Christian Sina

Christian Sina

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Christian Sina

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Seasonal Clock Changes Are Underappreciated Health Risks-Also in IBD?

Front Med (Lausanne) 2019 9;6:103. Epub 2019 May 9.

Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Lübeck, Germany.

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http://dx.doi.org/10.3389/fmed.2019.00103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521728PMC
May 2019

Dietary ursolic acid improves health span and life span in male Drosophila melanogaster.

Biofactors 2019 Mar 29;45(2):169-186. Epub 2018 Nov 29.

Institute of Human Nutrition and Food Science, University of Kiel, Kiel, Germany.

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http://dx.doi.org/10.1002/biof.1467DOI Listing
March 2019

Crohn's Disease Patients in Remission Display an Enhanced Intestinal IgM⁺ B Cell Count in Concert with a Strong Activation of the Intestinal Complement System.

Cells 2019 01 21;8(1). Epub 2019 Jan 21.

Institute of Nutritional Medicine, Molecular Gastroenterology, University Hospital Schleswig-Holstein, Campus Lübeck, D-23538 Lübeck, Germany.

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http://dx.doi.org/10.3390/cells8010078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356943PMC
January 2019

Lithocholic Acid Improves the Survival of Drosophila Melanogaster.

Mol Nutr Food Res 2018 10 3;62(20):e1800424. Epub 2018 Sep 3.

Institute of Nutritional Medicine, University of Lübeck, 23538, Lübeck, Germany.

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http://doi.wiley.com/10.1002/mnfr.201800424
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http://dx.doi.org/10.1002/mnfr.201800424DOI Listing
October 2018

The mitochondrial uncoupling protein 2 gene is causal for the spontaneous polycystic liver diseases in mice.

Mitochondrion 2018 09 14;42:50-53. Epub 2017 Nov 14.

Lübeck Institute of Experimental Dermatology, University of Lübeck, Germany; College of Medicine, Sharjah Institute for Medical Research, University of Sharjah, AE-27272, United Arab Emirates. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2017.10.011DOI Listing
September 2018

The intestinal complement system in inflammatory bowel disease: Shaping intestinal barrier function.

Semin Immunol 2018 06 24;37:66-73. Epub 2018 Feb 24.

Institute of Nutritional Medicine, Molecular Gastroenterology, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2018.02.008DOI Listing
June 2018

[Causes, Diagnostic and Therapeutical Procedures of Malassimilation].

Dtsch Med Wochenschr 2018 May 4;143(10):704-712. Epub 2018 May 4.

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http://dx.doi.org/10.1055/s-0043-121013DOI Listing
May 2018

Age-dependent alterations of glucose clearance and homeostasis are temporally separated and modulated by dietary fat.

J Nutr Biochem 2018 04 18;54:66-76. Epub 2017 Oct 18.

Laboratory of Genomics and Molecular Biomedicine, Department of Biology, Faculty of Science, University of Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2017.09.026DOI Listing
April 2018

Cold-Induced Brown Adipose Tissue Activity Alters Plasma Fatty Acids and Improves Glucose Metabolism in Men.

J Clin Endocrinol Metab 2017 11;102(11):4226-4234

Department of Internal Medicine I, Section of Endocrinology & Diabetes, University Hospital Schleswig-Holstein, 23538 Lübeck, Germany.

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http://dx.doi.org/10.1210/jc.2017-01250DOI Listing
November 2017

Regulation of epithelial cell expressed C3 in the intestine - Relevance for the pathophysiology of inflammatory bowel disease?

Mol Immunol 2017 10 24;90:227-238. Epub 2017 Aug 24.

Institute of Nutritional Medicine, Molecular Gastroenterology, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01615890173046
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http://dx.doi.org/10.1016/j.molimm.2017.08.003DOI Listing
October 2017

Experimental Laminin 332 Mucous Membrane Pemphigoid Critically Involves C5aR1 and Reflects Clinical and Immunopathological Characteristics of the Human Disease.

J Invest Dermatol 2017 08 26;137(8):1709-1718. Epub 2017 Apr 26.

Lübeck Institute for Experimental Dermatology (LIED), University of Lübeck, Lübeck, Germany; Department of Dermatology, University of Lübeck, Lübeck, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2017.03.037DOI Listing
August 2017

Dietary fat drives whole-body insulin resistance and promotes intestinal inflammation independent of body weight gain.

Metabolism 2016 Dec 12;65(12):1706-1719. Epub 2016 Sep 12.

Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Integrative Physiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2016.09.002DOI Listing
December 2016

Lifespan effects of mitochondrial mutations.

Nature 2016 12;540(7633):E13-E14

Lübeck Institute of Experimental Dermatology, University of Lübeck, Germany.

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http://dx.doi.org/10.1038/nature20778DOI Listing
December 2016

Male-specific association between MT-ND4 11719 A/G polymorphism and ulcerative colitis: a mitochondria-wide genetic association study.

BMC Gastroenterol 2016 Oct 3;16(1):118. Epub 2016 Oct 3.

Institute of Medical Biometry and Statistics, University of Lübeck, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048482PMC
http://dx.doi.org/10.1186/s12876-016-0509-1DOI Listing
October 2016

Uncoupling protein 2 protects mice from aging.

Mitochondrion 2016 09 27;30:42-50. Epub 2016 Jun 27.

Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15677249163007
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http://dx.doi.org/10.1016/j.mito.2016.06.004DOI Listing
September 2016

Fecal Microbiota Transfer in Patients With Chronic Antibiotic-Refractory Pouchitis.

Am J Gastroenterol 2016 Mar;111(3):441-3

Microbial Interactions and Processes Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany.

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http://dx.doi.org/10.1038/ajg.2015.436DOI Listing
March 2016

Pancreatic Autoantibodies Against CUZD1 and GP2 Are Associated with Distinct Clinical Phenotypes of Crohn's Disease.

Inflamm Bowel Dis 2015 Dec;21(12):2864-72

*Molecular Gastroenterology/Medical Department 1, University Hospital Schleswig Holstein, Campus Lübeck, Germany; †Institute for Anatomy, University of Lübeck, Campus Lübeck, Germany; ‡Department of Experimental Immunology, EUROIMMUN AG, Campus Lübeck, Germany; and §Medical Department 1, Gastroenterology, Institute for Systemic Inflammation Research, University of Lübeck, Campus Lübeck, Germany.

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http://dx.doi.org/10.1097/MIB.0000000000000564DOI Listing
December 2015

A Complement-Optimized EGFR Antibody Improves Cytotoxic Functions of Polymorphonuclear Cells against Tumor Cells.

J Immunol 2015 Nov 16;195(10):5077-87. Epub 2015 Oct 16.

Division of Stem Cell Transplantation and Immunotherapy, 2nd Department of Medicine, Christian-Albrechts-University and University Hospital Schleswig-Holstein, 24105 Kiel, Germany;

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http://dx.doi.org/10.4049/jimmunol.1501458DOI Listing
November 2015

Liver steatosis is a risk factor for hepatotoxicity in patients with inflammatory bowel disease under immunosuppressive treatment.

Eur J Gastroenterol Hepatol 2015 Jun;27(6):698-704

Departments of aMedicine I bDermatology, University Hospital Schleswig-Holstein, Campus Lübeck cGastroenterology Practice, Lübeck, Germany.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MEG.0000000000000350DOI Listing
June 2015

Autoantibodies against exocrine pancreas in Crohn's disease are directed against two antigens: the glycoproteins CUZD1 and GP2.

J Crohns Colitis 2013 Nov 7;7(10):780-90. Epub 2012 Nov 7.

Institute of Experimental Immunology, Euroimmun AG, Luebeck, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.crohns.2012.10.011DOI Listing
November 2013

Mitochondrial gene polymorphisms that protect mice from colitis.

Gastroenterology 2013 Nov 19;145(5):1055-1063.e3. Epub 2013 Jul 19.

Medical Department I, University Hospital Schleswig-Holstein, Lübeck, Germany; Institute of Anatomy, University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1053/j.gastro.2013.07.015DOI Listing
November 2013

Thiopurines in inflammatory bowel disease revisited.

World J Gastroenterol 2013 Mar;19(11):1699-706

Medical Department 1, University Hospital Schleswig Holstein, 23538 Lübeck, Germany.

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http://dx.doi.org/10.3748/wjg.v19.i11.1699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607746PMC
March 2013

Nod2 is essential for temporal development of intestinal microbial communities.

Gut 2011 Oct 18;60(10):1354-62. Epub 2011 Mar 18.

Institute for Clinical Molecular Biology (IKMB), Christian-Albrechts-University (CAU) Kiel, Germany.

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http://gut.bmj.com/content/60/10/1354.full.pdf
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http://dx.doi.org/10.1136/gut.2010.216259DOI Listing
October 2011

Alterations of pre-mRNA splicing in human inflammatory bowel disease.

Eur J Cell Biol 2011 Jun-Jul;90(6-7):603-11. Epub 2011 Feb 15.

Institute of Clinical Molecular Biology, Christian-Albrechts-University, Schittenhelmstrasse 12, 24105 Kiel, Germany.

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http://dx.doi.org/10.1016/j.ejcb.2010.11.010DOI Listing
September 2011

Towards a molecular risk map--recent advances on the etiology of inflammatory bowel disease.

Semin Immunol 2009 Dec 17;21(6):334-45. Epub 2009 Nov 17.

Institute for Clinical Molecular Biology, Christian-Albrechts University of Kiel, Schittenhelmstr. 12, D-24105 Kiel, Germany.

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http://dx.doi.org/10.1016/j.smim.2009.10.001DOI Listing
December 2009

Decreased sigmoidal ABCB1 (P-glycoprotein) expression in ulcerative colitis is associated with disease activity.

Pharmacogenomics 2009 Dec;10(12):1941-53

University Hospital Schleswig-Holstein, Arnold-Heller-Str. 3 (Hs. 30); D-24105 Kiel, Germany.

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http://dx.doi.org/10.2217/pgs.09.128DOI Listing
December 2009

DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses.

J Cell Sci 2009 Oct;122(Pt 19):3522-30

Institute of Clinical Molecular Biology, Christian-Albrechts-University, 24105 Kiel, Germany.

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http://dx.doi.org/10.1242/jcs.050690DOI Listing
October 2009

A role for membrane-bound CD147 in NOD2-mediated recognition of bacterial cytoinvasion.

J Cell Sci 2008 Feb;121(Pt 4):487-95

Institute for Clinical Molecular Biology, University Hospital Schleswig-Holstein, Campus Kiel, Schittenhelmstr 12, Kiel, Germany.

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http://dx.doi.org/10.1242/jcs.016980DOI Listing
February 2008

Gene-expression profiling of the early stages of MOG-induced EAE proves EAE-resistance as an active process.

J Neuroimmunol 2004 Jun;151(1-2):158-70

Department of Neurology, University of Rostock, Gehlsheimer Str. 20, Rostock D-18055, Germany.

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http://dx.doi.org/10.1016/j.jneuroim.2004.03.007DOI Listing
June 2004