Publications by authors named "Christian Young"

50Publications

Transforming Growth Factor-β Signaling in Fibrotic Diseases and Cancer-Associated Fibroblasts.

Biomolecules 2020 Dec 12;10(12). Epub 2020 Dec 12.

Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

View Article and Find Full Text PDF
December 2020

Case Report: Spontaneous Rupture of Inferior Epigastric Artery Masquerading as Inguinal Hernia.

Clin Pract Cases Emerg Med 2020 Nov;4(4):607-609

University of Nevada, Department of Emergency Medicine, Las Vegas, Nevada.

View Article and Find Full Text PDF
November 2020

Development of syngeneic murine cell lines for use in immunocompetent orthotopic lung cancer models.

Cancer Cell Int 2020 28;20:417. Epub 2020 Aug 28.

Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver Anschutz Medical Campus, 12700 E. 19th Avenue, RC2, Room #9112, Mail stop C272, Aurora, CO 80045 USA.

View Article and Find Full Text PDF
August 2020

Protection of swine by potent neutralizing anti-Japanese encephalitis virus monoclonal antibodies derived from vaccination.

Antiviral Res 2020 02 9;174:104675. Epub 2019 Dec 9.

Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA; Biosecurity Research Institute, Kansas State University, Manhattan, KS, USA. Electronic address:

View Article and Find Full Text PDF
February 2020

Lessons learned from SMAD4 loss in squamous cell carcinomas.

Mol Carcinog 2019 09 29;58(9):1648-1655. Epub 2019 May 29.

Department of Pathology, School of Medicine, University of Colorado, Aurora, Colorado.

View Article and Find Full Text PDF
September 2019

Smad7 Ameliorates TGF-β-Mediated Skin Inflammation and Associated Wound Healing Defects but Not Susceptibility to Experimental Skin Carcinogenesis.

J Invest Dermatol 2019 04 10;139(4):940-950. Epub 2018 Nov 10.

Department of Pathology, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA; Allander Biotechnologies, LLC, Aurora, Colorado, USA. Electronic address:

View Article and Find Full Text PDF
April 2019

Adenoviral vectors transduce alveolar macrophages in lung cancer models.

Oncoimmunology 2018;7(6):e1438105. Epub 2018 Mar 6.

Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver Anschutz Medical Campus, Aurora, CO.

View Article and Find Full Text PDF
March 2018

An ERBB1-3 Neutralizing Antibody Mixture With High Activity Against Drug-Resistant HER2+ Breast Cancers With ERBB Ligand Overexpression.

J Natl Cancer Inst 2017 11;109(11)

Department of Medicine and Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN; Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Nashville, TN; Department of Cancer Biology, Vanderbilt University, Nashville, TN; Symphogen, Ballerup, Denmark.

View Article and Find Full Text PDF
November 2017

Psychosocial factors associated with the mental health of indigenous children living in high income countries: a systematic review.

Int J Equity Health 2017 08 23;16(1):153. Epub 2017 Aug 23.

The Sax Institute, Level 13, Building 10, 235 Jones Street, Ultimo, NSW, 2007, Australia.

View Article and Find Full Text PDF
August 2017

Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis.

Breast Cancer Res 2017 Jun 30;19(1):74. Epub 2017 Jun 30.

Department of Cancer Biology, Vanderbilt University School of Medicine, 2220 Pierce Avenue, Rm 749 Preston Research Building, Nashville, TN, 37232, USA.

View Article and Find Full Text PDF
June 2017

Evaluation of genipin for stabilization of decellularized porcine cartilage.

J Orthop Res 2017 09 24;35(9):1949-1957. Epub 2017 Mar 24.

Department of Agricultural and Biological Engineering, Mississippi State University, P.O. Box 9632, Starkville 39762, Mississippi.

View Article and Find Full Text PDF
September 2017

Parental views on otitis media: systematic review of qualitative studies.

Eur J Pediatr 2016 Oct 10;175(10):1295-305. Epub 2016 Sep 10.

Kids Research Institute, The Children's Hospital at Westmead, Westmead, Sydney, NSW, 2145, Australia.

View Article and Find Full Text PDF
October 2016

Rictor/mTORC2 Drives Progression and Therapeutic Resistance of HER2-Amplified Breast Cancers.

Cancer Res 2016 08 25;76(16):4752-64. Epub 2016 Apr 25.

Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee. The Vanderbilt-Ingram Cancer Center at Vanderbilt University, Vanderbilt University, Nashville, Tennessee.

View Article and Find Full Text PDF
August 2016

Building better research partnerships by understanding how Aboriginal health communities perceive and use data: a semistructured interview study.

BMJ Open 2016 Apr 25;6(4):e010792. Epub 2016 Apr 25.

Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.

View Article and Find Full Text PDF
April 2016

Dual inhibition of Type I and Type III PI3 kinases increases tumor cell apoptosis in HER2+ breast cancers.

Breast Cancer Res 2015 Dec 4;17:148. Epub 2015 Dec 4.

Department of Cancer Biology, Vanderbilt University, 2220 Pierce Avenue, Nashville, TN, 37232, USA.

View Article and Find Full Text PDF
December 2015

Small molecule inhibitor of the bone morphogenetic protein pathway DMH1 reduces ovarian cancer cell growth.

Cancer Lett 2015 Nov 30;368(1):79-87. Epub 2015 Jul 30.

Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

View Article and Find Full Text PDF
November 2015

mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis.

PLoS Genet 2015 Jul 1;11(7):e1005291. Epub 2015 Jul 1.

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.

View Article and Find Full Text PDF
July 2015

Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets.

Cancer Discov 2014 Feb 19;4(2):232-45. Epub 2013 Dec 19.

Departments of 1Medicine, 2Pathology, Microbiology & Immunology, 3Cancer Biology, and 4Biochemistry; 5Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee; Departments of 6Cell & Tissue Biology and 7Medicine, University of California, San Francisco, San Francisco, California; 8Foundation Medicine, Cambridge, Massachusetts; 9Oncosalud; and 10Instituto Nacional de Enfermedades Neoplásicas (INEN), Lima, Perú

View Article and Find Full Text PDF
February 2014

HER3 is required for HER2-induced preneoplastic changes to the breast epithelium and tumor formation.

Cancer Res 2012 May 29;72(10):2672-82. Epub 2012 Mar 29.

Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232, USA.

View Article and Find Full Text PDF
May 2012

The receptor tyrosine kinase ErbB3 maintains the balance between luminal and basal breast epithelium.

Proc Natl Acad Sci U S A 2012 Jan 16;109(1):221-6. Epub 2011 Dec 16.

Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

View Article and Find Full Text PDF
January 2012

Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in vitro and in vivo.

PLoS One 2011 3;6(8):e23205. Epub 2011 Aug 3.

Department of Pathology, University of Colorado School of Medicine, Anshutz Medical Campus, Aurora, Colorado, United States of America.

View Article and Find Full Text PDF
December 2011

ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis.

Cancer Res 2011 Jun 11;71(11):3941-51. Epub 2011 Apr 11.

Department of Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

View Article and Find Full Text PDF
June 2011

AKT regulates BRCA1 stability in response to hormone signaling.

Mol Cell Endocrinol 2010 May 18;319(1-2):129-42. Epub 2010 Jan 18.

Department of Pathology, University of Colorado Denver, Aurora, CO 80045, USA.

View Article and Find Full Text PDF
May 2010

Rah, rah, ROS: metabolic changes caused by loss of adhesion induce cell death.

Breast Cancer Res 2009 18;11(6):307. Epub 2009 Nov 18.

Department of Pathology, Mailstop 8104, University of Colorado Denver, University of Colorado School of Medicine, P,O, Box 6511, Anshutz Medical Campus, Aurora, CO 80045, USA.

View Article and Find Full Text PDF
July 2010

Clinical characteristics and management of wound foreign bodies in the ED.

Am J Emerg Med 2008 Oct;26(8):918-22

Department of Emergency Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

View Article and Find Full Text PDF
October 2008

Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3.

Breast Cancer Res 2008 13;10(4):R70. Epub 2008 Aug 13.

Department of Pathology, University of Colorado Denver, Research Complex I, South Tower, Mail Stop 8104, 12801 East 17thAvenue, Aurora, CO 80045, USA.

View Article and Find Full Text PDF
April 2009

Sugar and fat - that's where it's at: metabolic changes in tumors.

Breast Cancer Res 2008 20;10(1):202. Epub 2008 Feb 20.

Department of Pathology and Program in Cancer Biology, University of Colorado Denver, Anschutz Medical Campus, East 17th Avenue, Aurora, Colorado 80045, USA.

View Article and Find Full Text PDF
June 2008

Mechanistic and pharmacodynamic studies of a 25-hydroxyvitamin D3 derivative in prostate cancer cells.

Biochem Biophys Res Commun 2007 Sep 16;361(1):189-95. Epub 2007 Jul 16.

Department of Pathology, University of Colorado Health Science Center, Aurora, CO, USA.

View Article and Find Full Text PDF
September 2007

Role of Ptc2 type 2C Ser/Thr phosphatase in yeast high-osmolarity glycerol pathway inactivation.

Eukaryot Cell 2002 Dec;1(6):1032-40

Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309-0215, USA.

View Article and Find Full Text PDF
December 2002