Publications by authors named "Christian Funck-Brentano"

131 Publications

Development and clinical validation of a simple and fast UPLC-ESI-MS/MS method for simultaneous quantification of nine kinase inhibitors and two antiandrogen drugs in human plasma: Interest for their therapeutic drug monitoring.

J Pharm Biomed Anal 2021 Feb 14;197:113968. Epub 2021 Feb 14.

AP-HP.Sorbonne Université, Department of Pharmacology and Clinical Investigation Center (CIC-1901), Pitié-Salpêtrière Hospital, INSERM, CIC-1901 and UMR-S 1166, Sorbonne Université, Faculty of Medicine Sorbonne Université, Faculty of Medicine, Paris, France. Electronic address:

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February 2021

Pharmacokinetics and pharmacodynamics of hydroxychloroquine in hospitalized patients with COVID-19.

Therapie 2021 Jan 28. Epub 2021 Jan 28.

AP-HP, Sorbonne Université, Pitié-Salpêtrière Hospital, Department of Pharmacology and Clinical Investigation Center, INSERM, CIC-1901, Sorbonne Université, Faculty of Medicine, 75013 Paris, France.

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January 2021

Sexual Dimorphisms, Anti-Hormonal Therapy and Cardiac Arrhythmias.

Int J Mol Sci 2021 Feb 2;22(3). Epub 2021 Feb 2.

INSERM, CIC-1901, AP-HP, Pitié-Salpêtrière Hospital, Regional Pharmacovigilance Center, UNICO-GRECO Cardio-Oncology Program, Department of Pharmacology and Clinical Investigation Center, CLIP2 Galilée, Sorbonne Université, F-75013 Paris, France.

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February 2021

Cardiotoxicity Associated with Gemcitabine: Literature Review and a Pharmacovigilance Study.

Pharmaceuticals (Basel) 2020 Oct 21;13(10). Epub 2020 Oct 21.

Department of Pharmacology, Regional Pharmacovigilance Centre, Pitié-Salpêtrière Hospital, INSERM CIC-1901, Sorbonne Université, AP-HP, 75006 Paris, France.

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October 2020

Indispensable but deceptive evidence-based medicine.

Diabetes Metab 2020 11 10;46(6):415-422. Epub 2020 Oct 10.

AP-HP Sorbonne Université, Pitié-Salpêtrière University Hospital, Department of Pharmacology and Clinical Investigation Centre, F-75013 Paris, France; INSERM, CIC-1901 and UMR-S 1166, Sorbonne University, Faculty of Medicine, F-75013 Paris, France. Electronic address:

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November 2020

Retraction and republication: cardiac toxicity of hydroxychloroquine in COVID-19.

Lancet 2020 07 9;396(10245):e2-e3. Epub 2020 Jul 9.

AP-HP, Sorbonne Université, Pitié-Salpêtrière Hospital, Department of Pharmacology and Clinical Investigation Centre, Paris 75013, France; INSERM, CIC-1901 and UMR-S 1166, Sorbonne Université, Faculty of Medicine, Paris, France.

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July 2020

Anticancer drugs and COVID-19 antiviral treatments in patients with cancer: What can we safely use?

Eur J Cancer 2020 09 10;136:1-3. Epub 2020 Jun 10.

Sorbonne Université, Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Department of Oncology, F-75013 Paris, France; Institut Universitaire de Cancérologie. AP-HP Sorbonne Université, Paris, France; INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, équipe Theravir, France.

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September 2020

Effect of congenital adrenal hyperplasia treated by glucocorticoids on plasma metabolome: a machine-learning-based analysis.

Sci Rep 2020 06 1;10(1):8859. Epub 2020 Jun 1.

Department of Endocrinology and Reproductive Medicine, Sorbonne Université, AP-HP, Pitié-Salpêtrière Hospital, Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Centre de Référence des Pathologies Gynécologiques Rares, ICAN, Paris, France.

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June 2020

Chloroquine or hydroxychloroquine for COVID-19: why might they be hazardous?

Lancet 2020 05 22. Epub 2020 May 22.

AP-HP, Sorbonne Université, Pitié-Salpêtrière Hospital, Department of Pharmacology and Clinical Investigation Centre, Paris 75013, France; INSERM, CIC-1901 and UMR-S 1166, Sorbonne Université, Faculty of Medicine, Paris, France.

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May 2020

Cardiovascular Toxicities Associated With Hydroxychloroquine and Azithromycin: An Analysis of the World Health Organization Pharmacovigilance Database.

Circulation 2020 Jul 22;142(3):303-305. Epub 2020 May 22.

Sorbonne Université, Institut national de la santé et de la recherche médicale (INSERM), Assistance Publique - Hopitaux de Paris, Clinical Investigation Center, Department of Pharmacology, Pitié-Salpêtrière Hospital, Paris, France (L.S.N., C.F., C.F.-B., J.-E.S.).

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July 2020

Identification of anticancer drugs associated with atrial fibrillation - analysis of the WHO pharmacovigilance database.

Eur Heart J Cardiovasc Pharmacother 2020 Apr 30. Epub 2020 Apr 30.

Normandie Univ, UNICAEN, CHU de Caen Normandie, PICARO Cardio-oncology Program, Department of Pharmacology, EA 4650, Signalisation, électrophysiologie et imagerie des lésions d'ischémie-reperfusion myocardique, F-14000 CAEN, France.

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April 2020

Uses of pharmacovigilance databases: An overview.

Therapie 2020 Nov - Dec;75(6):591-598. Epub 2020 Feb 26.

INSERM, CIC Pitié-Salpêtrière (CIC-1901), Sorbonne université, faculty of medicine, AP-HP, Pitié-Salpêtrière hospital, department of pharmacology and clinical investigation center, UNICO-GRECO Cardio-oncology program, 75013 Paris, France.

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February 2020

Response by Salem et al to Letter Regarding Article, "Androgenic Effects on Ventricular Repolarization: A Translational Study From the International Pharmacovigilance Database to iPSC-Cardiomyocytes".

Circulation 2020 02 3;141(5):e63-e64. Epub 2020 Feb 3.

Department of Medicine and Pharmacology, Cardio-Oncology Program (J.-E.S., J.J.M., D.M.R.), Vanderbilt University Medical Center, Nashville, TN.

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February 2020

Results of the 2017 inspection campaign of French phase I/II research sites in Île-de-France following the BIA 10-2474 accident: Medical vs. regulatory relevance.

Therapie 2020 Nov - Dec;75(6):517-525. Epub 2020 Jan 14.

INSERM, CIC-1901 and UMR ICAN 1166, Sorbonne university, faculty of medicine, AP-HP, Pitié-Salpêtrière hospital, department of pharmacology and clinical investigation center Paris-Est, institute of cardiometabolism and nutrition (ICAN), 75013 Paris, France. Electronic address:

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January 2020

Anti-ischaemic medication must be adapted to each patient's characteristics and preferences in patients with chronic coronary syndromes.

Eur Heart J 2020 01;41(3):480-481

Department of Clinical Pharmacology, Sorbonne Université, INSERM CIC Paris-Est, AP-HP.Sorbonne Université, ICAN, Pitié-Salpêtrière Hospital, 47-83 Blvd de l'Hôpital, F-75013 Paris, France.

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January 2020

Heart failure and atrial tachyarrhythmia on abiraterone: A pharmacovigilance study.

Arch Cardiovasc Dis 2020 Jan 2;113(1):9-21. Epub 2019 Nov 2.

Department of pharmacology, Sorbonne université, Inserm CIC Paris-Est, ICAN, UNICO-GRECO, Sorbonne Cardio-Oncology program, regional pharmacovigilance centre, Pitié-Salpêtrière hospital, AP-HP, 75013 Paris, France; Cardio-oncology program, department of medicine and pharmacology, Vanderbilt university medical center, 37232 Nashville, TN, USA. Electronic address:

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January 2020

[Early clinical drug development].

Rev Prat 2019 Jun;69(6):607-611

Sorbonne université, Inserm CIC Paris-Est, AP-HP, ICAN, service de pharmacologie médicale, groupe hospitalier La Pitié-Salpêtrière, Paris, France.

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June 2019

Cardiovascular Toxicities Associated With Ibrutinib.

J Am Coll Cardiol 2019 10;74(13):1667-1678

Departments of Medicine and Pharmacology, Cardio-Oncology program, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address:

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October 2019

Influence of hormones on the immunotolerogenic molecule HLA-G: a cross-sectional study in patients with congenital adrenal hyperplasia.

Eur J Endocrinol 2019 Nov;181(5):481-488

Department of Pharmacology, Sorbonne Université, INSERM CIC Paris-Est, UNICO AP-HP.6 Cardio-Oncology Program, Pitié-Salpêtrière Hospital, Paris, France.

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November 2019

Clinical characterization of men with long QT syndrome and torsades de pointes associated with hypogonadism: A review and pharmacovigilance study.

Arch Cardiovasc Dis 2019 Nov 30;112(11):699-712. Epub 2019 Aug 30.

Inserm, UNICO-GRECO Cardio-Oncology Programme, Department of Pharmacology, CIC-1421, Pharmacovigilance Unit, Pitié-Salpêtrière Hospital, Sorbonne Université, AP-HP, 75013 Paris, France.

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November 2019
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