Christian Gloeckner

Christian Gloeckner

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Christian Gloeckner

Publications by authors named "Christian Gloeckner"

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Biochemical and kinetic properties of the complex Roco G-protein cycle.

Biol Chem 2018 11;399(12):1447-1456

Department of Cell Biochemistry, University of Groningen, Groningen NL-9747 AG, TheNetherlands.

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http://dx.doi.org/10.1515/hsz-2018-0227DOI Listing
November 2018

Identification and characterization of ubiquitinylation sites in TAR DNA-binding protein of 43 kDa (TDP-43).

J Biol Chem 2018 10 17;293(41):16083-16099. Epub 2018 Aug 17.

From the German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen and

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http://dx.doi.org/10.1074/jbc.RA118.003440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187624PMC
October 2018

Regulation of LRRK2: insights from structural and biochemical analysis.

Biol Chem 2018 06;399(7):637-642

DZNE-German Center for Neurodegenerative Diseases, Otfried-Müller Str. 23, D-72076 Tübingen, Germany.

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http://dx.doi.org/10.1515/hsz-2018-0132DOI Listing
June 2018

Improved genome sequencing using an engineered transposase.

BMC Biotechnol 2017 01 17;17(1). Epub 2017 Jan 17.

Department of Protein Engineering, Illumina Inc, 5200 Illumina Way, San Diego, CA, USA.

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http://dx.doi.org/10.1186/s12896-016-0326-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240201PMC
January 2017

First model of dimeric LRRK2: the challenge of unrevealing the structure of a multidomain Parkinson's-associated protein.

Biochem Soc Trans 2016 12;44(6):1635-1641

German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.

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http://dx.doi.org/10.1042/BST20160226DOI Listing
December 2016

Autophosphorylation on S614 inhibits the activity and the transforming potential of BRAF.

Cell Signal 2016 09 21;28(9):1432-9. Epub 2016 Jun 21.

Medical Proteome Center, Division for Experimental Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2016.06.016DOI Listing
September 2016

LRRK2 transport is regulated by its novel interacting partner Rab32.

PLoS One 2014 31;9(10):e111632. Epub 2014 Oct 31.

Department of Experimental Tumorbiology, Westfälische Wilhelms University Muenster, Muenster, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111632PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216093PMC
December 2015

Mutational dynamics between primary and relapse neuroblastomas.

Nat Genet 2015 Aug 29;47(8):872-7. Epub 2015 Jun 29.

1] Pediatric Oncology and Hematology, University Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany. [2] Pediatric Oncology and Hematology, Charité University Medicine, Berlin, Germany. [3] German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.

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http://search.proquest.com/openview/bef3fe020af3cd6708016aba
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http://dx.doi.org/10.1038/ng.3349DOI Listing
August 2015

A visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology.

Proteomics 2015 Apr 21;15(8):1390-404. Epub 2015 Mar 21.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.

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http://dx.doi.org/10.1002/pmic.201400390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415485PMC
April 2015

Applying SILAC for the differential analysis of protein complexes.

Methods Mol Biol 2014 ;1188:177-90

Division of Experimental Ophthalmology and Medical Proteome Center, Center of Ophthalmology, Institute for Ophthalmic Research, University of Tübingen, Roentgenweg 11, 72076, Tübingen, Germany,

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http://dx.doi.org/10.1007/978-1-4939-1142-4_13DOI Listing
March 2015

The role of the plexin-A2 receptor in Sema3A and Sema3B signal transduction.

J Cell Sci 2014 Dec 21;127(Pt 24):5240-52. Epub 2014 Oct 21.

Cancer Research and Vascular Biology Center, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel

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http://dx.doi.org/10.1242/jcs.155960DOI Listing
December 2014

Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain.

Mol Cell Biol 2014 Jun 31;34(12):2147-61. Epub 2014 Mar 31.

Helmholtz Zentrum München, German Research Center for Environmental Health, Research Unit Protein Science, Neuherberg, Germany Eberhard Karls University Tübingen, Institute for Ophthalmic Research, Medical Proteome Center, Tübingen, Germany

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http://dx.doi.org/10.1128/MCB.00914-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054300PMC
June 2014

Calretinin interacts with huntingtin and reduces mutant huntingtin-caused cytotoxicity.

J Neurochem 2012 Nov 10;123(3):437-46. Epub 2012 Sep 10.

Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA.

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http://doi.wiley.com/10.1111/j.1471-4159.2012.07919.x
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http://dx.doi.org/10.1111/j.1471-4159.2012.07919.xDOI Listing
November 2012

Mass spectrometric identification of novel posttranslational modification sites in Huntingtin.

Proteomics 2012 Jun;12(12):2060-4

Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA.

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http://dx.doi.org/10.1002/pmic.201100380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845347PMC
June 2012

The use of small molecule probes to study spatially separated stimulus-induced signaling pathways.

Bioorg Med Chem Lett 2012 Mar 14;22(5):2043-5. Epub 2012 Jan 14.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, 92037 CA, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.01.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288742PMC
March 2012

Prothymosin-α interacts with mutant huntingtin and suppresses its cytotoxicity in cell culture.

J Biol Chem 2012 Jan 22;287(2):1279-89. Epub 2011 Nov 22.

Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota 57069, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.294280
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http://dx.doi.org/10.1074/jbc.M111.294280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256907PMC
January 2012

Targeting the Wolbachia cell division protein FtsZ as a new approach for antifilarial therapy.

PLoS Negl Trop Dis 2011 Nov 29;5(11):e1411. Epub 2011 Nov 29.

New England Biolabs, Division of Parasitology, Ipswich, Massachusetts, USA.

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http://dx.plos.org/10.1371/journal.pntd.0001411
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http://dx.doi.org/10.1371/journal.pntd.0001411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226453PMC
November 2011

Learning from directed evolution: Thermus aquaticus DNA polymerase mutants with translesion synthesis activity.

Chembiochem 2011 Jul 8;12(10):1574-80. Epub 2011 Apr 8.

Department of Chemistry, Konstanz Research School Chemical Biology, University of Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.1002/cbic.201000783DOI Listing
July 2011

Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus.

J Med Chem 2011 Jun 12;54(11):3963-72. Epub 2011 May 12.

Department of Chemistry, The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA.

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http://pubs.acs.org/doi/abs/10.1021/jm200364n
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http://dx.doi.org/10.1021/jm200364nDOI Listing
June 2011

The Enhancer of split transcription factor Her8a is a novel dimerisation partner for Her3 that controls anterior hindbrain neurogenesis in zebrafish.

BMC Dev Biol 2011 May 17;11:27. Epub 2011 May 17.

Zebrafish Neurogenetics Department, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr, 1, D-85764 Neuherberg, Germany.

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http://bmcdevbiol.biomedcentral.com/articles/10.1186/1471-21
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http://dx.doi.org/10.1186/1471-213X-11-27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125270PMC
May 2011

A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics.

Mol Cell Proteomics 2011 Jan 27;10(1):M110.001172. Epub 2010 Sep 27.

Department of Protein Science, Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1074/mcp.M110.001172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013447PMC
January 2011

Tandem affinity purification of ciliopathy-associated protein complexes.

Methods Cell Biol 2009 1;91:143-60. Epub 2009 Dec 1.

Department of Protein Science, Helmholtz Zentrum München, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1016/S0091-679X(08)91009-8DOI Listing
July 2010

Directed evolution of DNA polymerases: construction and screening of DNA polymerase mutant libraries.

Curr Protoc Chem Biol 2010 Jun;2(2):89-109

Department of Chemistry, University of Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.1002/9780470559277.ch090183DOI Listing
June 2010

Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

J Proteome Res 2010 Apr;9(4):1738-45

Helmholtz Zentrum München-German Research Center for Environmental Health, Department of Protein Science, Neuherberg, Germany.

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http://dx.doi.org/10.1021/pr9008578DOI Listing
April 2010

Inhibition of tumor metastasis: functional immune modulation of the CUB domain containing protein 1.

Mol Pharm 2010 Feb;7(1):245-53

The Skaggs Institute for Chemical Biology, Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1021/mp900236tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815031PMC
February 2010

Repositioning of an existing drug for the neglected tropical disease Onchocerciasis.

Proc Natl Acad Sci U S A 2010 Feb 8;107(8):3424-9. Epub 2010 Feb 8.

Department of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0915125107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840490PMC
February 2010

ARMS2 is a constituent of the extracellular matrix providing a link between familial and sporadic age-related macular degenerations.

Invest Ophthalmol Vis Sci 2010 Jan 20;51(1):79-88. Epub 2009 Aug 20.

Department of Protein Science, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich-Neuherberg, Germany.

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http://dx.doi.org/10.1167/iovs.09-3850DOI Listing
January 2010

Tandem affinity purification of protein complexes from mammalian cells by the Strep/FLAG (SF)-TAP tag.

Methods Mol Biol 2009 ;564:359-72

Department of Protein Science, Helmholtz Zentrum München-German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany.

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http://link.springer.com/content/pdf/10.1007/978-1-60761-157
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http://link.springer.com/10.1007/978-1-60761-157-8_21
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http://dx.doi.org/10.1007/978-1-60761-157-8_21DOI Listing
October 2009

Strep/FLAG tandem affinity purification (SF-TAP) to study protein interactions.

Curr Protoc Protein Sci 2009 Aug;Chapter 19:Unit19.20

Helmholtz Zentrum München, Neuherberg, Germany.

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http://dx.doi.org/10.1002/0471140864.ps1920s57DOI Listing
August 2009

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro.

J Neurochem 2009 May 3;109(4):959-68. Epub 2009 Mar 3.

Department of Protein Science, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06024.xDOI Listing
May 2009

Displacement of protein-bound aptamers with small molecules screened by fluorescence polarization.

Nat Protoc 2008 ;3(4):579-87

Program Unit Chemical Biology & Medicinal Chemistry, LIMES Institute, c/o Kekulé Institut für Organische Chemie und Biochemie, University of Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany.

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http://dx.doi.org/10.1038/nprot.2008.15DOI Listing
October 2008

Identification of paracrine neuroprotective candidate proteins by a functional assay-driven proteomics approach.

Mol Cell Proteomics 2008 Jul 23;7(7):1349-61. Epub 2008 Apr 23.

Institute of Human Genetics, Helmholtz Zentrum Muenchen-German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany.

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http://www.mcponline.org/lookup/doi/10.1074/mcp.M700456-MCP2
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http://dx.doi.org/10.1074/mcp.M700456-MCP200DOI Listing
July 2008

Relationship of Pax6 activity levels to the extent of eye development in the mouse, Mus musculus.

Genetics 2008 Jul 18;179(3):1345-55. Epub 2008 Jun 18.

Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764 Neuherberg, Germany.

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http://dx.doi.org/10.1534/genetics.108.088591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475738PMC
July 2008

Chemical biology of DNA polymerases: from selectivity to new functions.

Nucleic Acids Symp Ser (Oxf) 2007 (51):81-2

Department of Chemistry, Universitätsstrasse 10, D-78457 Konstanz, Germany.

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http://dx.doi.org/10.1093/nass/nrm041DOI Listing
April 2008

A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.

Proteomics 2007 Dec;7(23):4228-34

Institute of Human Genetics, GSF-National Research Center for Environment and Health, Neuherberg, Germany.

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http://dx.doi.org/10.1002/pmic.200700038DOI Listing
December 2007

An efficient method for the construction of functionalized DNA bearing amino acid groups through cross-coupling reactions of nucleoside triphosphates followed by primer extension or PCR.

Chemistry 2007 ;13(21):6196-203

Gilead Sciences & IOCB Research Center, Institute of Organic Chemistry and Biochemistry, v. v. i. Academy of Sciences of the Czech Republic, Flemingovo nam. 2, 16610 Prague 6, Czech Republic.

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http://dx.doi.org/10.1002/chem.200700220DOI Listing
September 2007

New branched DNA constructs.

Chemistry 2007 ;13(12):3558-64

Fachbereich Chemie, Universität Konstanz, Universitätsstrasse 10, M 726, 78457 Konstanz, Germany.

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http://dx.doi.org/10.1002/chem.200601473DOI Listing
August 2007

Membrane-initiated effects of progesterone on calcium dependent signaling and activation of VEGF gene expression in retinal glial cells.

Glia 2007 Aug;55(10):1061-73

Institute of Human Genetics, GSF National-Research Center for Environment and Health, Neuherberg, Germany.

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http://dx.doi.org/10.1002/glia.20523DOI Listing
August 2007

Evolving a thermostable DNA polymerase that amplifies from highly damaged templates.

Angew Chem Int Ed Engl 2007 ;46(17):3115-7

Department of Chemistry, Universität Konstanz, 78457 Konstanz, Germany.

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http://dx.doi.org/10.1002/anie.200603987DOI Listing
July 2007

Directed DNA polymerase evolution: effects of mutations in motif C on the mismatch-extension selectivity of thermus aquaticus DNA polymerase.

Chembiochem 2007 Mar;8(4):395-401

Fachbereich Chemie, Universität Konstanz, Universitätsstrasse 10, 78457 Konstanz, Germany.

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http://doi.wiley.com/10.1002/cbic.200600337
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http://dx.doi.org/10.1002/cbic.200600337DOI Listing
March 2007

Differential analysis of Saccharomyces cerevisiae mitochondria by free flow electrophoresis.

Mol Cell Proteomics 2006 Nov 17;5(11):2185-200. Epub 2006 Aug 17.

Institutes of Human Genetics and Toxicology, GSF-National Research Center for Environment and Health, 85764 Munich-Neuherberg, Germany.

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http://dx.doi.org/10.1074/mcp.T600018-MCP200DOI Listing
November 2006

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity.

Hum Mol Genet 2006 Jan 1;15(2):223-32. Epub 2005 Dec 1.

GSF-National Research Center for Environment and Health, Institute of Human Genetics, Munich-Neuherberg, Germany.

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http://dx.doi.org/10.1093/hmg/ddi439DOI Listing
January 2006

Proteomic analysis of the porcine interphotoreceptor matrix.

Proteomics 2005 Sep;5(14):3623-36

GSF-National Research Centre for Environment and Health, Institute of Human Genetics, Neuherberg, Germany.

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http://dx.doi.org/10.1002/pmic.200401223DOI Listing
September 2005

Genome-wide transcriptional responses to a lipid hydroperoxide: adaptation occurs without induction of oxidant defenses.

Free Radic Biol Med 2004 Jul;37(1):23-35

Ramaciotti Centre for Gene Function Analysis and School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, 2052 NSW, Australia.

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http://dx.doi.org/10.1016/j.freeradbiomed.2004.04.014DOI Listing
July 2004