Publications by authors named "Christian Schnell"

61Publications

Induced pluripotent stem cells derived from the developing striatum as a potential donor source for cell replacement therapy for Huntington disease.

Authors:
Narawadee Choompoo Oliver J M Bartley Sophie V Precious Ngoc-Nga Vinh Christian Schnell Ana Garcia Victoria H Roberton Nigel M Williams Paul J Kemp Claire M Kelly Anne E Rosser

Cytotherapy 2020 Nov 24. Epub 2020 Nov 24.

Brain Repair Group, School of Biosciences, Cardiff University, Cardiff, UK; MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK; Wales Brain Repair and Intracranial Neurotherapeutics Unit, School of Medicine, Cardiff University, Cardiff, UK. Electronic address:

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November 2020

Time-resolved protein activation.

Authors:
Christian Schnell

Nat Methods 2019 07;16(7):579

Nature Methods, .

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July 2019

Spatially resolved isotope labeling.

Authors:
Christian Schnell

Nat Methods 2019 Apr;16(4):287

Nature Methods, .

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April 2019

Quantum imaging in biological samples.

Authors:
Christian Schnell

Nat Methods 2019 Mar;16(3):214

Nature Methods, .

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March 2019

Characterization and phase I study of CLR457, an orally bioavailable pan-class I PI3-kinase inhibitor.

Authors:
James J Harding Todd M Bauer Daniel S W Tan Philippe L Bedard Jordi Rodon Toshihiko Doi Christian Schnell Varsha Iyer Fabienne Baffert Rajkumar Radhakrishnan Claire Fabre Dejan Juric

Invest New Drugs 2019 04 3;37(2):271-281. Epub 2018 Aug 3.

Massachusetts General Hospital, 55 Fruit St, Boston, MA, 02114, USA.

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April 2019

A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response.

Authors:
Walther Haenseler Stephen N Sansom Julian Buchrieser Sarah E Newey Craig S Moore Francesca J Nicholls Satyan Chintawar Christian Schnell Jack P Antel Nicholas D Allen M Zameel Cader Richard Wade-Martins William S James Sally A Cowley

Stem Cell Reports 2017 06;8(6):1727-1742

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK; Oxford Parkinson's Disease Centre, University of Oxford, South Parks Road, Oxford OX1 3QX, UK. Electronic address:

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June 2017

Limitations of Sulforhodamine 101 for Brain Imaging.

Authors:
Swen Hülsmann Liya Hagos Heike Heuer Christian Schnell

Front Cell Neurosci 2017 28;11:44. Epub 2017 Feb 28.

DFG Research Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB) Göttingen, Germany.

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February 2017

Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA.

Authors:
Paul J Kemp David J Rushton Polina L Yarova Christian Schnell Charlene Geater Jane M Hancock Annalena Wieland Alis Hughes Luned Badder Emma Cope Daniela Riccardi Andrew D Randall Jonathan T Brown Nicholas D Allen Vsevolod Telezhkin

J Physiol 2016 11;594(22):6583-6594

School of Biosciences, Cardiff University, Cardiff, UK.

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November 2016

Increasing metabolic stability via the deuterium kinetic isotope effect: An example from a proline-amide-urea aminothiazole series of phosphatidylinositol-3 kinase alpha inhibitors.

Authors:
Robin A Fairhurst Giorgio Caravatti Vito Guagnano Reiner Aichholz Joachim Blanz Francesca Blasco Peter Wipfli Christine Fritsch Sauveur-Michel Maira Christian Schnell Frank H Seiler

Bioorg Med Chem Lett 2016 10 17;26(19):4729-4734. Epub 2016 Aug 17.

Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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October 2016

Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.

Authors:
Robin A Fairhurst Thomas H Marsilje Stefan Stutz Andreas Boos Michel Niklaus Bei Chen Songchun Jiang Wenshuo Lu Pascal Furet Clive McCarthy Frédéric Stauffer Vito Guagnano Andrea Vaupel Pierre-Yves Michellys Christian Schnell Sébastien Jeay

Bioorg Med Chem Lett 2016 Apr 26;26(8):2057-64. Epub 2016 Feb 26.

Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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April 2016

Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons.

Authors:
Vsevolod Telezhkin Christian Schnell Polina Yarova Sun Yung Emma Cope Alis Hughes Belinda A Thompson Philip Sanders Charlene Geater Jane M Hancock Shona Joy Luned Badder Natalie Connor-Robson Andrea Comella Marco Straccia Georgina Bombau Jon T Brown Josep M Canals Andrew D Randall Nicholas D Allen Paul J Kemp

Am J Physiol Cell Physiol 2016 Apr 30;310(7):C520-41. Epub 2015 Dec 30.

School of Biosciences, Cardiff University, Cardiff, United Kingdom;

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April 2016

A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis.

Authors:
Guido Bold Christian Schnell Pascal Furet Paul McSheehy Josef Brüggen Jürgen Mestan Paul W Manley Peter Drückes Marion Burglin Ursula Dürler Jacqueline Loretan Robert Reuter Markus Wartmann Andreas Theuer Beatrice Bauer-Probst Georg Martiny-Baron Peter Allegrini Arnaud Goepfert Jeanette Wood Amanda Littlewood-Evans

J Med Chem 2016 Jan 21;59(1):132-46. Epub 2015 Dec 21.

Oncology Research, Novartis Institutes for BioMedical Research , 4002 Basel, Switzerland.

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January 2016

Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R Inhibition.

Authors:
Barbara Herkert Audrey Kauffmann Sandra Mollé Christian Schnell Thomas Ferrat Hans Voshol Janina Juengert Hélène Erasimus Grégory Marszalek Malika Kazic-Legueux Eric Billy David Ruddy Mark Stump Daniel Guthy Mitko Ristov Keith Calkins Sauveur-Michel Maira William R Sellers Francesco Hofmann Michael N Hall Saskia M Brachmann

Cancer Res 2016 Jan 17;76(2):390-402. Epub 2015 Nov 17.

Novartis Institutes for Biomedical Research (NIBR), Disease Area Oncology, Basel, Switzerland.

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January 2016

Norepinephrine-induced calcium signaling in astrocytes in the respiratory network of the ventrolateral medulla.

Authors:
Christian Schnell Mahmoud Negm Johannes Driehaus Anja Scheller Swen Hülsmann

Respir Physiol Neurobiol 2016 06 2;226:18-23. Epub 2015 Nov 2.

DFG Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Göttingen, Germany; Clinic for Anesthesiology, University Hospital Göttingen, 37099 Göttingen, Germany. Electronic address:

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June 2016

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response.

Authors:
Hui Gao Joshua M Korn Stéphane Ferretti John E Monahan Youzhen Wang Mallika Singh Chao Zhang Christian Schnell Guizhi Yang Yun Zhang O Alejandro Balbin Stéphanie Barbe Hongbo Cai Fergal Casey Susmita Chatterjee Derek Y Chiang Shannon Chuai Shawn M Cogan Scott D Collins Ernesta Dammassa Nicolas Ebel Millicent Embry John Green Audrey Kauffmann Colleen Kowal Rebecca J Leary Joseph Lehar Ying Liang Alice Loo Edward Lorenzana E Robert McDonald Margaret E McLaughlin Jason Merkin Ronald Meyer Tara L Naylor Montesa Patawaran Anupama Reddy Claudia Röelli David A Ruddy Fernando Salangsang Francesca Santacroce Angad P Singh Yan Tang Walter Tinetto Sonja Tobler Roberto Velazquez Kavitha Venkatesan Fabian Von Arx Hui Qin Wang Zongyao Wang Marion Wiesmann Daniel Wyss Fiona Xu Hans Bitter Peter Atadja Emma Lees Francesco Hofmann En Li Nicholas Keen Robert Cozens Michael Rugaard Jensen Nancy K Pryer Juliet A Williams William R Sellers

Nat Med 2015 Nov 19;21(11):1318-25. Epub 2015 Oct 19.

Oncology Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.

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November 2015

Identification and optimisation of 4,5-dihydrobenzo[1,2-d:3,4-d]bisthiazole and 4,5-dihydrothiazolo[4,5-h]quinazoline series of selective phosphatidylinositol-3 kinase alpha inhibitors.

Authors:
Robin A Fairhurst Marc Gerspacher Patricia Imbach-Weese Robert Mah Giorgio Caravatti Pascal Furet Christine Fritsch Christian Schnell Joachim Blanz Francesca Blasco Sandrine Desrayaud Daniel A Guthy Mark Knapp Dorothee Arz Jasmin Wirth Esther Roehn-Carnemolla Van Huy Luu

Bioorg Med Chem Lett 2015 Sep 26;25(17):3575-81. Epub 2015 Jun 26.

Novartis Institutes for BioMedical Research, Global Discovery Chemistry, Novartis Pharma AG, Werk Klybeck, Postfach, CH-4002 Basel, Switzerland.

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September 2015

Genetic ablation of VIAAT in glycinergic neurons causes a severe respiratory phenotype and perinatal death.

Authors:
Jamilur Rahman Stefanie Besser Christian Schnell Volker Eulenburg Johannes Hirrlinger Sonja M Wojcik Swen Hülsmann

Brain Struct Funct 2015 Sep 16;220(5):2835-49. Epub 2014 Jul 16.

Institute for Neurophysiology and Cellular Biophysics, Georg-August-University Göttingen, Humboldtallee 23, 37073, Göttingen, Germany.

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September 2015

Targeting PI3K/mTOR overcomes resistance to HER2-targeted therapy independent of feedback activation of AKT.

Authors:
Neil A O'Brien Karen McDonald Luo Tong Erika von Euw Ondrej Kalous Dylan Conklin Sara A Hurvitz Emmanuelle di Tomaso Christian Schnell Ronald Linnartz Richard S Finn Samit Hirawat Dennis J Slamon

Clin Cancer Res 2014 Jul 30;20(13):3507-20. Epub 2014 May 30.

Authors' Affiliations: Division of Hematology/Oncology, Department of Medicine, Geffen School of Medicine at UCLA, Los Angeles, California;

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July 2014

Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials.

Authors:
Christine Fritsch Alan Huang Christian Chatenay-Rivauday Christian Schnell Anupama Reddy Manway Liu Audrey Kauffmann Daniel Guthy Dirk Erdmann Alain De Pover Pascal Furet Hui Gao Stephane Ferretti Youzhen Wang Joerg Trappe Saskia M Brachmann Sauveur-Michel Maira Christopher Wilson Markus Boehm Carlos Garcia-Echeverria Patrick Chene Marion Wiesmann Robert Cozens Joseph Lehar Robert Schlegel Giorgio Caravatti Francesco Hofmann William R Sellers

Mol Cancer Ther 2014 May 7;13(5):1117-29. Epub 2014 Mar 7.

Authors' Affiliations: Novartis Institutes for BioMedical Research, Disease Area Oncology; Novartis Institutes for BioMedical Research, Global Discovery Chemistry; Novartis Institutes for BioMedical Research, Center for Proteomic Chemistry; Novartis Pharma AG, Oncology Translational Medicine, Basel, Switzerland; Novartis Pharma AG, Oncology Translational Medicine; Novartis Institutes for BioMedical Research, Developmental and Molecular Pathways, Cambridge, Massachusetts; and Novartis Institutes for BioMedical Research, Developmental and Molecular Pathways, Shangai, China.

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May 2014

The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes.

Authors:
Christian Schnell Ali Shahmoradi Sven P Wichert Steffen Mayerl Yohannes Hagos Heike Heuer Moritz J Rossner Swen Hülsmann

Brain Struct Funct 2015 Jan 16;220(1):193-203. Epub 2013 Oct 16.

Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Göttingen, Germany.

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January 2015