Christian P Speer

Christian P Speer

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Christian P Speer

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Ureaplasma species modulate cell adhesion molecules and growth factors in human brain microvascular endothelial cells.

Cytokine 2019 Sep 31;121:154737. Epub 2019 May 31.

University Childreńs Hospital, University of Wuerzburg, Josef-Schneider-Str. 2, 97080 Wuerzburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2019.154737DOI Listing
September 2019

An underestimated pathogen: Staphylococcus epidermidis induces pro-inflammatory responses in human alveolar epithelial cells.

Cytokine 2019 Jun 18;123:154761. Epub 2019 Jun 18.

University Children's Hospital, University of Wuerzburg, Wuerzburg, Germany.

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http://dx.doi.org/10.1016/j.cyto.2019.154761DOI Listing
June 2019

Late-onset sepsis caused by Gram-negative bacteria in very low birth weight infants: a systematic review.

Expert Rev Anti Infect Ther 2019 03 22;17(3):177-188. Epub 2019 Jan 22.

a University Children's Hospital , University of Wuerzburg , Wuerzburg , Germany.

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http://dx.doi.org/10.1080/14787210.2019.1568871DOI Listing
March 2019

More than just inflammation: Ureaplasma species induce apoptosis in human brain microvascular endothelial cells.

J Neuroinflammation 2019 Feb 14;16(1):38. Epub 2019 Feb 14.

University Children's Hospital, University of Wuerzburg, Josef-Schneider-Str. 2, 97080, Wuerzburg, Germany.

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http://dx.doi.org/10.1186/s12974-019-1413-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374915PMC
February 2019

Evaluation of the S100 protein A12 as a biomarker of neonatal sepsis.

J Matern Fetal Neonatal Med 2018 Dec 18:1-191. Epub 2018 Dec 18.

b University Children's Hospital , University of Würzburg , Würzburg , Germany.

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https://www.tandfonline.com/doi/full/10.1080/14767058.2018.1
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http://dx.doi.org/10.1080/14767058.2018.1560411DOI Listing
December 2018

Bo Sun and the Development of Neonatology in China.

Neonatology 2017 7;112(3):288-290. Epub 2017 Oct 7.

University Children's Hospital, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1159/000478083DOI Listing
November 2018

Progesterone Antagonizes Dexamethasone-Regulated Surfactant Proteins In Vitro.

Reprod Sci 2018 Oct 15:1933719118804668. Epub 2018 Oct 15.

2 University Children's Hospital, University of Wuerzburg, Wüerzburg, Germany.

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http://dx.doi.org/10.1177/1933719118804668DOI Listing
October 2018

Erratum versus Retraction.

Neonatology 2018 12;114(2):165. Epub 2018 Jun 12.

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http://dx.doi.org/10.1159/000489583DOI Listing
June 2018

New Threats from an Old Foe: Methicillin-Resistant Staphylococcus aureus Infections in Neonates.

Neonatology 2018 25;114(2):127-134. Epub 2018 May 25.

University Children's Hospital, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1159/000488582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159825PMC
May 2018

Editorial: Research Methods in Neonatal Medicine.

Neonatology 2018 14;114(1). Epub 2018 Mar 14.

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http://dx.doi.org/10.1159/000488092DOI Listing
March 2018

Ureaplasma-associated prenatal, perinatal, and neonatal morbidities.

Expert Rev Clin Immunol 2017 11 23;13(11):1073-1087. Epub 2017 Sep 23.

a University Children's Hospital , University of Wuerzburg , Wuerzburg , Germany.

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http://dx.doi.org/10.1080/1744666X.2017.1381559DOI Listing
November 2017

Secondary haemophagocytic lymphohistiocytosis triggered by postnatally acquired cytomegalovirus infection in a late preterm infant.

Infection 2017 Jun 16;45(3):355-359. Epub 2017 Jan 16.

Children's Hospital, University Hospital Wuerzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Germany.

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http://link.springer.com/10.1007/s15010-016-0970-3
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http://dx.doi.org/10.1007/s15010-016-0970-3DOI Listing
June 2017

Caffeine modulates glucocorticoid-induced expression of CTGF in lung epithelial cells and fibroblasts.

Respir Res 2017 03 23;18(1):51. Epub 2017 Mar 23.

University Children's Hospital, University of Wuerzburg, Josef-Schneider-Str. 2, 97080, Wuerzburg, Germany.

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http://dx.doi.org/10.1186/s12931-017-0535-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363056PMC
March 2017

Anti-inflammatory effects of the new generation synthetic surfactant CHF5633 on Ureaplasma-induced cytokine responses in human monocytes.

Expert Rev Anti Infect Ther 2017 02 18;15(2):181-189. Epub 2016 Nov 18.

a University Children´s Hospital , University of Wuerzburg , Wuerzburg , Germany.

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http://dx.doi.org/10.1080/14787210.2017.1259067DOI Listing
February 2017

A unique story in neonatal research: the development of a porcine surfactant.

Neonatology 2015 5;107(4):321-9. Epub 2015 Jun 5.

Section of Clinical Chemistry, Department of Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1159/000381117DOI Listing
April 2016

Early postnatal diagnosis of hereditary spherocytosis by combining light microscopy, acidified glycerol lysis test and eosin-5'-maleimide binding assay.

Ann Hematol 2015 Dec 4;94(12):1959-64. Epub 2015 Sep 4.

University Children's Hospital, University of Würzburg, Josef-Schneider-Straße 2, 97080, Würzburg, Germany.

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http://dx.doi.org/10.1007/s00277-015-2491-zDOI Listing
December 2015

Tore Curstedt - the basic science creator of porcine surfactant.

Neonatology 2014 5;106(3):242-4. Epub 2014 Oct 5.

University Children's Hospital, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1159/000365128DOI Listing
June 2015

Late-onset neonatal sepsis: recent developments.

Arch Dis Child Fetal Neonatal Ed 2015 May 25;100(3):F257-63. Epub 2014 Nov 25.

University Children's Hospital, University of Würzburg, Würzburg, Germany.

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http://fn.bmj.com/content/100/3/F257.full.pdf+html
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http://fn.bmj.com/lookup/doi/10.1136/archdischild-2014-30621
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http://dx.doi.org/10.1136/archdischild-2014-306213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413803PMC
May 2015

Neonatal CNS infection and inflammation caused by Ureaplasma species: rare or relevant?

Expert Rev Anti Infect Ther 2015 Feb;13(2):233-48

University Children's Hospital, University of Würzburg, Josef-Schneider-Str. 2, D-97080 Würzburg, Germany.

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http://dx.doi.org/10.1586/14787210.2015.999670DOI Listing
February 2015

Platelets in neonates: central mediators in haemostasis, antimicrobial defence and inflammation.

Thromb Haemost 2015 Jan 4;113(1):3-12. Epub 2014 Sep 4.

Dr. med. Oliver Andres, University Children's Hospital Würzburg, Josef-Schneider-Straße 2, 97080 Würzburg, Germany, Tel.: +49 931 201 27728, Fax: +49 931 201 6027799, E-mail:

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http://dx.doi.org/10.1160/TH14-05-0476DOI Listing
January 2015

Chorioamnionitis as a risk factor for retinopathy of prematurity: a systematic review and meta-analysis.

Neonatology 2014 24;105(3):189-99. Epub 2014 Jan 24.

Department of Paediatric Research, Oslo University Hospital, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1159/000357556DOI Listing
November 2014

The role of Staphylococcus epidermidis in neonatal sepsis: guarding angel or pathogenic devil?

Int J Med Microbiol 2014 Jul 6;304(5-6):513-20. Epub 2014 May 6.

University Children's Hospital, University of Würzburg, Würzburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijmm.2014.04.013DOI Listing
July 2014

Chorioamnionitis is essential in the evolution of bronchopulmonary dysplasia--the case in favour.

Paediatr Respir Rev 2014 Mar 13;15(1):49-52. Epub 2013 Oct 13.

University of Würzburg, University Children's Hospital, Josef-Schneider-Str. 2, 97080 Würzburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.prrv.2013.09.004DOI Listing
March 2014

European consensus guidelines on the management of neonatal respiratory distress syndrome in preterm infants--2013 update.

Neonatology 2013 31;103(4):353-68. Epub 2013 May 31.

Regional Neonatal Unit, Royal Maternity Hospital, Queen's University Belfast, Belfast, UK.

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http://dx.doi.org/10.1159/000349928DOI Listing
January 2014

Amplification of steroid-mediated SP-B expression by physiological levels of caffeine.

Am J Physiol Lung Cell Mol Physiol 2014 Jan 25;306(1):L101-9. Epub 2013 Oct 25.

Univ. Children's Hospital, Univ. of Wuerzburg, Josef-Schneider-Str. 2, D-97080 Wuerzburg, Germany.

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http://dx.doi.org/10.1152/ajplung.00257.2013DOI Listing
January 2014

Toll-like receptor signaling in neonatal sepsis and inflammation: a matter of orchestration and conditioning.

Expert Rev Clin Immunol 2013 Dec;9(12):1239-52

University Children's Hospital, University of Wuerzburg, Wuerzburg, Germany.

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http://dx.doi.org/10.1586/1744666X.2013.857275DOI Listing
December 2013

Surfactant therapy for neonatal respiratory distress syndrome in 2013.

J Matern Fetal Neonatal Med 2013 Oct;26 Suppl 2:27-9

Royal Maternity Hospital , Belfast , UK and.

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http://dx.doi.org/10.3109/14767058.2013.829695DOI Listing
October 2013

Surfactant therapy: past, present and future.

Early Hum Dev 2013 Jun;89 Suppl 1:S22-4

University Children's Hospital, University of Würzburg, Josef-Schneider-Strasse 2, Würzburg, Germany.

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http://dx.doi.org/10.1016/S0378-3782(13)70008-2DOI Listing
June 2013

Antenatal glucocorticoids counteract LPS changes in TGF-β pathway and caveolin-1 in ovine fetal lung.

Am J Physiol Lung Cell Mol Physiol 2013 Mar 18;304(6):L438-44. Epub 2013 Jan 18.

Department of Pediatrics, School for Oncology and Developmental Biology, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1152/ajplung.00251.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602746PMC
March 2013

IFN-γ and TNF-α synergize to inhibit CTGF expression in human lung endothelial cells.

PLoS One 2012 20;7(9):e45430. Epub 2012 Sep 20.

Orthopedic Center for Musculoskeletal Research, Molecular Orthopedics, University of Würzburg, Würzburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045430PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447888PMC
February 2013

Immunomodulatory properties of surfactant preparations.

Expert Rev Anti Infect Ther 2013 Jan;11(1):99-110

University Children's Hospital, University of Würzburg, Germany.

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http://dx.doi.org/10.1586/eri.12.156DOI Listing
January 2013

Lung endothelial cells strengthen, but brain endothelial cells weaken barrier properties of a human alveolar epithelium cell culture model.

Differentiation 2012 Nov 27;84(4):294-304. Epub 2012 Sep 27.

Department of Anaesthesia and Critical Care, University Hospital Wuerzburg, Germany.

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http://dx.doi.org/10.1016/j.diff.2012.08.006DOI Listing
November 2012

Familial pulmonary capillary hemangiomatosis early in life.

Case Rep Pulmonol 2011 19;2011:827591. Epub 2011 Dec 19.

University Children's Hospital, University of Wuerzburg, Josef-Schneider-Straße 2, 97080 Wuerzburg, Germany.

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https://www.hindawi.com/journals/cripu/2011/827591/
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http://dx.doi.org/10.1155/2011/827591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420428PMC
August 2012

Surfactant proteins A and D in pulmonary diseases of preterm infants.

Expert Rev Anti Infect Ther 2012 May;10(5):573-84

University Children's Hospital, Würzburg, Germany.

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http://dx.doi.org/10.1586/eri.12.34DOI Listing
May 2012

Chorioamnionitis--the good or the evil for neonatal outcome?

J Matern Fetal Neonatal Med 2012 Apr 5;25 Suppl 1:12-6. Epub 2012 Mar 5.

University Children's Hospital, University of Würzburg, Germany.

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http://dx.doi.org/10.3109/14767058.2012.663161DOI Listing
April 2012

Oxygen saturation in immature babies: revisited with updated recommendations.

Neonatology 2011 15;100(3):217-8. Epub 2011 Jul 15.

Department of Pediatric Research, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

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http://dx.doi.org/10.1159/000329845DOI Listing
March 2012

Mikko Hallman --a major translator of basic science into neonatal medicine.

Neonatology 2011 3;100(3):300-2. Epub 2011 Oct 3.

University Children's Hospital, University of Würzburg, Würzburg, Germany.

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https://www.karger.com/Article/FullText/329921
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http://dx.doi.org/10.1159/000329921DOI Listing
March 2012

Poractant alfa (Curosurf®) increases phagocytosis of apoptotic neutrophils by alveolar macrophages in vivo.

Respir Res 2012 Mar 9;13:17. Epub 2012 Mar 9.

Department of Pediatrics, School for Mental Health and Neuroscience (NUTRIM), School for Oncology and Developmental Biology (GROW), Maastricht University Medical Centre, Maastricht, The Netherlands.

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http://dx.doi.org/10.1186/1465-9921-13-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310829PMC
March 2012

Neonatal respiratory distress syndrome: an inflammatory disease?

Neonatology 2011 23;99(4):316-9. Epub 2011 Jun 23.

University Children's Hospital, Würzburg, Germany.

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http://dx.doi.org/10.1159/000326619DOI Listing
December 2011

Chorioamnionitis: important risk factor or innocent bystander for neonatal outcome?

Neonatology 2011 28;99(3):177-87. Epub 2010 Sep 28.

University Children's Hospital Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1159/000320170DOI Listing
August 2011

Airway angiopoietin-2 in ventilated very preterm infants: association with prenatal factors and neonatal outcome.

Pediatr Pulmonol 2011 Aug 18;46(8):777-84. Epub 2011 Feb 18.

University Children's Hospital, University of Würzburg, Germany.

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http://dx.doi.org/10.1002/ppul.21435DOI Listing
August 2011

Microbial pathogens causative of neonatal sepsis in Arabic countries.

J Matern Fetal Neonatal Med 2011 Aug 13;24(8):990-4. Epub 2011 Jun 13.

Pediatric Department, University Children's Hospital, Cairo University, Egypt.

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http://www.tandfonline.com/doi/full/10.3109/14767058.2010.53
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http://dx.doi.org/10.3109/14767058.2010.531330DOI Listing
August 2011

Infection of human coronary artery endothelial cells by group B streptococcus contributes to dysregulation of apoptosis, hemostasis, and innate immune responses.

Mediators Inflamm 2011 6;2011:971502. Epub 2011 Feb 6.

Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, D-97080 Wuerzburg, Germany.

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http://dx.doi.org/10.1155/2011/971502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061215PMC
July 2011

Funisitis is associated with increased interleukin-10 gene expression in cord blood mononuclear cells in preterm infants ≤32 weeks of gestation.

Eur J Obstet Gynecol Reprod Biol 2011 Mar 23;155(1):31-5. Epub 2010 Dec 23.

University Children's Hospital, University of Wuerzburg, Wuerzburg, Germany.

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http://dx.doi.org/10.1016/j.ejogrb.2010.11.013DOI Listing
March 2011

Response of leukocytes and nucleated red blood cells in very low-birth weight preterm infants after exposure to intrauterine inflammation.

J Matern Fetal Neonatal Med 2011 Feb 7;24(2):348-53. Epub 2010 Jul 7.

University Children's Hospital, University of Wuerzburg, Wuerzburg, Germany.

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http://dx.doi.org/10.3109/14767058.2010.497568DOI Listing
February 2011

Intrauterine growth retardation in preterm infants ≤32 weeks of gestation is associated with low white blood cell counts.

Am J Perinatol 2010 Nov 17;27(10):819-24. Epub 2010 May 17.

University Children's Hospital, University of Wuerzburg, Wuerzburg, Germany.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0030-1254547
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http://dx.doi.org/10.1055/s-0030-1254547DOI Listing
November 2010

Preface. Neonatology.

Neonatology 2009 4;95(4):340-1. Epub 2009 Jun 4.

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http://dx.doi.org/10.1159/000209298DOI Listing
September 2009

Chorioamnionitis, postnatal factors and proinflammatory response in the pathogenetic sequence of bronchopulmonary dysplasia.

Neonatology 2009 4;95(4):353-61. Epub 2009 Jun 4.

University Children's Hospital, Würzburg, Germany.

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http://dx.doi.org/10.1159/000209301DOI Listing
September 2009

Intravenous lipopolysaccharide-induced pulmonary maturation and structural changes in fetal sheep.

Am J Obstet Gynecol 2009 Feb 25;200(2):195.e1-10. Epub 2008 Dec 25.

Department of Pediatrics, Maastricht University Hospital Center, the Netherlands.

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http://dx.doi.org/10.1016/j.ajog.2008.09.009DOI Listing
February 2009

Editorial note: sources of neonatal medicine.

Neonatology 2008 9;94(3):143. Epub 2008 Jul 9.

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https://www.karger.com/Article/FullText/143392
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http://dx.doi.org/10.1159/000143392DOI Listing
January 2009

Ola Didrik Saugstad--an oxygen radical.

Neonatology 2008 2;94(3):188-9. Epub 2008 Oct 2.

University Children's Hospital, University of Wurzburg, Wurzburg, Germany.

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http://dx.doi.org/10.1159/000143720DOI Listing
January 2009

Serum and glucocorticoid-inducible kinase in pulmonary tissue of preterm fetuses exposed to chorioamnionitis.

Neonatology 2008 21;93(4):257-62. Epub 2007 Nov 21.

University Children's Hospital, University of Würzburg, Germany.

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https://www.karger.com/Article/FullText/111531
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http://dx.doi.org/10.1159/000111531DOI Listing
August 2008

Growth and development are similar in VLBW children born appropriate and small for gestational age: an interim report on 97 preschool children.

J Pediatr Endocrinol Metab 2007 Sep;20(9):1017-26

Paediatric Endocrinology Section, University Hospital for Children and Adolescents, Tuebingen, Germany.

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September 2007

Hirudin treatment for multiple thromboses in a preterm infant with inherited thrombophilia.

Blood Coagul Fibrinolysis 2007 Jun;18(4):381-3

University Children's Hospital, Wuerzburg, Germany.

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http://dx.doi.org/10.1097/MBC.0b013e3281139c44DOI Listing
June 2007

Prevention and therapy of bronchopulmonary dysplasia - evidence and clinical practice.

Zhongguo Dang Dai Er Ke Za Zhi 2007 Jun;9(3):264-77

University Children's Hospital, University of Wurzburg, Germany.

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June 2007

Antenatal inflammation induced TGF-beta1 but suppressed CTGF in preterm lungs.

Am J Physiol Lung Cell Mol Physiol 2007 Jan 25;292(1):L223-31. Epub 2006 Aug 25.

Department of Pediatrics, Academisch ziekenhuis Maastricht, Postbus 5800, 6202 AZ Maastricht, The Netherlands.

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http://dx.doi.org/10.1152/ajplung.00159.2006DOI Listing
January 2007

TGF-beta1 in SP-A preparations influence immune suppressive properties of SP-A on human CD4+ T lymphocytes.

Am J Physiol Lung Cell Mol Physiol 2006 Oct 28;291(4):L747-56. Epub 2006 Apr 28.

University Children's Hospital, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany.

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http://dx.doi.org/10.1152/ajplung.00401.2005DOI Listing
October 2006

Inflammation and bronchopulmonary dysplasia: a continuing story.

Semin Fetal Neonatal Med 2006 Oct 15;11(5):354-62. Epub 2006 May 15.

University Children's Hospital, Josef-Schneider-Str. 2, 97080 Wuerzburg, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S1744165X0600041
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http://dx.doi.org/10.1016/j.siny.2006.03.004DOI Listing
October 2006

Lucinactant versus poractant-alpha in premature lambs.

Pediatrics 2006 Jun;117(6):2324-5; author reply 2325

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http://dx.doi.org/10.1542/peds.2006-0469DOI Listing
June 2006