Publications by authors named "Christian Klein"

100Publications

Anti-CD20 treatment for B-cell malignancies: current status and future directions.

Expert Opin Biol Ther 2020 Sep 15. Epub 2020 Sep 15.

F. Hoffmann-La Roche Ltd , Basel, Switzerland.

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http://dx.doi.org/10.1080/14712598.2020.1822318DOI Listing
September 2020

The fluorescence of resin-based composites: An analysis after ten years of aging.

Dent Mater J 2020 Aug 28. Epub 2020 Aug 28.

Department of Conservative Dentistry, Periodontology and Endodontology, University Center of Dentistry, Oral Medicine and Maxillofacial Surgery, University Hospital Tübingen.

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http://dx.doi.org/10.4012/dmj.2019-320DOI Listing
August 2020

Nine typical injury patterns in German professional male football (soccer): a systematic visual video analysis of 345 match injuries.

Br J Sports Med 2020 Aug 26. Epub 2020 Aug 26.

Faculty of Sports Science, Department of Sports Medicine and Sports Nutrition, Ruhr University Bochum, Bochum, Germany.

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http://dx.doi.org/10.1136/bjsports-2019-101344DOI Listing
August 2020

Neuronal αδ proteins and brain disorders.

Pflugers Arch 2020 07 30;472(7):845-863. Epub 2020 Jun 30.

Institute of Physiology, Medical University Innsbruck, 6020, Innsbruck, Austria.

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http://dx.doi.org/10.1007/s00424-020-02420-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351808PMC
July 2020

A New Class of Dengue and West Nile Virus Protease Inhibitors with Submicromolar Activity in Reporter Gene DENV-2 Protease and Viral Replication Assays.

J Med Chem 2020 Aug 15;63(15):8179-8197. Epub 2020 Jul 15.

Medicinal Chemistry, Institute of Pharmacy and Molecular Biotechnology IPMB, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1021/acs.jmedchem.0c00413DOI Listing
August 2020

Tryptophan metabolites modify brain Aβ peptide degradation: A role in Alzheimer's disease?

Prog Neurobiol 2020 07 29;190:101800. Epub 2020 Apr 29.

Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bâtiment 3 de la Faculté de Médecine, Strasbourg, France. Electronic address:

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http://dx.doi.org/10.1016/j.pneurobio.2020.101800DOI Listing
July 2020

Conformational selection in the flaviviral NS2B-NS3 protease.

Biochimie 2020 Jul 23;174:117-125. Epub 2020 Apr 23.

Medicinal Chemistry, Institute of Pharmacy and Molecular Biotechnology IPMB, Heidelberg University, Im Neuenheimer Feld 364, 69120, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2020.04.014DOI Listing
July 2020

Nasally delivered VEGFD mimetics mitigate stroke-induced dendrite loss and brain damage.

Proc Natl Acad Sci U S A 2020 04 30;117(15):8616-8623. Epub 2020 Mar 30.

Department of Neurobiology, Interdisciplinary Center for Neurosciences (IZN), Heidelberg University, Im Neuenheimer Feld (INF) 366, 69120 Heidelberg, Germany;

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http://dx.doi.org/10.1073/pnas.2001563117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165430PMC
April 2020

Machine Learning in Mass Spectrometry: A MALDI-TOF MS Approach to Phenotypic Antibacterial Screening.

J Med Chem 2020 Aug 1;63(16):8849-8856. Epub 2020 Apr 1.

Medicinal Chemistry, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1021/acs.jmedchem.0c00040DOI Listing
August 2020

Establishment of Collagen: Hydroxyapatite/BMP-2 Mimetic Peptide Composites.

Materials (Basel) 2020 Mar 7;13(5). Epub 2020 Mar 7.

Department of Oral and Maxillofacial Surgery, University Hospital Tübingen, 72076 Tübingen, Germany.

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http://dx.doi.org/10.3390/ma13051203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085073PMC
March 2020

Contact - but not foul play - dominates injury mechanisms in men's professional handball: a video match analysis of 580 injuries.

Br J Sports Med 2020 Aug 22;54(16):984-990. Epub 2020 Jan 22.

Department of Trauma, Hand, Plastic and Reconstructive Surgery, Universitätsklinikum Würzburg, Würzburg, Bayern, Germany

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http://dx.doi.org/10.1136/bjsports-2018-100250DOI Listing
August 2020

CD16 pre-ligation by defucosylated tumor-targeting mAb sensitizes human NK cells to γ cytokine stimulation via PI3K/mTOR axis.

Cancer Immunol Immunother 2020 Apr 16;69(4):501-512. Epub 2020 Jan 16.

Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy.

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http://dx.doi.org/10.1007/s00262-020-02482-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113231PMC
April 2020

Peptide-β-lactam Inhibitors of Dengue and West Nile Virus NS2B-NS3 Protease Display Two Distinct Binding Modes.

J Med Chem 2020 01 24;63(1):140-156. Epub 2019 Dec 24.

Medicinal Chemistry, Institute of Pharmacy and Molecular Biotechnology IPMB , Heidelberg University , Im Neuenheimer Feld 364 , 69120 Heidelberg , Germany.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00759DOI Listing
January 2020

Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria.

Eur J Med Chem 2020 Jan 5;186:111850. Epub 2019 Nov 5.

Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, 47907, USA; Purdue Institute of Inflammation, Immunology, and Infectious Disease, West Lafayette, IN, 47907, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.111850DOI Listing
January 2020

Minimally invasive removal of tooth-colored restorations: evaluation of a novel handpiece using the fluorescence-aided identification technique (FIT).

Clin Oral Investig 2020 Aug 12;24(8):2735-2743. Epub 2019 Nov 12.

Department of Conservative Dentistry, Periodontology and Endodontology, University Centre of Dentistry, Oral Medicine and Maxillofacial Surgery, University Hospital Tübingen, Osianderstr. 2-8, 72076,, Tübingen, Germany.

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http://dx.doi.org/10.1007/s00784-019-03135-0DOI Listing
August 2020

P329G-CAR-J: a novel Jurkat-NFAT-based CAR-T reporter system recognizing the P329G Fc mutation.

Protein Eng Des Sel 2019 12;32(5):207-218

Roche Innovation Center Zurich, Roche Pharma Research & Early Development, Wagistrasse 10 CH-8952 Schlieren, Switzerland.

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http://dx.doi.org/10.1093/protein/gzz027DOI Listing
December 2019

A Tridimensional Model for NK Cell-Mediated ADCC of Follicular Lymphoma.

Front Immunol 2019 14;10:1943. Epub 2019 Aug 14.

Centre de Recherches en Cancérologie de Toulouse (CRCT), UMR1037 INSERM, Université Toulouse III: Paul-Sabatier, ERL5294 CNRS, Université de Toulouse, Toulouse, France.

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http://dx.doi.org/10.3389/fimmu.2019.01943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702952PMC
October 2020

Prodrug Activation by a Viral Protease: Evaluating Combretastatin Peptide Hybrids To Selectively Target Infected Cells.

ACS Med Chem Lett 2019 Aug 18;10(8):1115-1121. Epub 2019 Jul 18.

Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1021/acsmedchemlett.9b00058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691480PMC
August 2019

PKPD Assessment of the Anti-CD20 Antibody Obinutuzumab in Cynomolgus Monkey is Feasible Despite Marked Anti-Drug Antibody Response in This Species.

J Pharm Sci 2019 11 25;108(11):3729-3736. Epub 2019 Jul 25.

Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2019.07.013DOI Listing
November 2019

Injury burden differs considerably between single teams from German professional male football (soccer): surveillance of three consecutive seasons.

Knee Surg Sports Traumatol Arthrosc 2020 May 19;28(5):1656-1664. Epub 2019 Jul 19.

Ruhr-Universität Bochum, Fakultät für Sportwissenschaft, Lehr- und Forschungsbereich Sportmedizin und Sporternährung, Gesundheitscampus-Nord 10, 44801, Bochum, Germany.

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http://dx.doi.org/10.1007/s00167-019-05623-yDOI Listing
May 2020

Bispecific Antibodies Enable Synthetic Agonistic Receptor-Transduced T Cells for Tumor Immunotherapy.

Clin Cancer Res 2019 10 8;25(19):5890-5900. Epub 2019 Jul 8.

Center of Integrated Protein Science Munich (CIPS-M) and Division of Clinical Pharmacology, Department of Medicine IV, Klinikum der Universität München, LMU Munich, Germany, Member of the German Center for Lung Research (DZL).

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3927DOI Listing
October 2019

TSPO Ligands Boost Mitochondrial Function and Pregnenolone Synthesis.

J Alzheimers Dis 2019 ;72(4):1045-1058

University of Basel, Neurobiology Laboratory for Brain Aging and Mental Health, Transfaculty Research Platform, Molecular & Cognitive Neuroscience, Basel, Switzerland.

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http://dx.doi.org/10.3233/JAD-190127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971832PMC
January 2019

Backbone modifications in peptidic inhibitors of flaviviral proteases.

Bioorg Med Chem Lett 2019 08 28;29(15):1913-1917. Epub 2019 May 28.

Medicinal Chemistry, Institute of Pharmacy and Molecular Biotechnology (IPMB), Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.05.054DOI Listing
August 2019

Synthesis and structure-activity relationships of small-molecular di-basic esters, amides and carbamates as flaviviral protease inhibitors.

Eur J Med Chem 2019 Aug 8;176:187-194. Epub 2019 May 8.

Medicinal Chemistry, Institute of Pharmacy and Molecular Biotechnology IPMB, Heidelberg University, Im Neuenheimer Feld 364, 69120, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.05.025DOI Listing
August 2019

Risk Factors for High Mortality on the Liver Transplant Waiting List in Times of Organ Shortage: A Single-Center Analysis.

Ann Transplant 2019 May 3;24:242-251. Epub 2019 May 3.

Department of General, Visceral and Transplantation Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.12659/AOT.914246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519305PMC
May 2019

Virtues of Volatility: A Facile Transesterification Approach to Boronic Acids.

Org Lett 2019 05 23;21(9):3048-3052. Epub 2019 Apr 23.

Institute of Pharmacy and Molecular Biotechnology (IPMB), Medicinal Chemistry , University of Heidelberg , Im Neuenheimer Feld 364 , 69120 Heidelberg , Germany.

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http://dx.doi.org/10.1021/acs.orglett.9b00584DOI Listing
May 2019

Small-Molecule Inhibition of the UNC-Src Interaction Impairs Dynamic Src Localization in Cells.

Cell Chem Biol 2019 06 4;26(6):842-851.e7. Epub 2019 Apr 4.

Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Dortmund, North Rhine-Westphalia 44227, Germany; Faculty of Chemistry and Chemical Biology, TU Dortmund, Dortmund, North Rhine-Westphalia 44227, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.02.019DOI Listing
June 2019

Discovery of Nonstandard Macrocyclic Peptides as Noncompetitive Inhibitors of the Zika Virus NS2B-NS3 Protease.

ACS Med Chem Lett 2019 Feb 4;10(2):168-174. Epub 2019 Jan 4.

Research School of Chemistry, Australian National University, Canberra, ACT 2601, Australia.

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http://dx.doi.org/10.1021/acsmedchemlett.8b00535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378662PMC
February 2019

Synthesis, Biological Evaluation, and Molecular Docking of Combretastatin and Colchicine Derivatives and their hCE1-Activated Prodrugs as Antiviral Agents.

ChemMedChem 2019 02 25;14(4):469-483. Epub 2019 Jan 25.

Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, INF 364, 69120, Heidelberg, Germany.

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http://doi.wiley.com/10.1002/cmdc.201800641
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http://dx.doi.org/10.1002/cmdc.201800641DOI Listing
February 2019

5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer's disease.

Acta Neuropathol Commun 2018 12 11;6(1):136. Epub 2018 Dec 11.

Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bâtiment 3 de la Faculté de Médecine, Strasbourg, France.

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http://dx.doi.org/10.1186/s40478-018-0640-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290545PMC
December 2018

Engineering therapeutic bispecific antibodies using CrossMab technology.

Methods 2019 02 16;154:21-31. Epub 2018 Nov 16.

Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, 8952 Schlieren, Switzerland.

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http://dx.doi.org/10.1016/j.ymeth.2018.11.008DOI Listing
February 2019

A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease.

J Autoimmun 2018 12 13;95:1-14. Epub 2018 Nov 13.

JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK; JDRF/Wellcome Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, CB2 OXY, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183042
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http://dx.doi.org/10.1016/j.jaut.2018.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284106PMC
December 2018

High-affinity CD16-polymorphism and Fc-engineered antibodies enable activity of CD16-chimeric antigen receptor-modified T cells for cancer therapy.

Br J Cancer 2019 01 15;120(1):79-87. Epub 2018 Nov 15.

Center of Integrated Protein Science Munich (CIPS-M) and Division of Clinical Pharmacology, Department of Medicine IV, Klinikum der Universität München, LMU Munich (Member of the German Center for Lung Research (DZL), LMU Munich, Germany.

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http://dx.doi.org/10.1038/s41416-018-0341-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325122PMC
January 2019

PDEδ inhibition impedes the proliferation and survival of human colorectal cancer cell lines harboring oncogenic KRas.

Int J Cancer 2019 02 4;144(4):767-776. Epub 2018 Dec 4.

Department of Systemic Cell Biology, Max Planck Institute for Molecular Physiology, Dortmund, Germany.

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http://doi.wiley.com/10.1002/ijc.31859
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http://dx.doi.org/10.1002/ijc.31859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519276PMC
February 2019

Variable heavy-variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assembly.

Protein Eng Des Sel 2018 07;31(7-8):289-299

Roche Pharmaceutical Research and Early Development, Discovery Oncology, Roche Innovation Center Zurich, Schlieren, Switzerland.

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http://dx.doi.org/10.1093/protein/gzy021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277175PMC
July 2018

Special Issue: Monoclonal Antibodies.

Authors:
Christian Klein

Antibodies (Basel) 2018 Apr 10;7(2). Epub 2018 Apr 10.

Roche Pharmaceutical Research & Early Development, 8952 Schlieren, Switzerland.

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http://dx.doi.org/10.3390/antib7020017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698830PMC
April 2018

Pharmacokinetic properties of radiolabeled mutant Interleukin-2v: a PET imaging study.

Oncotarget 2018 Jan 2;9(6):7162-7174. Epub 2018 Jan 2.

Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.18632/oncotarget.23852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805544PMC
January 2018

Prediction of the Optimal Dosing Regimen Using a Mathematical Model of Tumor Uptake for Immunocytokine-Based Cancer Immunotherapy.

Clin Cancer Res 2018 07 20;24(14):3325-3333. Epub 2018 Feb 20.

Translational Medicine Oncology, Roche Pharmaceutical Research & Early Development, Roche Innovation Center, Zurich, Switzerland.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-17-2953DOI Listing
July 2018

Increased injury rates after the restructure of Germany's national second league of team handball.

Knee Surg Sports Traumatol Arthrosc 2018 Jul 5;26(7):1884-1891. Epub 2018 Feb 5.

Department of Trauma Surgery, University Medical Centre Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1007/s00167-018-4851-4DOI Listing
July 2018

Hypertonicity-induced cation channels in HepG2 cells: architecture and role in proliferation vs. apoptosis.

J Physiol 2018 04 25;596(7):1227-1241. Epub 2018 Feb 25.

Max Planck Institute of Molecular Physiology, Department of Systemic Cell Biology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.

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http://dx.doi.org/10.1113/JP275827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878218PMC
April 2018

Posttraumatic Stress Disorder, Quality of Life, and the Subjective Experience in Liver Transplant Recipients.

Prog Transplant 2018 03 15;28(1):70-76. Epub 2017 Dec 15.

1 Department of Psychosomatic Medicine and Psychotherapy, University Hospital Erlangen, Erlangen, Germany.

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http://journals.sagepub.com/doi/10.1177/1526924817746680
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http://dx.doi.org/10.1177/1526924817746680DOI Listing
March 2018

Chemotherapy-free, triple combination of obinutuzumab, venetoclax and idasanutlin: antitumor activity in xenograft models of non-Hodgkin lymphoma.

Leuk Lymphoma 2018 06 15;59(6):1482-1485. Epub 2017 Sep 15.

b Roche Pharmaceutical Research and Early Development , Roche Innovation Center Zurich , Zurich , Switzerland.

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http://dx.doi.org/10.1080/10428194.2017.1376740DOI Listing
June 2018

The translocator protein ligand XBD173 improves clinical symptoms and neuropathological markers in the SJL/J mouse model of multiple sclerosis.

Biochim Biophys Acta Mol Basis Dis 2017 12 9;1863(12):3016-3027. Epub 2017 Sep 9.

Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bâtiment 3 de la Faculté de Médecine, 11 rue Humann, 67 000 Strasbourg, France. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.09.007DOI Listing
December 2017

Preventing nausea and vomiting in women undergoing regional anesthesia for cesarean section: challenges and solutions.

Local Reg Anesth 2017 9;10:83-90. Epub 2017 Aug 9.

Department of Anesthesia and Critical Care, University Hospitals of Wuerzburg, Wuerzburg.

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http://dx.doi.org/10.2147/LRA.S111459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558589PMC
August 2017

Combination therapy with the type II anti-CD20 antibody obinutuzumab.

Expert Opin Investig Drugs 2017 Oct;26(10):1145-1162

b Pharma Development Clinical Oncology , F. Hoffmann-La Roche Ltd , Basel , Switzerland.

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http://dx.doi.org/10.1080/13543784.2017.1373087DOI Listing
October 2017

Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond.

Nat Rev Drug Discov 2017 Aug 5;16(8):565-586. Epub 2017 May 5.

Medicinal Chemistry, Institute of Pharmacy and Molecular Biotechnology IPMB, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany.

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http://www.nature.com/doifinder/10.1038/nrd.2017.33
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http://dx.doi.org/10.1038/nrd.2017.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925760PMC
August 2017

Obinutuzumab induces superior B-cell cytotoxicity to rituximab in rheumatoid arthritis and systemic lupus erythematosus patient samples.

Rheumatology (Oxford) 2017 07;56(7):1227-1237

Centre for Rheumatology, University College London, London, UK2Roche Pharmaceutical Research & Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland3Academic Unit of Cancer Sciences, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1093/rheumatology/kex067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808665PMC
July 2017

Solution conformations of a linked construct of the Zika virus NS2B-NS3 protease.

Antiviral Res 2017 06 21;142:141-147. Epub 2017 Mar 21.

Research School of Chemistry, The Australian National University, Canberra, ACT 2601, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2017.03.011DOI Listing
June 2017

Human neutrophils mediate trogocytosis rather than phagocytosis of CLL B cells opsonized with anti-CD20 antibodies.

Blood 2017 05 13;129(19):2636-2644. Epub 2017 Mar 13.

Center of Cellular Therapy G. Lanzani, Division of Hematology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.

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http://dx.doi.org/10.1182/blood-2016-08-735605DOI Listing
May 2017

Peptide-Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology.

J Med Chem 2017 01 14;60(1):511-516. Epub 2016 Dec 14.

Medicinal Chemistry, IPMB, Heidelberg University , INF-364, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01021DOI Listing
January 2017

A novel three-dimensional heterotypic spheroid model for the assessment of the activity of cancer immunotherapy agents.

Cancer Immunol Immunother 2017 01 17;66(1):129-140. Epub 2016 Nov 17.

Roche Pharmaceutical Research and Early Development, Oncology DTA, Roche Innovation Center Zurich, Wagistrasse 18, 8952, Schlieren, Switzerland.

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http://dx.doi.org/10.1007/s00262-016-1927-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222939PMC
January 2017

Identification of fused bicyclic derivatives of pyrrolidine and imidazolidinone as dengue virus-2 NS2B-NS3 protease inhibitors.

Eur J Med Chem 2017 Jan 21;125:751-759. Epub 2016 Sep 21.

School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, Jiangsu, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.09.063DOI Listing
January 2017

CEA TCB: A novel head-to-tail 2:1 T cell bispecific antibody for treatment of CEA-positive solid tumors.

Oncoimmunology 2016 Aug 24;5(8):e1203498. Epub 2016 Jun 24.

Roche Pharmaceutical Research & Early Development, Roche Innovation Center Zurich , Schlieren, Switzerland.

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http://dx.doi.org/10.1080/2162402X.2016.1203498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007959PMC
August 2016

A proposed preventive role for Gamma-hydroxybutyrate (Xyrem(R)) in Alzheimer's disease.

Alzheimers Res Ther 2016 09 6;8:37. Epub 2016 Sep 6.

Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, Bâtiment 3 de la Faculté de Médecine, 11 rue Humann, 67 000, Strasbourg, France.

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http://dx.doi.org/10.1186/s13195-016-0205-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013588PMC
September 2016

TetraMabs: simultaneous targeting of four oncogenic receptor tyrosine kinases for tumor growth inhibition in heterogeneous tumor cell populations.

Protein Eng Des Sel 2016 10 29;29(10):467-475. Epub 2016 Aug 29.

pRED, Roche Pharma Research & Early Development, Roche Large Molecule Research, Roche Innovation Center, Munich, Nonnenwald 2, 82377 Penzberg, Germany.

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http://dx.doi.org/10.1093/protein/gzw037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036864PMC
October 2016

Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions.

Protein Eng Des Sel 2016 10 29;29(10):457-466. Epub 2016 Aug 29.

Roche Pharmaceutical Research and Early Development, Large Molecules Research, Roche Innovation Center Zurich, Wagistrasse 18, CH-8952 Schlieren, Switzerland.

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http://dx.doi.org/10.1093/protein/gzw040DOI Listing
October 2016