Publications by authors named "Christian Johannes Gloeckner"

41Publications

Guilt-by-Association - Functional Insights Gained From Studying the LRRK2 Interactome.

Front Neurosci 2020 20;14:485. Epub 2020 May 20.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cherry Hinton, United Kingdom.

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http://dx.doi.org/10.3389/fnins.2020.00485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251075PMC
May 2020

Identification and characterization of ubiquitinylation sites in TAR DNA-binding protein of 43 kDa (TDP-43).

J Biol Chem 2018 10 17;293(41):16083-16099. Epub 2018 Aug 17.

From the German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen and

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http://dx.doi.org/10.1074/jbc.RA118.003440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187624PMC
October 2018

Biochemical and kinetic properties of the complex Roco G-protein cycle.

Biol Chem 2018 11;399(12):1447-1456

Department of Cell Biochemistry, University of Groningen, Groningen NL-9747 AG, TheNetherlands.

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http://dx.doi.org/10.1515/hsz-2018-0227DOI Listing
November 2018

Regulation of LRRK2: insights from structural and biochemical analysis.

Biol Chem 2018 06;399(7):637-642

DZNE-German Center for Neurodegenerative Diseases, Otfried-Müller Str. 23, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1515/hsz-2018-0132DOI Listing
June 2018

First model of dimeric LRRK2: the challenge of unrevealing the structure of a multidomain Parkinson's-associated protein.

Biochem Soc Trans 2016 12;44(6):1635-1641

German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.

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http://dx.doi.org/10.1042/BST20160226DOI Listing
December 2016

Autophosphorylation on S614 inhibits the activity and the transforming potential of BRAF.

Cell Signal 2016 09 21;28(9):1432-9. Epub 2016 Jun 21.

Medical Proteome Center, Division for Experimental Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2016.06.016DOI Listing
September 2016

A visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology.

Proteomics 2015 Apr 21;15(8):1390-404. Epub 2015 Mar 21.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.

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http://dx.doi.org/10.1002/pmic.201400390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415485PMC
April 2015

LRRK2 transport is regulated by its novel interacting partner Rab32.

PLoS One 2014 31;9(10):e111632. Epub 2014 Oct 31.

Department of Experimental Tumorbiology, Westfälische Wilhelms University Muenster, Muenster, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111632PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216093PMC
December 2015

The role of the plexin-A2 receptor in Sema3A and Sema3B signal transduction.

J Cell Sci 2014 Dec 21;127(Pt 24):5240-52. Epub 2014 Oct 21.

Cancer Research and Vascular Biology Center, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel

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http://dx.doi.org/10.1242/jcs.155960DOI Listing
December 2014

Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain.

Mol Cell Biol 2014 Jun 31;34(12):2147-61. Epub 2014 Mar 31.

Helmholtz Zentrum München, German Research Center for Environmental Health, Research Unit Protein Science, Neuherberg, Germany Eberhard Karls University Tübingen, Institute for Ophthalmic Research, Medical Proteome Center, Tübingen, Germany

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http://dx.doi.org/10.1128/MCB.00914-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054300PMC
June 2014

Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

J Proteome Res 2010 Apr;9(4):1738-45

Helmholtz Zentrum München-German Research Center for Environmental Health, Department of Protein Science, Neuherberg, Germany.

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http://dx.doi.org/10.1021/pr9008578DOI Listing
April 2010

Strep/FLAG tandem affinity purification (SF-TAP) to study protein interactions.

Curr Protoc Protein Sci 2009 Aug;Chapter 19:Unit19.20

Helmholtz Zentrum München, Neuherberg, Germany.

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http://dx.doi.org/10.1002/0471140864.ps1920s57DOI Listing
August 2009

Tandem affinity purification of protein complexes from mammalian cells by the Strep/FLAG (SF)-TAP tag.

Methods Mol Biol 2009 ;564:359-72

Department of Protein Science, Helmholtz Zentrum München-German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany.

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http://link.springer.com/content/pdf/10.1007/978-1-60761-157
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http://link.springer.com/10.1007/978-1-60761-157-8_21
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http://dx.doi.org/10.1007/978-1-60761-157-8_21DOI Listing
October 2009

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro.

J Neurochem 2009 May 3;109(4):959-68. Epub 2009 Mar 3.

Department of Protein Science, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06024.xDOI Listing
May 2009

Tandem affinity purification of ciliopathy-associated protein complexes.

Methods Cell Biol 2009 1;91:143-60. Epub 2009 Dec 1.

Department of Protein Science, Helmholtz Zentrum München, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1016/S0091-679X(08)91009-8DOI Listing
July 2010

Relationship of Pax6 activity levels to the extent of eye development in the mouse, Mus musculus.

Genetics 2008 Jul 18;179(3):1345-55. Epub 2008 Jun 18.

Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany.

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http://dx.doi.org/10.1534/genetics.108.088591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475738PMC
July 2008

A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.

Proteomics 2007 Dec;7(23):4228-34

Institute of Human Genetics, GSF-National Research Center for Environment and Health, Neuherberg, Germany.

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http://dx.doi.org/10.1002/pmic.200700038DOI Listing
December 2007

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity.

Hum Mol Genet 2006 Jan 1;15(2):223-32. Epub 2005 Dec 1.

GSF-National Research Center for Environment and Health, Institute of Human Genetics, Munich-Neuherberg, Germany.

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http://dx.doi.org/10.1093/hmg/ddi439DOI Listing
January 2006

Proteomic analysis of the porcine interphotoreceptor matrix.

Proteomics 2005 Sep;5(14):3623-36

GSF-National Research Centre for Environment and Health, Institute of Human Genetics, Neuherberg, Germany.

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http://dx.doi.org/10.1002/pmic.200401223DOI Listing
September 2005