Christian Reinhardt

Christian Reinhardt

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Christian Reinhardt

Christian Reinhardt

Publications by authors named "Christian Reinhardt"

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DNA double-strand break repair pathway choice - from basic biology to clinical exploitation.

Cell Cycle 2019 Jul 22;18(13):1423-1434. Epub 2019 May 22.

a Clinic I of Internal Medicine , University Hospital Cologne , Cologne , Germany.

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http://dx.doi.org/10.1080/15384101.2019.1618542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592229PMC
July 2019

Combined Targeted Resequencing of Cytosine DNA Methylation and Mutations of DNA Repair Genes with Potential Use for Poly(ADP-Ribose) Polymerase 1 Inhibitor Sensitivity Testing.

J Mol Diagn 2019 Mar 19;21(2):198-213. Epub 2018 Dec 19.

Department of Translational Epigenetics and Tumor Genetics, University Hospital Cologne, Cologne, Germany; Center for Molecular Medicine Cologne, University Hospital Cologne, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2018.10.007DOI Listing
March 2019

Unexpected role of natural killer cell-derived interferon-γ as a driver of NETosis and DVT.

J Thromb Haemost 2019 Feb;17(2):400-402

Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany.

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http://dx.doi.org/10.1111/jth.14368DOI Listing
February 2019

UBQLN4 promotes non-homologous end joining by repressing DNA end-resection.

Mol Cell Oncol 2019 20;6(2):1575692. Epub 2019 Feb 20.

Clinic I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

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http://dx.doi.org/10.1080/23723556.2019.1575692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512934PMC
February 2019

Oncogenic MYD88 mutations in lymphoma: novel insights and therapeutic possibilities.

Cancer Immunol Immunother 2018 Nov 11;67(11):1797-1807. Epub 2018 Sep 11.

Interfaculty Institute for Cell Biology, Department of Immunology, University of Tübingen, Auf der Morgenstelle 15, 72076, Tübingen, Germany.

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http://dx.doi.org/10.1007/s00262-018-2242-9DOI Listing
November 2018

DNA damage pathways and B-cell lymphomagenesis.

Curr Opin Hematol 2018 07;25(4):315-322

Department I of Internal Medicine, University Hospital of Cologne.

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http://dx.doi.org/10.1097/MOH.0000000000000433DOI Listing
July 2018

Increased Arterial Stiffness Might Be Caused by Sympathetic Activation.

Chest 2018 02;153(2):569

Respiratory Medicine/Cardiology, Lungenfachklinik Immenhausen, Immenhausen, Germany.

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http://dx.doi.org/10.1016/j.chest.2017.09.055DOI Listing
February 2018

Concepts of Chronic Lymphocytic Leukemia Pathogenesis: DNA Damage Response and Tumor Microenvironment.

Oncol Res Treat 2016 22;39(1-2):9-16. Epub 2016 Jan 22.

Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1159/000443820DOI Listing
December 2016

B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice.

Blood 2016 06 5;127(22):2732-41. Epub 2016 Apr 5.

Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, Cologne, Germany; Center of Integrated Oncology, University Hospital of Cologne, Cologne, Germany; and Center of Molecular Medicine, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1182/blood-2015-11-684183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891954PMC
June 2016

Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression.

PLoS One 2015 20;10(5):e0125745. Epub 2015 May 20.

Department I of Internal Medicine, University Hospital of Cologne, Weyertal 115B, 50931, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, Weyertal 115B, 50931, Cologne, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0125745PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439058PMC
February 2016

Editorial: Cancer-Associated Defects in the DNA Damage Response: Drivers for Malignant Transformation and Potential Therapeutic Targets.

Front Genet 2015 22;6:355. Epub 2015 Dec 22.

Department I of Internal Medicine, University Hospital CologneGermany; Cologne Graduate School of Ageing Research, University of CologneCologne, Germany.

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http://dx.doi.org/10.3389/fgene.2015.00355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686599PMC
January 2016

Comprehensive genomic profiles of small cell lung cancer.

Nature 2015 Aug 13;524(7563):47-53. Epub 2015 Jul 13.

1] Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany. [2] Department of Pathology, University Hospital Cologne, 50937 Cologne, Germany.

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http://dx.doi.org/10.1038/nature14664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861069PMC
August 2015

[Smoking cessation - what's new?--reply].

Dtsch Med Wochenschr 2015 Apr 31;140(7):528-9. Epub 2015 Mar 31.

Lungenfachklinik Immenhausen, pneumologische Lehrklinik Universitätsmedizin Göttingen.

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http://dx.doi.org/10.1055/s-0041-101238DOI Listing
April 2015

[Smoking cessation--what's new?].

Dtsch Med Wochenschr 2015 Feb 6;140(3):188-90. Epub 2015 Feb 6.

Lungenfachklinik Immenhausen, pneumologische Lehrklinik Universitätsmedizin Göttingen.

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http://dx.doi.org/10.1055/s-0041-100074DOI Listing
February 2015

Molecular pathways: exploiting tumor-specific molecular defects in DNA repair pathways for precision cancer therapy.

Clin Cancer Res 2014 Dec;20(23):5882-7

Department of Internal Medicine, University Hospital of Cologne, Cologne, Germany. Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1165DOI Listing
December 2014

Cancer-specific defects in DNA repair pathways as targets for personalized therapeutic approaches.

Trends Genet 2014 Aug 10;30(8):326-39. Epub 2014 Jul 10.

Department of Internal Medicine, University Hospital of Cologne, 50931 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, 50674 Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.tig.2014.06.003DOI Listing
August 2014

A functional cancer genomics screen identifies a druggable synthetic lethal interaction between MSH3 and PRKDC.

Cancer Discov 2014 May 20;4(5):592-605. Epub 2014 Feb 20.

1Department of Translational Genomics; 2Institute of Pathology; 3Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne; 4Department of Internal Medicine, University Hospital of Cologne, Cologne, Germany; and 5Michael F. Price Center, Albert Einstein College of Medicine, Bronx, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0907DOI Listing
May 2014

Cell-autonomous and non-cell-autonomous mechanisms of transformation by amplified FGFR1 in lung cancer.

Cancer Discov 2014 Feb 3;4(2):246-57. Epub 2013 Dec 3.

1Department of Translational Genomics, University of Cologne; 2Max-Planck-Institute for Neurological Research; Institutes of 3Pathology and 4Virology, University of Cologne;5Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne; 6Blackfield AG, Cologne; 7Technical University Dortmund, Dortmund, Germany; 8Medical Oncology and 9Institute of Pathology, Cantonal Hospital, Luzern; 10Novartis Pharma AG, Basel, Switzerland; and 11Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, India.

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http://cancerdiscovery.aacrjournals.org/cgi/doi/10.1158/2159
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http://dx.doi.org/10.1158/2159-8290.CD-13-0323DOI Listing
February 2014

A reversible gene-targeting strategy identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivo.

Cell Rep 2013 Nov 14;5(4):868-77. Epub 2013 Nov 14.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962842PMC
November 2013

Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response.

Nat Rev Mol Cell Biol 2013 Sep;14(9):563-80

David H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1038/nrm3640DOI Listing
September 2013

Posttranscriptional regulation of gene expression-adding another layer of complexity to the DNA damage response.

Front Genet 2012 25;3:159. Epub 2012 Aug 25.

Division of Hematology and Oncology, Center for Internal Medicine, University Hospital of Cologne Cologne, Germany.

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http://dx.doi.org/10.3389/fgene.2012.00159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427493PMC
October 2012

The p53 network: cellular and systemic DNA damage responses in aging and cancer.

Trends Genet 2012 Mar 20;28(3):128-36. Epub 2012 Jan 20.

Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, 50674 Cologne, Germany.

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http://dx.doi.org/10.1016/j.tig.2011.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120491PMC
March 2012

Is post-transcriptional stabilization, splicing and translation of selective mRNAs a key to the DNA damage response?

Cell Cycle 2011 Jan 1;10(1):23-7. Epub 2011 Jan 1.

University Hospital Cologne, Center for Internal Medicine, Division of Hematology and Oncology, Cologne, Germany.

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http://www.tandfonline.com/doi/abs/10.4161/cc.10.1.14351
Publisher Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048069PMC
http://dx.doi.org/10.4161/cc.10.1.14351DOI Listing
January 2011

Exploiting synthetic lethal interactions for targeted cancer therapy.

Cell Cycle 2009 Oct;8(19):3112-9

The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057180PMC
http://dx.doi.org/10.4161/cc.8.19.9626DOI Listing
October 2009

The combined status of ATM and p53 link tumor development with therapeutic response.

Genes Dev 2009 Aug 16;23(16):1895-909. Epub 2009 Jul 16.

The Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1101/gad.1815309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725944PMC
August 2009

Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.

Curr Opin Cell Biol 2009 Apr 21;21(2):245-55. Epub 2009 Feb 21.

David H Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09550674090002
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http://dx.doi.org/10.1016/j.ceb.2009.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699687PMC
April 2009

Cytokine-induced signaling networks prioritize dynamic range over signal strength.

Cell 2008 Oct;135(2):343-54

Koch Institute for Integrative Cancer Research, Center for Cell Decision Processes, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.cell.2008.08.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635014PMC
October 2008

14-3-3sigma controls mitotic translation to facilitate cytokinesis.

Nature 2007 Mar;446(7133):329-32

Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nature05584DOI Listing
March 2007

p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage.

Cancer Cell 2007 Feb;11(2):175-89

Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E18-580, Cambridge, MA 02139, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S153561080600382
Publisher Site
http://dx.doi.org/10.1016/j.ccr.2006.11.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742175PMC
February 2007