Publications by authors named "Christian N Parker"

39Publications

Two low complexity ultra-high throughput methods to identify diverse chemically bioactive molecules using Saccharomyces cerevisiae.

Authors:
Katarina Petrovic Martin Pfeifer Christian N Parker Sven Schuierer John Tallarico Dominic Hoepfner N Rao Movva Gunther Scheel Stephen B Helliwell

Microbiol Res 2017 Jun 21;199:10-18. Epub 2017 Feb 21.

Novartis Institutes for Biomedical Research, Novartis AG, Basel, Switzerland. Electronic address:

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June 2017

Screening of Intestinal Crypt Organoids: A Simple Readout for Complex Biology.

Authors:
Svenja Ley Olaf Galuba Adrian Salathe Nicolas Melin Alexandra Aebi Monika Pikiolek Judith Knehr Walter Carbone Martin Beibel Florian Nigsch Guglielmo Roma Giovanni d'Ario Susan Kirkland Laure C Bouchez Caroline Gubser Keller Tewis Bouwmeester Christian N Parker Heinz Ruffner

SLAS Discov 2017 06 6;22(5):571-582. Epub 2017 Jan 6.

1 Novartis Institutes for BioMedical Research (NIBR), Developmental and Molecular Pathways (DMP), Basel, Switzerland.

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June 2017

Jenkins-CI, an Open-Source Continuous Integration System, as a Scientific Data and Image-Processing Platform.

Authors:
Ioannis K Moutsatsos Imtiaz Hossain Claudia Agarinis Fred Harbinski Yann Abraham Luc Dobler Xian Zhang Christopher J Wilson Jeremy L Jenkins Nicholas Holway John Tallarico Christian N Parker

SLAS Discov 2017 03 13;22(3):238-249. Epub 2016 Dec 13.

3 Developmental and Molecular Pathways, NIBR, Postfach, Basel, Switzerland.

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March 2017

MiR-210 promotes sensory hair cell formation in the organ of corti.

Authors:
Sabrina Riccardi Sebastian Bergling Frederic Sigoillot Martin Beibel Annick Werner Juliet Leighton-Davies Judith Knehr Tewis Bouwmeester Christian N Parker Guglielmo Roma Bernd Kinzel

BMC Genomics 2016 Apr 27;17:309. Epub 2016 Apr 27.

Developmental and Molecular Pathways, Novartis Institute for Biomedical Research, Basel, Switzerland.

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April 2016

Recent advances in quantitative high throughput and high content data analysis.

Authors:
Ioannis K Moutsatsos Christian N Parker

Expert Opin Drug Discov 2016 9;11(4):415-23. Epub 2016 Mar 9.

a Novartis Institute of Biomedical Research , Novartis - Developmental and Molecular Pathways (DMP) , Basel , Switzerland.

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December 2016

Dark chemical matter as a promising starting point for drug lead discovery.

Authors:
Anne Mai Wassermann Eugen Lounkine Dominic Hoepfner Gaelle Le Goff Frederick J King Christian Studer John M Peltier Melissa L Grippo Vivian Prindle Jianshi Tao Ansgar Schuffenhauer Iain M Wallace Shanni Chen Philipp Krastel Amanda Cobos-Correa Christian N Parker John W Davies Meir Glick

Nat Chem Biol 2015 Dec 19;11(12):958-66. Epub 2015 Oct 19.

Novartis Institutes for BioMedical Research Inc., Cambridge, Massachusetts, USA.

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December 2015

FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p.

Authors:
Stephen B Helliwell Shantanu Karkare Marc Bergdoll Alain Rahier Juliet R Leighton-Davis Celine Fioretto Thomas Aust Ireos Filipuzzi Mathias Frederiksen John Gounarides Dominic Hoepfner Andreas Hofmann Pierre-Eloi Imbert Rolf Jeker Richard Knochenmuss Philipp Krastel Anais Margerit Klaus Memmert Charlotte V Miault N Rao Movva Alban Muller Hans-Ulrich Naegeli Lukas Oberer Vivian Prindle Ralph Riedl Sven Schuierer Jessica A Sexton Jianshi Tao Trixie Wagner Hong Yin Juan Zhang Silvio Roggo Stefan Reinker Christian N Parker

Nat Commun 2015 Oct 12;6:8613. Epub 2015 Oct 12.

Novartis Institutes for BioMedical Research, Novartis Campus, Basel, CH-4056, Switzerland.

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October 2015

YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors.

Authors:
Patricia Marti Claudia Stein Tanja Blumer Yann Abraham Michael T Dill Monika Pikiolek Vanessa Orsini Giorgia Jurisic Philippe Megel Zuzanna Makowska Claudia Agarinis Luigi Tornillo Tewis Bouwmeester Heinz Ruffner Andreas Bauer Christian N Parker Tobias Schmelzle Luigi M Terracciano Markus H Heim Jan S Tchorz

Hepatology 2015 Nov 25;62(5):1497-510. Epub 2015 Aug 25.

Novartis Institutes for Biomedical Research, Developmental and Molecular Pathways, Novartis Pharma AG, Basel, Switzerland.

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November 2015

Multiparametric Analysis of Screening Data: Growing Beyond the Single Dimension to Infinity and Beyond.

Authors:
Yann Abraham Xian Zhang Christian N Parker

J Biomol Screen 2014 Jun 5;19(5):628-39. Epub 2014 Mar 5.

Novartis Institute for Biomedical Research, Basel, Switzerland.

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June 2014

Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells.

Authors:
Sebastien Hannedouche Valerie Beck Juliet Leighton-Davies Martin Beibel Guglielmo Roma Edward J Oakeley Vincent Lannoy Jerome Bernard Jacques Hamon Samuel Barbieri Inga Preuss Marie-Christine Lasbennes Andreas W Sailer Thomas Suply Klaus Seuwen Christian N Parker Frederic Bassilana

J Biol Chem 2013 Sep 12;288(38):27434-43. Epub 2013 Aug 12.

From Novartis AG, Novartis Campus, CH-4056 Basel, Switzerland and.

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September 2013

Glucocorticoid receptor ligands modulate Cardiovirus encephalomyocarditis virus internal ribosome entry site activity.

Authors:
Marie-Cecile Didiot Claudia Agarinis Thibault Varin Hua Wu Thomas Nelson Douglas W Selinger Frederick King Ansgar Schuffenhauer Christian N Parker

Assay Drug Dev Technol 2013 Jul 1;11(6):355-66. Epub 2013 Aug 1.

Novartis Institute for Biomedical Research, Basel, Switzerland.

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July 2013

Identification of cardiac glycoside molecules as inhibitors of c-Myc IRES-mediated translation.

Authors:
Marie-Cecile Didiot Jeffrey Hewett Thibault Varin Felix Freuler Douglas Selinger Hanspeter Nick Juergen Reinhardt Alan Buckler Vic Myer Ansgar Schuffenhauer Chantale T Guy Christian N Parker

J Biomol Screen 2013 Apr 13;18(4):407-19. Epub 2012 Nov 13.

Novartis Institutes for Biomedical Research, Basel, CH-4056 Switzerland.

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April 2013

R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5.

Authors:
Heinz Ruffner Joëlle Sprunger Olga Charlat Juliet Leighton-Davies Bianka Grosshans Adrian Salathe Svenja Zietzling Valérie Beck Maxime Therier Andrea Isken Yang Xie Yue Zhang Huaixiang Hao Xiaoying Shi Dong Liu Qinhui Song Ieuan Clay Gabriele Hintzen Jan Tchorz Laure C Bouchez Gregory Michaud Peter Finan Vic E Myer Tewis Bouwmeester Jeff Porter Marc Hild Fred Bassilana Christian N Parker Feng Cong

PLoS One 2012 16;7(7):e40976. Epub 2012 Jul 16.

Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Postfach, Basel, Switzerland.

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January 2013

An integrated approach for identification and target validation of antifungal compounds active against Erg11p.

Authors:
Dominic Hoepfner Shantanu Karkare Stephen B Helliwell Martin Pfeifer Markus Trunzer Sophie De Bonnechose Alfred Zimmerlin Jianshi Tao Daryl Richie Andreas Hofmann Stefan Reinker Mathias Frederiksen N Rao Movva Jeffrey A Porter Neil S Ryder Christian N Parker

Antimicrob Agents Chemother 2012 Aug 21;56(8):4233-40. Epub 2012 May 21.

Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland.

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August 2012

Differentiation and visualization of diverse cellular phenotypic responses in primary high-content screening.

Authors:
Anne Kümmel Paul Selzer Daniela Siebert Isabel Schmidt Jürgen Reinhardt Marjo Götte Yvonne Ibig-Rehm Christian N Parker Daniela Gabriel

J Biomol Screen 2012 Jul 6;17(6):843-9. Epub 2012 Mar 6.

Modeling and Simulation, Novartis Campus, Basel, Switzerland.

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July 2012

Latent hit series hidden in high-throughput screening data.

Authors:
Thibault Varin Marie-Cecile Didiot Christian N Parker Ansgar Schuffenhauer

J Med Chem 2012 Feb 23;55(3):1161-70. Epub 2012 Jan 23.

Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus, CH-4056 Basel, Switzerland.

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February 2012

A screen for enhancers of clearance identifies huntingtin as a heat shock protein 90 (Hsp90) client protein.

Authors:
Barbara Baldo Andreas Weiss Christian N Parker Miriam Bibel Paolo Paganetti Klemens Kaupmann

J Biol Chem 2012 Jan 28;287(2):1406-14. Epub 2011 Nov 28.

Neuroscience Pathway, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4002 Basel, Switzerland.

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January 2012

Multiplexed reporter gene assays: monitoring the cell viability and the compound kinetics on luciferase activity.

Authors:
Marie-Cecile Didiot Sergio Serafini Martin J Pfeifer Frederick J King Christian N Parker

J Biomol Screen 2011 Aug 21;16(7):786-93. Epub 2011 Jun 21.

Novartis Institute for Biomedical Research, Basel, Switzerland.

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August 2011

Comparison of multivariate data analysis strategies for high-content screening.

Authors:
Anne Kümmel Paul Selzer Martin Beibel Hanspeter Gubler Christian N Parker Daniela Gabriel

J Biomol Screen 2011 Mar 18;16(3):338-47. Epub 2011 Feb 18.

Novartis Institutes of BioMedical Research, Basel, Switzerland.

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March 2011

Compound set enrichment: a novel approach to analysis of primary HTS data.

Authors:
Thibault Varin Hanspeter Gubler Christian N Parker Ji-Hu Zhang Pichai Raman Peter Ertl Ansgar Schuffenhauer

J Chem Inf Model 2010 Dec 12;50(12):2067-78. Epub 2010 Nov 12.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1, Novartis Campus, CH-4056 Basel, Switzerland, and 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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December 2010