Publications by authors named "Christine Klein"

98Publications

First Case of Parkinsonian-Pyramidal Syndrome Associated with a TBK1 Mutation.

Mov Disord 2020 Nov 27. Epub 2020 Nov 27.

Institute of Neurogenetics, University of Lübeck and University Hospital Schleswig-Holstein, Lübeck, Germany.

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http://dx.doi.org/10.1002/mds.28405DOI Listing
November 2020

Mitochondria and Parkinson's Disease: Clinical, Molecular, and Translational Aspects.

J Parkinsons Dis 2020 Oct 10. Epub 2020 Oct 10.

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.3233/JPD-201981DOI Listing
October 2020

Genetic Risk of Alzheimer's Disease - Sleepless with the Enemy.

Ann Neurol 2020 Oct 18. Epub 2020 Oct 18.

Institute of Neurogenetics, University of Luebeck, Luebeck, Germany.

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http://dx.doi.org/10.1002/ana.25938DOI Listing
October 2020

Mitochondrial Mechanisms of LRRK2 G2019S Penetrance.

Front Neurol 2020 25;11:881. Epub 2020 Aug 25.

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.

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http://dx.doi.org/10.3389/fneur.2020.00881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477385PMC
August 2020

Parkin-linked Parkinson's disease: From clinical insights to pathogenic mechanisms and novel therapeutic approaches.

Neurosci Res 2020 Sep 17. Epub 2020 Sep 17.

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neures.2020.09.001DOI Listing
September 2020

'Moving genes': how dystonia genes functionally converge on the transcriptome.

Brain 2020 Sep;143(9):2631-2634

Institute of Neurogenetics, University of Luebeck, Luebeck, Germany.

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http://dx.doi.org/10.1093/brain/awaa253DOI Listing
September 2020

Age at Onset of LRRK2 p.Gly2019Ser Is Related to Environmental and Lifestyle Factors.

Mov Disord 2020 10 2;35(10):1854-1858. Epub 2020 Sep 2.

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1002/mds.28238DOI Listing
October 2020

PINK1 p.Leu347Pro mutations in Malays: Prevalence and illustrative cases.

Parkinsonism Relat Disord 2020 Aug 19;79:34-39. Epub 2020 Aug 19.

Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; The Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, University of Malaya, Kuala Lumpur, Malaysia. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2020.08.015DOI Listing
August 2020

Risk for infective endocarditis in bacteremia with Gram positive cocci.

Infection 2020 Dec 25;48(6):905-912. Epub 2020 Aug 25.

Department of Cardiology, Herlev-Gentofte hospital, University of Copenhagen, Herlev Ringvej 75, Herlev, 2730, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/s15010-020-01504-6DOI Listing
December 2020

Don't do harm by diagnosis - An abnormal cranial CT: Still fa(h)r from a disease.

Parkinsonism Relat Disord 2020 06;75:116-118

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany; Department of Psychiatry, University Hospital Schleswig-Holstein, Campus Lübeck, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2020.02.016DOI Listing
June 2020

Clinical Phenotype of LRRK2 R1441C in 2 Chinese Sisters.

Neurodegener Dis 2020 24;20(1):39-45. Epub 2020 Jun 24.

Institute of Neurogenetics, University of Lubeck, Lubeck, Germany.

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http://dx.doi.org/10.1159/000508131DOI Listing
June 2020

Simulated medication adherence: First and second-year pharmacy students' perceptions of adhering to a multi-drug medication regimen.

Curr Pharm Teach Learn 2020 Jul 18;12(7):858-863. Epub 2020 Mar 18.

Mercer University College of Pharmacy, 3001 Mercer University Drive, Atlanta, GA 30341, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cptl.2020.02.009DOI Listing
July 2020

Importance of Tissue Selection for Genetic Testing: Detection of a Terminal 18q Deletion after Stem Cell Transplantation.

Mov Disord Clin Pract 2020 May 3;7(4):453-455. Epub 2020 Apr 3.

Department of Neurology Charité University Medicine Berlin Berlin Germany.

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http://dx.doi.org/10.1002/mdc3.12931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197318PMC
May 2020

Primary brain calcification due to a homozygous MYORG mutation causing isolated paroxysmal kinesigenic dyskinesia.

Brain 2020 05;143(5):e36

Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/brain/awaa086DOI Listing
May 2020

Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis.

Thromb Haemost 2020 Apr 14;120(4):538-564. Epub 2020 Apr 14.

Laboratory for Clinical Thrombosis and Hemostasis, Department of Biochemistry and Internal Medicine and Thrombosis Expert Center, Maastricht University Medical Center and CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands.

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http://dx.doi.org/10.1055/s-0040-1708035DOI Listing
April 2020

Impaired differentiation of human induced neural stem cells by TOR1A overexpression.

Mol Biol Rep 2020 May 1;47(5):3993-4001. Epub 2020 Apr 1.

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1007/s11033-020-05390-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239838PMC
May 2020

Mild dopa-responsive dystonia in heterozygous tyrosine hydroxylase mutation carrier: Evidence of symptomatic enzyme deficiency?

Parkinsonism Relat Disord 2020 02 30;71:44-45. Epub 2020 Jan 30.

Edmond J. Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2020.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109519PMC
February 2020

LRRK2 in Parkinson disease: challenges of clinical trials.

Nat Rev Neurol 2020 02 24;16(2):97-107. Epub 2020 Jan 24.

Clinical Investigation Center CIC1436, Departments of Clinical Pharmacology and Neurosciences, NS-Park/FCRIN network and NeuroToul Center of Excellence for Neurodegeneration, INSERM, University Hospital of Toulouse and University of Toulouse, Toulouse, France.

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http://dx.doi.org/10.1038/s41582-019-0301-2DOI Listing
February 2020

Needle in a Haystack: The Common Can Inform the Rare in Restless Legs Syndrome.

Ann Neurol 2020 02 11;87(2):172-174. Epub 2020 Jan 11.

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1002/ana.25663DOI Listing
February 2020

Essential phenotypes of NOTCH2NLC-related repeat expansion disorder.

Brain 2020 01;143(1):5-8

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1093/brain/awz404DOI Listing
January 2020

'Atypical' Parkinson's disease - genetic.

Int Rev Neurobiol 2019 25;149:207-235. Epub 2019 Nov 25.

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1016/bs.irn.2019.10.011DOI Listing
June 2020

Risky behaviors and Parkinson disease: A mendelian randomization study.

Neurology 2019 10 16;93(15):e1412-e1424. Epub 2019 Sep 16.

From the Institut für Medizinische Biometrie und Statistik (S.G., I.R.K.), Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck; Genetic and Molecular Epidemiology Group (C.M.L.), Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics & Cardiogenetics, Institute of Neurogenetics (M.K.), Department of Psychiatry and Psychotherapy, and Institute of Neurogenetics (C.K.), Universität zu Lübeck, Germany; and Institute for Biomedicine (F.D.G.M.), Eurac Research, Bolzano, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000008245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010323PMC
October 2019

Imaging gradual neurodegeneration in a basal ganglia model disease.

Ann Neurol 2019 10 23;86(4):517-526. Epub 2019 Aug 23.

Department of Neurology, University Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1002/ana.25566DOI Listing
October 2019

The sooner, the later - Delayed diagnosis in Parkinson's disease due to Parkin mutations.

Parkinsonism Relat Disord 2019 08 23;65:284-285. Epub 2019 Jun 23.

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany; Department of Neurology, University Hospital Schleswig-Holstein, Campus Lübeck, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2019.06.020DOI Listing
August 2019

[Model for personalized diagnostics and treatment in neurology-German Academy for Rare Neurological Diseases].

Nervenarzt 2019 Aug;90(8):796-803

Institut für Medizinische Genetik und angewandte Genomik und Zentrum für Seltene Erkrankungen, Universitätsklinikum und Universität Tübingen, Tübingen, Deutschland.

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http://dx.doi.org/10.1007/s00115-019-0750-2DOI Listing
August 2019

Discordance in monozygotic Parkinson's disease twins - continuum or dichotomy?

Ann Clin Transl Neurol 2019 Jun 2;6(6):1102-1105. Epub 2019 May 2.

Institute of Neurogenetics University of Lübeck Lübeck Germany.

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http://dx.doi.org/10.1002/acn3.775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562023PMC
June 2019

Parkinson's disease in the Western Pacific Region.

Lancet Neurol 2019 09 4;18(9):865-879. Epub 2019 Jun 4.

Edmond J Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/S1474-4422(19)30195-4DOI Listing
September 2019

Primary familial brain calcifications: genetic and clinical update.

Curr Opin Neurol 2019 08;32(4):571-578

Institute of Neurogenetics.

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http://dx.doi.org/10.1097/WCO.0000000000000712DOI Listing
August 2019

Using global team science to identify genetic parkinson's disease worldwide.

Ann Neurol 2019 08 26;86(2):153-157. Epub 2019 Jun 26.

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1002/ana.25514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410260PMC
August 2019

Mitochondrial DNA Deletions Discriminate Affected from Unaffected LRRK2 Mutation Carriers.

Ann Neurol 2019 08 12;86(2):324-326. Epub 2019 Jun 12.

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.

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http://dx.doi.org/10.1002/ana.25510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900150PMC
August 2019

In-hospital metabolite changes in infective endocarditis-a longitudinal H NMR-based study.

Eur J Clin Microbiol Infect Dis 2019 Aug 22;38(8):1553-1560. Epub 2019 May 22.

Department of Chemistry, Lund University, P.O. Box 124, SE-22100, Lund, Sweden.

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http://dx.doi.org/10.1007/s10096-019-03586-zDOI Listing
August 2019

Will genotype drive treatment options?

Mov Disord 2019 09 10;34(9):1294-1299. Epub 2019 Apr 10.

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/mds.27699
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http://dx.doi.org/10.1002/mds.27699DOI Listing
September 2019

De-novo KMT2B mutation in a consanguineous family: 15-Year follow-up of an Afghan dystonia patient.

Parkinsonism Relat Disord 2019 07 25;64:337-339. Epub 2019 Mar 25.

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2019.03.018DOI Listing
July 2019

How Do I Confirm that a New Mutation is Pathogenic?

Mov Disord Clin Pract 2018 Mar-Apr;5(2):229. Epub 2018 Mar 23.

Institute of Neurogenetics Luebeck Germany.

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http://dx.doi.org/10.1002/mdc3.12600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407058PMC
March 2018

MDSGene: Closing Data Gaps in Genotype-Phenotype Correlations of Monogenic Parkinson's Disease.

J Parkinsons Dis 2018 ;8(s1):S25-S30

Department of Neurology, Juntendo University, Bunkyo, Tokyo, Japan.

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http://dx.doi.org/10.3233/JPD-181505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311364PMC
October 2019

Association of SNCA variants with α-synuclein of gastric and colonic mucosa in Parkinson's disease.

Parkinsonism Relat Disord 2019 04 26;61:151-155. Epub 2018 Oct 26.

Institute of Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2018.10.028DOI Listing
April 2019

Genotype-phenotype relations for the Parkinson's disease genes SNCA, LRRK2, VPS35: MDSGene systematic review.

Mov Disord 2018 12 24;33(12):1857-1870. Epub 2018 Oct 24.

The Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/mds.27527DOI Listing
December 2018

Eye movement deficits in X-linked dystonia-parkinsonism are related to striatal degeneration.

Parkinsonism Relat Disord 2019 04 15;61:170-178. Epub 2018 Oct 15.

Department of Neurology, University of Luebeck, Luebeck, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2018.10.016DOI Listing
April 2019

An interprofessional education approach to fall prevention: preparing members of the interprofessional healthcare team to implement STEADI into practice.

Gerontol Geriatr Educ 2019 Jan-Mar;40(1):105-120. Epub 2018 Oct 15.

e Department of Pharmacy Practice, College of Pharmacy , Mercer University College of Pharmacy , Atlanta, GA , USA.

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http://dx.doi.org/10.1080/02701960.2018.1530226DOI Listing
May 2019

Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis.

N Engl J Med 2019 01 28;380(5):415-424. Epub 2018 Aug 28.

From the Department of Cardiology, Herlev-Gentofte University Hospital (K.I., M.S., C.F.K.), Department of Cardiology, the Heart Center, Rigshospitalet, Copenhagen University Hospital (N.I., D.E.H., E.L.F., L.K., H.B.), the Departments of Infectious Diseases (J.H.-L.) and Clinical Microbiology (C.M.), Rigshospitalet, the Department of Cardiology, Hillerød Hospital (N.T.), and the Department of Clinical Microbiology, Slagelse Hospital and Institute of Clinical Medicine (J.J.C.), University of Copenhagen, Copenhagen, the Departments of Cardiology (S.U.G.) and Clinical Microbiology (F.R.), Odense University Hospital, Odense, the Departments of Cardiology (T.M.) and Cardiology and Epidemiology and Biostatistics (C.T.-P.), Aalborg University Hospital, the Department of Clinical Microbiology, Aalborg University Hospital, Aalborg University (H.C.S.), and the Department of Health Science and Technology, Aalborg University (C.T.-P.), Aalborg, the Department of Cardiology, Zealand University Hospital, Roskilde (H.E.), the Department of Cardiology, Aarhus University Hospital, Aarhus (K.T.J.), the Department of Cardiology, University Hospital of Copenhagen, Gentofte (N.E.B.), and the Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen (K.F.) - all in Denmark.

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http://www.nejm.org/doi/10.1056/NEJMoa1808312
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http://dx.doi.org/10.1056/NEJMoa1808312DOI Listing
January 2019

Parkin and PINK1 mitigate STING-induced inflammation.

Nature 2018 09 22;561(7722):258-262. Epub 2018 Aug 22.

Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

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http://www.nature.com/articles/s41586-018-0448-9
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http://dx.doi.org/10.1038/s41586-018-0448-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362342PMC
September 2018

Field synopsis and systematic meta-analyses of genetic association studies in isolated dystonia.

Parkinsonism Relat Disord 2018 12 27;57:50-57. Epub 2018 Jul 27.

Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany; School of Public Health, Faculty of Medicine, Imperial College, London, UK; Dept of Psychology, University of Oslo, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2018.07.018DOI Listing
December 2018

A KAT6A variant in a family with autosomal dominantly inherited microcephaly and developmental delay.

J Hum Genet 2018 Sep 13;63(9):997-1001. Epub 2018 Jun 13.

Institute of Neurogenetics, University of Lübeck, 23538, Lübeck, Germany.

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http://dx.doi.org/10.1038/s10038-018-0469-0DOI Listing
September 2018

ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson's Disease.

Neuron 2018 06 7;98(6):1155-1169.e6. Epub 2018 Jun 7.

VIB-KU Leuven Center for Brain and Disease Research, 3000 Leuven, Belgium; Department of Neurosciences, Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.05.022DOI Listing
June 2018

Personality profiles are different in musician's dystonia and other isolated focal dystonias.

Psychiatry Res 2018 08 7;266:26-29. Epub 2018 May 7.

Berlin Center for Musicians' Medicine, Charité - University Medicine Berlin, Berlin, Germany; Kurt Singer Institute for Music Physiology and Musicians' Health, Hanns Eisler School of Music Berlin, Berlin, Germany; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.psychres.2018.05.017DOI Listing
August 2018

Neuroimaging abnormalities in individuals exhibiting Parkinson's disease risk markers.

Mov Disord 2018 09 14;33(9):1412-1422. Epub 2018 May 14.

Department of Neurology, University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1002/mds.27313DOI Listing
September 2018

The genetic nomenclature of recessive cerebellar ataxias.

Mov Disord 2018 07 14;33(7):1056-1076. Epub 2018 May 14.

Department of Neurology, Donders Institute for Brain, Cognition & Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/mds.27415DOI Listing
July 2018

High prevalence of olfactory dysfunction in cervical dystonia.

Parkinsonism Relat Disord 2018 08 25;53:33-36. Epub 2018 Apr 25.

Department of Neurology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1016/j.parkreldis.2018.04.028DOI Listing
August 2018

mutations may cause a mutation-negative Rett syndrome phenotype.

Neurol Genet 2018 Apr 27;4(2):e227. Epub 2018 Mar 27.

Institute of Neurogenetics (L.K., C.K., A.W.), University of Lübeck, Germany; Department of Metabolism and Clinical Genetics (A.S.), Mother and Child Health Care Institute of Serbia, Belgrade; Centre for Human Molecular Genetics (D.S.-P.), Faculty of Biology, University of Belgrade, Serbia; and Lübeck Interdisciplinary Platform for Genome Analytics (LIGA) (V.D.), University of Lübeck, Germany.

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http://dx.doi.org/10.1212/NXG.0000000000000227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873728PMC
April 2018

Increased insula-putamen connectivity in X-linked dystonia-parkinsonism.

Neuroimage Clin 2018 28;17:835-846. Epub 2017 Oct 28.

Department of Neurology, University of Lübeck, Lübeck, Germany; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22131582173026
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http://dx.doi.org/10.1016/j.nicl.2017.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842648PMC
January 2019

Dissecting the Causal Mechanism of X-Linked Dystonia-Parkinsonism by Integrating Genome and Transcriptome Assembly.

Cell 2018 02;172(5):897-909.e21

Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Program in Medical and Population Genetics and Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA 02142, USA; The Collaborative Center for X-linked Dystonia-Parkinsonism, Massachusetts General Hospital, Charlestown, MA 02129, USA; Departments of Psychiatry and Pathology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183015
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http://dx.doi.org/10.1016/j.cell.2018.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831509PMC
February 2018

Single Heterozygous ATP13A2 Mutations Cause Cellular Dysfunction Associated with Parkinson's Disease.

Mov Disord 2018 05 14;33(5):852-854. Epub 2018 Feb 14.

Department of Neurogenetics, Kolling Institute, Northern Sydney Local Health District, St. Leonards, New South Wales, Australia.

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http://dx.doi.org/10.1002/mds.27327DOI Listing
May 2018