Christian U Blank

Christian U Blank

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Christian U Blank

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The Promise of Neoadjuvant Immunotherapy and Surgery for Cancer Treatment.

Clin Cancer Res 2019 Oct 30;25(19):5743-5751. Epub 2019 Apr 30.

Cancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-2641DOI Listing
October 2019

Defining 'T cell exhaustion'.

Nat Rev Immunol 2019 Sep 30. Epub 2019 Sep 30.

Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.

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http://dx.doi.org/10.1038/s41577-019-0221-9DOI Listing
September 2019

Susceptible loci associated with autoimmune disease as potential biomarkers for checkpoint inhibitor-induced immune-related adverse events.

ESMO Open 2019 21;4(4):e000472. Epub 2019 Jul 21.

Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1136/esmoopen-2018-000472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677983PMC
July 2019

Combining checkpoint inhibition and targeted therapy in melanoma.

Nat Med 2019 06;25(6):879-882

Department of Medical Oncology and Division of Molecular pathology and Immunology, the Netherlands Cancer Institute, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1038/s41591-019-0482-7DOI Listing
June 2019

The Cancer Immunogram as a Framework for Personalized Immunotherapy in Urothelial Cancer.

Eur Urol 2019 03 28;75(3):435-444. Epub 2018 Sep 28.

Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2018.09.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697269PMC
March 2019

Batf3 DCs and type I IFN are critical for the efficacy of neoadjuvant cancer immunotherapy.

Oncoimmunology 2019 22;8(2):e1546068. Epub 2018 Nov 22.

Cancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.

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http://dx.doi.org/10.1080/2162402X.2018.1546068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343771PMC
November 2018

Targeting tumor-associated acidity in cancer immunotherapy.

Cancer Immunol Immunother 2018 Sep 5;67(9):1331-1348. Epub 2018 Jul 5.

Department of Molecular Oncology and Immunology, Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00262-018-2195-zDOI Listing
September 2018

Advanced Melanoma: Current Treatment Options, Biomarkers, and Future Perspectives.

Am J Clin Dermatol 2018 Jun;19(3):303-317

Department of Medical Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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http://link.springer.com/10.1007/s40257-017-0325-6
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http://dx.doi.org/10.1007/s40257-017-0325-6DOI Listing
June 2018

Adjuvant Pembrolizumab versus Placebo in Resected Stage III Melanoma.

N Engl J Med 2018 May 15;378(19):1789-1801. Epub 2018 Apr 15.

From the Gustave Roussy Cancer Campus Grand Paris and University Paris-Saclay, Villejuif (A.M.M.E., C.R.), Hospices Civils de Lyon Cancer Institute, Cancer Research Center of Lyon, Lyon University, Lyon (S.D.), and Aix-Marseille University, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille, Marseille (J.-J.G.) - all in France; Netherlands Cancer Institute-Antoni van Leeuwenhoek (C.U.B., A.C.J.A.) and VU University Medical Center (A.J.M.E.), Amsterdam, and Radboud University Medical Center Nijmegen, Nijmegen (R.K.) - all in the Netherlands; Azienda Ospedaliera Papa Giovanni XXIII, Bergamo (M. Mandala), Istituto Nazionale Tumori Istituto di Ricovero e Cura a Carattere Scientifico Fondazione G. Pascale, Naples (P.A.A.), and Universita Degli Studi Di Siena-Policlinico le Scotte, Siena (M. Maio) - all in Italy; Melanoma Institute Australia, the University of Sydney, and Mater and Royal North Shore Hospitals (G.V.L.) and Westmead and Blacktown Hospitals, Melanoma Institute Australia and the University of Sydney (M.S.C.), Sydney, Princess Alexandra Hospital, University of Queensland, Brisbane (V.A.), Alfred Hospital (A.H.) and Peter MacCallum Cancer Centre (S. Sandhu), Melbourne, VIC, and Fiona Stanley Hospital-University of Western Australia-Edith Cowan University Perth, Perth (A.K.) - all in Australia; Cancer Research Center, Moscow (M.L.); Royal Marsden Hospital, London (J.L.); Hospital Clinic Universitari de Barcelona, Barcelona (S.P.); Maria Sklodowska-Curie Institute-Oncology Center, Warsaw, Poland (P.R.); University Hospital Essen, Essen and German Cancer Consortium, Heidelberg (D.S.), and the Skin Cancer Center, Department of Dermatology, Hannover Medical School, Hannover (R.G.) - all in Germany; Washington University School of Medicine, St. Louis (L.H.-A.); Centre Hospitalier de l'Université de Montréal (CHUM), Centre de Recherche du CHUM, Montreal (R.J.); Christie NHS Foundation Trust, Manchester, United Kingdom (P.L.); Merck, Kenilworth, NJ (N.I.); and the European Organization for the Research and Treatment of Cancer Headquarters, Brussels (S.M., S. Suciu).

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http://dx.doi.org/10.1056/NEJMoa1802357DOI Listing
May 2018

Observation After Cytoreductive Nephrectomy in Patients With Synchronous Not Completely Resected Metastases of Renal Cell Carcinoma.

Urology 2017 11 2;109:127-133. Epub 2017 Aug 2.

Department of Urology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.urology.2017.06.048DOI Listing
November 2017

Cancer drug addiction is relayed by an ERK2-dependent phenotype switch.

Nature 2017 10 4;550(7675):270-274. Epub 2017 Oct 4.

Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nature24037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640985PMC
October 2017

Open-label, multicentre safety study of vemurafenib in 3219 patients with BRAF mutation-positive metastatic melanoma: 2-year follow-up data and long-term responders' analysis.

Eur J Cancer 2017 07 11;79:176-184. Epub 2017 May 11.

Cancer Clinical Trials Unit, Royal Adelaide Hospital, Adelaide, Australia; Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, Australia; Discipline of Medicine, University of Adelaide, Adelaide, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.04.007DOI Listing
July 2017

Dermal Delivery of Constructs Encoding Cre Recombinase to Induce Skin Tumors in Pten;Braf Mice.

Int J Mol Sci 2016 Dec 20;17(12). Epub 2016 Dec 20.

Department of Immunology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://www.mdpi.com/1422-0067/17/12/2149
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http://dx.doi.org/10.3390/ijms17122149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187949PMC
December 2016

Targeting the MAPK and PI3K pathways in combination with PD1 blockade in melanoma.

Oncoimmunology 2016 14;5(12):e1238557. Epub 2016 Oct 14.

Department of Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1080/2162402X.2016.1238557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215252PMC
October 2016

Systematic review of the use of granulocyte-macrophage colony-stimulating factor in patients with advanced melanoma.

Cancer Immunol Immunother 2016 09 2;65(9):1015-34. Epub 2016 Jul 2.

Division of Immunology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands.

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http://dx.doi.org/10.1007/s00262-016-1860-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995227PMC
September 2016

CANCER IMMUNOLOGY. The "cancer immunogram".

Science 2016 May;352(6286):658-60

Division of Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.

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http://www.sciencemag.org/cgi/doi/10.1126/science.aaf2834
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http://dx.doi.org/10.1126/science.aaf2834DOI Listing
May 2016

Toxicity patterns with immunomodulating antibodies and their combinations.

Semin Oncol 2015 Jun 14;42(3):423-8. Epub 2015 Feb 14.

Division of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1053/j.seminoncol.2015.02.011DOI Listing
June 2015

Therapeutic use of anti-CTLA-4 antibodies.

Int Immunol 2015 Jan 18;27(1):3-10. Epub 2014 Jul 18.

Department of Dermatology, The University of Heidelberg, Im Neunheimer Feld 440, 69115 Heidelberg, Germany.

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https://academic.oup.com/intimm/article-lookup/doi/10.1093/i
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http://dx.doi.org/10.1093/intimm/dxu076DOI Listing
January 2015

Interferon-induced programmed death-ligand 1 (PD-L1/B7-H1) expression increases on human acute myeloid leukemia blast cells during treatment.

Eur J Haematol 2014 Mar 26;92(3):195-203. Epub 2013 Nov 26.

Department of Hematology and Medical Oncology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1111/ejh.12228DOI Listing
March 2014

The perspective of immunotherapy: new molecules and new mechanisms of action in immune modulation.

Curr Opin Oncol 2014 Mar;26(2):204-14

The Netherlands Cancer Institute, Department of Medical Oncology and Division of Immunology, Amsterdam, The Netherlands.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/CCO.0000000000000054DOI Listing
March 2014

The effect of seasonal variation and secretion of sunitinib in sweat on the development of hand-foot syndrome.

Eur J Clin Pharmacol 2013 Dec 31;69(12):2065-72. Epub 2013 Aug 31.

Department of Pharmacy & Pharmacology, Slotervaart Hospital/The Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands,

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http://dx.doi.org/10.1007/s00228-013-1579-4DOI Listing
December 2013

Synchronous BRAF(V600E) and MEK inhibition leads to superior control of murine melanoma by limiting MEK inhibitor induced skin toxicity.

Onco Targets Ther 2013 28;6:1649-58. Epub 2013 Nov 28.

Department of Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands ; Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.2147/OTT.S52552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849083PMC
December 2013

Neurological immune-related adverse events of ipilimumab.

Pract Neurol 2013 Aug 13;13(4):278-80. Epub 2013 Mar 13.

Department of Neurology, Antoni van Leeuwenhoek Hospital/Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://pn.bmj.com/lookup/doi/10.1136/practneurol-2012-000447
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http://dx.doi.org/10.1136/practneurol-2012-000447DOI Listing
August 2013

Mimicking homeostatic proliferation in vitro generates T cells with high anti-tumor function in non-lymphopenic hosts.

Cancer Immunol Immunother 2013 Mar 23;62(3):503-15. Epub 2012 Sep 23.

Division of Immunology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NKI-AVL), Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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http://link.springer.com/content/pdf/10.1007/s00262-012-1350
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http://link.springer.com/10.1007/s00262-012-1350-1
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http://dx.doi.org/10.1007/s00262-012-1350-1DOI Listing
March 2013

Targeting BRAFV600E in an inducible murine model of melanoma.

Am J Pathol 2012 Sep 11;181(3):785-94. Epub 2012 Jul 11.

Department of Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ajpath.2012.06.002DOI Listing
September 2012

Selective BRAF inhibition decreases tumor-resident lymphocyte frequencies in a mouse model of human melanoma.

Oncoimmunology 2012 Aug;1(5):609-617

Department of Immunology; The Netherlands Cancer Institute; Amsterdam, The Netherlands.

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http://dx.doi.org/10.4161/onci.20226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429565PMC
August 2012

Ipilimumab-induced sarcoidosis in a patient with metastatic melanoma undergoing complete remission.

J Clin Oncol 2012 Jan 28;30(2):e7-e10. Epub 2011 Nov 28.

Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NKI-AVL), Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.

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http://dx.doi.org/10.1200/JCO.2011.37.9693DOI Listing
January 2012

Combination of targeted therapy and immunotherapy in melanoma.

Cancer Immunol Immunother 2011 Oct 17;60(10):1359-71. Epub 2011 Aug 17.

Division of Immunology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Ziekenhuis, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00262-011-1079-2DOI Listing
October 2011

Determination of sunitinib and its active metabolite N-desethylsunitinib in sweat of a patient.

J Anal Toxicol 2011 Oct;35(8):558-65

Department of Pharmacy & Pharmacology, Slotervaart Hospital/The Netherlands Cancer Institute, Louwesweg 6, 1066 EC Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/anatox/35.8.558DOI Listing
October 2011