Christiane Margue

Systematic Transcriptional Profiling of Responses to STAT1- and STAT3-Activating Cytokines in Different Cancer Types.

Authors:

Mélanie Kirchmeyer Florence Servais Aurélien Ginolhac Petr V Nazarov Christiane Margue Demetra Philippidou Nathalie Nicot Iris Behrmann Claude Haan Stephanie Kreis

J Mol Biol 2020 11 18;432(22):5902-5919. Epub 2020 Sep 18.

Signal Transduction Laboratory, Department of Life Sciences and Medicine, University of Luxembourg, 6 Avenue du Swing, L-4367 Belvaux, Luxembourg. Electronic address:

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November 2020

Distinct Cargos of Small Extracellular Vesicles Derived from Hypoxic Cells and Their Effect on Cancer Cells.

Authors:

Geoffroy Walbrecq Christiane Margue Iris Behrmann Stephanie Kreis

Int J Mol Sci 2020 Jul 17;21(14). Epub 2020 Jul 17.

Department of Life Sciences and Medicine (DLSM), University of Luxembourg, 6, avenue du Swing, L-4367 Belvaux, Luxembourg.

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July 2020

Hypoxia-Induced Adaptations of miRNomes and Proteomes in Melanoma Cells and Their Secreted Extracellular Vesicles.

Authors:

Geoffroy Walbrecq Odile Lecha Anthoula Gaigneaux Miriam R Fougeras Demetra Philippidou Christiane Margue Milène Tetsi Nomigni François Bernardin Gunnar Dittmar Iris Behrmann Stephanie Kreis

Cancers (Basel) 2020 Mar 14;12(3). Epub 2020 Mar 14.

Department of Life Sciences and Medicine, University of Luxembourg, 6, avenue du Swing, L-4367 Belvaux, Luxembourg.

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March 2020

Many ways to resistance: How melanoma cells evade targeted therapies.

Authors:

Ines Kozar Christiane Margue Sonja Rothengatter Claude Haan Stephanie Kreis

Biochim Biophys Acta Rev Cancer 2019 04 15;1871(2):313-322. Epub 2019 Feb 15.

Life Sciences Research Unit, University of Luxembourg, 6, avenue du Swing, L-4367 Belvaux, Luxembourg. Electronic address:

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April 2019

Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells.

Authors:

Christiane Margue Demetra Philippidou Ines Kozar Giulia Cesi Paul Felten Dagmar Kulms Elisabeth Letellier Claude Haan Stephanie Kreis

J Exp Clin Cancer Res 2019 Feb 6;38(1):56. Epub 2019 Feb 6.

Life Sciences Research Unit, University of Luxembourg, 6, av. du Swing, L-4367, Belvaux, Luxembourg.

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February 2019

The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by α-PD-L1 or α-IL6 antibodies.

Authors:

Catherine Rolvering Andreas D Zimmer Aurélien Ginolhac Christiane Margue Mélanie Kirchmeyer Florence Servais Heike M Hermanns Sabine Hergovits Petr V Nazarov Nathalie Nicot Stephanie Kreis Serge Haan Iris Behrmann Claude Haan

J Leukoc Biol 2018 11 24;104(5):969-985. Epub 2018 Jul 24.

University of Luxembourg, Life Sciences Research Unit-Signal Transduction Laboratory, Belvaux, Luxembourg.

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November 2018

Impact of BRAF kinase inhibitors on the miRNomes and transcriptomes of melanoma cells.

Authors:

Ines Kozar Giulia Cesi Christiane Margue Demetra Philippidou Stephanie Kreis

Biochim Biophys Acta Gen Subj 2017 Nov 10;1861(11 Pt B):2980-2992. Epub 2017 Apr 10.

Life Sciences Research Unit, University of Luxembourg, 6, avenue du Swing, L-4367 Belvaux, Luxembourg. Electronic address:

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November 2017

The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner.

Authors:

Mathieu Heulot Nadja Chevalier Julien Puyal Christiane Margue Sébastien Michel Stephanie Kreis Dagmar Kulms David Barras Aimable Nahimana Christian Widmann

Oncotarget 2016 Sep;7(39):64342-64359

Department of Physiology, University of Lausanne, Lausanne, Switzerland.

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September 2016

Transferring intercellular signals and traits between cancer cells: extracellular vesicles as "homing pigeons".

Authors:

Giulia Cesi Geoffroy Walbrecq Christiane Margue Stephanie Kreis

Cell Commun Signal 2016 Jun 10;14(1):13. Epub 2016 Jun 10.

Life Sciences Research Unit, University of Luxembourg, 6, av. du Swing, L-4367, Belvaux, Luxembourg.

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June 2016

Circulating microRNAs as Candidate Biomarkers for the Surveillance of Melanoma Patients.

Authors:

Iris Behrmann Christiane Margue Stephanie Kreis

EBioMedicine 2015 Jul 13;2(7):625-6. Epub 2015 Jul 13.

Life Sciences Research Unit, University of Luxembourg, L-1533, Luxembourg.

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July 2015

Comparison of a healthy miRNome with melanoma patient miRNomes: are microRNAs suitable serum biomarkers for cancer?

Authors:

Christiane Margue Susanne Reinsbach Demetra Philippidou Nicolas Beaume Casandra Walters Jochen G Schneider Dorothée Nashan Iris Behrmann Stephanie Kreis

Oncotarget 2015 May;6(14):12110-27

Life Sciences Research Unit, University of Luxembourg, Luxembourg.

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May 2015

New target genes of MITF-induced microRNA-211 contribute to melanoma cell invasion.

Authors:

Christiane Margue Demetra Philippidou Susanne E Reinsbach Martina Schmitt Iris Behrmann Stephanie Kreis

PLoS One 2013 5;8(9):e73473. Epub 2013 Sep 5.

Signal Transduction Laboratory, Life Sciences Research Unit, University of Luxembourg, Luxembourg, Luxembourg.

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June 2014

Interferon-γ-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells.

Authors:

Martina J Schmitt Demetra Philippidou Susanne E Reinsbach Christiane Margue Anke Wienecke-Baldacchino Dorothee Nashan Iris Behrmann Stephanie Kreis

Cell Commun Signal 2012 Dec 17;10(1):41. Epub 2012 Dec 17.

Signal Transduction Laboratory, University of Luxembourg, 162A Avenue de la Faïencerie, Luxembourg, L-1511, Luxembourg.

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December 2012

Signatures of microRNAs and selected microRNA target genes in human melanoma.

Authors:

Demetra Philippidou Martina Schmitt Dirk Moser Christiane Margue Petr V Nazarov Arnaud Muller Laurent Vallar Dorothee Nashan Iris Behrmann Stephanie Kreis

Cancer Res 2010 May 4;70(10):4163-73. Epub 2010 May 4.

Life Sciences Research Unit, University of Luxembourg, Freiburg, Germany.

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May 2010

The novel S527F mutation in the integrin beta3 chain induces a high affinity alphaIIbbeta3 receptor by hindering adoption of the bent conformation.

Authors:

Karen Vanhoorelbeke Simon F De Meyer Inge Pareyn Chantal Melchior Sebastien Plançon Christiane Margue Olivier Pradier Pierre Fondu Nelly Kieffer Timothy A Springer Hans Deckmyn

J Biol Chem 2009 May 27;284(22):14914-20. Epub 2009 Mar 27.

Laboratory for Thrombosis Research, Interdisciplinary Research Center, Katholieke Universiteit Leuven Campus Kortrijk, 8500 Kortrijk, Belgium.

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May 2009

Dual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation.

Authors:

Serge Haan Christiane Margue Arnaud Engrand Catherine Rolvering Hildegard Schmitz-Van de Leur Peter C Heinrich Iris Behrmann Claude Haan

J Immunol 2008 Jan;180(2):998-1007

Life Science Research Unit, Faculté des Sciences, de la Technologie et de la Communication, Université du Luxembourg, Luxembourg.

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January 2008

Recombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells.

Authors:

Stephanie Kreis Demetra Philippidou Christiane Margue Catherine Rolvering Claude Haan Laure Dumoutier Jean-Christophe Renauld Iris Behrmann

PLoS One 2007 Dec 12;2(12):e1300. Epub 2007 Dec 12.

Laboratoire de Biologie et Physiologie Intégrée, Life Science Research Unit, University of Luxembourg, Luxembourg.

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December 2007

Complete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasis.

Authors:

Martine Schmitz Gérard Grignard Christiane Margue Walter Dippel Catherine Capesius Joël Mossong Michel Nathan Sandro Giacchi René Scheiden Nelly Kieffer

Int J Cancer 2007 Mar;120(6):1284-92

Laboratoire de Biologie et Physiologie Intégrée (LBPI), Université du Luxembourg, 162A avenue de la Faïencerie, L-1511 Luxembourg.

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March 2007

Jaks and cytokine receptors--an intimate relationship.

Authors:

Claude Haan Stephanie Kreis Christiane Margue Iris Behrmann

Biochem Pharmacol 2006 Nov 27;72(11):1538-46. Epub 2006 Apr 27.

Laboratoire de Biologie et Physiologie Intégrée (LBPI), University of Luxembourg, 162a avenue de la Faïencerie, L-1511 Luxembourg, Luxembourg.

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November 2006

ILK as a potential marker gene to ascertain specific adenocarcinoma cell mRNA isolation from frozen prostate biopsy tissue sections.

Authors:

Nelly Kieffer Martine Schmitz Sébastien Plançon Christiane Margue Fanny Huselstein Gérard Grignard Walter Dippel Michel Nathan Sandro Giacchi René Scheiden

Int J Oncol 2005 Jun;26(6):1549-58

Laboratoire de Biologie et Physiologie Intégrée LBPI, Université du Luxembourg, L-1511 Luxembourg, Luxembourg.

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June 2005

Integrin alpha(v)beta3 expression confers on tumor cells a greater propensity to metastasize to bone.

Authors:

Isabelle Pécheur Olivier Peyruchaud Claire-Marie Serre Julien Guglielmi Carole Voland Francois Bourre Christiane Margue Martine Cohen-Solal Annie Buffet Nelly Kieffer Philippe Clézardin

FASEB J 2002 Aug 21;16(10):1266-8. Epub 2002 Jun 21.

INSERM Research Unit 403, Faculty of Medicine Laënnec, Lyon, France.

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August 2002

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