Christian Speck

Christian Speck

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Christian Speck

Christian Speck

Publications by authors named "Christian Speck"

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36Publications

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Evolution of an amniote-specific mechanism for modulating ubiquitin signalling via phosphoregulation of the E2 enzyme UBE2D3.

Mol Biol Evol 2020 Mar 7. Epub 2020 Mar 7.

Gene Regulation and Chromatin Group, MRC London Institute of Medical Sciences, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1093/molbev/msaa060DOI Listing
March 2020

Chromosomal Sil system contributes to silver resistance in E. coli ATCC 8739.

Biometals 2018 12 4;31(6):1101-1114. Epub 2018 Oct 4.

Institute of Food, Nutrition and Health, ETH Zurich, Schmelzbergstrasse 7, 8092, Zurich, Switzerland.

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http://link.springer.com/10.1007/s10534-018-0143-1
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http://dx.doi.org/10.1007/s10534-018-0143-1DOI Listing
December 2018

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.

Cancer Cell 2018 02;33(2):322-336.e8

Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Medical Department of Hematology, Oncology and Tumor Immunology, Virchow Campus, and Molekulares Krebsforschungszentrum, 13353 Berlin, Germany; Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner Site Berlin, Germany.

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http://dx.doi.org/10.1016/j.ccell.2018.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977991PMC
February 2018

Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model.

Proc Natl Acad Sci U S A 2017 11 25;114(45):E9529-E9538. Epub 2017 Oct 25.

Cryo-EM Structural Biology Laboratory, Van Andel Research Institute, Grand Rapids, MI 49503;

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http://dx.doi.org/10.1073/pnas.1712537114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692578PMC
November 2017

From structure to mechanism-understanding initiation of DNA replication.

Genes Dev 2017 06;31(11):1073-1088

DNA Replication Group, Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.1101/gad.298232.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538431PMC
June 2017

Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1.

Nat Struct Mol Biol 2017 03 13;24(3):316-324. Epub 2017 Feb 13.

Cryo-EM Structural Biology Laboratory, Van Andel Research Institute, Grand Rapids, Michigan, USA.

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http://dx.doi.org/10.1038/nsmb.3372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503505PMC
March 2017

Metabolic Effects of Glucose-Fructose Co-Ingestion Compared to Glucose Alone during Exercise in Type 1 Diabetes.

Nutrients 2017 Feb 21;9(2). Epub 2017 Feb 21.

Department of Diabetes, Endocrinology, Clinical Nutrition and Metabolism, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.

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http://dx.doi.org/10.3390/nu9020164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331595PMC
February 2017

Exceeding the limits - Cdc45 overexpression turns bad.

Authors:
Christian Speck

Cell Cycle 2016 07 6;15(14):1809-10. Epub 2016 May 6.

a DNA Replication Group, Institute of Clinical Sciences, Imperial College London , London , UK.

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http://dx.doi.org/10.1080/15384101.2016.1184512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968895PMC
July 2016

Replicating repetitive DNA.

Nat Cell Biol 2016 05;18(6):593-4

DNA Replication Group, Institute of Clinical Sciences, Imperial College London, London, W12 0NN, UK.

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http://dx.doi.org/10.1038/ncb3367DOI Listing
May 2016

Metabolic and hormonal response to intermittent high-intensity and continuous moderate intensity exercise in individuals with type 1 diabetes: a randomised crossover study.

Diabetologia 2016 Apr 6;59(4):776-84. Epub 2016 Jan 6.

Division of Endocrinology, Diabetes and Clinical Nutrition, Inselspital, Bern University Hospital, and University of Bern, CH-3010, Bern, Switzerland.

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http://dx.doi.org/10.1007/s00125-015-3854-7DOI Listing
April 2016

A reconstituted system reveals how activating and inhibitory interactions control DDK dependent assembly of the eukaryotic replicative helicase.

Nucleic Acids Res 2015 Dec 3;43(21):10238-50. Epub 2015 Sep 3.

DNA Replication Group, Institute of Clinical Sciences, Imperial College London, London W12 0NN, UK

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666391PMC
http://dx.doi.org/10.1093/nar/gkv881DOI Listing
December 2015

Opening the gate to DNA replication.

Cell Cycle 2015 ;14(1):6-8

a DNA Replication Group; Institute of Clinical Science; Imperial College ; London , UK.

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http://dx.doi.org/10.4161/15384101.2014.987624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353067PMC
September 2015

Switch on the engine: how the eukaryotic replicative helicase MCM2-7 becomes activated.

Chromosoma 2015 Mar 12;124(1):13-26. Epub 2014 Oct 12.

DNA Replication Group, Institute of Clinical Science, Imperial College, London, W12 0NN, UK.

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http://link.springer.com/10.1007/s00412-014-0489-2
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http://dx.doi.org/10.1007/s00412-014-0489-2DOI Listing
March 2015

The fidelity of synaptonemal complex assembly is regulated by a signaling mechanism that controls early meiotic progression.

Dev Cell 2014 Nov 6;31(4):503-11. Epub 2014 Nov 6.

Meiosis Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.10.001DOI Listing
November 2014

Structural and mechanistic insights into Mcm2-7 double-hexamer assembly and function.

Genes Dev 2014 Oct;28(20):2291-303

Biosciences Department, Brookhaven National Laboratory, Upton, New York 11973, USA; Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794, USA

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http://dx.doi.org/10.1101/gad.242313.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201289PMC
October 2014

Helicase loading: how to build a MCM2-7 double-hexamer.

Semin Cell Dev Biol 2014 Jun 14;30:104-9. Epub 2014 Mar 14.

DNA Replication Group, Faculty of Medicine, Institute of Clinical Sciences, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2014.03.008DOI Listing
June 2014

The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation.

Nucleic Acids Res 2014 Feb 14;42(4):2257-69. Epub 2013 Nov 14.

DNA Replication Group, MRC Clinical Sciences Centre, Imperial College, Du Cane Road, London W12 0NN, UK and Microscopy Unit, Max Planck Institute for Molecular Genetics, Berlin 14195, Germany.

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http://dx.doi.org/10.1093/nar/gkt1148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936773PMC
February 2014

Seeing is believing: the MCM2-7 helicase trapped in complex with its DNA loader.

Cell Cycle 2013 Sep 21;12(18):2917-8. Epub 2013 Aug 21.

DNA Replication Group; MRC Clinical Sciences Centre; Imperial College; London, UK.

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http://dx.doi.org/10.4161/cc.26132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875658PMC
September 2013

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA.

Nat Struct Mol Biol 2013 Aug 14;20(8):944-51. Epub 2013 Jul 14.

Biosciences Department, Brookhaven National Laboratory, Upton, New York, USA.

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http://dx.doi.org/10.1038/nsmb.2629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735830PMC
August 2013

In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization.

Nucleic Acids Res 2013 Mar 1;41(5):3162-72. Epub 2013 Feb 1.

DNA Replication Group, MRC Clinical Sciences Centre, Imperial College, London W12 0NN, UK.

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http://dx.doi.org/10.1093/nar/gkt043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597701PMC
March 2013

A top-down view on DNA replication and recombination from 9,000 feet above sea level.

Genome Biol 2011 27;12(4):304. Epub 2011 Apr 27.

Department of Medical Biochemistry and Biophysics, Umeå University, SE 90187 Umeå, Sweden.

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http://dx.doi.org/10.1186/gb-2011-12-4-304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218856PMC
February 2012

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication.

Proc Natl Acad Sci U S A 2009 Dec 12;106(48):20240-5. Epub 2009 Nov 12.

DNA Replication Group, Medical Research Council Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0911500106
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http://dx.doi.org/10.1073/pnas.0911500106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787165PMC
December 2009

The architecture of the DNA replication origin recognition complex in Saccharomyces cerevisiae.

Proc Natl Acad Sci U S A 2008 Jul 22;105(30):10326-31. Epub 2008 Jul 22.

Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA.

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http://dx.doi.org/10.1073/pnas.0803829105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2480615PMC
July 2008

Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication.

J Biol Chem 2007 Apr 21;282(16):11705-14. Epub 2007 Feb 21.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

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http://dx.doi.org/10.1074/jbc.M700399200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033201PMC
April 2007

Analysis of protein-DNA interactions using surface plasmon resonance.

Adv Biochem Eng Biotechnol 2007 ;104:13-36

Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.

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March 2007

ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.

Nat Struct Mol Biol 2005 Nov;12(11):965-71

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.

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http://dx.doi.org/10.1038/nsmb1002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952294PMC
November 2005