Christina Kiel

Christina Kiel

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Christina Kiel

Christina Kiel

Publications by authors named "Christina Kiel"

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42Publications

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Systems level expression correlation of Ras GTPase regulators.

Cell Commun Signal 2018 Aug 15;16(1):46. Epub 2018 Aug 15.

Centre for Genomic Regulation (CRG), Systems Biology Programme. The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Spain.

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August 2018

Y chromosome mosaicism is associated with age-related macular degeneration.

Eur J Hum Genet 2018 Aug 29. Epub 2018 Aug 29.

Institute of Human Genetics, University of Regensburg, Regensburg, Germany.

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August 2018

From oncogenic mutation to dynamic code.

Science 2018 08;361(6405):844-845

Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.

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August 2018

Pleiotropic Effects of Risk Factors in Age-Related Macular Degeneration and Seemingly Unrelated Complex Diseases.

Adv Exp Med Biol 2018 ;1074:247-255

Institute of Human Genetics, University of Regensburg, Regensburg, Germany.

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January 2018

Interaction Dynamics Determine Signaling and Output Pathway Responses.

Cell Rep 2017 04;19(1):136-149

EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra, 08003 Barcelona, Spain. Electronic address:

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April 2017

A Comprehensive View of the β-Arrestinome.

Front Endocrinol (Lausanne) 2017 6;8:32. Epub 2017 Mar 6.

EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain.

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March 2017

Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits.

Genome Med 2017 03 27;9(1):29. Epub 2017 Mar 27.

Institute of Human Genetics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.

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March 2017

An Eye on Age-Related Macular Degeneration: The Role of MicroRNAs in Disease Pathology.

Mol Diagn Ther 2017 02;21(1):31-43

Institute of Human Genetics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.

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February 2017

Simple and complex retinal dystrophies are associated with profoundly different disease networks.

Sci Rep 2017 01 31;7:41835. Epub 2017 Jan 31.

EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain.

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January 2017

The yin-yang of kinase activation and unfolding explains the peculiarity of Val600 in the activation segment of BRAF.

Elife 2016 Jan 8;5:e12814. Epub 2016 Jan 8.

EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation, Barcelona, Spain.

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January 2016

Tuneable endogenous mammalian target complementation via multiplexed plasmid-based recombineering.

Sci Rep 2015 Nov 27;5:17432. Epub 2015 Nov 27.

EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain.

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November 2015

Dissecting the calcium-induced differentiation of human primary keratinocytes stem cells by integrative and structural network analyses.

PLoS Comput Biol 2015 May 6;11(5):e1004256. Epub 2015 May 6.

EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain.

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May 2015

TAPAS: tools to assist the targeted protein quantification of human alternative splice variants.

Bioinformatics 2014 Oct 4;30(20):2989-90. Epub 2014 Jul 4.

EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Universitat Pompeu Fabra (UPF), Proteomics Unit, Centre for Genomic Regulation (CRG), 08003 Barcelona and Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Universitat Pompeu Fabra (UPF), Proteomics Unit, Centre for Genomic Regulation (CRG), 08003 Barcelona and Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain.

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October 2014

Assessing the correlation between mutant rhodopsin stability and the severity of retinitis pigmentosa.

Mol Vis 2014 7;20:183-99. Epub 2014 Feb 7.

Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia.

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September 2014

Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain.

Mol Cell Biol 2014 Jun 31;34(12):2147-61. Epub 2014 Mar 31.

Helmholtz Zentrum München, German Research Center for Environmental Health, Research Unit Protein Science, Neuherberg, Germany Eberhard Karls University Tübingen, Institute for Ophthalmic Research, Medical Proteome Center, Tübingen, Germany

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June 2014

Protein conservation and variation suggest mechanisms of cell type-specific modulation of signaling pathways.

PLoS Comput Biol 2014 Jun 12;10(6):e1003659. Epub 2014 Jun 12.

EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain.

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June 2014

Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations.

Mol Syst Biol 2014 May 6;10:727. Epub 2014 May 6.

EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Barcelona, Spain.

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May 2014

Quantification of ErbB network proteins in three cell types using complementary approaches identifies cell-general and cell-type-specific signaling proteins.

J Proteome Res 2014 Jan 9;13(1):300-13. Epub 2013 Dec 9.

EMBL/CRG Systems Biology Research Unit, ‡Proteomics Unit, §Advanced Light Microscopy Core Facility, Centre for Genomic Regulation (CRG) , Dr. Aiguader 88, 08003 Barcelona, Spain.

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January 2014

Integration of protein abundance and structure data reveals competition in the ErbB signaling network.

Sci Signal 2013 Dec 17;6(306):ra109. Epub 2013 Dec 17.

1European Molecular Biology Laboratory and Centre for Genomic Regulation Systems Biology Research Unit, Dr. Aiguader Street 88, 08003 Barcelona, Spain.

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December 2013

SAPIN: a framework for the structural analysis of protein interaction networks.

Bioinformatics 2012 Nov 6;28(22):2998-9. Epub 2012 Sep 6.

EMBL/CRG, Design of Biological Systems, Systems Biology Research Unit, Centre for Genomic Regulation-CRG, UPF, 08003 Barcelona, Spain.

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November 2012

Structural data in synthetic biology approaches for studying general design principles of cellular signaling networks.

Structure 2012 Nov;20(11):1806-13

EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation-CRG, Dr. Aiguader 88, 08003 Barcelona, Spain.

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November 2012

Challenges ahead in signal transduction: MAPK as an example.

Curr Opin Biotechnol 2012 Jun 28;23(3):305-14. Epub 2011 Oct 28.

EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, Barcelona, Dr. Aiguader 88, 08003 Barcelona, Spain.

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June 2012

Analysis of disease-linked rhodopsin mutations based on structure, function, and protein stability calculations.

J Mol Biol 2011 Jan 19;405(2):584-606. Epub 2010 Nov 19.

University of Western Australia, Crawley, Western Australia, Australia.

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January 2011

Engineering signal transduction pathways.

Cell 2010 Jan;140(1):33-47

EMBL-CRG Systems Biology Unit, Design of Biological Systems, Centre de Regulació Genòmica, Dr. Aiguader 88, 08003 Barcelona, Spain.

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January 2010

Improved binding of raf to Ras.GDP is correlated with biological activity.

J Biol Chem 2009 Nov 23;284(46):31893-902. Epub 2009 Sep 23.

Abteilung Strukturelle Biologie, Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.

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November 2009

Protein design in biological networks: from manipulating the input to modifying the output.

Protein Eng Des Sel 2009 Sep 2;22(9):537-42. Epub 2009 Jul 2.

CRG-EMBL Systems Biology Program, Design of Biological Systems, Centre de Regulació Genòmica, 08003 Barcelona, Spain.

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September 2009

Cell type-specific importance of ras-c-raf complex association rate constants for MAPK signaling.

Sci Signal 2009 Jul 28;2(81):ra38. Epub 2009 Jul 28.

European molecular biology laboratory-centre for genomic regulation (CRG), systems biology unit, university pompeu fabra (UPF), Universitat Pompeu Fabra, Dr. Aiguader 88, 08003 Barcelona, Spain.

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July 2009

Association rate constants of ras-effector interactions are evolutionarily conserved.

PLoS Comput Biol 2008 Dec 19;4(12):e1000245. Epub 2008 Dec 19.

EMBL-CRG Systems Biology Unit, Centre de Regulacio Genomica, Barcelona, Spain.

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December 2008

Analyzing protein interaction networks using structural information.

Annu Rev Biochem 2008 ;77:415-41

EMBL-CRG Systems Biology Unit, Center de Regulacio Genomica, Barcelona 08003, Spain.

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September 2008

Shaping dots and lines: adding modularity into protein interaction networks using structural information.

FEBS Lett 2008 Apr 20;582(8):1231-6. Epub 2008 Feb 20.

EMBL-CRG Systems Biology Unit, CRG-Centre de Regulacio Genomica, Dr. Aiguader 88, 08003 Barcelona, Spain.

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April 2008

Prediction of Ras-effector interactions using position energy matrices.

Bioinformatics 2007 Sep 28;23(17):2226-30. Epub 2007 Jun 28.

EMBL-CRG Systems Biology Unit, CRG-Centre de Regulacio Genomica, Dr Aiguader 88, 08003 Barcelona, Spain.

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September 2007

A genome-wide Ras-effector interaction network.

J Mol Biol 2007 Jul 22;370(5):1020-32. Epub 2007 May 22.

Structural and computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

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July 2007

Structures in systems biology.

Curr Opin Struct Biol 2007 Jun 15;17(3):378-84. Epub 2007 Jun 15.

European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg D69115, Germany.

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June 2007

The ubiquitin domain superfold: structure-based sequence alignments and characterization of binding epitopes.

J Mol Biol 2006 Jan 8;355(4):821-44. Epub 2005 Nov 8.

European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

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January 2006

Recognizing and defining true Ras binding domains I: biochemical analysis.

J Mol Biol 2005 May;348(3):741-58

Max-Planck-Institut für Molekulare Physiologie, Abteilung Strukturelle Biologie, Otto-Hahn Str. 11, Dortmund 44227, Germany.

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May 2005

A detailed thermodynamic analysis of ras/effector complex interfaces.

J Mol Biol 2004 Jul;340(5):1039-58

Max-Planck-Institut für Molekulare Physiologie, Abteilung Strukturelle Biologie, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany.

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July 2004

Insights into protein-protein binding by binding free energy calculation and free energy decomposition for the Ras-Raf and Ras-RalGDS complexes.

J Mol Biol 2003 Jul;330(4):891-913

Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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July 2003

Structural fingerprints of the Ras-GTPase activating proteins neurofibromin and p120GAP.

J Mol Biol 2003 Jun;329(4):699-710

Department Structural Biology, Max-Planck-Institute for Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.

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June 2003

The activation of RalGDS can be achieved independently of its Ras binding domain. Implications of an activation mechanism in Ras effector specificity and signal distribution.

J Biol Chem 2002 Mar 17;277(10):7831-7. Epub 2001 Dec 17.

Abteilung Strukturelle Biologie, Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Strasse 11, Dortmund 44227, Germany.

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March 2002