Christian Siebold

Christian Siebold

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Christian Siebold

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Acylation-coupled lipophilic induction of polarisation (Acyl-cLIP): a universal assay for lipid transferase and hydrolase enzymes.

Chem Sci 2019 Oct 1;10(39):8995-9000. Epub 2019 Jul 1.

Department of Chemistry , Imperial College London , London , W12 0BZ , UK . Email: ; Email: ; Tel: +44 0207 5943752 ; Tel: +44 0207 5945821.

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http://dx.doi.org/10.1039/c9sc01785bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855259PMC
October 2019

Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling.

Curr Opin Struct Biol 2019 08 24;57:204-214. Epub 2019 Jun 24.

Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2019.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744280PMC
August 2019

iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition.

Proc Natl Acad Sci U S A 2019 08 8;116(35):17470-17479. Epub 2019 Aug 8.

Ludwig Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1909393116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717262PMC
August 2019

Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning.

Nat Commun 2019 08 15;10(1):3691. Epub 2019 Aug 15.

Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1038/s41467-019-11683-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695400PMC
August 2019

Biochemical mechanisms of vertebrate hedgehog signaling.

Development 2019 05 15;146(10). Epub 2019 May 15.

Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA

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http://dev.biologists.org/lookup/doi/10.1242/dev.166892
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http://dx.doi.org/10.1242/dev.166892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550017PMC
May 2019

Cholesterol Interaction Sites on the Transmembrane Domain of the Hedgehog Signal Transducer and Class F G Protein-Coupled Receptor Smoothened.

Structure 2019 03 27;27(3):549-559.e2. Epub 2018 Dec 27.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.str.2018.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408332PMC
March 2019

Calcium-sensing receptor residues with loss- and gain-of-function mutations are located in regions of conformational change and cause signalling bias.

Hum Mol Genet 2018 11;27(21):3720-3733

Academic Endocrine Unit, Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford OX3 7LJ, UK.

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http://dx.doi.org/10.1093/hmg/ddy263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196656PMC
November 2018

Cilia-Associated Oxysterols Activate Smoothened.

Mol Cell 2018 10;72(2):316-327.e5

Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765183069
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http://dx.doi.org/10.1016/j.molcel.2018.08.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503851PMC
October 2018

Calibration-free In Vitro Quantification of Protein Homo-oligomerization Using Commercial Instrumentation and Free, Open Source Brightness Analysis Software.

J Vis Exp 2018 07 17(137). Epub 2018 Jul 17.

Cellular Imaging Group, Wellcome Centre Human Genetics, University of Oxford; Division of Structural Biology, Wellcome Centre Human Genetics, University of Oxford; Dynamic Structural Virology Group, Biocruces Health Research Centre; IKERBASQUE, Basque Foundation for Science;

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http://dx.doi.org/10.3791/58157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126508PMC
July 2018

Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates.

Curr Opin Cell Biol 2018 04 18;51:81-88. Epub 2017 Dec 18.

Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09550674173013
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http://dx.doi.org/10.1016/j.ceb.2017.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949240PMC
April 2018

A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling.

Sci Signal 2018 02 20;11(518). Epub 2018 Feb 20.

Academic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LJ, UK.

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http://dx.doi.org/10.1126/scisignal.aan3714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166785PMC
February 2018

RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling.

Trends Cell Biol 2017 05 19;27(5):365-378. Epub 2016 Dec 19.

Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2016.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404723PMC
May 2017

Initiation of T cell signaling by CD45 segregation at 'close contacts'.

Nat Immunol 2016 May 21;17(5):574-582. Epub 2016 Mar 21.

Radcliffe Department of Medicine and MRC Human Immunology Unit, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, United Kingdom.

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http://dx.doi.org/10.1038/ni.3392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839504PMC
May 2016

Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.

Dev Cell 2015 Dec;35(5):537-552

Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584 CG Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2015.11.008DOI Listing
December 2015

Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein.

Nat Struct Mol Biol 2015 Jun 4;22(6):458-65. Epub 2015 May 4.

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/nsmb.3016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456160PMC
June 2015

Structural insights into proteoglycan-shaped Hedgehog signaling.

Proc Natl Acad Sci U S A 2013 Oct 23;110(41):16420-5. Epub 2013 Sep 23.

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1310097110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799379PMC
October 2013

Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub.

Science 2013 Jul 6;341(6141):77-80. Epub 2013 Jun 6.

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1126/science.1232322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730555PMC
July 2013

Structural insights into semaphorins and their receptors.

Semin Cell Dev Biol 2013 Mar 17;24(3):139-45. Epub 2012 Dec 17.

Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1016/j.semcdb.2012.11.003DOI Listing
March 2013

Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.

Nat Struct Mol Biol 2012 Dec 28;19(12):1293-9. Epub 2012 Oct 28.

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/nsmb.2416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590443PMC
December 2012

Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling.

Dev Cell 2011 Nov 13;21(5):848-61. Epub 2011 Oct 13.

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1016/j.devcel.2011.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564486PMC
November 2011

Automation of large scale transient protein expression in mammalian cells.

J Struct Biol 2011 Aug 6;175(2):209-15. Epub 2011 May 6.

Division of Structural Biology (STRUBI), Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX37BN, UK.

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http://dx.doi.org/10.1016/j.jsb.2011.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477309PMC
August 2011

Recording information on protein complexes in an information management system.

J Struct Biol 2011 Aug 14;175(2):224-9. Epub 2011 May 14.

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX37BN, UK.

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http://dx.doi.org/10.1016/j.jsb.2011.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477311PMC
August 2011

A dual binding mode for RhoGTPases in plexin signalling.

PLoS Biol 2011 Aug 30;9(8):e1001134. Epub 2011 Aug 30.

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1371/journal.pbio.1001134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166162PMC
August 2011

Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1.

Nat Struct Mol Biol 2011 Jul 10;18(8):886-93. Epub 2011 Jul 10.

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/nsmb.2081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430870PMC
July 2011

Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis.

Acta Crystallogr D Biol Crystallogr 2011 May 13;67(Pt 5):447-54. Epub 2011 Apr 13.

Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX39DS, England.

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http://dx.doi.org/10.1107/S0907444911007888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087623PMC
May 2011

Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension.

Science 2011 Apr 31;332(6028):484-8. Epub 2011 Mar 31.

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1200840
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http://dx.doi.org/10.1126/science.1200840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154093PMC
April 2011

Structural basis of semaphorin-plexin signalling.

Nature 2010 Oct 26;467(7319):1118-22. Epub 2010 Sep 26.

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1038/nature09468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587840PMC
October 2010

Interactions between Hedgehog proteins and their binding partners come into view.

Genes Dev 2010 Sep;24(18):2001-12

Department of Developmental Biology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1101/gad.1951710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939362PMC
September 2010

Crystal structure of enzyme I of the phosphoenolpyruvate sugar phosphotransferase system in the dephosphorylated state.

J Biol Chem 2009 Nov 28;284(48):33169-76. Epub 2009 Sep 28.

Departement für Chemie und Biochemie, Universität Bern, Freiestrasse 3, CH-3012 Bern, Switzerland.

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http://dx.doi.org/10.1074/jbc.M109.057612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785159PMC
November 2009

Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors.

J Mol Biol 2009 Oct 3;392(5):1125-32. Epub 2009 Aug 3.

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK.

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http://dx.doi.org/10.1016/j.jmb.2009.07.082DOI Listing
October 2009

Structural plasticity of eph receptor A4 facilitates cross-class ephrin signaling.

Structure 2009 Oct;17(10):1386-97

Division of Structural Biology, University of Oxford, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford, UK.

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http://dx.doi.org/10.1016/j.str.2009.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832735PMC
October 2009

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.

Nat Struct Mol Biol 2009 Jul 28;16(7):698-703. Epub 2009 Jun 28.

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/nsmb.1607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709225PMC
July 2009

Receptor protein tyrosine phosphatase micro: measuring where to stick.

Biochem Soc Trans 2008 Apr;36(Pt 2):167-72

Cancer Research UK Receptor Structure Research Group, University of Oxford, Henry Wellcome Building of Genomic Medicine, Division of Structural Biology, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1042/BST0360167DOI Listing
April 2008

Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73.

Structure 2008 Feb;16(2):259-68

Cancer Research UK Receptor Structure Research Group, Division of Structural Biology, Henry Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom.

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http://dx.doi.org/10.1016/j.str.2007.11.012DOI Listing
February 2008

Structure and functional analysis of the IGF-II/IGF2R interaction.

EMBO J 2008 Jan 29;27(1):265-76. Epub 2007 Nov 29.

Cancer Research UK Receptor Structure Research Group, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, UK.

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http://dx.doi.org/10.1038/sj.emboj.7601938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206120PMC
January 2008

Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism.

Science 2007 Aug;317(5842):1217-20

Cancer Research UK Receptor Structure Research Group, University of Oxford, Henry Wellcome Building of Genomic Medicine, Division of Structural Biology, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1126/science.1144646DOI Listing
August 2007

Structure of the fungal beta-glucan-binding immune receptor dectin-1: implications for function.

Protein Sci 2007 Jun 1;16(6):1042-52. Epub 2007 May 1.

CR-UK Receptor Structure Research Group, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom.

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http://doi.wiley.com/10.1110/ps.072791207
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http://dx.doi.org/10.1110/ps.072791207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2206667PMC
June 2007

A tick protein with a modified Kunitz fold inhibits human tryptase.

J Mol Biol 2007 May 14;368(4):1172-86. Epub 2007 Mar 14.

CEH, Mansfield Road, Oxford, OX1 3SR, UK.

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http://dx.doi.org/10.1016/j.jmb.2007.03.011DOI Listing
May 2007

MHC class II proteins and disease: a structural perspective.

Nat Rev Immunol 2006 Apr;6(4):271-82

Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, The University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.

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http://www.nature.com/articles/nri1805
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http://dx.doi.org/10.1038/nri1805DOI Listing
April 2006

Molecular analysis of receptor protein tyrosine phosphatase mu-mediated cell adhesion.

EMBO J 2006 Feb 2;25(4):701-12. Epub 2006 Feb 2.

Division of Structural Biology, Henry Wellcome Building of Genomic Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/sj.emboj.7600974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1383555PMC
February 2006

High-resolution structure of the catalytic region of MICAL (molecule interacting with CasL), a multidomain flavoenzyme-signaling molecule.

Proc Natl Acad Sci U S A 2005 Nov 7;102(46):16836-41. Epub 2005 Nov 7.

Cancer Research UK Receptor Structure Research Group, Division of Structural Biology, University of Oxford, UK.

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http://dx.doi.org/10.1073/pnas.0504997102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1277969PMC
November 2005

A procedure for setting up high-throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and optimization.

Acta Crystallogr D Biol Crystallogr 2005 Jun 26;61(Pt 6):651-7. Epub 2005 May 26.

Oxford Protein Production Facility, Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Headington, Oxford OX3 7BN, England.

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http://dx.doi.org/10.1107/S0907444905007808DOI Listing
June 2005

Crystal structure of the phosphoenolpyruvate-binding enzyme I-domain from the Thermoanaerobacter tengcongensis PEP: sugar phosphotransferase system (PTS).

J Mol Biol 2005 Feb 22;346(2):521-32. Epub 2004 Dec 22.

Department of Chemistry and Biochemistry, University of Berne, Freiestrasse 3, CH-3012 Bern, Switzerland.

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http://dx.doi.org/10.1016/j.jmb.2004.11.077DOI Listing
February 2005

Multiple sclerosis: MHC associations and therapeutic implications.

Expert Rev Mol Med 2005 Feb 14;7(3):1-17. Epub 2005 Feb 14.

Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, The University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1017/S1462399405008914DOI Listing
February 2005

The structure and function of the outer coat protein VP9 of Banna virus.

Structure 2005 Jan;13(1):17-28

Unité des Virus Emergents EA3292, EFS Alpes-Méditerranée and Faculté de Médecine, Université de la Méditerranée, 27 Bd Jean Moulin, 13005 Marseille, France.

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http://dx.doi.org/10.1016/j.str.2004.10.017DOI Listing
January 2005

Phosphoenolpyruvate- and ATP-dependent dihydroxyacetone kinases: covalent substrate-binding and kinetic mechanism.

Biochemistry 2004 Oct;43(41):13037-45

Department of Chemistry and Biochemistry and Laboratory for Chemical and Mineralogical Crystallography, University of Berne, CH-3012 Berne, Switzerland.

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http://dx.doi.org/10.1021/bi048575mDOI Listing
October 2004

Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy.

Proc Natl Acad Sci U S A 2004 Feb 9;101(7):1999-2004. Epub 2004 Feb 9.

Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.

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http://www.pnas.org/lookup/doi/10.1073/pnas.0308458100
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http://dx.doi.org/10.1073/pnas.0308458100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC357041PMC
February 2004

Crystal structure of the Citrobacter freundii dihydroxyacetone kinase reveals an eight-stranded alpha-helical barrel ATP-binding domain.

J Biol Chem 2003 Nov 9;278(48):48236-44. Epub 2003 Sep 9.

Departement für Chemie und Biochemie, Universität Bern, Freiestrasse 3, CH-3012 Bern, Switzerland.

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http://dx.doi.org/10.1074/jbc.M305942200DOI Listing
November 2003

A mechanism of covalent substrate binding in the x-ray structure of subunit K of the Escherichia coli dihydroxyacetone kinase.

Proc Natl Acad Sci U S A 2003 Jul 17;100(14):8188-92. Epub 2003 Jun 17.

Departement für Chemie und Biochemie, Universität Bern, Freiestrasse 3, CH-3012 Bern, Switzerland.

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http://dx.doi.org/10.1073/pnas.0932787100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC166204PMC
July 2003

Intein-mediated cyclization of a soluble and a membrane protein in vivo: function and stability.

Biophys Chem 2002 May;96(2-3):163-71

Departement für Chemie und Biochemie, Universität Bern, Bern, Switzerland.

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http://dx.doi.org/10.1016/s0301-4622(02)00012-1DOI Listing
May 2002

Mechanism-based inhibition of enzyme I of the Escherichia coli phosphotransferase system. Cysteine 502 is an essential residue.

J Biol Chem 2002 Mar 7;277(9):6934-42. Epub 2001 Dec 7.

Departement für Chemie und Biochemie and the Mass-Spectrometry Laboratory, Universität Bern, Freiestrasse 3, Bern CH-3012, Switzerland.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110067200
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http://dx.doi.org/10.1074/jbc.M110067200DOI Listing
March 2002