Christian Jäger

Heteroaromatic Inhibitors of the Astacin Proteinases Meprin α, Meprin β and Ovastacin Discovered by a Scaffold-Hopping Approach.

Authors:

Kathrin Tan Christian Jäger Hagen Körschgen Stefanie Geissler Dagmar Schlenzig Mirko Buchholz Walter Stöcker Daniel Ramsbeck

ChemMedChem 2020 Dec 23. Epub 2020 Dec 23.

Department of Drug Design and Target Validation MWT, Fraunhofer Institute for Cell Therapy and Immunology IZI, Biocenter, Weinbergweg 22, 06120, Halle (Saale), Germany.

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December 2020

Integration of time-series meta-omics data reveals how microbial ecosystems respond to disturbance.

Nat Commun 2020 10 19;11(1):5281. Epub 2020 Oct 19.

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7 Avenue des Hauts-Fourneaux, 4362, Esch-sur-Alzette, Luxembourg, Luxembourg.

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October 2020

A Primary Evaluation of Potential Small-Molecule Inhibitors of the Astacin Metalloproteinase Ovastacin, a Novel Drug Target in Female Infertility Treatment.

Authors:

Hagen Körschgen Christian Jäger Kathrin Tan Mirko Buchholz Walter Stöcker Daniel Ramsbeck

ChemMedChem 2020 08 2;15(16):1499-1504. Epub 2020 Jul 2.

Department of Drug Design and Target Validation MWT, Fraunhofer Institute for Cell Therapy and Immunology IZI Biocenter, Weinbergweg 22, 06120, Halle (Saale), Germany.

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August 2020

GBA Variants in Parkinson's Disease: Clinical, Metabolomic, and Multimodal Neuroimaging Phenotypes.

Authors:

Andrea Greuel Jean-Pierre Trezzi Enrico Glaab Marina C Ruppert Franziska Maier Christian Jäger Zdenka Hodak Katja Lohmann Yilong Ma David Eidelberg Lars Timmermann Karsten Hiller Marc Tittgemeyer Alexander Drzezga Nico Diederich Carsten Eggers

Mov Disord 2020 12 27;35(12):2201-2210. Epub 2020 Aug 27.

Department of Neurology, University Hospital Giessen and Marburg, Marburg, Germany.

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December 2020

A HF Loaded Lewis-Acidic Aluminium Chlorofluoride for Hydrofluorination Reactions.

Authors:

Maëva-Charlotte Kervarec Erhard Kemnitz Gudrun Scholz Svemir Rudić Thomas Braun Christian Jäger Adam A L Michalchuk Franziska Emmerling

Chemistry 2020 Jun 26;26(32):7314-7322. Epub 2020 May 26.

BAM Federal Institute for Materials Research and Testing, Richard-Willstätter-Straße, 12489, Berlin, Germany.

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June 2020

Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function.

Cell Metab 2020 May 25;31(5):920-936.e7. Epub 2020 Mar 25.

Experimental & Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, 29 Rue Henri Koch, Esch-sur-Alzette, Luxembourg; Odense Research Center for Anaphylaxis (ORCA), Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, Denmark; Immunology & Genetics, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7 Avenue des Hauts Fourneaux, Esch-sur-Alzette, Luxembourg. Electronic address:

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May 2020

Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis.

Authors:

Gemma Gomez-Giro Jonathan Arias-Fuenzalida Javier Jarazo Dagmar Zeuschner Muhammad Ali Nina Possemis Silvia Bolognin Rashi Halder Christian Jäger Willemijn F E Kuper Peter M van Hasselt Holm Zaehres Antonio Del Sol Herman van der Putten Hans R Schöler Jens C Schwamborn

Acta Neuropathol Commun 2019 12 30;7(1):222. Epub 2019 Dec 30.

Luxembourg Centre for Systems Biomedicine (LCSB), Laboratory of Developmental and Cellular Biology, University of Luxembourg, Avenue du Swing 6, Belvaux, Luxembourg.

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December 2019

Metabolite profiling of the cold adaptation of Pseudomonas putida KT2440 and cold-sensitive mutants.

Authors:

Sarah Dethlefsen Christian Jäger Jens Klockgether Dietmar Schomburg Burkhard Tümmler

Environ Microbiol Rep 2019 12 10;11(6):777-783. Epub 2019 Oct 10.

Molecular Pathology of Cystic Fibrosis and Pseudomonas Genomics, Clinical Research Group, Hannover Medical School, 30625, Hannover, Germany.

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December 2019

Integrative analysis of blood metabolomics and PET brain neuroimaging data for Parkinson's disease.

Authors:

Enrico Glaab Jean-Pierre Trezzi Andrea Greuel Christian Jäger Zdenka Hodak Alexander Drzezga Lars Timmermann Marc Tittgemeyer Nico Jean Diederich Carsten Eggers

Neurobiol Dis 2019 04 9;124:555-562. Epub 2019 Jan 9.

Clinic for Neurology, University Hospital Giessen and Marburg, Marburg, Germany.

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April 2019

Tertiary-Amine-Based Inhibitors of the Astacin Protease Meprin α.

Authors:

Kathrin Tan Christian Jäger Dagmar Schlenzig Stephan Schilling Mirko Buchholz Daniel Ramsbeck

ChemMedChem 2018 08 16;13(16):1619-1624. Epub 2018 Jul 16.

Department of Drug Design and Target Validation MWT, Fraunhofer Institute for Cell Therapy and Immunology IZI, Biocenter, Weinbergweg 22, 06120, Halle (Saale), Germany.

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August 2018

Quantification of Stable Isotope Traces Close to Natural Enrichment in Human Plasma Metabolites Using Gas Chromatography-Mass Spectrometry.

Authors:

Lisa Krämer Christian Jäger Jean-Pierre Trezzi Doris M Jacobs Karsten Hiller

Metabolites 2018 Feb 14;8(1). Epub 2018 Feb 14.

Department of Bioinformatics and Biochemistry, BRICS, Technische Universität Braunschweig, 38106 Braunschweig, Germany.

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February 2018

Glutathione Primes T Cell Metabolism for Inflammation.

Immunity 2017 06;46(6):1089-1090

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June 2017

Glutathione Primes T Cell Metabolism for Inflammation.

Immunity 2017 04;46(4):675-689

Department of Infection and Immunity, Experimental and Molecular Immunology, Luxembourg Institute of Health, Esch-sur-Alzette, L-4354, Luxembourg; Odense Research Center for Anaphylaxis, Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, DK-5000, Denmark. Electronic address:

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April 2017

Metabolic profiling of body fluids and multivariate data analysis.

Authors:

Jean-Pierre Trezzi Christian Jäger Sara Galozzi Katalin Barkovits Katrin Marcus Brit Mollenhauer Karsten Hiller

MethodsX 2017 20;4:95-103. Epub 2017 Feb 20.

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg; Braunschweig Integrated Centre of Systems Biology, University of Braunschweig, Rebenring 56, Braunschweig, Germany; Department of Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Braunschweig, Germany.

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February 2017

Generation of genome-scale metabolic reconstructions for 773 members of the human gut microbiota.

Authors:

Stefanía Magnúsdóttir Almut Heinken Laura Kutt Dmitry A Ravcheev Eugen Bauer Alberto Noronha Kacy Greenhalgh Christian Jäger Joanna Baginska Paul Wilmes Ronan M T Fleming Ines Thiele

Nat Biotechnol 2017 Jan 28;35(1):81-89. Epub 2016 Nov 28.

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.

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January 2017

Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors.

Authors:

Doriane Lorendeau Gianmarco Rinaldi Ruben Boon Pieter Spincemaille Kristine Metzger Christian Jäger Stefan Christen Xiangyi Dong Sabine Kuenen Karin Voordeckers Patrik Verstreken David Cassiman Pieter Vermeersch Catherine Verfaillie Karsten Hiller Sarah-Maria Fendt

Metab Eng 2017 09 12;43(Pt B):187-197. Epub 2016 Nov 12.

Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB Leuven, 3000 Leuven, Belgium; Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, 3000 Leuven, Belgium. Electronic address:

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September 2017

Mechanochemically Induced Conversion of Crystalline Benzamide Polymorphs by Seeding.

Authors:

Franziska Fischer Sebastian Greiser Dietmar Pfeifer Christian Jäger Klaus Rademann Franziska Emmerling

Angew Chem Int Ed Engl 2016 11 20;55(46):14281-14285. Epub 2016 Oct 20.

BAM Federal Institute for Materials Research and Testing, Richard-Willstätter-Str. 11, 12489, Berlin, Germany.

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November 2016

Metabolic Profiling and Quantification of Neurotransmitters in Mouse Brain by Gas Chromatography-Mass Spectrometry.

Authors:

Christian Jäger Karsten Hiller Manuel Buttini

Curr Protoc Mouse Biol 2016 Sep 1;6(3):333-342. Epub 2016 Sep 1.

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg.

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September 2016

Distinct Metabolic States Can Support Self-Renewal and Lipogenesis in Human Pluripotent Stem Cells under Different Culture Conditions.

Authors:

Hui Zhang Mehmet G Badur Ajit S Divakaruni Seth J Parker Christian Jäger Karsten Hiller Anne N Murphy Christian M Metallo

Cell Rep 2016 08 28;16(6):1536-1547. Epub 2016 Jul 28.

Department of Bioengineering, University of California, San Diego, La Jolla, CA 92037, USA; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address:

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August 2016

A microfluidics-based in vitro model of the gastrointestinal human-microbe interface.

Authors:

Pranjul Shah Joëlle V Fritz Enrico Glaab Mahesh S Desai Kacy Greenhalgh Audrey Frachet Magdalena Niegowska Matthew Estes Christian Jäger Carole Seguin-Devaux Frederic Zenhausern Paul Wilmes

Nat Commun 2016 05 11;7:11535. Epub 2016 May 11.

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 6 avenue du Swing, Belvaux L-4367, Luxembourg.

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May 2016

11th German Conference on Chemoinformatics (GCC 2015) : Fulda, Germany. 8-10 November 2015.

Authors:

Uli Fechner Chris de Graaf Andrew E Torda Stefan Güssregen Andreas Evers Hans Matter Gerhard Hessler Nicola J Richmond Peter Schmidtke Marwin H S Segler Mark P Waller Stefanie Pleik Joan-Emma Shea Zachary Levine Ryan Mullen Karina van den Broek Matthias Epple Hubert Kuhn Andreas Truszkowski Achim Zielesny Johannes Hans Fraaije Ruben Serral Gracia Stefan M Kast Krishna C Bulusu Andreas Bender Abraham Yosipof Oren Nahum Hanoch Senderowitz Timo Krotzky Robert Schulz Gerhard Wolber Stefan Bietz Matthias Rarey Markus O Zimmermann Andreas Lange Manuel Ruff Johannes Heidrich Ionut Onlia Thomas E Exner Frank M Boeckler Marcel Bermudez Dzmitry S Firaha Oldamur Hollóczki Barbara Kirchner Christofer S Tautermann Andrea Volkamer Sameh Eid Samo Turk Friedrich Rippmann Simone Fulle Noureldin Saleh Giorgio Saladino Francesco L Gervasio Elke Haensele Lee Banting David C Whitley Jana Sopkova-de Oliveira Santos Ronan Bureau Timothy Clark Achim Sandmann Harald Lanig Patrick Kibies Jochen Heil Franziska Hoffgaard Roland Frach Julian Engel Steven Smith Debjit Basu Daniel Rauh Oliver Kohlbacher Frank M Boeckler Jonathan W Essex Michael S Bodnarchuk Gregory A Ross Arndt R Finkelmann Andreas H Göller Gisbert Schneider Tamara Husch Christoph Schütter Andrea Balducci Martin Korth Fidele Ntie-Kang Stefan Günther Wolfgang Sippl Luc Meva'a Mbaze Fidele Ntie-Kang Conrad V Simoben Lydia L Lifongo Fidele Ntie-Kang Philip Judson Jiří Barilla Miloš V Lokajíček Hana Pisaková Pavel Simr Natalia Kireeva Alexandre Petrov Denis Ostroumov Vitaly P Solovev Vladislav S Pervov Nils-Ole Friedrich Kai Sommer Matthias Rarey Johannes Kirchmair Eugen Proschak Julia Weber Daniel Moser Lena Kalinowski Janosch Achenbach Mark Mackey Tim Cheeseright Gerrit Renner Gerrit Renner Torsten C Schmidt Jürgen Schram Marion Egelkraut-Holtus Albert van Oeyen Tuomo Kalliokoski Denis Fourches Akachukwu Ibezim Chika J Mbah Umale M Adikwu Ngozi J Nwodo Alexander Steudle Brian B Masek Stephan Nagy David Baker Fred Soltanshahi Roman Dorfman Karen Dubrucq Hitesh Patel Oliver Koch Florian Mrugalla Stefan M Kast Qurrat U Ain Julian E Fuchs Robert M Owen Kiyoyuki Omoto Rubben Torella David C Pryde Robert Glen Andreas Bender Petr Hošek Vojtěch Spiwok Lewis H Mervin Ian Barrett Mike Firth David C Murray Lisa McWilliams Qing Cao Ola Engkvist Dawid Warszycki Marek Śmieja Andrzej J Bojarski Natalia Aniceto Alex Freitas Taravat Ghafourian Guido Herrmann Valentina Eigner-Pitto Alexandra Naß Rafał Kurczab Andrzej J Bojarski Andreas Lange Marcel B Günther Susanne Hennig Felix M Büttner Christoph Schall Adrian Sievers-Engler Francesco Ansideri Pierre Koch Thilo Stehle Stefan Laufer Frank M Böckler Barbara Zdrazil Floriane Montanari Gerhard F Ecker Christoph Grebner Anders Hogner Johan Ulander Karl Edman Victor Guallar Christian Tyrchan Johan Ulander Christian Tyrchan Wolfgang Klute Fredrik Bergström Christian Kramer Quoc Dat Nguyen Roland Frach Patrick Kibies Steven Strohfeldt Saraphina Böttcher Tim Pongratz Dominik Horinek Stefan M Kast Bernd Rupp Raed Al-Yamori Michael Lisurek Ronald Kühne Filipe Furtado Karina van den Broek Ludger Wessjohann Miriam Mathea Knut Baumann Siti Zuraidah Mohamad-Zobir Xianjun Fu Tai-Ping Fan Andreas Bender Maximilian A Kuhn Christoph A Sotriffer Azedine Zoufir Xitong Li Lewis Mervin Ellen Berg Mark Polokoff Wolf D Ihlenfeldt Wolf D Ihlenfeldt Jette Pretzel Zayan Alhalabi Robert Fraczkiewicz Marvin Waldman Robert D Clark Neem Shaikh Prabha Garg Alexander Kos Hans-Jürgen Himmler Achim Sandmann Christophe Jardin Heinrich Sticht Thomas B Steinbrecher Markus Dahlgren Daniel Cappel Teng Lin Lingle Wang Goran Krilov Robert Abel Richard Friesner Woody Sherman Ina A Pöhner Joanna Panecka Rebecca C Wade Stefan Bietz Karen T Schomburg Matthias Hilbig Matthias Rarey Christian Jäger Vivien Wieczorek Lance M Westerhoff Oleg Y Borbulevych Hans-Ulrich Demuth Mirko Buchholz Denis Schmidt Thomas Rickmeyer Timo Krotzky Peter Kolb Sumit Mittal Elsa Sánchez-García Mauro S Nogueira Tiago B Oliveira Fernando B da Costa Thomas J Schmidt

J Cheminform 2016 Apr 26;8(Suppl 1):18. Epub 2016 Apr 26.

Central Institute for Scientific Computing (ZISC), FAU-Erlangen-Nürnberg, Martensstr. 5a, 91058, Erlangen, Germany.

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April 2016

Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages.

Authors:

Aravind Tallam Thaneer M Perumal Paul M Antony Christian Jäger Joëlle V Fritz Laurent Vallar Rudi Balling Antonio Del Sol Alessandro Michelucci

PLoS One 2016 12;11(2):e0149050. Epub 2016 Feb 12.

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.

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July 2016

Isotopologue ratio normalization for non-targeted metabolomics.

Authors:

Daniel Weindl André Wegner Christian Jäger Karsten Hiller

J Chromatogr A 2015 Apr 17;1389:112-9. Epub 2015 Feb 17.

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7, Avenue des Hauts-Fourneaux, L-4362 Esch-Belval, Luxembourg. Electronic address:

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April 2015