Christian Heinis

Christian Heinis

UNVERIFIED PROFILE

Are you Christian Heinis?   Register this Author

Register author
Christian Heinis

Christian Heinis

Publications by authors named "Christian Heinis"

Are you Christian Heinis?   Register this Author

63Publications

1196Reads

25Profile Views

A releasable disulfide-linked peptide tag facilitates the synthesis and purification of short peptides.

Chem Commun (Camb) 2020 Mar 10;56(19):2917-2920. Epub 2020 Feb 10.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9cc09247aDOI Listing
March 2020

Synthesis of DNA-Encoded Disulfide- and Thioether-Cyclized Peptides.

Chembiochem 2020 Feb 17;21(4):543-549. Epub 2019 Oct 17.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fedérale de Lausanne, CH A3 398, Station 6, 1015, Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.201900390DOI Listing
February 2020

Engineered Peptide Macrocycles Can Inhibit Matrix Metalloproteinases with High Selectivity.

Angew Chem Int Ed Engl 2019 Aug 24;58(34):11801-11805. Epub 2019 Jul 24.

Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201906791DOI Listing
August 2019

The Partnership of DMCCB and LS².

Chimia (Aarau) 2018 11;72(11):817-818

Novartis Institutes for BioMedical Research, WKL-136.6.82, Klybeckstrasse 141, CH-4057 Basel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2533/chimia.2018.817DOI Listing
November 2018

Cyclization of peptides with two chemical bridges affords large scaffold diversities.

Nat Chem 2018 07 30;10(7):715-723. Epub 2018 Apr 30.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41557-018-0042-7DOI Listing
July 2018

Drugs Based on de -developed Peptides are Coming of Age mune is a.

Chimia (Aarau) 2018 Jun;72(6):426-427

École Polytechnique Fédéral de Lausanne (EPFL), Laboratory of Therapeutic Peptides and Proteins, BCH 5305 CH-1015 Lausanne;, Email:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2533/chimia.2018.426DOI Listing
June 2018

Bypassing bacterial infection in phage display by sequencing DNA released from phage particles.

Protein Eng Des Sel 2017 Nov;30(11):761-768

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://academic.oup.com/peds/article/30/11/761/4675113
Publisher Site
http://dx.doi.org/10.1093/protein/gzx057DOI Listing
November 2017

Phage Selection of Cyclic Peptides for Application in Research and Drug Development.

Acc Chem Res 2017 08 18;50(8):1866-1874. Epub 2017 Jul 18.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL) , CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.accounts.7b00184DOI Listing
August 2017

Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides.

Nat Commun 2017 07 17;8:16092. Epub 2017 Jul 17.

Institute of Chemical Sciences and Engineering, School of Basic Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne CH-1015, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms16092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520048PMC
July 2017

Cyclic peptide therapeutics: past, present and future.

Curr Opin Chem Biol 2017 Jun 27;38:24-29. Epub 2017 Feb 27.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbpa.2017.02.006DOI Listing
June 2017

Precisely Regulated and Efficient Locking of Linear Peptides into Stable Multicyclic Topologies through a One-Pot Reaction.

Angew Chem Int Ed Engl 2017 04 27;56(16):4458-4463. Epub 2017 Feb 27.

The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P.R. China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201610942DOI Listing
April 2017

Polar Hinges as Functionalized Conformational Constraints in (Bi)cyclic Peptides.

Chembiochem 2017 02 16;18(4):387-395. Epub 2017 Jan 16.

School of Chemistry, University of Glasgow, Joseph Black Building, University Avenue, Glasgow, G12 8QQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.201600612DOI Listing
February 2017

Peptide Macrocycle Inhibitor of Coagulation Factor XII with Subnanomolar Affinity and High Target Selectivity.

J Med Chem 2017 02 20;60(3):1151-1158. Epub 2017 Jan 20.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL) , CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.6b01548DOI Listing
February 2017

Improving the Binding Affinity of in-Vitro-Evolved Cyclic Peptides by Inserting Atoms into the Macrocycle Backbone.

Chembiochem 2016 Dec 11;17(24):2299-2303. Epub 2016 Nov 11.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, EPFL), 1015, Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.201600336DOI Listing
December 2016

Development of Potent and Selective S. aureus Sortase A Inhibitors Based on Peptide Macrocycles.

ACS Med Chem Lett 2016 Jun 14;7(6):606-11. Epub 2016 Apr 14.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne , CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsmedchemlett.6b00045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904248PMC
June 2016

Phage Selection of Chemically Stabilized α-Helical Peptide Ligands.

ACS Chem Biol 2016 05 11;11(5):1422-7. Epub 2016 Mar 11.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne , CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschembio.5b00963DOI Listing
May 2016

Phage Selection of Peptide Macrocycles against β-Catenin To Interfere with Wnt Signaling.

ChemMedChem 2016 Apr 26;11(8):834-9. Epub 2016 Jan 26.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cmdc.201500557DOI Listing
April 2016

Phage Selection of Bicyclic Peptide Ligands of the Notch1 Receptor.

ChemMedChem 2015 Oct 25;10(10):1754-61. Epub 2015 Aug 25.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cmdc.201500261DOI Listing
October 2015

Phage selection of bicyclic peptides based on two disulfide bridges.

Methods Mol Biol 2015 ;1248:119-37

Ecole Polytechnique Fédérale de Lausanne (EPFL), Institute of Chemical Sciences and Engineering, EPFL SB ISIC LPPT, BCH 5305 (Bâtochime), CH-1015, Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-2020-4_9DOI Listing
September 2015

A Synthetic Factor XIIa Inhibitor Blocks Selectively Intrinsic Coagulation Initiation.

ACS Chem Biol 2015 Aug 19;10(8):1861-70. Epub 2015 May 19.

†Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschembio.5b00103DOI Listing
August 2015

Encoded libraries of chemically modified peptides.

Curr Opin Chem Biol 2015 Jun 11;26:89-98. Epub 2015 Mar 11.

MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge CB2 0QH, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbpa.2015.02.008DOI Listing
June 2015

Bicyclic peptides conjugated to an albumin-binding tag diffuse efficiently into solid tumors.

Mol Cancer Ther 2015 Jan 7;14(1):151-61. Epub 2014 Nov 7.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://mct.aacrjournals.org/content/early/2014/11/07/1535-71
Web Search
http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-14
Publisher Site
http://dx.doi.org/10.1158/1535-7163.MCT-14-0534DOI Listing
January 2015

Chemical biology & drug discovery.

Eur J Med Chem 2014 Dec 8;88:1-2. Epub 2014 Oct 8.

Laboratory of Therapeutic Proteins and Peptides (LPPT), École Polytechnique Fédérale de Lausanne (EPFL), BCH 5305 (Bâtochime), Lausanne CH-1015, Switzerland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2014.10.017DOI Listing
December 2014

Identification of target-binding peptide motifs by high-throughput sequencing of phage-selected peptides.

Nucleic Acids Res 2014 Dec 27;42(22):e169. Epub 2014 Oct 27.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland

View Article

Download full-text PDF

Source
http://nar.oxfordjournals.org/content/early/2014/10/27/nar.g
Web Search
http://nar.oxfordjournals.org/lookup/doi/10.1093/nar/gku940
Publisher Site
http://dx.doi.org/10.1093/nar/gku940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267670PMC
December 2014

Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides.

Nat Chem 2014 Nov 31;6(11):1009-16. Epub 2014 Aug 31.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nchem.2043
Publisher Site
http://dx.doi.org/10.1038/nchem.2043DOI Listing
November 2014

Drug discovery: tools and rules for macrocycles.

Authors:
Christian Heinis

Nat Chem Biol 2014 Sep 20;10(9):696-8. Epub 2014 Jul 20.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchembio.1605DOI Listing
September 2014

Tracking chemical reactions on the surface of filamentous phage using mass spectrometry.

Chem Commun (Camb) 2014 May 29;50(40):5267-9. Epub 2013 Nov 29.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c3cc47496hDOI Listing
May 2014

Directed evolution of bicyclic peptides for therapeutic application.

Chimia (Aarau) 2013 ;67(12-13):910-5

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2533/chimia.2013.910DOI Listing
April 2014

Phage selection of photoswitchable peptide ligands.

J Am Chem Soc 2014 Apr 11;136(16):5880-3. Epub 2014 Apr 11.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne , CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja501861mDOI Listing
April 2014

Peptide ligands stabilized by small molecules.

Angew Chem Int Ed Engl 2014 Feb 22;53(6):1602-6. Epub 2014 Jan 22.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne (Switzerland).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201309459DOI Listing
February 2014

Pattern-based sensing of peptides and aminoglycosides with a single molecular probe.

Org Lett 2013 Jul 24;15(13):3456-9. Epub 2013 Jun 24.

Institut des Sciences et Ingénierie Chimiques, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ol401495cDOI Listing
July 2013

Improving binding affinity and stability of peptide ligands by substituting glycines with D-amino acids.

Chembiochem 2013 Jul 4;14(11):1316-22. Epub 2013 Jul 4.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, BCH 5305 (Batochime), Avenue Forel 2, 1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.201300228DOI Listing
July 2013

Bicyclic peptide ligands pulled out of cysteine-rich peptide libraries.

J Am Chem Soc 2013 May 17;135(17):6562-9. Epub 2013 Apr 17.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja400461hDOI Listing
May 2013

Development of a selective peptide macrocycle inhibitor of coagulation factor XII toward the generation of a safe antithrombotic therapy.

J Med Chem 2013 May 25;56(9):3742-6. Epub 2013 Apr 25.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne EPFL, CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm400236jDOI Listing
May 2013

Phage selection of bicyclic peptides.

Methods 2013 Mar 10;60(1):46-54. Epub 2013 Jan 10.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymeth.2012.12.008DOI Listing
March 2013

Polycyclic peptide therapeutics.

ChemMedChem 2013 Mar 25;8(3):377-84. Epub 2013 Jan 25.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cmdc.201200513DOI Listing
March 2013

Phage selection of cyclic peptide antagonists with increased stability toward intestinal proteases.

Protein Eng Des Sel 2013 Jan 24;26(1):81-9. Epub 2012 Oct 24.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/protein/gzs085DOI Listing
January 2013

Bicyclization and tethering to albumin yields long-acting peptide antagonists.

J Med Chem 2012 Nov 5;55(22):10187-97. Epub 2012 Nov 5.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne , CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm301276eDOI Listing
November 2012

Chemical macrocyclization of peptides fused to antibody Fc fragments.

Bioconjug Chem 2012 Sep 10;23(9):1856-63. Epub 2012 Aug 10.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bc300184mDOI Listing
September 2012

Measuring net protease activities in biological samples using selective peptidic inhibitors.

Anal Biochem 2012 Aug 28;427(1):18-20. Epub 2012 Apr 28.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ab.2012.04.025DOI Listing
August 2012

Bicyclic peptides with optimized ring size inhibit human plasma kallikrein and its orthologues while sparing paralogous proteases.

ChemMedChem 2012 Jul 11;7(7):1173-6. Epub 2012 Apr 11.

Institute of Chemical Sciences and Engineering (ISIC), Ecole Polytechnique Fédérale de Lausanne (EPFL), CH B3 391, Station 6, 1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/cmdc.201200071
Publisher Site
http://dx.doi.org/10.1002/cmdc.201200071DOI Listing
July 2012

Boosting the sensitivity of ligand-protein screening by NMR of long-lived states.

J Am Chem Soc 2012 Jul 27;134(27):11076-9. Epub 2012 Jun 27.

Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja303301wDOI Listing
July 2012

Bicyclic peptide inhibitor reveals large contact interface with a protease target.

ACS Chem Biol 2012 May 15;7(5):817-21. Epub 2012 Feb 15.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/cb200478tDOI Listing
May 2012

Structurally diverse cyclisation linkers impose different backbone conformations in bicyclic peptides.

Chembiochem 2012 May 11;13(7):1032-8. Epub 2012 Apr 11.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.201200049DOI Listing
May 2012

Screening of large molecule diversities by phage display.

Chimia (Aarau) 2011 ;65(11):843-5

Ecole Polytechnique Fédérale de Lausanne, EPFL Institute of Chemical Sciences and Engineering, CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://www.ingentaconnect.com/content/10.2533/chimia.2011.84
Publisher Site
http://dx.doi.org/10.2533/chimia.2011.843DOI Listing
February 2012

Chemical biology approaches to membrane homeostasis and function.

Chimia (Aarau) 2011 ;65(11):849-52

Departments of Biochemistry, Organic Chemistry and Molecular Biology, University of Geneva, 30 quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2533/chimia.2011.849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289194PMC
February 2012

Synthesis and photochemical properties of oligo-ortho-azobenzenes.

J Org Chem 2011 Dec 1;76(23):9826-34. Epub 2011 Nov 1.

Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jo201996wDOI Listing
December 2011

Bicyclic peptide antagonists derived from genetically encoded combinatorial libraries.

Authors:
Christian Heinis

Chimia (Aarau) 2011 ;65(9):677-9

Ecole Polytechnique Fédérale de Lausanne, EPFL Institute of Chemical Sciences and Engineering, CH1015 Lausanne.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2533/chimia.2011.677DOI Listing
December 2011

The 4 Young Faculty Meeting - Science and Funding in its Different Varieties.

Chimia (Aarau) 2011 Oct;65(10):818-820

Laboratory of Asymmetric Catalysis and Synthesis, Ecole Polytechnique Fédérale de Lausanne (EPFL), BCH 4305 (Bât. BCH), CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2533/chimia.2011.818DOI Listing
October 2011

Post-translational modification of genetically encoded polypeptide libraries.

Curr Opin Chem Biol 2011 Jun 12;15(3):355-61. Epub 2011 Apr 12.

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbpa.2011.03.009DOI Listing
June 2011

Measuring in vivo protein half-life.

Chem Biol 2011 Jun;18(6):805-15

School of Life Sciences, Frontiers-in-Genetics National Program, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2011.03.014DOI Listing
June 2011

Enzymatic cyclisation of peptides with a transglutaminase.

Chembiochem 2011 Jan;12(1):38-42

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.201000451DOI Listing
January 2011

Using peptide loop insertion mutagenesis for the evolution of proteins.

Methods Mol Biol 2010 ;634:217-32

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de, Lausanne (EPFL), Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-60761-652-8_16DOI Listing
December 2010

Phage-encoded combinatorial chemical libraries based on bicyclic peptides.

Nat Chem Biol 2009 Jul;5(7):502-7

Laboratory of Molecular Biology, Medical Research Council, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchembio.184DOI Listing
July 2009

An engineered protein tag for multiprotein labeling in living cells.

Chem Biol 2008 Feb;15(2):128-36

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S107455210800041
Publisher Site
http://dx.doi.org/10.1016/j.chembiol.2008.01.007DOI Listing
February 2008

Evolving the substrate specificity of O6-alkylguanine-DNA alkyltransferase through loop insertion for applications in molecular imaging.

ACS Chem Biol 2006 Oct;1(9):575-84

Ecole Polytechnique Fédérale de Lausanne (EPFL), Institute of Chemical Sciences and Engineering, CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/cb6003146DOI Listing
October 2006

Directed evolution of O6-alkylguanine-DNA alkyltransferase for applications in protein labeling.

Protein Eng Des Sel 2006 Jul 25;19(7):309-16. Epub 2006 Apr 25.

Ecole Polytechnique Fédérale de Lausanne (EPFL), Institute of Chemical Sciences and Engineering CH-1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/protein/gzl014DOI Listing
July 2006

Engineering substrate specificity of O6-alkylguanine-DNA alkyltransferase for specific protein labeling in living cells.

Chembiochem 2005 Jul;6(7):1263-9

Ecole Polytechnique Fédérale de Lausanne, Institute of Chemical Sciences and Engineering, 1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/cbic.200400431
Publisher Site
http://dx.doi.org/10.1002/cbic.200400431DOI Listing
July 2005

Fast directed evolution of non-immunoglobulin proteins by somatic hypermutation in immune cells.

Chembiochem 2005 May;6(5):804-6

Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.200500011DOI Listing
May 2005

Serum ionized magnesium levels and ionized calcium-to-magnesium ratios in adult patients with sickle cell anemia.

Am J Hematol 2004 Nov;77(3):215-22

Department of Emergency Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/ajh.20187
Publisher Site
http://dx.doi.org/10.1002/ajh.20187DOI Listing
November 2004

Engineering a thermostable human prolyl endopeptidase for antibody-directed enzyme prodrug therapy.

Biochemistry 2004 May;43(20):6293-303

Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi0361160DOI Listing
May 2004

Calmodulin-tagged phage and two-filter sandwich assays for the identification of enzymatic activities.

Methods Mol Biol 2003 ;230:313-28

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1385/1-59259-396-8:313DOI Listing
October 2003

Two general methods for the isolation of enzyme activities by colony filter screening.

Chem Biol 2002 Mar;9(3):383-90

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1074-5521(02)00113-8DOI Listing
March 2002