Christine Allen

Christine Allen

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Heat-activated drug delivery increases tumor accumulation of synergistic chemotherapies.

J Control Release 2019 Aug 11;308:197-208. Epub 2019 Jun 11.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2019.06.012DOI Listing
August 2019

Can we overcome the most significant barrier to treatment of neurodegenerative disorders?

Authors:
Christine Allen

J Control Release 2019 Jun 11;303:319-320. Epub 2019 May 11.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2019.05.014DOI Listing
June 2019

The question of toxicity of nanomaterials and nanoparticles.

Authors:
Christine Allen

J Control Release 2019 Jun 8;304:288. Epub 2019 Jun 8.

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http://dx.doi.org/10.1016/j.jconrel.2019.06.008DOI Listing
June 2019

What do we do next?

J Control Release 2019 May 24;302:203. Epub 2019 Apr 24.

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http://dx.doi.org/10.1016/j.jconrel.2019.04.024DOI Listing
May 2019

Development of a Bioluminescent BRCA1-Deficient Xenograft Model of Disseminated, High-Grade Serous Ovarian Cancer.

Int J Mol Sci 2019 May 21;20(10). Epub 2019 May 21.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.

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https://www.mdpi.com/1422-0067/20/10/2498
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http://dx.doi.org/10.3390/ijms20102498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566953PMC
May 2019

In Vivo Evaluation of Dual-Targeted Nanoparticles Encapsulating Paclitaxel and Everolimus.

Cancers (Basel) 2019 May 29;11(6). Epub 2019 May 29.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, M5S 3M2, Canada.

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http://dx.doi.org/10.3390/cancers11060752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628352PMC
May 2019

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016: A Systematic Analysis for the Global Burden of Disease Study.

Authors:
Christina Fitzmaurice Tomi F Akinyemiju Faris Hasan Al Lami Tahiya Alam Reza Alizadeh-Navaei Christine Allen Ubai Alsharif Nelson Alvis-Guzman Erfan Amini Benjamin O Anderson Olatunde Aremu Al Artaman Solomon Weldegebreal Asgedom Reza Assadi Tesfay Mehari Atey Leticia Avila-Burgos Ashish Awasthi Huda Omer Ba Saleem Aleksandra Barac James R Bennett Isabela M Bensenor Nickhill Bhakta Hermann Brenner Lucero Cahuana-Hurtado Carlos A Castañeda-Orjuela Ferrán Catalá-López Jee-Young Jasmine Choi Devasahayam Jesudas Christopher Sheng-Chia Chung Maria Paula Curado Lalit Dandona Rakhi Dandona José das Neves Subhojit Dey Samath D Dharmaratne David Teye Doku Tim R Driscoll Manisha Dubey Hedyeh Ebrahimi Dumessa Edessa Ziad El-Khatib Aman Yesuf Endries Florian Fischer Lisa M Force Kyle J Foreman Solomon Weldemariam Gebrehiwot Sameer Vali Gopalani Giuseppe Grosso Rahul Gupta Bishal Gyawali Randah Ribhi Hamadeh Samer Hamidi James Harvey Hamid Yimam Hassen Roderick J Hay Simon I Hay Behzad Heibati Molla Kahssay Hiluf Nobuyuki Horita H Dean Hosgood Olayinka S Ilesanmi Kaire Innos Farhad Islami Mihajlo B Jakovljevic Sarah Charlotte Johnson Jost B Jonas Amir Kasaeian Tesfaye Dessale Kassa Yousef Saleh Khader Ejaz Ahmad Khan Gulfaraz Khan Young-Ho Khang Mohammad Hossein Khosravi Jagdish Khubchandani Jacek A Kopec G Anil Kumar Michael Kutz Deepesh Pravinkumar Lad Alessandra Lafranconi Qing Lan Yirga Legesse James Leigh Shai Linn Raimundas Lunevicius Azeem Majeed Reza Malekzadeh Deborah Carvalho Malta Lorenzo G Mantovani Brian J McMahon Toni Meier Yohannes Adama Melaku Mulugeta Melku Peter Memiah Walter Mendoza Tuomo J Meretoja Haftay Berhane Mezgebe Ted R Miller Shafiu Mohammed Ali H Mokdad Mahmood Moosazadeh Paula Moraga Seyyed Meysam Mousavi Vinay Nangia Cuong Tat Nguyen Vuong Minh Nong Felix Akpojene Ogbo Andrew Toyin Olagunju Mahesh Pa Eun-Kee Park Tejas Patel David M Pereira Farhad Pishgar Maarten J Postma Farshad Pourmalek Mostafa Qorbani Anwar Rafay Salman Rawaf David Laith Rawaf Gholamreza Roshandel Saeid Safiri Hamideh Salimzadeh Juan Ramon Sanabria Milena M Santric Milicevic Benn Sartorius Maheswar Satpathy Sadaf G Sepanlou Katya Anne Shackelford Masood Ali Shaikh Mahdi Sharif-Alhoseini Jun She Min-Jeong Shin Ivy Shiue Mark G Shrime Abiy Hiruye Sinke Mekonnen Sisay Amber Sligar Muawiyyah Babale Sufiyan Bryan L Sykes Rafael Tabarés-Seisdedos Gizachew Assefa Tessema Roman Topor-Madry Tung Thanh Tran Bach Xuan Tran Kingsley Nnanna Ukwaja Vasiliy Victorovich Vlassov Stein Emil Vollset Elisabete Weiderpass Hywel C Williams Nigus Bililign Yimer Naohiro Yonemoto Mustafa Z Younis Christopher J L Murray Mohsen Naghavi

JAMA Oncol 2018 11;4(11):1553-1568

Institute for Health Metrics and Evaluation, University of Washington, Seattle.

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http://dx.doi.org/10.1001/jamaoncol.2018.2706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248091PMC
November 2018

Off-Label Medication use in Children, More Common than We Think: A Systematic Review of the Literature.

J Okla State Med Assoc 2018 Oct;111(8):776-783

Department of Pediatrics: Section of General and Community Pediatrics, University of Oklahoma College of Medicine, Oklahoma City, OK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677268PMC
October 2018

Codelivery of Paclitaxel and Everolimus at the Optimal Synergistic Ratio: A Promising Solution for the Treatment of Breast Cancer.

Mol Pharm 2018 09 14;15(9):3672-3681. Epub 2018 Jun 14.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy , University of Toronto , Toronto M5S 3M2 , Canada.

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http://dx.doi.org/10.1021/acs.molpharmaceut.8b00217DOI Listing
September 2018

Radiation and Heat Improve the Delivery and Efficacy of Nanotherapeutics by Modulating Intratumoral Fluid Dynamics.

ACS Nano 2018 08 20;12(8):7583-7600. Epub 2018 Jul 20.

Department of Medical Biophysics , University of Toronto , Toronto , ON M5G 1L7 , Canada.

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http://dx.doi.org/10.1021/acsnano.7b06301DOI Listing
August 2018

Hyperthermia-mediated drug delivery induces biological effects at the tumor and molecular levels that improve cisplatin efficacy in triple negative breast cancer.

J Control Release 2018 07 16;282:35-45. Epub 2018 Apr 16.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2018.04.029DOI Listing
July 2018

BRCA Status Does Not Predict Synergism of a Carboplatin and Olaparib Combination in High-Grade Serous Ovarian Cancer Cell Lines.

Mol Pharm 2018 07 1;15(7):2742-2753. Epub 2018 Jun 1.

Leslie Dan Faculty of Pharmacy , University of Toronto , 144 College Street , Toronto , Ontario M5S 3M2 , Canada.

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http://dx.doi.org/10.1021/acs.molpharmaceut.8b00246DOI Listing
July 2018

Factors Controlling Drug Release in Cross-linked Poly(valerolactone) Based Matrices.

Mol Pharm 2018 04 2;15(4):1565-1577. Epub 2018 Mar 2.

Leslie Dan Faculty of Pharmacy , University of Toronto , 44 College Street , Ontario M5S 3M2 , Canada.

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http://dx.doi.org/10.1021/acs.molpharmaceut.7b01102DOI Listing
April 2018

Ratio-Dependent Synergism of a Doxorubicin and Olaparib Combination in 2D and Spheroid Models of Ovarian Cancer.

Mol Pharm 2018 02 22;15(2):472-485. Epub 2018 Jan 22.

Leslie Dan Faculty of Pharmacy, University of Toronto , 144 College Street, Toronto, Ontario M5S 3M2, Canada.

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http://dx.doi.org/10.1021/acs.molpharmaceut.7b00843DOI Listing
February 2018

The battle of "nano" paclitaxel.

Adv Drug Deliv Rev 2017 12 28;122:20-30. Epub 2017 Feb 28.

Leslie Dan Faculty of Pharmacy, Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0169409X173003
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http://dx.doi.org/10.1016/j.addr.2017.02.003DOI Listing
December 2017

The Burden of Primary Liver Cancer and Underlying Etiologies From 1990 to 2015 at the Global, Regional, and National Level: Results From the Global Burden of Disease Study 2015.

JAMA Oncol 2017 12;3(12):1683-1691

University of Washington, Institute for Health Metrics and Evaluation, Seattle

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http://dx.doi.org/10.1001/jamaoncol.2017.3055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824275PMC
December 2017

Tumor microenvironment determines response to a heat-activated thermosensitive liposome formulation of cisplatin in cervical carcinoma.

J Control Release 2017 Sep 29;262:182-191. Epub 2017 Jul 29.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2017.07.039DOI Listing
September 2017

Radiosensitization by gold nanoparticles: Will they ever make it to the clinic?

Radiother Oncol 2017 09 4;124(3):344-356. Epub 2017 Aug 4.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Canada; STTARR Innovation Centre, Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2017.07.007DOI Listing
September 2017

Overcoming the Road Blocks: Advancement of Block Copolymer Micelles for Cancer Therapy in the Clinic.

Mol Pharm 2017 08 18;14(8):2503-2517. Epub 2017 May 18.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto , Toronto, Ontario, Canada M5S 3M2.

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http://dx.doi.org/10.1021/acs.molpharmaceut.7b00188DOI Listing
August 2017

Editorial.

Drug Deliv Transl Res 2017 08;7(4):465

University of Manitoba, Winnipeg, Manitoba, Canada.

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http://dx.doi.org/10.1007/s13346-017-0410-7DOI Listing
August 2017

Intravenous Immunoglobulin Therapy for Cerebral Vasculitis Associated with Rocky Mountain Spotted Fever.

J Pediatr Intensive Care 2017 Jun 8;6(2):142-144. Epub 2016 Aug 8.

Section of Pediatric Critical Care, Department of Pediatrics, University of Oklahoma, Oklahoma City, Oklahoma, United States.

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http://dx.doi.org/10.1055/s-0036-1587327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260288PMC
June 2017

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study.

Authors:
Christina Fitzmaurice Christine Allen Ryan M Barber Lars Barregard Zulfiqar A Bhutta Hermann Brenner Daniel J Dicker Odgerel Chimed-Orchir Rakhi Dandona Lalit Dandona Tom Fleming Mohammad H Forouzanfar Jamie Hancock Roderick J Hay Rachel Hunter-Merrill Chantal Huynh H Dean Hosgood Catherine O Johnson Jost B Jonas Jagdish Khubchandani G Anil Kumar Michael Kutz Qing Lan Heidi J Larson Xiaofeng Liang Stephen S Lim Alan D Lopez Michael F MacIntyre Laurie Marczak Neal Marquez Ali H Mokdad Christine Pinho Farshad Pourmalek Joshua A Salomon Juan Ramon Sanabria Logan Sandar Benn Sartorius Stephen M Schwartz Katya A Shackelford Kenji Shibuya Jeff Stanaway Caitlyn Steiner Jiandong Sun Ken Takahashi Stein Emil Vollset Theo Vos Joseph A Wagner Haidong Wang Ronny Westerman Hajo Zeeb Leo Zoeckler Foad Abd-Allah Muktar Beshir Ahmed Samer Alabed Noore K Alam Saleh Fahed Aldhahri Girma Alem Mulubirhan Assefa Alemayohu Raghib Ali Rajaa Al-Raddadi Azmeraw Amare Yaw Amoako Al Artaman Hamid Asayesh Niguse Atnafu Ashish Awasthi Huda Ba Saleem Aleksandra Barac Neeraj Bedi Isabela Bensenor Adugnaw Berhane Eduardo Bernabé Balem Betsu Agnes Binagwaho Dube Boneya Ismael Campos-Nonato Carlos Castañeda-Orjuela Ferrán Catalá-López Peggy Chiang Chioma Chibueze Abdulaal Chitheer Jee-Young Choi Benjamin Cowie Solomon Damtew José das Neves Suhojit Dey Samath Dharmaratne Preet Dhillon Eric Ding Tim Driscoll Donatus Ekwueme Aman Yesuf Endries Maryam Farvid Farshad Farzadfar Joao Fernandes Florian Fischer Tsegaye Tewelde G/Hiwot Alemseged Gebru Sameer Gopalani Alemayehu Hailu Masako Horino Nobuyuki Horita Abdullatif Husseini Inge Huybrechts Manami Inoue Farhad Islami Mihajlo Jakovljevic Spencer James Mehdi Javanbakht Sun Ha Jee Amir Kasaeian Muktar Sano Kedir Yousef S Khader Young-Ho Khang Daniel Kim James Leigh Shai Linn Raimundas Lunevicius Hassan Magdy Abd El Razek Reza Malekzadeh Deborah Carvalho Malta Wagner Marcenes Desalegn Markos Yohannes A Melaku Kidanu G Meles Walter Mendoza Desalegn Tadese Mengiste Tuomo J Meretoja Ted R Miller Karzan Abdulmuhsin Mohammad Alireza Mohammadi Shafiu Mohammed Maziar Moradi-Lakeh Gabriele Nagel Devina Nand Quyen Le Nguyen Sandra Nolte Felix A Ogbo Kelechi E Oladimeji Eyal Oren Mahesh Pa Eun-Kee Park David M Pereira Dietrich Plass Mostafa Qorbani Amir Radfar Anwar Rafay Mahfuzar Rahman Saleem M Rana Kjetil Søreide Maheswar Satpathy Monika Sawhney Sadaf G Sepanlou Masood Ali Shaikh Jun She Ivy Shiue Hirbo Roba Shore Mark G Shrime Samuel So Samir Soneji Vasiliki Stathopoulou Konstantinos Stroumpoulis Muawiyyah Babale Sufiyan Bryan L Sykes Rafael Tabarés-Seisdedos Fentaw Tadese Bemnet Amare Tedla Gizachew Assefa Tessema J S Thakur Bach Xuan Tran Kingsley Nnanna Ukwaja Benjamin S Chudi Uzochukwu Vasiliy Victorovich Vlassov Elisabete Weiderpass Mamo Wubshet Terefe Henock Gebremedhin Yebyo Hassen Hamid Yimam Naohiro Yonemoto Mustafa Z Younis Chuanhua Yu Zoubida Zaidi Maysaa El Sayed Zaki Zerihun Menlkalew Zenebe Christopher J L Murray Mohsen Naghavi

JAMA Oncol 2017 Apr;3(4):524-548

Institute for Health Metrics and Evaluation, University of Washington, Seattle.

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http://dx.doi.org/10.1001/jamaoncol.2016.5688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103527PMC
April 2017

To heat or not to heat: Challenges with clinical translation of thermosensitive liposomes.

J Control Release 2017 03 22;249:63-73. Epub 2017 Jan 22.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, M5S 3M2, ON, Canada; Physical Sciences, Odette Cancer Research Program, Sunnybrook Research Institute, Toronto, M4N 3M5, ON, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, M5S 3G9, ON, Canada; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, M5S 3E5, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2017.01.025DOI Listing
March 2017

Use of Simulation to Improve Cardiopulmonary Resuscitation Performance and Code Team Communication for Pediatric Residents.

MedEdPORTAL 2017 Mar 16;13:10555. Epub 2017 Mar 16.

Assistant Professor, Department of Pediatrics, University of Oklahoma College of Medicine.

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http://dx.doi.org/10.15766/mep_2374-8265.10555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342167PMC
March 2017

Significant Radiation Enhancement Effects by Gold Nanoparticles in Combination with Cisplatin in Triple Negative Breast Cancer Cells and Tumor Xenografts.

Radiat Res 2017 02 13;187(2):147-160. Epub 2017 Jan 13.

Departments of a   Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy.

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http://dx.doi.org/10.1667/RR14578.1DOI Listing
February 2017

Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements.

Adv Drug Deliv Rev 2017 01 19;109:84-101. Epub 2015 Dec 19.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada; STTARR Innovation Centre, Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2015.12.012DOI Listing
January 2017

Radiotherapy for Cancer: Present and Future.

Adv Drug Deliv Rev 2017 Jan;109:1-2

Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Department of Radiation Physics, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; STTARR Innovation Centre, Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Techna Institute, University Health Network, Toronto, Ontario, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.addr.2017.01.004DOI Listing
January 2017

Why I'm Holding onto Hope for Nano in Oncology.

Authors:
Christine Allen

Mol Pharm 2016 08 15;13(8):2603-4. Epub 2016 Jul 15.

Leslie Dan Faculty of Pharmacy, University of Toronto , 144 College Street Toronto, Ontario, Canada , M5S 3M2.

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http://dx.doi.org/10.1021/acs.molpharmaceut.6b00547DOI Listing
August 2016

Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors.

J Vis Exp 2016 08 18(114). Epub 2016 Aug 18.

Department of Medical Biophysics, University of Toronto; Leslie Dan Faculty of Pharmacy, University of Toronto; STTARR Innovation Centre, Princess Margaret Cancer Centre; Institute of Biomaterials and Biomedical Engineering, University of Toronto; Techna Institute, University Health Network; Radiation Medicine Program, Princess Margaret Cancer Centre.

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http://dx.doi.org/10.3791/54226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091925PMC
August 2016

Functionalization of Cellulose Nanocrystals with PEG-Metal-Chelating Block Copolymers via Controlled Conjugation in Aqueous Media.

ACS Omega 2016 Jul 18;1(1):93-107. Epub 2016 Jul 18.

Department of Chemistry, University of Toronto, 80 Street George Street, Toronto, Ontario M5S 3H6, Canada.

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http://dx.doi.org/10.1021/acsomega.6b00055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044632PMC
July 2016

Hydrogels Containing Core Cross-Linked Block Co-Polymer Micelles.

J Biomater Sci Polym Ed 2012 ;23(8):1069-90

a Leslie Dan Faculty of Pharmacy, and Department of Chemistry, Faculty of Arts and Science, University of Toronto, 144 College Street, Toronto, ON, Canada M5S 3M2.

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http://dx.doi.org/10.1163/092050611X575414DOI Listing
June 2016

Dual Action Enhancement of Gold Nanoparticle Radiosensitization by Pentamidine in Triple Negative Breast Cancer.

Radiat Res 2016 05 2;185(5):549-62. Epub 2016 May 2.

a   Departments of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy.

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http://dx.doi.org/10.1667/RR14315.1DOI Listing
May 2016

Vancomycin Dosing and Pharmacokinetics in Postoperative Pediatric Cardiothoracic Surgery Patients.

J Pediatr Pharmacol Ther 2016 Jan-Feb;21(1):66-74

Department of Pharmacy: Clinical and Administrative Sciences, University of Oklahoma College of Pharmacy, Oklahoma City, Oklahoma.

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http://dx.doi.org/10.5863/1551-6776-21.1.66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778698PMC
March 2016

Integration of imaging into clinical practice to assess the delivery and performance of macromolecular and nanotechnology-based oncology therapies.

J Control Release 2015 Dec 25;219:295-312. Epub 2015 Sep 25.

Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, M5S 3M2, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01683659153013
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http://dx.doi.org/10.1016/j.jconrel.2015.09.036DOI Listing
December 2015

Preclinical imaging and translational animal models of cancer for accelerated clinical implementation of nanotechnologies and macromolecular agents.

J Control Release 2015 Dec 25;219:313-330. Epub 2015 Sep 25.

Leslie Dan Faculty of Pharmacy, 144 College Street, Toronto, Ontario M5S 3M2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2015.09.041DOI Listing
December 2015

Effects of Doxorubicin Delivery Systems and Mild Hyperthermia on Tissue Penetration in 3D Cell Culture Models of Ovarian Cancer Residual Disease.

Mol Pharm 2015 Nov 2;12(11):3973-85. Epub 2015 Oct 2.

Leslie Dan Faculty of Pharmacy, University of Toronto , 144 College Street, Toronto, Ontario M5S 3M2, Canada.

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http://dx.doi.org/10.1021/acs.molpharmaceut.5b00426DOI Listing
November 2015

A multimodal nano agent for image-guided cancer surgery.

Biomaterials 2015 Oct 14;67:160-8. Epub 2015 Jul 14.

Techna Institute, University Health Network, 100 College Street, Toronto, Ontario, M5G 1P5, Canada; Princess Margaret Cancer Centre, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada; University of Toronto, Institute of Biomaterials and Biomedical Engineering, 164 College Street, Rm 407, Toronto, Ontario, M5S 3G9, Canada; University of Toronto, Medical Biophysics, 610 University Avenue, Rm 7-411, Toronto, Ontario, M5G 1L7, Canada; University of Toronto, Radiation Oncology, 150 College Street, Rm 106, Toronto, Ontario, M5S 3E2, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S01429612150058
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http://dx.doi.org/10.1016/j.biomaterials.2015.07.010DOI Listing
October 2015

The challenges facing block copolymer micelles for cancer therapy: In vivo barriers and clinical translation.

Adv Drug Deliv Rev 2015 Aug 13;91:7-22. Epub 2014 Oct 13.

Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario M5S 3M2, Canada; Techna Institute, Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, 124-100 College Street, Toronto, Ontario M5G 1P5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2014.10.001DOI Listing
August 2015

The intra-tumoral relationship between microcirculation, interstitial fluid pressure and liposome accumulation.

J Control Release 2015 Aug 10;211:163-70. Epub 2015 Jun 10.

Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; STTARR Innovation Centre, Princess Margaret Cancer Centre, Toronto, ON, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada; Techna Institute, University Health Network, Toronto, ON, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S01683659150061
Publisher Site
http://dx.doi.org/10.1016/j.jconrel.2015.06.008DOI Listing
August 2015

Development of a liposome formulation for improved biodistribution and tumor accumulation of pentamidine for oncology applications.

Int J Pharm 2015 Jul 21;488(1-2):154-64. Epub 2015 Apr 21.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2015.04.060DOI Listing
July 2015

The Global Burden of Cancer 2013.

Authors:
Christina Fitzmaurice Daniel Dicker Amanda Pain Hannah Hamavid Maziar Moradi-Lakeh Michael F MacIntyre Christine Allen Gillian Hansen Rachel Woodbrook Charles Wolfe Randah R Hamadeh Ami Moore Andrea Werdecker Bradford D Gessner Braden Te Ao Brian McMahon Chante Karimkhani Chuanhua Yu Graham S Cooke David C Schwebel David O Carpenter David M Pereira Denis Nash Dhruv S Kazi Diego De Leo Dietrich Plass Kingsley N Ukwaja George D Thurston Kim Yun Jin Edgar P Simard Edward Mills Eun-Kee Park Ferrán Catalá-López Gabrielle deVeber Carolyn Gotay Gulfaraz Khan H Dean Hosgood Itamar S Santos Janet L Leasher Jasvinder Singh James Leigh Jost B Jonas Jost Jonas Juan Sanabria Justin Beardsley Kathryn H Jacobsen Ken Takahashi Richard C Franklin Luca Ronfani Marcella Montico Luigi Naldi Marcello Tonelli Johanna Geleijnse Max Petzold Mark G Shrime Mustafa Younis Naohiro Yonemoto Nicholas Breitborde Paul Yip Farshad Pourmalek Paulo A Lotufo Alireza Esteghamati Graeme J Hankey Raghib Ali Raimundas Lunevicius Reza Malekzadeh Robert Dellavalle Robert Weintraub Robyn Lucas Roderick Hay David Rojas-Rueda Ronny Westerman Sadaf G Sepanlou Sandra Nolte Scott Patten Scott Weichenthal Semaw Ferede Abera Seyed-Mohammad Fereshtehnejad Ivy Shiue Tim Driscoll Tommi Vasankari Ubai Alsharif Vafa Rahimi-Movaghar Vasiliy V Vlassov W S Marcenes Wubegzier Mekonnen Yohannes Adama Melaku Yuichiro Yano Al Artaman Ismael Campos Jennifer MacLachlan Ulrich Mueller Daniel Kim Matias Trillini Babak Eshrati Hywel C Williams Kenji Shibuya Rakhi Dandona Kinnari Murthy Benjamin Cowie Azmeraw T Amare Carl Abelardo Antonio Carlos Castañeda-Orjuela Coen H van Gool Francesco Violante In-Hwan Oh Kedede Deribe Kjetil Soreide Luke Knibbs Maia Kereselidze Mark Green Rosario Cardenas Nobhojit Roy Taavi Tillmann Taavi Tillman Yongmei Li Hans Krueger Lorenzo Monasta Subhojit Dey Sara Sheikhbahaei Nima Hafezi-Nejad G Anil Kumar Chandrashekhar T Sreeramareddy Lalit Dandona Haidong Wang Stein Emil Vollset Ali Mokdad Joshua A Salomon Rafael Lozano Theo Vos Mohammad Forouzanfar Alan Lopez Christopher Murray Mohsen Naghavi

JAMA Oncol 2015 Jul;1(4):505-27

Institute for Health Metrics and Evaluation, University of Washington, Seattle.

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http://dx.doi.org/10.1001/jamaoncol.2015.0735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500822PMC
July 2015

Spatial and temporal mapping of heterogeneity in liposome uptake and microvascular distribution in an orthotopic tumor xenograft model.

J Control Release 2015 Jun 8;207:101-11. Epub 2015 Apr 8.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2015.04.006DOI Listing
June 2015

(125)I-Labelled 2-Iodoestrone-3-sulfate: synthesis, characterization and OATP mediated transport studies in hormone dependent and independent breast cancer cells.

Nucl Med Biol 2015 Mar 8;42(3):274-82. Epub 2014 Nov 8.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.nucmedbio.2014.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673477PMC
March 2015

Hypoxia and cellular localization influence the radiosensitizing effect of gold nanoparticles (AuNPs) in breast cancer cells.

Radiat Res 2014 Nov 31;182(5):475-88. Epub 2014 Oct 31.

a  Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

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http://www.bioone.org/doi/10.1667/RR13642.1
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November 2014

A mathematical model of the enhanced permeability and retention effect for liposome transport in solid tumors.

PLoS One 2013 2;8(12):e81157. Epub 2013 Dec 2.

Department of Medical Biophysics, University of Toronto, Ontario, Canada ; STTARR Innovation Centre, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081157PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846845PMC
August 2014

Expression of membrane transporters and metabolic enzymes involved in estrone-3-sulphate disposition in human breast tumour tissues.

Breast Cancer Res Treat 2014 Jun 16;145(3):647-61. Epub 2014 May 16.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, M5S 3M2, Canada.

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http://dx.doi.org/10.1007/s10549-014-2990-yDOI Listing
June 2014

Estrone-3-sulphate, a potential novel ligand for targeting breast cancers.

PLoS One 2013 22;8(5):e64069. Epub 2013 May 22.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661587PMC
April 2014

Image-based analysis of the size- and time-dependent penetration of polymeric micelles in multicellular tumor spheroids and tumor xenografts.

Int J Pharm 2014 Apr 17;464(1-2):168-77. Epub 2014 Jan 17.

Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario M5S 3M2, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario M5S 3E1, Canada; Spatio-Temporal Targeting and Amplification Radiation Response (STTARR) Innovation Centre, 101 College Street, Toronto, Ontario M5G 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2014.01.010DOI Listing
April 2014

The impact of sustained and intermittent docetaxel chemotherapy regimens on cognition and neural morphology in healthy mice.

Psychopharmacology (Berl) 2014 Mar 8;231(5):841-52. Epub 2013 Oct 8.

School of Psychology, The University of Sydney, Sydney, Australia.

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http://dx.doi.org/10.1007/s00213-013-3301-8DOI Listing
March 2014

Heat-activated thermosensitive liposomal cisplatin (HTLC) results in effective growth delay of cervical carcinoma in mice.

J Control Release 2014 Mar 15;178:69-78. Epub 2014 Jan 15.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada; STTARR Innovation Center, University Health Network, Toronto, ON M5G 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2014.01.009DOI Listing
March 2014

Multi-arm PEG/silica hydrogel for sustained ocular drug delivery.

J Pharm Sci 2014 Jan 27;103(1):216-26. Epub 2013 Nov 27.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/jps.23777DOI Listing
January 2014

Tumor perfusion imaging predicts the intra-tumoral accumulation of liposomes.

J Control Release 2013 Nov 7;172(1):351-357. Epub 2013 Sep 7.

TECHNA Institute and Ontario Cancer Institute, University Health Network, Toronto, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada; Departments of Radiation Oncology, Medical Biophysics, and IBBME, University of Toronto, Canada.

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http://dx.doi.org/10.1016/j.jconrel.2013.08.296DOI Listing
November 2013

Active targeting of block copolymer micelles with trastuzumab Fab fragments and nuclear localization signal leads to increased tumor uptake and nuclear localization in HER2-overexpressing xenografts.

Mol Pharm 2013 Nov 22;10(11):4229-41. Epub 2013 Oct 22.

Leslie Dan Faculty of Pharmacy, ‡Department of Chemistry, and §Department of Medical Imaging, University of Toronto , 144 College St., Toronto, Ontario, M5S 3M2, Canada.

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http://dx.doi.org/10.1021/mp400315pDOI Listing
November 2013

Thermosensitive depot-forming injectable phosphatidylcholine blends tailored for localized drug delivery.

J Pharm Sci 2013 Oct 19;102(10):3623-31. Epub 2013 Jul 19.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/jps.23664DOI Listing
October 2013

Continuous intraperitoneal carboplatin delivery for the treatment of late-stage ovarian cancer.

Mol Pharm 2013 Sep 21;10(9):3315-22. Epub 2013 Aug 21.

Department of Pharmaceutical Sciences, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1021/mp400345hDOI Listing
September 2013

Implementation of a bowel regimen protocol in critically ill children: A pilot study.

J Pediatr Intensive Care 2013 Jun;2(2):63-69

Clinical and Administrative Sciences, Department of Pharmacy, College of Pharmacy, University of Oklahoma, Oklahoma City, OK, USA.

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http://dx.doi.org/10.3233/PIC-13051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530715PMC
June 2013

Comparison of computed tomography- and optical image-based assessment of liposome distribution.

Mol Imaging 2013 May;12(3):148-60

Leslie Dan Faculty of Pharmacy, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.

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May 2013

Neoplastic cell response to tiopronin-coated gold nanoparticles.

Nanomedicine 2013 Feb 9;9(2):264-73. Epub 2012 Jun 9.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.nano.2012.05.016DOI Listing
February 2013

Hydrogel containing silica shell cross-linked micelles for ocular drug delivery.

J Pharm Sci 2013 Feb 30;102(2):627-37. Epub 2012 Nov 30.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada.

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http://dx.doi.org/10.1002/jps.23390DOI Listing
February 2013

Differential role of organic anion-transporting polypeptides in estrone-3-sulphate uptake by breast epithelial cells and breast cancer cells.

J Pharmacol Exp Ther 2012 Aug 15;342(2):510-9. Epub 2012 May 15.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, Canada M5S 3M2.

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August 2012

Recent advances in drug delivery strategies for treatment of ovarian cancer.

Expert Opin Drug Deliv 2012 May 27;9(5):567-83. Epub 2012 Mar 27.

University of Toronto, Leslie Dan Faculty of Pharmacy , 144 College Street, Toronto, Ontario M5S-3M2 , Canada.

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http://dx.doi.org/10.1517/17425247.2012.665366DOI Listing
May 2012

An injectable depot system for sustained intraperitoneal chemotherapy of ovarian cancer results in favorable drug distribution at the whole body, peritoneal and intratumoral levels.

J Control Release 2012 Mar 26;158(3):379-85. Epub 2011 Nov 26.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.jconrel.2011.11.025DOI Listing
March 2012

Influence of formulation variables on the biodistribution of multifunctional block copolymer micelles.

J Control Release 2012 Feb 1;157(3):366-74. Epub 2011 Oct 1.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.jconrel.2011.09.088DOI Listing
February 2012

Block copolymer micelles target Auger electron radiotherapy to the nucleus of HER2-positive breast cancer cells.

Biomacromolecules 2012 Feb 17;13(2):455-65. Epub 2012 Jan 17.

Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, Canada M5S 3M2.

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http://pubs.acs.org/doi/10.1021/bm201479t
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February 2012

Computational approaches to the rational design of nanoemulsions, polymeric micelles, and dendrimers for drug delivery.

Nanomedicine 2012 Jan 25;8(1):20-36. Epub 2011 May 25.

Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.nano.2011.05.006DOI Listing
January 2012

APN/CD13-targeting as a strategy to alter the tumor accumulation of liposomes.

J Control Release 2011 Sep 27;154(3):298-305. Epub 2011 May 27.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.jconrel.2011.05.022DOI Listing
September 2011

Docetaxel distribution following intraperitoneal administration in mice.

J Pharm Pharm Sci 2011 ;14(1):90-9

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.

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August 2011

Chemotherapy dosing schedule influences drug resistance development in ovarian cancer.

Mol Cancer Ther 2011 Jul 6;10(7):1289-99. Epub 2011 May 6.

Department of Pharmaceutical Sciences, University of Toronto, 144 College Street, Toronto, Ontario, Canada M5S 3M2.

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http://dx.doi.org/10.1158/1535-7163.MCT-11-0058DOI Listing
July 2011

Combination drug delivery strategy for the treatment of multidrug resistant ovarian cancer.

Mol Pharm 2011 Feb 17;8(1):260-9. Epub 2010 Dec 17.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1021/mp100323zDOI Listing
February 2011

Liposome contrast agent for CT-based detection and localization of neoplastic and inflammatory lesions in rabbits: validation with FDG-PET and histology.

Contrast Media Mol Imaging 2010 May-Jun;5(3):147-54

Department Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1002/cmmi.378
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January 2011

In vivo distribution of polymeric nanoparticles at the whole-body, tumor, and cellular levels.

Pharm Res 2010 Nov 2;27(11):2343-55. Epub 2010 Mar 2.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College St., Toronto, Ontario, Canada.

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http://dx.doi.org/10.1007/s11095-010-0068-zDOI Listing
November 2010

Polymeric drug delivery systems for localized cancer chemotherapy.

Drug Deliv 2010 Aug;17(6):365-75

Department of Pharmaceutical Sciences, University of Toronto, 144 College Street, Toronto, Ontario, M5S-3M2, Canada.

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http://www.tandfonline.com/doi/full/10.3109/1071754100376285
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August 2010

The effects of particle size and molecular targeting on the intratumoral and subcellular distribution of polymeric nanoparticles.

Mol Pharm 2010 Aug;7(4):1195-208

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, Division of Nuclear Medicine, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1021/mp100038hDOI Listing
August 2010

Utility of transdermal fentanyl for prevention of iatrogenic opioid abstinence syndrome in children.

J Opioid Manag 2010 Mar-Apr;6(2):117-24

University of Oklahoma College of Medicine, Oklahoma City, Oklahoma, USA.

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June 2010

Gold nanoparticles as radiation sensitizers in cancer therapy.

Radiat Res 2010 Jun;173(6):719-28

STTARR Innovation Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1667/RR1984.1DOI Listing
June 2010

Continuous docetaxel chemotherapy improves therapeutic efficacy in murine models of ovarian cancer.

Mol Cancer Ther 2010 Jun 8;9(6):1820-30. Epub 2010 Jun 8.

Department of Pharmaceutical Sciences, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1535-7163.MCT-10-0249DOI Listing
June 2010

Poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelles containing chemically conjugated and physically entrapped docetaxel: synthesis, characterization, and the influence of the drug on micelle morphology.

Biomacromolecules 2010 May;11(5):1273-80

Leslie Dan Faculty of Pharmacy, Institute of Biomaterials and Biomedical Engineering, University of Toronto 144 College Street, Toronto, Ontario, Canada M5S 3M2.

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http://dx.doi.org/10.1021/bm100073sDOI Listing
May 2010

Cellular uptake and transport of gold nanoparticles incorporated in a liposomal carrier.

Nanomedicine 2010 Feb 15;6(1):161-9. Epub 2009 May 15.

Department of Radiation Physics, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.nano.2009.04.009DOI Listing
February 2010

Multifunctional block copolymer micelles for the delivery of 111In to EGFR-positive breast cancer cells for targeted Auger electron radiotherapy.

Mol Pharm 2010 Feb;7(1):177-86

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1021/mp900201vDOI Listing
February 2010

Neurologic withdrawal symptoms following abrupt discontinuation of a prolonged dexmedetomidine infusion in a child.

J Pediatr Pharmacol Ther 2010 Jan;15(1):38-42

Department of Pharmacy, Clinical and Administrative Sciences, University of Oklahoma College of Pharmacy, and.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017408PMC
January 2010

Sixth International Nanomedicine and Drug Delivery Symposium (NanoDDS'08).

Authors:
Christine Allen

J Control Release 2009 Sep 28;138(3):187. Epub 2009 Jun 28.

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http://dx.doi.org/10.1016/j.jconrel.2009.06.021DOI Listing
September 2009

Enhancement of docetaxel solubility via conjugation of formulation-compatible moieties.

Org Biomol Chem 2009 Sep 2;7(17):3437-46. Epub 2009 Jul 2.

Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, M5S 3M2, Canada.

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http://xlink.rsc.org/?DOI=b906862g
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September 2009

Noninvasive monitoring of the fate of 111In-labeled block copolymer micelles by high resolution and high sensitivity microSPECT/CT imaging.

Mol Pharm 2009 Mar-Apr;6(2):581-92

Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1021/mp8002418DOI Listing
September 2009

Biocompatibility of injectable chitosan-phospholipid implant systems.

Biomaterials 2009 Aug 26;30(23-24):3818-24. Epub 2009 Apr 26.

Department of Pharmaceutical Sciences, University of Toronto, 144 College Street, Toronto, Ontario, Canada M5S-3M2.

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http://dx.doi.org/10.1016/j.biomaterials.2009.04.003DOI Listing
August 2009

Chitosan-phospholipid blend for sustained and localized delivery of docetaxel to the peritoneal cavity.

Int J Pharm 2009 Jul 12;377(1-2):76-84. Epub 2009 May 12.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, Canada M5S 3M2.

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http://dx.doi.org/10.1016/j.ijpharm.2009.05.003DOI Listing
July 2009

Intracellular uptake, transport, and processing of nanostructures in cancer cells.

Nanomedicine 2009 Jun;5(2):118-27

Department of Radiation Physics, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.

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June 2009