Publications by authors named "Christian M Hedrich"

69Publications

Lupus IgG deposition causes arthritis but inhibits bone destruction through competitive occupation of FcγRI and reduced RANKL signalling.

Clin Transl Immunology 2020 6;9(9):e1174. Epub 2020 Sep 6.

Department of Rheumatology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cti2.1174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507387PMC
September 2020

SARS-CoV-2 infections in children and young people.

Clin Immunol 2020 11 6;220:108588. Epub 2020 Sep 6.

Department of Women's & Children's Health, Institute of Live Course and Medical Sciences, University of Liverpool, Liverpool, UK; Department of Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2020.108588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474910PMC
November 2020

COVID-19 in children and young people.

Lancet Rheumatol 2020 Sep 29;2(9):e514-e516. Epub 2020 Jun 29.

Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool L14 5AB, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2665-9913(20)30212-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324116PMC
September 2020

Urine and serum S100A8/A9 and S100A12 associate with active lupus nephritis and may predict response to rituximab treatment.

RMD Open 2020 07;6(2)

Department of Women's and Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/rmdopen-2020-001257DOI Listing
July 2020

New Insights into Adult and Paediatric Chronic Non-bacterial Osteomyelitis CNO.

Curr Rheumatol Rep 2020 Jul 23;22(9):52. Epub 2020 Jul 23.

Vivantes Klinikum Friedrichshain, Children's Hospital, Landsberger Allee 49, 10249, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11926-020-00928-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378119PMC
July 2020

Biosimilars in pediatric rheumatology and their introduction into routine care.

Clin Immunol 2020 Jul 1;216:108447. Epub 2020 May 1.

Department of Women's & Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, UK; Department of Pediatric Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2020.108447DOI Listing
July 2020

COVID-19: Immunology and treatment options.

Clin Immunol 2020 06 27;215:108448. Epub 2020 Apr 27.

Department of Women's & Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, UK; Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2020.108448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185015PMC
June 2020

COVID-19 - Considerations for the paediatric rheumatologist.

Clin Immunol 2020 05 10;214:108420. Epub 2020 Apr 10.

Department of Women's & Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, UK; Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2020.108420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151358PMC
May 2020

Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases.

J Clin Invest 2020 Apr;130(4):1669-1682

Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI129301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108905PMC
April 2020

High-dose intravenous methylprednisolone in juvenile non-infectious uveitis: A retrospective analysis.

Clin Immunol 2020 02 18;211:108327. Epub 2019 Dec 18.

Pediatric Rheumatology, Department of Pediatrics, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Germany; Department of Women's & Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom; Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2019.108327DOI Listing
February 2020

Orbital inflammation and colitis in pediatric IgG4-related disease: A case report and review of the literature.

Eur J Rheumatol 2019 Dec 3:1-7. Epub 2019 Dec 3.

Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5152/eurjrheum.2019.19165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004272PMC
December 2019

Linking genetic variation with epigenetic profiles in Sjögren's syndrome.

Clin Immunol 2020 01 22;210:108314. Epub 2019 Nov 22.

Laboratory of Immunology and Immunotherapy, Brest University Medical School Hospital, Brest, France; UMR1227, Lymphocytes B et Autoimmunité, Université de Brest, INSERM, CHU de Brest, Brest, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2019.108314DOI Listing
January 2020

cAMP Response Element Modulator α Induces Dual Specificity Protein Phosphatase 4 to Promote Effector T Cells in Juvenile-Onset Lupus.

J Immunol 2019 12 25;203(11):2807-2816. Epub 2019 Oct 25.

Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Carl Gustav Carus, TU Dresden, D01307 Dresden, Germany;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1900760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864280PMC
December 2019

Innately Adaptive or Truly Autoimmune: Is There Something Unique About Systemic Juvenile Idiopathic Arthritis?

Arthritis Rheumatol 2020 02 2;72(2):210-219. Epub 2020 Jan 2.

University of Munster, Munster, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.41107DOI Listing
February 2020

Mast cells enhance sterile inflammation in chronic nonbacterial osteomyelitis.

Dis Model Mech 2019 08 20;12(8). Epub 2019 Aug 20.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dmm.040097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737947PMC
August 2019

SNPs talk to genes using landlines: long-range chromatin interactions link genetic risk with epigenetic patterns in Takayasu arteritis.

Ann Rheum Dis 2019 10 7;78(10):1293-1295. Epub 2019 Aug 7.

Division of Rheumatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/annrheumdis-2019-215957DOI Listing
October 2019

The German National Registry of Primary Immunodeficiencies (2012-2017).

Authors:
Sabine M El-Helou Anika-Kerstin Biegner Sebastian Bode Stephan R Ehl Maximilian Heeg Maria E Maccari Henrike Ritterbusch Carsten Speckmann Stephan Rusch Raphael Scheible Klaus Warnatz Faranaz Atschekzei Renata Beider Diana Ernst Stev Gerschmann Alexandra Jablonka Gudrun Mielke Reinhold E Schmidt Gesine Schürmann Georgios Sogkas Ulrich H Baumann Christian Klemann Dorothee Viemann Horst von Bernuth Renate Krüger Leif G Hanitsch Carmen M Scheibenbogen Kirsten Wittke Michael H Albert Anna Eichinger Fabian Hauck Christoph Klein Anita Rack-Hoch Franz M Sollinger Anne Avila Michael Borte Stephan Borte Maria Fasshauer Anja Hauenherm Nils Kellner Anna H Müller Anett Ülzen Peter Bader Shahrzad Bakhtiar Jae-Yun Lee Ursula Heß Ralf Schubert Sandra Wölke Stefan Zielen Sujal Ghosh Hans-Juergen Laws Jennifer Neubert Prasad T Oommen Manfred Hönig Ansgar Schulz Sandra Steinmann Klaus Schwarz Gregor Dückers Beate Lamers Vanessa Langemeyer Tim Niehues Sonu Shai Dagmar Graf Carmen Müglich Marc T Schmalzing Eva C Schwaneck Hans-Peter Tony Johannes Dirks Gabriele Haase Johannes G Liese Henner Morbach Dirk Foell Antje Hellige Helmut Wittkowski Katja Masjosthusmann Michael Mohr Linda Geberzahn Christian M Hedrich Christiane Müller Angela Rösen-Wolff Joachim Roesler Antje Zimmermann Uta Behrends Nikolaus Rieber Uwe Schauer Rupert Handgretinger Ursula Holzer Jörg Henes Lothar Kanz Christoph Boesecke Jürgen K Rockstroh Carolynne Schwarze-Zander Jan-Christian Wasmuth Dagmar Dilloo Brigitte Hülsmann Stefan Schönberger Stefan Schreiber Rainald Zeuner Tobias Ankermann Philipp von Bismarck Hans-Iko Huppertz Petra Kaiser-Labusch Johann Greil Donate Jakoby Andreas E Kulozik Markus Metzler Nora Naumann-Bartsch Bettina Sobik Norbert Graf Sabine Heine Robin Kobbe Kai Lehmberg Ingo Müller Friedrich Herrmann Gerd Horneff Ariane Klein Joachim Peitz Nadine Schmidt Stefan Bielack Ute Groß-Wieltsch Carl F Classen Jessica Klasen Peter Deutz Dirk Kamitz Lisa Lassay Klaus Tenbrock Norbert Wagner Benedikt Bernbeck Bastian Brummel Eusebia Lara-Villacanas Esther Münstermann Dominik T Schneider Nadine Tietsch Marco Westkemper Michael Weiß Christof Kramm Ingrid Kühnle Silke Kullmann Hermann Girschick Christof Specker Elisabeth Vinnemeier-Laubenthal Henriette Haenicke Claudia Schulz Lothar Schweigerer Thomas G Müller Martina Stiefel Bernd H Belohradsky Veronika Soetedjo Gerhard Kindle Bodo Grimbacher

Front Immunol 2019 19;10:1272. Epub 2019 Jul 19.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2019.01272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659583PMC
October 2020

The Role of Epigenetics in Autoimmune/Inflammatory Disease.

Front Immunol 2019 4;10:1525. Epub 2019 Jul 4.

Department of Women's and Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2019.01525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620790PMC
October 2020

The role of epigenetics in paediatric rheumatic disease.

Curr Opin Rheumatol 2019 09;31(5):450-463

Department of Women's and Children's Health, Institute of Translational Medicine, University of Liverpool.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/BOR.0000000000000627DOI Listing
September 2019

Vasculitis in Juvenile-Onset Systemic Lupus Erythematosus.

Front Pediatr 2019 9;7:149. Epub 2019 May 9.

Department of Women and Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fped.2019.00149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521594PMC
May 2019

Interference of canakinumab with commercial IL-1β ELISAs.

Clin Immunol 2019 08 13;205:6-7. Epub 2019 May 13.

Department of Pediatrics, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2019.05.008DOI Listing
August 2019

Childhood Vasculitis.

Front Pediatr 2018 10;6:421. Epub 2019 Jan 10.

Pädiatrische Rheumatologie, Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Carl Gustav Carus, TU Dresden, Dresden, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fped.2018.00421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335362PMC
January 2019

Kawasaki Disease.

Front Pediatr 2018 10;6:198. Epub 2018 Jul 10.

Zentrum für Pädiatrische Rheumatologie am Klinikum Stuttgart, Stuttgart, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fped.2018.00198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048561PMC
July 2018

Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)-LRR oligomerization interface.

J Allergy Clin Immunol 2018 12 17;142(6):1956-1967.e6. Epub 2018 May 17.

Inflammation Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia; Department of Medical Biology, University of Melbourne, Parkville, Australia; Immunology Laboratory, Guangzhou Institute of Paediatrics, Guangzhou, China. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00916749183071
Publisher Site
http://dx.doi.org/10.1016/j.jaci.2018.04.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281029PMC
December 2018

Juvenile-onset systemic lupus erythematosus (jSLE) - Pathophysiological concepts and treatment options.

Best Pract Res Clin Rheumatol 2017 08 1;31(4):488-504. Epub 2018 Mar 1.

Department of Women's & Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, UK; Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.berh.2018.02.001DOI Listing
August 2017

Cell-Specific Requirements for STAT Proteins and Type I IFN Receptor Signaling Discretely Regulate IL-24 and IL-10 Expression in NK Cells and Macrophages.

J Immunol 2018 03 7;200(6):2154-2164. Epub 2018 Feb 7.

Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205; and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1701340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840025PMC
March 2018

SLE-Associated Defects Promote Altered T Cell Function.

Crit Rev Immunol 2017 ;37(1):39-58

Department of Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://www.dl.begellhouse.com/journals/2ff21abf44b19838,7906
Publisher Site
http://dx.doi.org/10.1615/CritRevImmunol.2018025213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314197PMC
April 2019

An optimized whole blood assay measuring expression and activity of NLRP3, NLRC4 and AIM2 inflammasomes.

Clin Immunol 2018 06 26;191:100-109. Epub 2017 Nov 26.

Department of Pediatrics, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2017.11.011DOI Listing
June 2018

Chronic Recurrent Multifocal Osteomyelitis (CRMO): Presentation, Pathogenesis, and Treatment.

Curr Osteoporos Rep 2017 12;15(6):542-554

Pediatric Rheumatology and Immunology, Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11914-017-0405-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705736PMC
December 2017

Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016.

Authors:
Rhea van den Bruck Patrick P Weil Thomas Ziegenhals Philipp Schreiner Stefan Juranek Daniel Gödde Silvia Vogel Frauke Schuster Valerie Orth Johannes Dörner Daniel Pembaur Meike Röper Stefan Störkel Hubert Zirngibl Stefan Wirth Andreas C W Jenke Jan Postberg Nikolas Boy Jana Heringer Gisela Haege Esther M Glahn Georg F Hoffmann Sven F Garbade Peter Burgard Stefan Kölker Cho-Ming Chao Faady Yahya Alena Moiseenko Amit Shrestha Negah Ahmadvand Jennifer Quantius Jochen Wilhelm Elie El-Agha Klaus-Peter Zimmer Saverio Bellusci Christian Staufner Stefan Kölker Holger Prokisch Georg F Hoffmann Stephan Seeliger Matthias Müller Andreas Hippe Henrik Steinkraus Roland Wauer Burkhard Lachmann Sigrun R Hofmann Christian M Hedrich Jakob Zierk Farhad Arzideh Rainer Haeckel Wolfgang Rascher Manfred Rauh Markus Metzler Sebastian Thieme Joanna Bandoła Cornelia Richter Martin Ryser Arshad Jamal Michelle P Ashton Malte von Bonin Matthias Kuhn Christian M Hedrich Ezio Bonifacio Reinhard Berner Sebastian Brenner Johanna Hammersen Cristina Has Nora Naumann-Bartsch Daniel Stachel Dimitra Kiritsi Stephan Söder Mathilde Tardieu Markus Metzler Leena Bruckner-Tuderman Holm Schneider F Bohne D Langer R Cencic T Eggermann U Zechner J Pelletier F Zepp T Enklaar D Prawitt Martin Pech Markus Weckmann Femke-Anouska Heinsen Andre Franke Christine Happle Anna-Maria Dittrich Gesine Hansen Oliver Fuchs Erika von Mutius Brian G Oliver Matthias V Kopp Claudia Paret Alexandra Russo Johanna Theruvath Bettina Keller Khalifa El Malki Nadine Lehmann Arthur Wingerter Marie A Neu Gerhold-Ay Aslihan Wolfgang Wagner Clemens Sommer Torsten Pietsch Larissa Seidmann Jörg Faber Felix Schreiner Merle Ackermann Michael Michalik Eva Rother Andras Bilkei-Gorzo Ildiko Racz Laura Bindila Beat Lutz Jörg Dötsch Andreas Zimmer Joachim Woelfle Hendrik S Fischer Tim L Ullrich Christoph Bührer Christoph Czernik Gerd Schmalisch Robert Stein Sigrun R Hofmann Judith Hagenbuchner Ursula Kiechl-Kohlendorfer Petra Obexer Michael J Ausserlechner Niki T Loges Adrien Tobias Frommer Julia Wallmeier Heymut Omran Soner Öner-Sieben Martina Gimpfl Jan Rozman Martin Irmler Johannes Beckers Martin Hrabe De Angelis Adelbert Roscher Eckhard Wolf Regina Ensenauer Karolina Nemes Michael Frühwald Martin Hasselblatt Reiner Siebert Uwe Kordes Marcel Kool Haicui Wang Holly Hardy Osama Refai Katy E S Barwick Holly H Zimmerman Joachim Weis Emma L Baple Andrew H Crosby Sebahattin Cirak C Hellmuth O Uhl M Standl J Heinrich E Thiering B Koletzko Lena Blümel Kornelius Kerl Daniel Picard Michael C Frühwald Max C Liebau Guido Reifenberger Arndt Borkhardt Martin Hasselblatt Marc Remke D Tews M Wabitsch P Fischer-Posovszky Mike-Andrew Westhoff Lisa Nonnenmacher Julia Langhans Lukas Schneele Nancy Trenkler Klaus-Michael Debatin

Mol Cell Pediatr 2017 May;4(Suppl 1)

Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40348-017-0071-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435609PMC
May 2017

Treatment Response and Longterm Outcomes in Children with Chronic Nonbacterial Osteomyelitis.

J Rheumatol 2017 07 1;44(7):1058-1065. Epub 2017 May 1.

From the Pediatric Rheumatology and Immunology Section, Department of Pediatrics, and Department of Radiology, and the Institute for Medical Informatics and Biometry, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3899/jrheum.161255DOI Listing
July 2017

Childhood primary large vessel CNS vasculitis: single-centre experience and review of the literature.

Clin Exp Rheumatol 2017 Mar-Apr;35 Suppl 103(1):213-220. Epub 2017 Mar 28.

Klinik- und Poliklinik für Kinder- und Jugendmedizin, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Germany.

View Article

Download full-text PDF

Source
July 2017

DNA methylation in systemic lupus erythematosus.

Epigenomics 2017 04 25;9(4):505-525. Epub 2016 Nov 25.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/epi-2016-0096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040049PMC
April 2017

Chronic Nonbacterial Osteomyelitis: Pathophysiological Concepts and Current Treatment Strategies.

J Rheumatol 2016 11 1;43(11):1956-1964. Epub 2016 Sep 1.

From the Pediatric Rheumatology and Immunology, Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden; Department of Pediatrics, University of Würzburg, Würzburg; Children's Hospital, Vivantes Klinikum-Friedrichshain, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3899/jrheum.160256DOI Listing
November 2016

Shaping the spectrum - From autoinflammation to autoimmunity.

Clin Immunol 2016 Apr 3;165:21-8. Epub 2016 Mar 3.

Pediatric Rheumatology and Immunology Section, Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307 Dresden, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2016.03.002DOI Listing
April 2016

Fluorescent tags influence the enzymatic activity and subcellular localization of procaspase-1.

Clin Immunol 2015 Oct 27;160(2):172-9. Epub 2015 May 27.

Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2015.05.011DOI Listing
October 2015

Current understanding of the pathophysiology of systemic juvenile idiopathic arthritis (sJIA) and target-directed therapeutic approaches.

Clin Immunol 2015 Jul 6;159(1):72-83. Epub 2015 May 6.

Pediatric Rheumatology and Immunology, Children's Hospital Dresden, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2015.04.018DOI Listing
July 2015

Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling.

Proc Natl Acad Sci U S A 2014 Sep 3;111(37):13457-62. Epub 2014 Sep 3.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1408023111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169908PMC
September 2014

Epigenetic regulation of cytokine expression in systemic lupus erythematosus with special focus on T cells.

Autoimmunity 2014 Jun 24;47(4):234-41. Epub 2014 Apr 24.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, Massachusetts , USA.

View Article

Download full-text PDF

Source
http://www.tandfonline.com/doi/full/10.3109/08916934.2013.80
Publisher Site
http://dx.doi.org/10.3109/08916934.2013.801462DOI Listing
June 2014

Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO).

Pediatr Rheumatol Online J 2013 Dec 23;11(1):47. Epub 2013 Dec 23.

Division of Pediatric Rheumatology and Immunology, Children's Hospital Dresden, University Medical Center Carl Gustav Carus, TU Dresden, Dresden, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1546-0096-11-47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881012PMC
December 2013

A clinical and pathomechanistic profile of chronic nonbacterial osteomyelitis/chronic recurrent multifocal osteomyelitis and challenges facing the field.

Expert Rev Clin Immunol 2013 Sep;9(9):845-54

Department of Medicine, Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/1744666X.2013.824670DOI Listing
September 2013

cAMP-responsive element modulator α (CREMα) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease.

J Biol Chem 2013 Nov 18;288(44):31880-7. Epub 2013 Sep 18.

From the Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M113.508655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814780PMC
November 2013

Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling.

J Biol Chem 2013 Sep 5;288(37):26775-84. Epub 2013 Aug 5.

From the Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M113.483743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772223PMC
September 2013

Gene-function studies in systemic lupus erythematosus.

Nat Rev Rheumatol 2013 Aug 4;9(8):476-84. Epub 2013 Jun 4.

Division of Rheumatology, Beth Israel Deaconess Medical Centre, Harvard Medical School, 330 Brookline Avenue, Dana 517-C, Boston, MA 02215, USA. jcrispin@ bidmc.harvard.edu

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrrheum.2013.78DOI Listing
August 2013

Bridging the gap between autoinflammation and autoimmunity.

Clin Immunol 2013 Jun 26;147(3):151-4. Epub 2013 Mar 26.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2013.03.006DOI Listing
June 2013

cAMP responsive element modulator: a critical regulator of cytokine production.

Trends Mol Med 2013 Apr 13;19(4):262-9. Epub 2013 Mar 13.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmed.2013.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891595PMC
April 2013

Autoinflammatory bone disorders.

Clin Immunol 2013 Jun 5;147(3):185-96. Epub 2013 Jan 5.

Department of Pediatrics, University of Würzburg, Würzburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2012.12.012DOI Listing
June 2013

cAMP-responsive element modulator α (CREMα) contributes to decreased Notch-1 expression in T cells from patients with active systemic lupus erythematosus (SLE).

J Biol Chem 2012 Dec 2;287(51):42525-32. Epub 2012 Nov 2.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M112.425371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522254PMC
December 2012

cAMP response element modulator α controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus.

Proc Natl Acad Sci U S A 2012 Oct 26;109(41):16606-11. Epub 2012 Sep 26.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1210129109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478624PMC
October 2012

CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances RORγt recruitment to the IL17A promoter in human T lymphocytes.

J Biol Chem 2012 Nov 18;287(45):38168-77. Epub 2012 Sep 18.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess MedicalCenter, Harvard Medical School, Boston, Massachusetts 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M112.415067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488086PMC
November 2012

Attenuated TLR4/MAPK signaling in monocytes from patients with CRMO results in impaired IL-10 expression.

Clin Immunol 2012 Oct 4;145(1):69-76. Epub 2012 Aug 4.

Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, D-01307 Dresden, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2012.07.012DOI Listing
October 2012

Update: Cytokine Dysregulation in Chronic Nonbacterial Osteomyelitis (CNO).

Int J Rheumatol 2012 21;2012:310206. Epub 2012 May 21.

Department of Pediatrics, University Hospital Carl Gustav Carus, Fetscherstra β e 74, 01307 Dresden, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2012/310206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364585PMC
August 2012

Increased expression of SLAM receptors SLAMF3 and SLAMF6 in systemic lupus erythematosus T lymphocytes promotes Th17 differentiation.

J Immunol 2012 Feb 19;188(3):1206-12. Epub 2011 Dec 19.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1102773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262878PMC
February 2012

cAMP-responsive element modulator α (CREMα) suppresses IL-17F protein expression in T lymphocytes from patients with systemic lupus erythematosus (SLE).

J Biol Chem 2012 Feb 19;287(7):4715-25. Epub 2011 Dec 19.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M111.323261
Publisher Site
http://dx.doi.org/10.1074/jbc.M111.323261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281648PMC
February 2012

cAMP-responsive element modulator (CREM)α protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus.

J Biol Chem 2011 Dec 24;286(50):43437-46. Epub 2011 Oct 24.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111.299313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234851PMC
December 2011

cAMP-responsive element modulator (CREM)α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus.

J Biol Chem 2011 Dec 5;286(50):43429-36. Epub 2011 Oct 5.

Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111.299339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234875PMC
December 2011

Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases.

Trends Mol Med 2011 Dec 30;17(12):714-24. Epub 2011 Aug 30.

Department of Medicine, Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmed.2011.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225699PMC
December 2011

Dynamic DNA methylation patterns across the mouse and human IL10 genes during CD4+ T cell activation; influence of IL-27.

Mol Immunol 2010 Nov-Dec;48(1-3):73-81. Epub 2010 Oct 16.

Johns Hopkins Bloomberg School of Public Health, Department of Molecular Microbiology and Immunology, N. Wolfe Street, E5410, Baltimore, MD 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molimm.2010.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993837PMC
January 2011

Cell type-specific regulation of IL-10 expression in inflammation and disease.

Immunol Res 2010 Jul;47(1-3):185-206

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Room E5624, Baltimore, MD 21205-1901, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12026-009-8150-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892196PMC
July 2010

A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome.

Proc Natl Acad Sci U S A 2009 Oct 9;106(40):17123-8. Epub 2009 Sep 9.

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205-1901, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0904955106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761349PMC
October 2009