Publications by authors named "Christine Huppertz"

11Publications

The NLRP3 inflammasome pathway is activated in sarcoidosis and involved in granuloma formation.

Authors:
Christine Huppertz Benedikt Jäger Grazyna Wieczorek Peggy Engelhard Stephen J Oliver Franz-Georg Bauernfeind Amanda Littlewood-Evans Tobias Welte Veit Hornung Antje Prasse

Eur Respir J 2020 03 26;55(3). Epub 2020 Mar 26.

Fraunhofer ITEM, Hannover, Germany

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March 2020

IκBζ is a key player in the antipsoriatic effects of secukinumab.

Authors:
Trine Bertelsen Christine Ljungberg Thomas Litman Christine Huppertz Robert Hennze Kirsten Rønholt Lars Iversen Claus Johansen

J Allergy Clin Immunol 2020 01 14;145(1):379-390. Epub 2019 Oct 14.

Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.

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January 2020

Modulating ADME Properties by Fluorination: MK2 Inhibitors with Improved Oral Exposure.

Authors:
Juraj Velcicky Achim Schlapbach Richard Heng Laszlo Revesz Daniel Pflieger Ernst Blum Stuart Hawtin Christine Huppertz Roland Feifel Rene Hersperger

ACS Med Chem Lett 2018 Apr 20;9(4):392-396. Epub 2018 Mar 20.

Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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April 2018

Selective MALT1 paracaspase inhibition does not block TNF-α production downstream of TLR4 in myeloid cells.

Authors:
Adeline Unterreiner Natacha Stoehr Christine Huppertz Thomas Calzascia Christopher J Farady Frédéric Bornancin

Immunol Lett 2017 12 24;192:48-51. Epub 2017 Oct 24.

Novartis Institutes for BioMedical Research, Basel, Switzerland. Electronic address:

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December 2017

Autocrine Loop Involving IL-6 Family Member LIF, LIF Receptor, and STAT4 Drives Sustained Fibroblast Production of Inflammatory Mediators.

Authors:
Hung N Nguyen Erika H Noss Fumitaka Mizoguchi Christine Huppertz Kevin S Wei Gerald F M Watts Michael B Brenner

Immunity 2017 02;46(2):220-232

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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February 2017

IL-17A and Multiple Sclerosis: Signaling Pathways, Producing Cells and Target Cells in the Central Nervous System.

Authors:
Frank Kolbinger Christine Huppertz Anis Mir Franco Di Padova

Curr Drug Targets 2016 ;17(16):1882-1893

Novartis Institutes for Biomedical Research, WSJ 386.11.48.38, 4002, Basel, Switzerland.

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August 2017

In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part I.

Authors:
Laszlo Revesz Achim Schlapbach Reiner Aichholz Roland Feifel Stuart Hawtin Richard Heng Peter Hiestand Wolfgang Jahnke Guido Koch Markus Kroemer Henrik Möbitz Clemens Scheufler Juraj Velcicky Christine Huppertz

Bioorg Med Chem Lett 2010 Aug 13;20(15):4715-8. Epub 2010 Apr 13.

Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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August 2010

In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part II.

Authors:
Laszlo Revesz Achim Schlapbach Reiner Aichholz Janet Dawson Roland Feifel Stuart Hawtin Amanda Littlewood-Evans Guido Koch Markus Kroemer Henrik Möbitz Clemens Scheufler Juraj Velcicky Christine Huppertz

Bioorg Med Chem Lett 2010 Aug 11;20(15):4719-23. Epub 2010 Apr 11.

Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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August 2010

Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy.

Authors:
Juraj Velcicky Roland Feifel Stuart Hawtin Richard Heng Christine Huppertz Guido Koch Markus Kroemer Henrik Moebitz Laszlo Revesz Clemens Scheufler Achim Schlapbach

Bioorg Med Chem Lett 2010 Feb 3;20(3):1293-7. Epub 2009 Nov 3.

Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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February 2010

Low-molecular-weight MK2 inhibitors: a tough nut to crack!

Authors:
Achim Schlapbach Christine Huppertz

Future Med Chem 2009 Oct;1(7):1243-57

Novartis Institutes for BioMedical Research, Global Discovery Chemistry, CH-4056 Basel, Switzerland.

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October 2009

Pyrrolo-pyrimidones: a novel class of MK2 inhibitors with potent cellular activity.

Authors:
Achim Schlapbach Roland Feifel Stuart Hawtin Richard Heng Guido Koch Henrik Moebitz Laszlo Revesz Clemens Scheufler Juraj Velcicky Rudolf Waelchli Christine Huppertz

Bioorg Med Chem Lett 2008 Dec 11;18(23):6142-6. Epub 2008 Oct 11.

Novartis Institutes for BioMedical Research, global Discovery Chemistry, WSJ-88.508, CH-4002 Basel, Switzerland.

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December 2008