Publications by authors named "Christian T Happi"

70Publications

Accelerating genomics-based surveillance for COVID-19 response in Africa.

Lancet Microbe 2020 Oct 18;1(6):e227-e228. Epub 2020 Aug 18.

Africa Centres for Disease Control and Prevention, African Union Headquarters, Addis Ababa W21K19, Ethiopia.

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http://dx.doi.org/10.1016/S2666-5247(20)30117-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434434PMC
October 2020

Lassa Virus Genetics.

Curr Top Microbiol Immunol 2020 May 17. Epub 2020 May 17.

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://dx.doi.org/10.1007/82_2020_212DOI Listing
May 2020

Lassa fever diagnostics: past, present, and future.

Curr Opin Virol 2019 08 11;37:132-138. Epub 2019 Sep 11.

U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coviro.2019.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768724PMC
August 2019

Preparing for the next Ebola outbreak: in-country genomic capacity in Africa.

Lancet Infect Dis 2019 06 15;19(6):569-570. Epub 2019 Apr 15.

Department of Biological Sciences, College of Natural Sciences, Redeemer's University, Ede 200012, Nigeria; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede 200012, Nigeria. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(19)30173-2DOI Listing
June 2019

Genomic Analysis of Lassa Virus during an Increase in Cases in Nigeria in 2018.

N Engl J Med 2018 11 17;379(18):1745-1753. Epub 2018 Oct 17.

From the Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard University (K.J.S., K.G.B., S.M., S.F.S., S.M.W., R.R.S., J.Q., S.W., P.B., S.Y., B.C., D.K., A.C., A.G.-Y., C.A.F., D.J.P., N.L.Y., B.L.M., P.C.S.), the Center for Systems Biology, Department of Organismic and Evolutionary Biology (K.J.S., K.G.B., S.F.S., S.W., B.C., D.K., C.A.F., N.L.Y., P.C.S.), and the Faculty of Arts and Sciences (M.N.), Harvard University, Harvard University Extension School (R.R.S.), and Harvard-MIT Health Sciences and Technology, MIT (S.Y., P.C.S.), Cambridge, and the Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health (K.G.B., S.F.S., B.L.M., P.C.S., C.T.H.), and Beth Israel Deaconess Medical Center, Division of Infectious Diseases (S.M.), Boston - all in Massachusetts; the African Center of Excellence for Genomics of Infectious Diseases (P.E., J.U.O., E.U., T.K., F.A., J.U., A.G., M.M., I.N., P.O., O.T., O.A.F., C.T.H.) and the Department of Biological Sciences, College of Natural Sciences (J.U.O., E.U., T.K., F.A., J.U., P.O., O.A.F., C.T.H.), Redeemer's University, Ede, the Institute of Lassa Fever Research and Control (I.O., C. Iruolagbe, J.A., E.U., P.A., G.O., O.O., B.O., E.B.M., M.A., R.E., B.E., E.O.-E., G.A., S.O., P.O.O., C.T.H.) and the Department of Medicine (P.O.O.), Irrua Specialist Teaching Hospital, Irrua, the Nigeria Center for Disease Control, Abuja (C. Ihekweazu), and the Department of Medicine, Faculty of Clinical Sciences, Ambrose Alli University, Ekpoma (P.O.O.) - all in Nigeria; the Laboratory of Parasitology/Mycology HALD, Cheikh Anta Diop University of Dakar, Dakar, Senegal (A.G.); Kenema Government Hospital, Kenema, Sierra Leone (M.M.); Tulane Health Sciences Center, Tulane University, New Orleans (R.F.G.); the Departments of Immunology and Microbial Science and Integrative Structural and Computational Biology, Scripps Research Institute, and the Scripps Translational Science Institute, La Jolla, CA (K.G.A.); and Howard Hughes Medical Institute, Chevy Chase, MD (P.C.S.).

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http://dx.doi.org/10.1056/NEJMoa1804498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181183PMC
November 2018

Virus genomes reveal factors that spread and sustained the Ebola epidemic.

Nature 2017 04 12;544(7650):309-315. Epub 2017 Apr 12.

Institute of Evolutionary Biology, University of Edinburgh, King's Buildings, Edinburgh EH9 3FL, UK.

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http://dx.doi.org/10.1038/nature22040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712493PMC
April 2017

An Outbreak of Ebola Virus Disease in the Lassa Fever Zone.

J Infect Dis 2016 10 11;214(suppl 3):S110-S121. Epub 2016 Jul 11.

Department of Microbiology and Immunology Zalgen Labs, Germantown, Maryland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050470PMC
http://dx.doi.org/10.1093/infdis/jiw239DOI Listing
October 2016

Roots, Not Parachutes: Research Collaborations Combat Outbreaks.

Cell 2016 Jun;166(1):5-8

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, CA 92037, USA; Scripps Translational Science Institute, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.06.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210219PMC
June 2016

Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus.

Cell 2015 Aug;162(4):738-50

FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA; Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115, USA. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(15)00897-1.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S009286741500897
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http://dx.doi.org/10.1016/j.cell.2015.07.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537774PMC
August 2015

Filovirus RefSeq entries: evaluation and selection of filovirus type variants, type sequences, and names.

Viruses 2014 Sep 26;6(9):3663-82. Epub 2014 Sep 26.

IViral Special Pathogens Branch, Division of High-Consequence Pathogens Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

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http://dx.doi.org/10.3390/v6093663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189044PMC
September 2014

Interaction between rifampicin, amodiaquine and artemether in mice infected with chloroquine resistant Plasmodium berghei.

Malar J 2014 Aug 5;13:299. Epub 2014 Aug 5.

Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria.

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http://dx.doi.org/10.1186/1475-2875-13-299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237866PMC
August 2014

Research capacity. Enabling the genomic revolution in Africa.

Authors:
Charles Rotimi Akin Abayomi Alash'le Abimiku Victoria May Adabayeri Clement Adebamowo Ezekiel Adebiyi Adebowale D Ademola Adebowale Adeyemo Dwomoa Adu Dissou Affolabi Godfred Agongo Samuel Ajayi Sally Akarolo-Anthony Rufus Akinyemi Albert Akpalu Marianne Alberts Orlando Alonso Betancourt Ahmed Mansour Alzohairy Gobena Ameni Olukemi Amodu Gabriel Anabwani Kristian Andersen Fatiu Arogundade Oyedunni Arulogun Danny Asogun Rasheed Bakare Naby Balde Mary Lynn Baniecki Christine Beiswanger Alia Benkahla Lara Bethke Micheal Boehnke Vincent Boima James Brandful Andrew I Brooks Frank C Brosius Chester Brown Bruno Bucheton David T Burke Barrington G Burnett Stacy Carrington-Lawrence Nadia Carstens John Chisi Alan Christoffels Richard Cooper Heather Cordell Nigel Crowther Talishiea Croxton Jantina de Vries Leslie Derr Peter Donkor Seydou Doumbia Audrey Duncanson Ivy Ekem Ahmed El Sayed Mark E Engel John C K Enyaru Dean Everett Faisal M Fadlelmola Eyitayo Fakunle Kenneth H Fischbeck Anne Fischer Onikepe Folarin Junaid Gamieldien Robert F Garry Simani Gaseitsiwe Rasheed Gbadegesin Anita Ghansah Maria Giovanni Parham Goesbeck F Xavier Gomez-Olive Donald S Grant Ravnit Grewal Mark Guyer Neil A Hanchard Christian T Happi Scott Hazelhurst Branwen J Hennig Christiane Hertz- Fowler Winston Hide Friedhelm Hilderbrandt Christopher Hugo-Hamman Muntaser E Ibrahim Regina James Yasmina Jaufeerally-Fakim Carolyn Jenkins Ute Jentsch Pan-Pan Jiang Moses Joloba Victor Jongeneel Fourie Joubert Mukthar Kader Kathleen Kahn Pontiano Kaleebu Saidi H Kapiga Samar Kamal Kassim Ishmael Kasvosve Jonathan Kayondo Bernard Keavney Adeodata Kekitiinwa Sheik Humarr Khan Paul Kimmel Mary-Claire King Robert Kleta Mathurin Koffi Jeffrey Kopp Matthias Kretzler Judit Kumuthini Samuel Kyobe Catherine Kyobutungi Daniel T Lackland Karen A Lacourciere Guida Landouré Rita Lawlor Thomas Lehner Maia Lesosky Naomi Levitt Katherine Littler Zane Lombard Jeanne F Loring Sylvester Lyantagaye Annette Macleod Ebony B Madden Chengetai R Mahomva Julie Makani Manmak Mamven Marape Marape Graeme Mardon Patricia Marshall Darren P Martin Daniel Masiga Robin Mason Michael Mate-Kole Enock Matovu Mary Mayige Bongani M Mayosi Jean Claude Mbanya Sheryl A McCurdy Mark I McCarthy Helen McIlleron S O Mc'Ligeyo Corrine Merle Ana Olga Mocumbi Charles Mondo John V Moran Ayesha Motala Marva Moxey-Mims Wata Sununguko Mpoloka Chisomo L Msefula Thuli Mthiyane Nicola Mulder Gebregziab her Mulugeta Dieuodonne Mumba John Musuku Mo Nagdee Oyekanmi Nash Daouda Ndiaye Anh Quynh Nguyen Mark Nicol Oathokwa Nkomazana Shane Norris Betty Nsangi Alexander Nyarko Moffat Nyirenda Eileen Obe Reginald Obiakor Abraham Oduro Solomon F Ofori-Acquah Okechukwu Ogah Stephen Ogendo Kwaku Ohene-Frempong Akinlolu Ojo Timothy Olanrewaju John Oli Charlotte Osafo Odile Ouwe Missi Oukem-Boyer Bruce Ovbiagele Andrew Owen Mayowa Ojo Owolabi Lukman Owolabi Ellis Owusu-Dabo Guillaume Pare Rulan Parekh Hugh G Patterton Margaret B Penno Jane Peterson Rembert Pieper Jacob Plange-Rhule Martin Pollak Julia Puzak Rajkumar S Ramesar Michele Ramsay Rebekah Rasooly Shiksha Reddy Pardis C Sabeti Kwamena Sagoe Tunde Salako Oumar Samassékou Manjinder S Sandhu Osman Sankoh Fred Stephen Sarfo Marie Sarr Gasnat Shaboodien Issa Sidibe Gustave Simo Martin Simuunza Liam Smeeth Eugene Sobngwi Himla Soodyall Hermann Sorgho Oumou Sow Bah Sudha Srinivasan Dan J Stein Ezra S Susser Carmen Swanepoel Godfred Tangwa Andrew Tareila Ozlem Tastan Bishop Bamidele Tayo Nicki Tiffin Halidou Tinto Ekaete Tobin Stephen Meir Tollman Mahamadou Traoré Marsha J Treadwell Jennifer Troyer Masego Tsimako-Johnstone Vincent Tukei Ifeoma Ulasi Nzovu Ulenga Beverley van Rooyen Ablo Prudence Wachinou Salina P Waddy Alisha Wade Misaki Wayengera James Whitworth Louise Wideroff Cheryl A Winkler Sarah Winnicki Ambroise Wonkam Mengistu Yewondwos Tadase sen Nathan Yozwiak Heather Zar

Science 2014 Jun;344(6190):1346-8

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http://dx.doi.org/10.1126/science.1251546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138491PMC
June 2014

A high performance liquid chromatographic assay of mefloquine in saliva after a single oral dose in healthy adult Africans.

Malar J 2012 Feb 27;11:59. Epub 2012 Feb 27.

Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria.

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http://dx.doi.org/10.1186/1475-2875-11-59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311565PMC
February 2012

Genome-wide scans provide evidence for positive selection of genes implicated in Lassa fever.

Philos Trans R Soc Lond B Biol Sci 2012 Mar;367(1590):868-77

Department of Organismic and Evolutionary Biology, FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1098/rstb.2011.0299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267117PMC
March 2012

Risk factors for gametocyte carriage in uncomplicated falciparum malaria in children before and after artemisinin-based combination treatments.

Chemotherapy 2011 19;57(6):497-504. Epub 2012 Jan 19.

Department of Pharmacology and Therapeutics, University of Ibadan, Nigeria.

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http://dx.doi.org/10.1159/000334126DOI Listing
November 2012

A simple dose regimen of artesunate and amodiaquine based on arm span- or age range for childhood falciparum malaria: a preliminary evaluation.

J Trop Pediatr 2012 Aug 3;58(4):263-8. Epub 2011 Nov 3.

Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria Institute for Medical Research Training, University of Ibadan, Ibadan, Nigeria.

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http://dx.doi.org/10.1093/tropej/fmr091DOI Listing
August 2012

Risk factors for Plasmodium falciparum hyperparasitaemia in malarious children.

BMC Infect Dis 2011 Oct 9;11:268. Epub 2011 Oct 9.

Department of Pharmacology & Therapeutics and Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria.

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http://dx.doi.org/10.1186/1471-2334-11-268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199259PMC
October 2011

Interaction between ciprofloxacin and chloroquine in mice infected with chloroquine resistant Plasmodium berghei: interaction between ciprofloxacin and chloroqune.

Parasitol Res 2012 Feb 9;110(2):895-9. Epub 2011 Aug 9.

Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria.

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http://dx.doi.org/10.1007/s00436-011-2573-3DOI Listing
February 2012

Therapeutic efficacies of artemisinin-based combination therapies in Nigerian children with uncomplicated falciparum malaria during five years of adoption as first-line treatments.

Am J Trop Med Hyg 2011 Jun;84(6):936-43

Department of Pharmacology and Therapeutics and Institute for Medical Research and Training, University of Ibadan, Ibadan, Oyo State, Nigeria.

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http://dx.doi.org/10.4269/ajtmh.2011.10-0722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110368PMC
June 2011

Oral artesunate-amodiaquine and artemether-lumefantrine in the treatment of uncomplicated hyperparasitaemic Plasmodium falciparum malaria in children.

J Trop Pediatr 2012 Apr 26;58(2):151-3. Epub 2011 May 26.

Department of Pharmacology and Therapeutics, & Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria.

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http://dx.doi.org/10.1093/tropej/fmr045DOI Listing
April 2012

Comparison of SYBR Green I-, PicoGreen-, and [3H]-hypoxanthine-based assays for in vitro antimalarial screening of plants from Nigerian ethnomedicine.

Parasitol Res 2010 Mar 18;106(4):933-9. Epub 2010 Feb 18.

Department of Pharmacology and Therapeutics, College of Health Sciences, Ladoke Akintola University of Technology, Oshogbo, Nigeria.

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http://dx.doi.org/10.1007/s00436-010-1743-zDOI Listing
March 2010

Potential contribution of prescription practices to the emergence and spread of chloroquine resistance in south-west Nigeria: caution in the use of artemisinin combination therapy.

Malar J 2009 Dec 30;8:313. Epub 2009 Dec 30.

Malaria Research Laboratories, Institute of Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.

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http://dx.doi.org/10.1186/1475-2875-8-313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807872PMC
December 2009

Effects of mefloquine and artesunate mefloquine on the emergence, clearance and sex ratio of Plasmodium falciparum gametocytes in malarious children.

Malar J 2009 Dec 16;8:297. Epub 2009 Dec 16.

Department of Pharmacology & Therapeutics, Institute for Medical Research and Training, University College Hospital, Ibadan, Nigeria.

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http://dx.doi.org/10.1186/1475-2875-8-297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805687PMC
December 2009

Factors contributing to anaemia after uncomplicated Plasmodiumfalciparum malaria in children.

Acta Trop 2010 Feb 27;113(2):155-61. Epub 2009 Oct 27.

Department of Pharmacology & Therapeutics, Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria.

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http://dx.doi.org/10.1016/j.actatropica.2009.10.011DOI Listing
February 2010

A simple cost-effective high performance liquid chromatographic assay of sulphadoxine in whole blood spotted on filter paper for field studies.

Malar J 2009 Oct 24;8:238. Epub 2009 Oct 24.

Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria.

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http://dx.doi.org/10.1186/1475-2875-8-238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773786PMC
October 2009

Population structure of Plasmodium falciparum gametocyte sex ratios in malarious children in an endemic area.

Parasitol Int 2009 Dec 31;58(4):438-43. Epub 2009 Aug 31.

Department of Pharmacology & Therapeutics, University of Ibadan, Ibadan, Nigeria.

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http://dx.doi.org/10.1016/j.parint.2009.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782424PMC
December 2009

Some features of primary and recrudescent amodiaquine-resistant Plasmodium falciparum infections in Nigerian children.

Mem Inst Oswaldo Cruz 2008 Dec;103(8):754-9

Department of Pharmacology and Therapeutics, Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria.

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http://dx.doi.org/10.1590/s0074-02762008000800002DOI Listing
December 2008

Plasmodium falciparum gametocyte sex ratios in symptomatic children treated with antimalarial drugs.

Acta Trop 2009 Feb 5;109(2):108-17. Epub 2008 Nov 5.

Department of Pharmacology & Therapeutics and Institute for Medical Research and Training, University of Ibadan, Nigeria.

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http://dx.doi.org/10.1016/j.actatropica.2008.10.010DOI Listing
February 2009

Effects of amodiaquine, artesunate, and artesunate-amodiaquine on Plasmodium falciparum malaria-associated anaemia in children.

Acta Trop 2009 Jan 17;109(1):55-60. Epub 2008 Oct 17.

Department of Pharmacology & Therapeutics and Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria.

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http://dx.doi.org/10.1016/j.actatropica.2008.09.022DOI Listing
January 2009

Plasmodium falciparum gametocyte sex ratios in children with acute, symptomatic, uncomplicated infections treated with amodiaquine.

Malar J 2008 Sep 2;7:169. Epub 2008 Sep 2.

Department of Pharmacology & Therapeutics and Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria.

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http://dx.doi.org/10.1186/1475-2875-7-169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2542388PMC
September 2008

Activities of artemether-lumefantrine and amodiaquine-sulfalene-pyrimethamine against sexual-stage parasites in falciparum malaria in children.

Chemotherapy 2008 18;54(3):201-8. Epub 2008 Jun 18.

Department of Pharmacology and Therapeutics, Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria.

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http://dx.doi.org/10.1159/000140463DOI Listing
August 2008

Therapeutic efficacy and effects of artemether-lumefantrine and amodiaquine-sulfalene-pyrimethamine on gametocyte carriage in children with uncomplicated Plasmodium falciparum malaria in southwestern Nigeria.

Am J Trop Med Hyg 2007 Aug;77(2):235-41

Department of Pharmacology and Therapeutics and Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria.

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August 2007

Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo.

Mem Inst Oswaldo Cruz 2007 Jun;102(3):417-9

Department of Pharmacology and Therapeutics, Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria.

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http://dx.doi.org/10.1590/s0074-02762007005000038DOI Listing
June 2007

Effects of acute Plasmodium falciparum malaria on body weight in children in an endemic area.

Parasitol Res 2007 Jul 25;101(2):343-9. Epub 2007 Feb 25.

Department of Pharmacology & Therapeutics and Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria.

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http://dx.doi.org/10.1007/s00436-007-0494-yDOI Listing
July 2007