Christian J Buchholz

Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany; Division for Medical Biotechnology, Paul-Ehrlich-Institut, Langen, Germany; Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Germany. Electronic address:

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August 2020

CD8-Specific Designed Ankyrin Repeat Proteins Improve Selective Gene Delivery into Human and Primate T Lymphocytes.

Authors:

Annika M Frank Tatjana Weidner Julia Brynza Wolfgang Uckert Christian J Buchholz Jessica Hartmann

Hum Gene Ther 2020 06 23;31(11-12):679-691. Epub 2020 Apr 23.

Division of Medical Biotechnology, Paul-Ehrlich-Institut, Langen, Germany.

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June 2020

generated human CAR T cells eradicate tumor cells.

Authors:

Shiwani Agarwal Tatjana Weidner Frederic B Thalheimer Christian J Buchholz

Oncoimmunology 2019;8(12):e1671761. Epub 2019 Oct 10.

Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany.

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October 2019

GluA4-Targeted AAV Vectors Deliver Genes Selectively to Interneurons while Relying on the AAV Receptor for Entry.

Authors:

Jessica Hartmann Frederic B Thalheimer Felix Höpfner Thomas Kerzel Konstantin Khodosevich Diego García-González Hannah Monyer Ilka Diester Hildegard Büning Jan E Carette Pascal Fries Christian J Buchholz

Mol Ther Methods Clin Dev 2019 Sep 23;14:252-260. Epub 2019 Jul 23.

Division of Medical Biotechnology, Paul-Ehrlich-Institut, 63225 Langen, Germany.

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September 2019

Highly Efficient and Selective CAR-Gene Transfer Using CD4- and CD8-Targeted Lentiviral Vectors.

Authors:

Arezoo Jamali Laura Kapitza Thomas Schaser Ian C D Johnston Christian J Buchholz Jessica Hartmann

Mol Ther Methods Clin Dev 2019 Jun 16;13:371-379. Epub 2019 Mar 16.

Division of Molecular Biotechnology, Paul-Ehrlich-Institut, 63225 Langen, Germany.

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June 2019

Tumor-Specific Delivery of Immune Checkpoint Inhibitors by Engineered AAV Vectors.

Authors:

Johanna Reul Janina Frisch Christine E Engeland Frederic B Thalheimer Jessica Hartmann Guy Ungerechts Christian J Buchholz

Front Oncol 2019 14;9:52. Epub 2019 Feb 14.

Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany.

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February 2019

Ligand Coupling to the AAV Capsid for Cell-Specific Gene Transfer.

Authors:

Johanna Reul Alexander Muik Christian J Buchholz

Methods Mol Biol 2019 ;1950:35-50

Paul-Ehrlich-Institut, Molecular Biotechnology and Gene Therapy, Langen, Germany.

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July 2019

Surface-Engineered Lentiviral Vectors for Selective Gene Transfer into Subtypes of Lymphocytes.

Authors:

Annika M Frank Christian J Buchholz

Mol Ther Methods Clin Dev 2019 Mar 17;12:19-31. Epub 2018 Oct 17.

Division of Medical Biotechnology, Paul-Ehrlich-Institut, 63225 Langen, Germany.

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March 2019

generation of human CD19-CAR T cells results in B-cell depletion and signs of cytokine release syndrome.

Authors:

Anett Pfeiffer Frederic B Thalheimer Sylvia Hartmann Annika M Frank Ruben R Bender Simon Danisch Caroline Costa Winfried S Wels Ute Modlich Renata Stripecke Els Verhoeyen Christian J Buchholz

EMBO Mol Med 2018 11;10(11)

Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany

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November 2018

A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral Vectors.

Authors:

Jessica Hartmann Robert C Münch Ruth-Therese Freiling Irene C Schneider Birgit Dreier Washington Samukange Joachim Koch Markus A Seeger Andreas Plückthun Christian J Buchholz

Mol Ther Methods Clin Dev 2018 Sep 6;10:128-143. Epub 2018 Jul 6.

Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, 63225 Langen, Germany.

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September 2018

Distinct roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition.

Authors:

Max C Richter Susann Ludewig Alex Winschel Tobias Abel Charlotte Bold Leonie R Salzburger Susanne Klein Kang Han Sascha W Weyer Ann-Kristina Fritz Bodo Laube David P Wolfer Christian J Buchholz Martin Korte Ulrike C Müller

EMBO J 2018 06 16;37(11). Epub 2018 Apr 16.

Institute of Pharmacy and Molecular Biotechnology (IPMB), Ruprecht-Karls University Heidelberg, Heidelberg, Germany

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June 2018

CD30-targeted oncolytic viruses as novel therapeutic approach against classical Hodgkin lymphoma.

Authors:

Julia D S Hanauer Benjamin Rengstl Dina Kleinlützum Johanna Reul Anett Pfeiffer Thorsten Friedel Irene C Schneider Sebastian Newrzela Martin-Leo Hansmann Christian J Buchholz Alexander Muik

Oncotarget 2018 Feb 12;9(16):12971-12981. Epub 2018 Jan 12.

Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany.

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February 2018

Displaying Tetra-Membrane Spanning Claudins on Enveloped Virus-Like Particles for Cancer Immunotherapy.

Authors:

Irene C Schneider Jessica Hartmann Gundula Braun Jörn Stitz Thorsten Klamp Mahjoub Bihi Ugur Sahin Christian J Buchholz

Biotechnol J 2018 Mar 23;13(3):e1700345. Epub 2017 Nov 23.

Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, Langen, Germany.

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March 2018

Virotherapy Research in Germany: From Engineering to Translation.

Authors:

Guy Ungerechts Christine E Engeland Christian J Buchholz Jürgen Eberle Henry Fechner Karsten Geletneky Per Sonne Holm Florian Kreppel Florian Kühnel Karl Sebastian Lang Mathias F Leber Antonio Marchini Markus Moehler Michael D Mühlebach Jean Rommelaere Christoph Springfeld Ulrich M Lauer Dirk M Nettelbeck

Hum Gene Ther 2017 10;28(10):800-819

19 German Cancer Research Center (DKFZ), Heidelberg, Germany .

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October 2017

Covalent coupling of high-affinity ligands to the surface of viral vector particles by protein trans-splicing mediates cell type-specific gene transfer.

Authors:

Alexander Muik Johanna Reul Thorsten Friedel Anke Muth Karen Patricia Hartmann Irene C Schneider Robert C Münch Christian J Buchholz

Biomaterials 2017 Nov 25;144:84-94. Epub 2017 Jul 25.

Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institut, 63225, Langen, Germany. Electronic address:

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November 2017

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