennie Piotr J Balwierz Anthony G Beckhouse Swati Pradhan-Bhatt Judith A Blake Antje Blumenthal Beatrice Bodega Alessandro Bonetti James Briggs Frank Brombacher A Maxwell Burroughs Andrea Califano Carlo V Cannistraci Daniel Carbajo Yun Chen Marco Chierici Yari Ciani Hans C Clevers Emiliano Dalla Carrie A Davis Michael Detmar Alexander D Diehl Taeko Dohi Finn Drabløs Albert S B Edge Matthias Edinger Karl Ekwall Mitsuhiro Endoh Hideki Enomoto Michela Fagiolini Lynsey Fairbairn Hai Fang Mary C Farach-Carson Geoffrey J Faulkner Alexander V Favorov Malcolm E Fisher Martin C Frith Rie Fujita Shiro Fukuda Cesare Furlanello Masaaki Furino Jun-ichi Furusawa Teunis B Geijtenbeek Andrew P Gibson Thomas Gingeras Daniel Goldowitz Julian Gough Sven Guhl Reto Guler Stefano Gustincich Thomas J Ha Masahide Hamaguchi Mitsuko Hara Matthias Harbers Jayson Harshbarger Akira Hasegawa Yuki Hasegawa Takehiro Hashimoto Meenhard Herlyn Kelly J Hitchens Shannan J Ho Sui Oliver M Hofmann Ilka Hoof Furni Hori Lukasz Huminiecki Kei Iida Tomokatsu Ikawa Boris R Jankovic Hui Jia Anagha Joshi Giuseppe Jurman Bogumil Kaczkowski Chieko Kai Kaoru Kaida Ai Kaiho Kazuhiro Kajiyama Mutsumi Kanamori-Katayama Artem S Kasianov Takeya Kasukawa Shintaro Katayama Sachi Kato Shuji Kawaguchi Hiroshi Kawamoto Yuki I Kawamura Tsugumi Kawashima Judith S Kempfle Tony J Kenna Juha Kere Levon M Khachigian Toshio Kitamura S Peter Klinken Alan J Knox Miki Kojima Soichi Kojima Naoto Kondo Haruhiko Koseki Shigeo Koyasu Sarah Krampitz Atsutaka Kubosaki Andrew T Kwon Jeroen F J Laros Weonju Lee Andreas Lennartsson Kang Li Berit Lilje Leonard Lipovich Alan Mackay-Sim Ri-ichiroh Manabe Jessica C Mar Benoit Marchand Anthony Mathelier Niklas Mejhert Alison Meynert Yosuke Mizuno David A de Lima Morais Hiromasa Morikawa Mitsuru Morimoto Kazuyo Moro Efthymios Motakis Hozumi Motohashi Christine L Mummery Mitsuyoshi Murata Sayaka Nagao-Sato Yutaka Nakachi Fumio Nakahara Toshiyuki Nakamura Yukio Nakamura Kenichi Nakazato Erik van Nimwegen Noriko Ninomiya Hiromi Nishiyori Shohei Noma Shohei Noma Tadasuke Noazaki Soichi Ogishima Naganari Ohkura Hiroko Ohimiya Hiroshi Ohno Mitsuhiro Ohshima Mariko Okada-Hatakeyama Yasushi Okazaki Valerio Orlando Dmitry A Ovchinnikov Arnab Pain Robert Passier Margaret Patrikakis Helena Persson Silvano Piazza James G D Prendergast Owen J L Rackham Jordan A Ramilowski Mamoon Rashid Timothy Ravasi Patrizia Rizzu Marco Roncador Sugata Roy Morten B Rye Eri Saijyo Antti Sajantila Akiko Saka Shimon Sakaguchi Mizuho Sakai Hiroki Sato Suzana Savvi Alka Saxena Claudio Schneider Erik A Schultes Gundula G Schulze-Tanzil Anita Schwegmann Thierry Sengstag Guojun Sheng Hisashi Shimoji Yishai Shimoni Jay W Shin Christophe Simon Daisuke Sugiyama Takaai Sugiyama Masanori Suzuki Naoko Suzuki Rolf K Swoboda Peter A C 't Hoen Michihira Tagami Naoko Takahashi Jun Takai Hiroshi Tanaka Hideki Tatsukawa Zuotian Tatum Mark Thompson Hiroo Toyodo Tetsuro Toyoda Elvind Valen Marc van de Wetering Linda M van den Berg Roberto Verado Dipti Vijayan Ilya E Vorontsov Wyeth W Wasserman Shoko Watanabe Christine A Wells Louise N Winteringham Ernst Wolvetang Emily J Wood Yoko Yamaguchi Masayuki Yamamoto Misako Yoneda Yohei Yonekura Shigehiro Yoshida Susan E Zabierowski Peter G Zhang Xiaobei Zhao Silvia Zucchelli Kim M Summers Harukazu Suzuki Carsten O Daub Jun Kawai Peter Heutink Winston Hide Tom C Freeman Boris Lenhard Vladimir B Bajic Martin S Taylor Vsevolod J Makeev Albin Sandelin David A Hume Piero Carninci Yoshihide Hayashizaki

Nature 2014 Mar;507(7493):462-70

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http://dx.doi.org/10.1038/nature13182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529748PMC
March 2014

Functionality of endothelial cells and pericytes from human pluripotent stem cells demonstrated in cultured vascular plexus and zebrafish xenografts.

Arterioscler Thromb Vasc Biol 2014 Jan 24;34(1):177-86. Epub 2013 Oct 24.

From the Department of Anatomy and Embryology (V.V.O., C.F., S.P.-R., F.E.v.d.H., S.M., C.L.M.) and Department of Molecular Cell Biology (V.V.O., Y.D., P.t.D.), Cancer Genomics Centre and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1161/ATVBAHA.113.302598DOI Listing
January 2014

Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device.

Lab Chip 2013 Sep;13(18):3562-8

BIOS/Lab on a Chip, MESA+ Institute for Nanotechnology, University of Twente, The Netherlands.

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http://xlink.rsc.org/?DOI=c3lc50435b
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http://dx.doi.org/10.1039/c3lc50435bDOI Listing
September 2013

Direct cardiomyocyte reprogramming: a new direction for cardiovascular regenerative medicine.

Cold Spring Harb Perspect Med 2013 Sep 1;3(9):a014050. Epub 2013 Sep 1.

Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114.

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http://dx.doi.org/10.1101/cshperspect.a014050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753721PMC
September 2013

Stem cells: Cloning human embryos.

Nature 2013 Jun;498(7453):174-5

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http://dx.doi.org/10.1038/498174aDOI Listing
June 2013

From stealing fire to cellular reprogramming: a scientific history leading to the 2012 Nobel Prize.

Stem Cell Reports 2013 Jun 4;1(1):5-17. Epub 2013 Jun 4.

Department of Pediatrics, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA ; Division of Hematology/Oncology, Howard Hughes Medical Institute/Boston Children's Hospital, 1 Blackfan Circle, Boston, MA 02115, USA ; Harvard Stem Cell Institute, Holyoke Center, Suite 727W, 1350 Massachusetts Avenue, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.stemcr.2013.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757737PMC
June 2013

Model systems for cardiovascular regenerative biology.

Cold Spring Harb Perspect Med 2013 Apr 1;3(4):a014019. Epub 2013 Apr 1.

Boston Children's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1101/cshperspect.a014019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684004PMC
April 2013

Is heart regeneration on the right track?

Nat Med 2013 Apr;19(4):412-3

Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/nm.3158DOI Listing
April 2013

Induced pluripotent stem cells: the new patient?

Nat Rev Mol Cell Biol 2012 Nov 4;13(11):713-26. Epub 2012 Oct 4.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/nrm3448DOI Listing
November 2012

Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmias.

Front Physiol 2012 31;3:346. Epub 2012 Aug 31.

Department of Clinical and Experimental Cardiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fphys.2012.00346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449331PMC
October 2012

Tbx6 is a determinant of cardiac and neural cell fate decisions in multipotent P19CL6 cells.

Differentiation 2012 Sep 19;84(2):176-84. Epub 2012 Jun 19.

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.diff.2012.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835676PMC
September 2012

Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades.

Dev Cell 2012 Mar 23;22(3):501-14. Epub 2012 Feb 23.

VIB11 Center for the Biology of Disease, Laboratory of Developmental Signaling, VIB and Center for Human Genetics, KU Leuven, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.devcel.2012.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544746PMC
March 2012

Smooth muscle diversity from human pluripotent cells.

Nat Biotechnol 2012 Feb 8;30(2):152-4. Epub 2012 Feb 8.

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http://dx.doi.org/10.1038/nbt.2117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690307PMC
February 2012

Pluripotent stem cell models of cardiac disease and their implication for drug discovery and development.

Trends Mol Med 2011 Sep 22;17(9):475-84. Epub 2011 Jun 22.

Department of Anatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.molmed.2011.05.001DOI Listing
September 2011

New perspectives on regeneration of the heart.

Circ Res 2011 Sep;109(8):828-9

Department of Anatomy and Embryology, Leiden University Medical Center, the Netherlands.

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http://dx.doi.org/10.1161/RES.0b013e3182349a8aDOI Listing
September 2011

Cardiomyocyte differentiation of pluripotent stem cells and their use as cardiac disease models.

Biochem J 2011 Feb;434(1):25-35

Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1042/BJ20101707DOI Listing
February 2011

On the streets of San Francisco: highlights from the ISSCR Annual Meeting 2010.

Cell Stem Cell 2010 Oct;7(4):443-50

Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria, 3800, Australia.

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http://dx.doi.org/10.1016/j.stem.2010.09.002DOI Listing
October 2010

Challenges in using stem cells for cardiac repair.

Sci Transl Med 2010 Apr;2(27):27ps17

Department of Anatomy and Embryology, Leiden University Medical Centre, 2300 RC Leiden, Netherlands.

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http://stm.sciencemag.org/cgi/doi/10.1126/scitranslmed.30005
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April 2010

Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes.

Stem Cell Res 2010 Mar 3;4(2):107-16. Epub 2009 Dec 3.

Department of Anatomy and Embryology, Leiden University Medical Centre, Leiden, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S18735061090013
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http://dx.doi.org/10.1016/j.scr.2009.11.004DOI Listing
March 2010

Identification of cell surface proteins for antibody-based selection of human embryonic stem cell-derived cardiomyocytes.

J Proteome Res 2010 Mar;9(3):1610-8

Hubrecht Institute, Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

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http://dx.doi.org/10.1021/pr901138aDOI Listing
March 2010