Publications by authors named "Christine A Pratilas"

45Publications

Socioeconomic and health care coverage disparities in children, adolescents, and young adults with sarcoma.

Pediatr Blood Cancer 2020 Sep 17:e28708. Epub 2020 Sep 17.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1002/pbc.28708DOI Listing
September 2020

Special Issue: "Genomics and Models of Nerve Sheath Tumors".

Genes (Basel) 2020 Sep 1;11(9). Epub 2020 Sep 1.

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.3390/genes11091024DOI Listing
September 2020

From Genes to -Omics: The Evolving Molecular Landscape of Malignant Peripheral Nerve Sheath Tumor.

Genes (Basel) 2020 Jun 24;11(6). Epub 2020 Jun 24.

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, 401 N Broadway, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.3390/genes11060691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349243PMC
June 2020

FLT3-IRAK dual targeting: an exciting new therapeutic option guided by adaptive activation of immune response pathways.

Ann Transl Med 2020 Apr;8(7):511

Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.

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http://dx.doi.org/10.21037/atm.2020.01.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210206PMC
April 2020

BRAF V600E-mutated metastatic pediatric Wilms tumor with complete response to targeted RAF/MEK inhibition.

Cold Spring Harb Mol Case Stud 2020 04 1;6(2). Epub 2020 Apr 1.

Division of Pediatric Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1101/mcs.a004820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133746PMC
April 2020

BRAF Mutations and the Utility of RAF and MEK Inhibitors in Primary Brain Tumors.

Cancers (Basel) 2019 Aug 28;11(9). Epub 2019 Aug 28.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.3390/cancers11091262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769482PMC
August 2019

Rare BRAF mutations in pancreatic neuroendocrine tumors may predict response to RAF and MEK inhibition.

PLoS One 2019 3;14(6):e0217399. Epub 2019 Jun 3.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217399PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546234PMC
February 2020

Sporadic Malignant Glomus Tumor of the Brachial Plexus With Response to Targeted Therapy Directed Against Oncogenic .

JCO Precis Oncol 2018 4;2018. Epub 2018 May 4.

Johns Hopkins University School of Medicine. Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292440PMC
http://dx.doi.org/10.1200/PO.17.00261DOI Listing
May 2018

Size-based detection of sarcoma circulating tumor cells and cell clusters.

Oncotarget 2017 Oct 24;8(45):78965-78977. Epub 2017 Aug 24.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.20697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668012PMC
October 2017

Adaptation to TKI Treatment Reactivates ERK Signaling in Tyrosine Kinase-Driven Leukemias and Other Malignancies.

Cancer Res 2017 10 18;77(20):5554-5563. Epub 2017 Sep 18.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819342PMC
October 2017

The promise of signal transduction in genetically driven sarcomas of the nerve.

Exp Neurol 2018 01 30;299(Pt B):317-325. Epub 2017 Aug 30.

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2017.08.014DOI Listing
January 2018

Targeted therapy for soft tissue sarcomas in adolescents and young adults.

Adolesc Health Med Ther 2017 30;8:41-55. Epub 2017 Mar 30.

Division of Pediatric Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.2147/AHMT.S70377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384699PMC
March 2017

Dermatologic adverse events in pediatric patients receiving targeted anticancer therapies: a pooled analysis.

Pediatr Blood Cancer 2015 May 12;62(5):798-806. Epub 2015 Feb 12.

Department of Dermatology, Memorial Sloan Kettering Cancer Center, New York, NY USA.

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http://dx.doi.org/10.1002/pbc.25429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376610PMC
May 2015

Ifosfamide dose-intensification for patients with metastatic Ewing sarcoma.

Pediatr Blood Cancer 2015 Apr 28;62(4):594-7. Epub 2015 Jan 28.

Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1002/pbc.25373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4474186PMC
April 2015

Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence.

Cancer Res 2014 Apr 27;74(8):2340-50. Epub 2014 Feb 27.

Authors' Affiliations: Louis V. Gerstner, Jr. Graduate School of Biomedical Science; Human Oncology and Pathogenesis Program; Departments of Pediatrics, Pathology, and Medicine; Programs in Molecular Pharmacology and Chemistry; Computational Biology; Ludwig Collaborative Lab, Memorial Sloan-Kettering Cancer Center, New York, New York; Department of Medicine, Jonsson Comprehensive Cancer Center, University of California, Los Angeles; Departments of Epidemiology and Biostatistics and Medicine, and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005042PMC
April 2014

Targeting oncogenic BRAF in human cancer.

Curr Top Microbiol Immunol 2012 ;355:83-98

Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1007/82_2011_162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508196PMC
August 2014

Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response.

Clin Cancer Res 2010 Jul 14;16(13):3329-34. Epub 2010 May 14.

Department of Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-3064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912210PMC
July 2010

(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway.

Proc Natl Acad Sci U S A 2009 Mar 27;106(11):4519-24. Epub 2009 Feb 27.

Department of Pediatrics, Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1073/pnas.0900780106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649208PMC
March 2009

Therapeutic strategies for targeting BRAF in human cancer.

Rev Recent Clin Trials 2007 May;2(2):121-34

Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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http://dx.doi.org/10.2174/157488707780599393DOI Listing
May 2007

BRAFV600E mutation is associated with preferential sensitivity to mitogen-activated protein kinase kinase inhibition in thyroid cancer cell lines.

J Clin Endocrinol Metab 2008 Jun 1;93(6):2194-201. Epub 2008 Apr 1.

Department of Medicine and Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1210/jc.2007-2825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435640PMC
June 2008

BRAF mutation predicts sensitivity to MEK inhibition.

Nature 2006 Jan 6;439(7074):358-62. Epub 2005 Nov 6.

Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nature04304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306236PMC
January 2006

New efficient synthesis of resorcinylic macrolides via ynolides: establishment of cycloproparadicicol as synthetically feasible preclinical anticancer agent based on Hsp90 as the target.

J Am Chem Soc 2004 Jun;126(25):7881-9

Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1021/ja0484348DOI Listing
June 2004