Publications by authors named "Christian Hurtz"

18 Publications

  • Page 1 of 1

Signalling input from divergent pathways subverts B cell transformation.

Authors:
Lai N Chan Mark A Murakami Mark E Robinson Rebecca Caeser Teresa Sadras Jaewoong Lee Kadriye Nehir Cosgun Kohei Kume Vishal Khairnar Gang Xiao Mohamed A Ahmed Eamon Aghania Gauri Deb Christian Hurtz Seyedmehdi Shojaee Chao Hong Petri Pölönen Matthew A Nix Zhengshan Chen Chun Wei Chen Jianjun Chen Andreas Vogt Merja Heinäniemi Olli Lohi Arun P Wiita Shai Izraeli Huimin Geng David M Weinstock Markus Müschen

Nature 2020 07 22;583(7818):845-851. Epub 2020 Jul 22.

Department of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, CA, USA.

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July 2020

Oncogene-independent BCR-like signaling adaptation confers drug resistance in Ph-like ALL.

Authors:
Christian Hurtz Gerald B Wertheim Joseph P Loftus Daniel Blumenthal Anne Lehman Yong Li Asen Bagashev Bryan Manning Katherine D Cummins Janis K Burkhardt Alexander E Perl Martin Carroll Sarah K Tasian

J Clin Invest 2020 07;130(7):3637-3653

Division of Oncology, and.

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July 2020

Rationale for targeting BCL6 in -rearranged acute lymphoblastic leukemia.

Authors:
Christian Hurtz Lai N Chan Huimin Geng Erica Ballabio Gang Xiao Gauri Deb Haytham Khoury Chun-Wei Chen Scott A Armstrong Jianjun Chen Patricia Ernst Ari Melnick Thomas Milne Markus Müschen

Genes Dev 2019 09 8;33(17-18):1265-1279. Epub 2019 Aug 8.

Department of Systems Biology, City of Hope Comprehensive Cancer Center, Monrovia, California 91016, USA.

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September 2019

Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors.

Authors:
Lai N Chan Zhengshan Chen Daniel Braas Jae-Woong Lee Gang Xiao Huimin Geng Kadriye Nehir Cosgun Christian Hurtz Seyedmehdi Shojaee Valeria Cazzaniga Hilde Schjerven Thomas Ernst Andreas Hochhaus Steven M Kornblau Marina Konopleva Miles A Pufall Giovanni Cazzaniga Grace J Liu Thomas A Milne H Phillip Koeffler Theodora S Ross Isidro Sánchez-García Arndt Borkhardt Keith R Yamamoto Ross A Dickins Thomas G Graeber Markus Müschen

Nature 2018 06;558(7711):E5

Department of Systems Biology, Beckman Research Institute and City of Hope National Medical Center, Pasadena, California, 91016, USA.

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June 2018

Extrafollicular CD4 T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.

Authors:
Ruishu Deng Christian Hurtz Qingxiao Song Chanyu Yue Gang Xiao Hua Yu Xiwei Wu Markus Muschen Stephen Forman Paul J Martin Defu Zeng

Nat Commun 2017 10 17;8(1):978. Epub 2017 Oct 17.

Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA.

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October 2017

Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures.

Authors:
Nicholas A Graham Aspram Minasyan Anastasia Lomova Ashley Cass Nikolas G Balanis Michael Friedman Shawna Chan Sophie Zhao Adrian Delgado James Go Lillie Beck Christian Hurtz Carina Ng Rong Qiao Johanna Ten Hoeve Nicolaos Palaskas Hong Wu Markus Müschen Asha S Multani Elisa Port Steven M Larson Nikolaus Schultz Daniel Braas Heather R Christofk Ingo K Mellinghoff Thomas G Graeber

Mol Syst Biol 2017 02 15;13(2):914. Epub 2017 Feb 15.

Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles, CA, USA

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February 2017

Metabolic gatekeeper function of B-lymphoid transcription factors.

Authors:
Lai N Chan Zhengshan Chen Daniel Braas Jae-Woong Lee Gang Xiao Huimin Geng Kadriye Nehir Cosgun Christian Hurtz Seyedmehdi Shojaee Valeria Cazzaniga Hilde Schjerven Thomas Ernst Andreas Hochhaus Steven M Kornblau Marina Konopleva Miles A Pufall Giovanni Cazzaniga Grace J Liu Thomas A Milne H Phillip Koeffler Theodora S Ross Isidro Sánchez-García Arndt Borkhardt Keith R Yamamoto Ross A Dickins Thomas G Graeber Markus Müschen

Nature 2017 02 13;542(7642):479-483. Epub 2017 Feb 13.

Department of Systems Biology, Beckman Research Institute and City of Hope National Medical Center, Pasadena, California 91016, USA.

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February 2017

Ibrutinib inhibits pre-BCR B-cell acute lymphoblastic leukemia progression by targeting BTK and BLK.

Authors:
Ekaterina Kim Christian Hurtz Stefan Koehrer Zhiqiang Wang Sriram Balasubramanian Betty Y Chang Markus Müschen R Eric Davis Jan A Burger

Blood 2017 03 28;129(9):1155-1165. Epub 2016 Dec 28.

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX.

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March 2017

Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia.

Authors:
Seyedmehdi Shojaee Rebecca Caeser Maike Buchner Eugene Park Srividya Swaminathan Christian Hurtz Huimin Geng Lai N Chan Lars Klemm Wolf-Karsten Hofmann Yi Hua Qiu Nianxiang Zhang Kevin R Coombes Elisabeth Paietta Jeffery Molkentin H Phillip Koeffler Cheryl L Willman Stephen P Hunger Ari Melnick Steven M Kornblau Markus Müschen

Cancer Cell 2015 Jul 11;28(1):114-28. Epub 2015 Jun 11.

Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address:

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July 2015

Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia.

Authors:
Huimin Geng Christian Hurtz Kyle B Lenz Zhengshan Chen Dirk Baumjohann Sarah Thompson Natalya A Goloviznina Wei-Yi Chen Jianya Huan Dorian LaTocha Erica Ballabio Gang Xiao Jae-Woong Lee Anne Deucher Zhongxia Qi Eugene Park Chuanxin Huang Rahul Nahar Soo-Mi Kweon Seyedmehdi Shojaee Lai N Chan Jingwei Yu Steven M Kornblau Janetta J Bijl B Hilda Ye K Mark Ansel Elisabeth Paietta Ari Melnick Stephen P Hunger Peter Kurre Jeffrey W Tyner Mignon L Loh Robert G Roeder Brian J Druker Jan A Burger Thomas A Milne Bill H Chang Markus Müschen

Cancer Cell 2015 Mar;27(3):409-25

Departments of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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March 2015

Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia.

Authors:
Behzad Kharabi Masouleh Huimin Geng Christian Hurtz Lai N Chan Aaron C Logan Mi Sook Chang Chuanxin Huang Srividya Swaminathan Haibo Sun Elisabeth Paietta Ari M Melnick Phillip Koeffler Markus Müschen

Proc Natl Acad Sci U S A 2014 May 12;111(21):E2219-28. Epub 2014 May 12.

Department of Laboratory Medicine and

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May 2014

BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint.

Authors:
Srividya Swaminathan Chuanxin Huang Huimin Geng Zhengshan Chen Richard Harvey Huining Kang Carina Ng Björn Titz Christian Hurtz Mohammed Firas Sadiyah Daniel Nowak Gabriela B Thoennissen Vikki Rand Thomas G Graeber H Phillip Koeffler William L Carroll Cheryl L Willman Andrew G Hall Kazuhiko Igarashi Ari Melnick Markus Müschen

Nat Med 2013 Aug 14;19(8):1014-22. Epub 2013 Jul 14.

Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.

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August 2013

O-acetylated N-acetylneuraminic acid as a novel target for therapy in human pre-B acute lymphoblastic leukemia.

Authors:
Reshmi Parameswaran Min Lim Anna Arutyunyan Hisham Abdel-Azim Christian Hurtz Kam Lau Markus Müschen Robert K Yu Mark von Itzstein Nora Heisterkamp John Groffen

J Exp Med 2013 Apr 11;210(4):805-19. Epub 2013 Mar 11.

Section of Molecular Carcinogenesis, Division of Hematology/Oncology, The Saban Research Institute, Children's Hospital Los Angeles, CA 90089, USA.

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April 2013

SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia.

Authors:
Parham Ramezani-Rad Huimin Geng Christian Hurtz Lai N Chan Zhengshan Chen Hassan Jumaa Ari Melnick Elisabeth Paietta William L Carroll Cheryl L Willman Véronique Lefebvre Markus Müschen

Blood 2013 Jan 14;121(1):148-55. Epub 2012 Nov 14.

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

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January 2013

Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia.

Authors:
Huimin Geng Sarah Brennan Thomas A Milne Wei-Yi Chen Yushan Li Christian Hurtz Soo-Mi Kweon Lynette Zickl Seyedmehdi Shojaee Donna Neuberg Chuanxin Huang Debabrata Biswas Yuan Xin Janis Racevskis Rhett P Ketterling Selina M Luger Hillard Lazarus Martin S Tallman Jacob M Rowe Mark R Litzow Monica L Guzman C David Allis Robert G Roeder Markus Müschen Elisabeth Paietta Olivier Elemento Ari M Melnick

Cancer Discov 2012 Nov 29;2(11):1004-23. Epub 2012 Oct 29.

Department of Medicine/Hematology-Oncology Division, Weill Medical College of Cornell University, New York, NY 10065, USA.

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November 2012

BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia.

Authors:
Christian Hurtz Katerina Hatzi Leandro Cerchietti Melanie Braig Eugene Park Yong-mi Kim Sebastian Herzog Parham Ramezani-Rad Hassan Jumaa Martin C Müller Wolf-Karsten Hofmann Andreas Hochhaus B Hilda Ye Anupriya Agarwal Brian J Druker Neil P Shah Ari M Melnick Markus Müschen

J Exp Med 2011 Oct 12;208(11):2163-74. Epub 2011 Sep 12.

Department of Laboratory Medicine, University of California-San Francisco, CA 94143, USA.

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October 2011

BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition.

Authors:
Cihangir Duy Christian Hurtz Seyedmehdi Shojaee Leandro Cerchietti Huimin Geng Srividya Swaminathan Lars Klemm Soo-mi Kweon Rahul Nahar Melanie Braig Eugene Park Yong-mi Kim Wolf-Karsten Hofmann Sebastian Herzog Hassan Jumaa H Phillip Koeffler J Jessica Yu Nora Heisterkamp Thomas G Graeber Hong Wu B Hilda Ye Ari Melnick Markus Müschen

Nature 2011 May;473(7347):384-8

Department of Laboratory Medicine, University of California San Francisco, San Francisco, California 94143, USA.

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May 2011

BCL6 is critical for the development of a diverse primary B cell repertoire.

Authors:
Cihangir Duy J Jessica Yu Rahul Nahar Srividya Swaminathan Soo-Mi Kweon Jose M Polo Ester Valls Lars Klemm Seyedmehdi Shojaee Leandro Cerchietti Wolfgang Schuh Hans-Martin Jäck Christian Hurtz Parham Ramezani-Rad Sebastian Herzog Hassan Jumaa H Phillip Koeffler Ignacio Moreno de Alborán Ari M Melnick B Hilda Ye Markus Müschen

J Exp Med 2010 Jun 24;207(6):1209-21. Epub 2010 May 24.

Childrens Hospital Los Angeles and Leukemia and Lymphoma Program, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90027, USA.

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June 2010