Christian Flotho

Christian Flotho

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Christian Flotho

Christian Flotho

Publications by authors named "Christian Flotho"

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Genotyping circulating tumor DNA of pediatric Hodgkin lymphoma.

Authors:
Ann-Kathrin Desch Kristin Hartung Ante Botzen Alexander Brobeil Mathias Rummel Lars Kurch Thomas Georgi Theresa Jox Stefan Bielack Stefan Burdach Carl Friedrich Classen Alexander Claviez Klaus-Michael Debatin Martin Ebinger Angelika Eggert Jörg Faber Christian Flotho Michael Frühwald Norbert Graf Norbert Jorch Udo Kontny Christof Kramm Andreas Kulozik Joachim Kühr Karl-Walter Sykora Markus Metzler Hermann L Müller Michaela Nathrath Thomas Nüßlein Michael Paulussen Arnulf Pekrun Dirk Reinhardt Harald Reinhard Claudia Rössig Axel Sauerbrey Paul-Gerhardt Schlegel Dominik T Schneider Wolfram Scheurlen Lothar Schweigerer Thorsten Simon Meinolf Suttorp Peter Vorwerk Roland Schmitz Regine Kluge Christine Mauz-Körholz Dieter Körholz Stefan Gattenlöhner Andreas Bräuninger

Leukemia 2020 Jan 20;34(1):151-166. Epub 2019 Aug 20.

Institute of Pathology, Justus-Liebig-University, Giessen, Germany.

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http://dx.doi.org/10.1038/s41375-019-0541-6DOI Listing
January 2020

Proteomic Analysis of an Induced Pluripotent Stem Cell Model Reveals Strategies to Treat Juvenile Myelomonocytic Leukemia.

Authors:
Stella Pearson Baoqiang Guo Andrew Pierce Narges Azadbakht Julie A Brazzatti Stefano Patassini Sonia Mulero-Navarro Stefan Meyer Christian Flotho Bruce D Gelb Anthony D Whetton

J Proteome Res 2020 Jan 12;19(1):194-203. Epub 2019 Nov 12.

Stem Cell and Leukaemia Proteomics Laboratory, Manchester Academic Health Science Centre , The University of Manchester, Wolfson Molecular Imaging Centre , 27 Palatine Road , Withington, Manchester M20 3LJ , U.K.

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http://dx.doi.org/10.1021/acs.jproteome.9b00495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942217PMC
January 2020

Randomized post-induction and delayed intensification therapy in high-risk pediatric acute lymphoblastic leukemia: long-term results of the international AIEOP-BFM ALL 2000 trial.

Authors:
Andishe Attarbaschi Georg Mann Martin Zimmermann Peter Bader Elena Barisone Giuseppe Basso Andrea Biondi Gunnar Cario Gianni Cazzaniga Antonella Colombini Christian Flotho Michaela Kuhlen Peter Lang Melchior Lauten Christin Linderkamp Franco Locatelli Luca Lo Nigro Anja Möricke Felix Niggli Renate Panzer-Grümayer Rosanna Parasole Christina Peters Maria Caterina Putti Carmelo Rizzari Meinolf Suttorp Maria Grazia Valsecchi Valentino Conter Martin Schrappe

Leukemia 2019 Dec 5. Epub 2019 Dec 5.

Department of Pediatrics, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.

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http://dx.doi.org/10.1038/s41375-019-0670-yDOI Listing
December 2019

Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia.

Authors:
Cornelis M van Tilburg Till Milde Ruth Witt Jonas Ecker Thomas Hielscher Angelika Seitz Jens-Peter Schenk Juliane L Buhl Dennis Riehl Michael C Frühwald Arnulf Pekrun Claudia Rossig Regina Wieland Christian Flotho Uwe Kordes Bernd Gruhn Thorsten Simon Christin Linderkamp Felix Sahm Lenka Taylor Angelika Freitag Jürgen Burhenne Kathrin I Foerster Andreas D Meid Stefan M Pfister Irini Karapanagiotou-Schenkel Olaf Witt

Clin Epigenetics 2019 Dec 10;11(1):188. Epub 2019 Dec 10.

KiTZ Clinical Trial Unit, Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ) and Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s13148-019-0775-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902473PMC
December 2019

Noonan syndrome-associated myeloproliferative disorder with somatically acquired monosomy 7: impact on clinical decision making.

Authors:
Mattias Hofmans Rieke Schröder Tim Lammens Christian Flotho Charlotte Niemeyer Nadine Van Roy Wim Decaluwe Jan Philippé Barbara De Moerloose

Br J Haematol 2019 Nov 15;187(4):E83-E86. Epub 2019 Oct 15.

Division of Paediatric Haematology-Oncology and Stem Cell Transplantation, Department of Paediatrics, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1111/bjh.16191DOI Listing
November 2019

Outcome of adolescent patients with acute lymphoblastic leukaemia aged 10-14 years as compared with those aged 15-17 years: Long-term results of 1094 patients of the AIEOP-BFM ALL 2000 study.

Authors:
Anna Maria Testi Andishe Attarbaschi Maria Grazia Valsecchi Anja Möricke Gunnar Cario Felix Niggli Daniela Silvestri Peter Bader Michaela Kuhlen Rosanna Parasole Maria Caterina Putti Peter Lang Christian Flotho Georg Mann Carmelo Rizzari Elena Barisone Franco Locatelli Christin Linderkamp Melchior Lauten Meinolf Suttorp Martin Zimmermann Guiseppe Basso Andrea Biondi Valentino Conter Martin Schrappe

Eur J Cancer 2019 Nov 17;122:61-71. Epub 2019 Oct 17.

Department of Pediatrics, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.

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http://dx.doi.org/10.1016/j.ejca.2019.09.004DOI Listing
November 2019

Azacitidine is effective for targeting leukemia-initiating cells in juvenile myelomonocytic leukemia.

Authors:
Christopher F Krombholz Lorena Gallego-Villar Sushree S Sahoo Pritam K Panda Marcin W Wlodarski Konrad Aumann Mark Hartmann Daniel B Lipka Michael Daskalakis Christoph Plass Charlotte M Niemeyer Miriam Erlacher Christian Flotho

Leukemia 2019 07 24;33(7):1805-1810. Epub 2019 Jan 24.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1038/s41375-018-0343-2DOI Listing
July 2019

Juvenile myelomonocytic leukemia: who's the driver at the wheel?

Authors:
Charlotte M Niemeyer Christian Flotho

Blood 2019 03 22;133(10):1060-1070. Epub 2019 Jan 22.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1182/blood-2018-11-844688DOI Listing
March 2019

Gene mutations do not operate in a vacuum: the increasing importance of epigenetics in juvenile myelomonocytic leukemia.

Authors:
Christian Flotho

Epigenetics 2019 Mar 8;14(3):236-244. Epub 2019 Mar 8.

a Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine , University of Freiburg , Freiburg , Germany.

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http://dx.doi.org/10.1080/15592294.2019.1583039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557547PMC
March 2019

The long non-coding RNA landscape in juvenile myelomonocytic leukemia.

Authors:
Mattias Hofmans Tim Lammens Hetty H Helsmoortel Silvia Bresolin Hélène Cavé Christian Flotho Henrik Hasle Marry M van den Heuvel-Eibrink Charlotte Niemeyer Jan Stary Nadine Van Roy Pieter Van Vlierberghe Jan Philippé Barbara De Moerloose

Haematologica 2018 11 1;103(11):e501-e504. Epub 2018 Jun 1.

Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium.

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http://dx.doi.org/10.3324/haematol.2018.189977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278979PMC
November 2018

DNA-hypomethylating agents as epigenetic therapy before and after allogeneic hematopoietic stem cell transplantation in myelodysplastic syndromes and juvenile myelomonocytic leukemia.

Authors:
Christian Flotho Sebastian Sommer Michael Lübbert

Semin Cancer Biol 2018 08 9;51:68-79. Epub 2017 Nov 9.

Department of Hematology-Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), Freiburg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.semcancer.2017.10.011DOI Listing
August 2018

Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia.

Authors:
Elliot Stieglitz Tali Mazor Adam B Olshen Huimin Geng Laura C Gelston Jon Akutagawa Daniel B Lipka Christoph Plass Christian Flotho Farid F Chehab Benjamin S Braun Joseph F Costello Mignon L Loh

Nat Commun 2017 12 19;8(1):2127. Epub 2017 Dec 19.

Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, 1450 3rd Street, San Francisco, CA, 94158, USA.

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http://dx.doi.org/10.1038/s41467-017-02178-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736624PMC
December 2017

RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia.

Authors:
Daniel B Lipka Tania Witte Reka Toth Jing Yang Manuel Wiesenfarth Peter Nöllke Alexandra Fischer David Brocks Zuguang Gu Jeongbin Park Brigitte Strahm Marcin Wlodarski Ayami Yoshimi Rainer Claus Michael Lübbert Hauke Busch Melanie Boerries Mark Hartmann Maximilian Schönung Umut Kilik Jens Langstein Justyna A Wierzbinska Caroline Pabst Swati Garg Albert Catalá Barbara De Moerloose Michael Dworzak Henrik Hasle Franco Locatelli Riccardo Masetti Markus Schmugge Owen Smith Jan Stary Marek Ussowicz Marry M van den Heuvel-Eibrink Yassen Assenov Matthias Schlesner Charlotte Niemeyer Christian Flotho Christoph Plass

Nat Commun 2017 12 19;8(1):2126. Epub 2017 Dec 19.

Cancer Epigenetics Group, Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), INF 280, 69120, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41467-017-02177-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736667PMC
December 2017

First experience of the AML-Berlin-Frankfurt-Münster group in pediatric patients with standard-risk acute promyelocytic leukemia treated with arsenic trioxide and all-trans retinoid acid.

Authors:
Ursula Creutzig Michael N Dworzak Konrad Bochennek Jörg Faber Christian Flotho Norbert Graf Udo Kontny Claudia Rossig Irene Schmid Arend von Stackelberg Jans-Enno Mueller Christine von Neuhoff Dirk Reinhardt Nils von Neuhoff

Pediatr Blood Cancer 2017 Aug 23;64(8). Epub 2017 Jan 23.

Department of Pediatric Hematology-Oncology, University of Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1002/pbc.26461DOI Listing
August 2017

Epigenetic dysregulation of the erythropoietic transcription factor KLF1 and the β-like globin locus in juvenile myelomonocytic leukemia.

Authors:
Silvia Fluhr Christopher Felix Krombholz Angelina Meier Thomas Epting Oliver Mücke Christoph Plass Charlotte M Niemeyer Christian Flotho

Epigenetics 2017 08 27;12(8):715-723. Epub 2017 Jul 27.

a Department of Pediatrics and Adolescent Medicine , Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg , Freiburg , Germany.

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http://dx.doi.org/10.1080/15592294.2017.1356959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687323PMC
August 2017

Epigenetic silencing of AKAP12 in juvenile myelomonocytic leukemia.

Authors:
Thomas Wilhelm Daniel B Lipka Tania Witte Justyna A Wierzbinska Silvia Fluhr Monika Helf Oliver Mücke Rainer Claus Carolin Konermann Peter Nöllke Charlotte M Niemeyer Christian Flotho Christoph Plass

Epigenetics 2016 18;11(2):110-9. Epub 2016 Feb 18.

a Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center , Heidelberg , Germany.

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http://dx.doi.org/10.1080/15592294.2016.1145327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846096PMC
December 2016

CREBBP is a target of epigenetic, but not genetic, modification in juvenile myelomonocytic leukemia.

Authors:
Silvia Fluhr Melanie Boerries Hauke Busch Aikaterini Symeonidi Tania Witte Daniel B Lipka Oliver Mücke Peter Nöllke Christopher Felix Krombholz Charlotte M Niemeyer Christoph Plass Christian Flotho

Clin Epigenetics 2016 5;8:50. Epub 2016 May 5.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center, Mathildenstrasse 1, 79106 Freiburg, Germany.

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http://dx.doi.org/10.1186/s13148-016-0216-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858931PMC
December 2016

MicroRNA fingerprints in juvenile myelomonocytic leukemia (JMML) identified miR-150-5p as a tumor suppressor and potential target for treatment.

Authors:
Pier Paolo Leoncini Alice Bertaina Dimitrios Papaioannou Christian Flotho Riccardo Masetti Silvia Bresolin Giuseppe Menna Nicola Santoro Marco Zecca Giuseppe Basso Giovanni Nigita Dario Veneziano Sara Pagotto Katia D'Ovidio Rossella Rota Adrienne Dorrance Carlo M Croce Charlotte Niemeyer Franco Locatelli Ramiro Garzon

Oncotarget 2016 Aug;7(34):55395-55408

Division of Hematology, Arthur G. James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.18632/oncotarget.10577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342425PMC
August 2016

LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19.

Authors:
Hetty H Helsmoortel Barbara De Moerloose Tim Pieters Farzaneh Ghazavi Silvia Bresolin Hélène Cavé Andrica de Vries Valerie de Haas Christian Flotho Veerle Labarque Charlotte Niemeyer Pascale De Paepe Nadine Van Roy Jan Stary Marry M van den Heuvel-Eibrink Yves Benoit Johannes Schulte Steven Goossens Geert Berx Jody J Haigh Frank Speleman Pieter Van Vlierberghe Tim Lammens

Haematologica 2016 06 11;101(6):e240-4. Epub 2016 Mar 11.

Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium

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http://dx.doi.org/10.3324/haematol.2016.143818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013963PMC
June 2016

Long-term serial xenotransplantation of juvenile myelomonocytic leukemia recapitulates human disease in Rag2-/-γc-/- mice.

Authors:
Christopher Felix Krombholz Konrad Aumann Matthias Kollek Daniela Bertele Silvia Fluhr Mirjam Kunze Charlotte M Niemeyer Christian Flotho Miriam Erlacher

Haematologica 2016 05 17;101(5):597-606. Epub 2016 Feb 17.

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center, Freiburg, Germany The German Cancer Consortium, Heidelberg, Germany

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http://dx.doi.org/10.3324/haematol.2015.138545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004370PMC
May 2016

LIN28B overexpression defines a novel fetal-like subgroup of juvenile myelomonocytic leukemia.

Authors:
Hetty H Helsmoortel Silvia Bresolin Tim Lammens Hélène Cavé Peter Noellke Aurélie Caye Farzaneh Ghazavi Andrica de Vries Henrik Hasle Veerle Labarque Riccardo Masetti Jan Stary Marry M van den Heuvel-Eibrink Jan Philippé Nadine Van Roy Yves Benoit Frank Speleman Charlotte Niemeyer Christian Flotho Giuseppe Basso Geertruy Te Kronnie Pieter Van Vlierberghe Barbara De Moerloose

Blood 2016 Mar 28;127(9):1163-72. Epub 2015 Dec 28.

Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium;

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http://dx.doi.org/10.1182/blood-2015-09-667808DOI Listing
March 2016

Therapy with low-dose azacitidine for MDS in children and young adults: a retrospective analysis of the EWOG-MDS study group.

Authors:
Annamaria M Cseh Charlotte M Niemeyer Ayami Yoshimi Albert Catala Michael C Frühwald Henrik Hasle Mary M van den Heuvel-Eibrink Melchior Lauten Barbara De Moerloose Owen P Smith Toralf Bernig Bernd Gruhn Andreas E Kulozik Markus Metzler Lale Olcay Meinolf Suttorp Ingrid Furlan Brigitte Strahm Christian Flotho

Br J Haematol 2016 Mar 13;172(6):930-6. Epub 2016 Jan 13.

Division of Paediatric Haematology-Oncology, Department of Paediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1111/bjh.13915DOI Listing
March 2016

Bridging to transplant with azacitidine in juvenile myelomonocytic leukemia: a retrospective analysis of the EWOG-MDS study group.

Authors:
Annamaria Cseh Charlotte M Niemeyer Ayami Yoshimi Michael Dworzak Henrik Hasle Marry M van den Heuvel-Eibrink Franco Locatelli Riccardo Masetti Markus Schmugge Ute Groß-Wieltsch Andrea Candás Andreas E Kulozik Lale Olcay Meinolf Suttorp Ingrid Furlan Brigitte Strahm Christian Flotho

Blood 2015 Apr;125(14):2311-3

Division of Pediatric Hematology-Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany German Cancer Consortium (DKTK), Heidelberg, Germany.

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http://dx.doi.org/10.1182/blood-2015-01-619734DOI Listing
April 2015

Criteria for evaluating response and outcome in clinical trials for children with juvenile myelomonocytic leukemia.

Authors:
Charlotte M Niemeyer Mignon L Loh Annamaria Cseh Todd Cooper Christopher C Dvorak Rebecca Chan Blanca Xicoy Ulrich Germing Seiji Kojima Atsushi Manabe Michael Dworzak Barbara De Moerloose Jan Starý Owen P Smith Riccardo Masetti Albert Catala Eva Bergstraesser Marek Ussowicz Oskana Fabri André Baruchel Hélène Cavé Michel Zwaan Franco Locatelli Henrik Hasle Marry M van den Heuvel-Eibrink Christian Flotho Ayami Yoshimi

Haematologica 2015 Jan;100(1):17-22

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology University of Freiburg, Germany.

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http://dx.doi.org/10.3324/haematol.2014.109892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281308PMC
January 2015

RASA4 undergoes DNA hypermethylation in resistant juvenile myelomonocytic leukemia.

Authors:
Anna R Poetsch Daniel B Lipka Tania Witte Rainer Claus Peter Nöllke Manuela Zucknick Christiane Olk-Batz Silvia Fluhr Michael Dworzak Barbara De Moerloose Jan Starý Marco Zecca Henrik Hasle Markus Schmugge Marry M van den Heuvel-Eibrink Franco Locatelli Charlotte M Niemeyer Christian Flotho Christoph Plass

Epigenetics 2014 Sep 31;9(9):1252-60. Epub 2014 Jul 31.

Division of Epigenomics and Cancer Risk Factors (C010); German Cancer Research Center; Heidelberg, Germany; The German Cancer Consortium; Heidelberg, Germany.

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http://dx.doi.org/10.4161/epi.29941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169017PMC
September 2014

Tracing the development of acute myeloid leukemia in CBL syndrome.

Authors:
Heiko Becker Kenichi Yoshida Nadja Blagitko-Dorfs Rainer Claus Milena Pantic Mahmoud Abdelkarim Christoph Niemöller Christine Greil Björn Hackanson Yuichi Shiraishi Kenichi Chiba Hiroko Tanaka Satoru Miyano Konstanze Döhner Susanne Schnittger Philipp Henneke Charlotte M Niemeyer Christian Flotho Dietmar Pfeifer Seishi Ogawa Michael Lübbert

Blood 2014 Mar 3;123(12):1883-6. Epub 2014 Feb 3.

Department of Medicine I, Medical Center-University of Freiburg, Freiburg, Germany;

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http://dx.doi.org/10.1182/blood-2013-10-533844DOI Listing
March 2014

Pediatric Acute Lymphoblastic Leukemia: Efficacy and safety of recombinant E. coli-asparaginase in infants (less than one year of age) with acute lymphoblastic leukemia.

Authors:
Inge van der Sluis Anja Möricke Gabriele Escherich Arend von Stackelberg Wolfgang Holter Thomas Klingebiel Christian Flotho Sabine Legien Wim Tissing Marc Bierings Cecile Guimbal-Schmolck Uwe Pichlmeier Hans-Jürgen Kühnel Rob Pieters

Haematologica 2013 Nov 10;98(11):1697-701. Epub 2013 Jun 10.

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http://dx.doi.org/10.3324/haematol.2013.090563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815169PMC
November 2013

Spliceosomal gene aberrations are rare, coexist with oncogenic mutations, and are unlikely to exert a driver effect in childhood MDS and JMML.

Authors:
Shinsuke Hirabayashi Christian Flotho Jessica Moetter Michael Heuser Henrik Hasle Bernd Gruhn Thomas Klingebiel Felicitas Thol Brigitte Schlegelberger Irith Baumann Brigitte Strahm Jan Stary Franco Locatelli Marco Zecca Eva Bergstraesser Michael Dworzak Marry M van den Heuvel-Eibrink Barbara De Moerloose Seishi Ogawa Charlotte M Niemeyer Marcin W Wlodarski

Blood 2012 Mar 11;119(11):e96-9. Epub 2012 Jan 11.

Pediatric Hematology and Oncology, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1182/blood-2011-12-395087DOI Listing
March 2012

Constitutional trisomy 8p11.21-q11.21 mosaicism: a germline alteration predisposing to myeloid leukaemia.

Authors:
Tim Ripperger Marcel Tauscher Inka Praulich Brigitte Pabst Andrea Teigler-Schlegel Allen Yeoh Gudrun Göhring Brigitte Schlegelberger Christian Flotho Charlotte M Niemeyer Doris Steinemann

Br J Haematol 2011 Oct 18;155(2):209-17. Epub 2011 Aug 18.

Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany.

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http://doi.wiley.com/10.1111/j.1365-2141.2011.08817.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2141.2011.08817.xDOI Listing
October 2011

Abnormal promoter DNA methylation in juvenile myelomonocytic leukemia is not caused by mutation in DNMT3A.

Authors:
Marcin W Wlodarski Jessica Mötter Thomas A Gorr Christiane Olk-Batz Henrik Hasle Michael Dworzak Charlotte M Niemeyer Christian Flotho

Blood 2011 Oct;118(16):4490-1

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http://dx.doi.org/10.1182/blood-2011-07-370684DOI Listing
October 2011

Aberrant DNA methylation characterizes juvenile myelomonocytic leukemia with poor outcome.

Authors:
Christiane Olk-Batz Anna R Poetsch Peter Nöllke Rainer Claus Manuela Zucknick Inga Sandrock Tania Witte Brigitte Strahm Henrik Hasle Marco Zecca Jan Stary Eva Bergstraesser Barbara De Moerloose Monika Trebo Marry M van den Heuvel-Eibrink Dorota Wojcik Franco Locatelli Christoph Plass Charlotte M Niemeyer Christian Flotho

Blood 2011 May 15;117(18):4871-80. Epub 2011 Mar 15.

Department of Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany.

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http://dx.doi.org/10.1182/blood-2010-08-298968DOI Listing
May 2011

Long-term outcome of hemizygous and heterozygous carriers of a germline GATA1 (G208R) mutation.

Authors:
Ulrich Dührsen Christian P Kratz Christian Flotho Thomas Lauenstein Martin Bommer Erika König Günter Brittinger Hermann Heimpel

Ann Hematol 2011 Mar 5;90(3):301-6. Epub 2010 Oct 5.

Klinik für Hämatologie, Universitätsklinikum Essen, Hufelandstrasse 55, Essen, Germany.

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http://link.springer.com/10.1007/s00277-010-1088-9
Publisher Site
http://dx.doi.org/10.1007/s00277-010-1088-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115595PMC
March 2011

Clonal heterogeneity in childhood myelodysplastic syndromes--challenge for the detection of chromosomal imbalances by array-CGH.

Authors:
Inka Praulich Marcel Tauscher Gudrun Göhring Stefanie Glaser Winfried Hofmann Simone Feurstein Christian Flotho Peter Lichter Charlotte M Niemeyer Brigitte Schlegelberger Doris Steinemann

Genes Chromosomes Cancer 2010 Oct;49(10):885-900

Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/gcc.20797DOI Listing
October 2010

Mutations in the let-7 binding site - a mechanism of RAS activation in juvenile myelomonocytic leukemia?

Authors:
Doris Steinemann Marcel Tauscher Inka Praulich Charlotte M Niemeyer Christian Flotho Brigitte Schlegelberger

Haematologica 2010 Sep 11;95(9):1616. Epub 2010 May 11.

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http://dx.doi.org/10.3324/haematol.2010.024984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930968PMC
September 2010

Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia.

Authors:
Charlotte M Niemeyer Michelle W Kang Danielle H Shin Ingrid Furlan Miriam Erlacher Nancy J Bunin Severa Bunda Jerry Z Finklestein Thomas A Gorr Parinda Mehta Irene Schmid Gabriele Kropshofer Selim Corbacioglu Peter J Lang Christoph Klein Paul-Gerhard Schlegel Andrea Heinzmann Michaela Schneider Jan Starý Marry M van den Heuvel-Eibrink Henrik Hasle Franco Locatelli Debbie Sakai Sophie Archambeault Leslie Chen Ryan C Russell Stephanie S Sybingco Michael Ohh Benjamin S Braun Christian Flotho Mignon L Loh

Nat Genet 2010 Sep 8;42(9):794-800. Epub 2010 Aug 8.

Department of Pediatrics and the Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, United States.

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http://dx.doi.org/10.1038/ng.641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297285PMC
September 2010

Mutations of the Shwachman-Bodian-Diamond syndrome gene in patients presenting with refractory cytopenia--do we have to screen?

Authors:
Axel Karow Christian Flotho Michaela Schneider Manfred Fliegauf Charlotte M Niemeyer

Haematologica 2010 Apr 30;95(4):689-90. Epub 2009 Nov 30.

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http://dx.doi.org/10.3324/haematol.2009.015008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857206PMC
April 2010

Gene expression-based classification as an independent predictor of clinical outcome in juvenile myelomonocytic leukemia.

Authors:
Silvia Bresolin Marco Zecca Christian Flotho Luca Trentin Andrea Zangrando Laura Sainati Jan Stary Barbara de Moerloose Henrik Hasle Charlotte M Niemeyer Geertruy Te Kronnie Franco Locatelli Giuseppe Basso

J Clin Oncol 2010 Apr 15;28(11):1919-27. Epub 2010 Mar 15.

Laboratory of Oncohematology, Department of Pediatrics, University of Padova, Pavia, Italy.

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http://dx.doi.org/10.1200/JCO.2009.24.4426DOI Listing
April 2010

Does SPRED1 contribute to leukemogenesis in juvenile myelomonocytic leukemia (JMML)?

Authors:
Christiane Batz Henrik Hasle Eva Bergsträsser Marry M van den Heuvel-Eibrink Marco Zecca Charlotte M Niemeyer Christian Flotho

Blood 2010 Mar;115(12):2557-8

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http://dx.doi.org/10.1182/blood-2009-12-260901DOI Listing
March 2010

Mitotic recombination and compound-heterozygous mutations are predominant NF1-inactivating mechanisms in children with juvenile myelomonocytic leukemia and neurofibromatosis type 1.

Authors:
Doris Steinemann Larissa Arning Inka Praulich Manfred Stuhrmann Henrik Hasle Jan Stary Brigitte Schlegelberger Charlotte M Niemeyer Christian Flotho

Haematologica 2010 Feb 16;95(2):320-3. Epub 2009 Dec 16.

Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.3324/haematol.2009.010355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817036PMC
February 2010

Mutational analysis of SHOC2, a novel gene for Noonan-like syndrome, in JMML.

Authors:
Christian Flotho Christiane Batz Henrik Hasle Eva Bergsträsser Marry M van den Heuvel-Eibrink Marco Zecca Charlotte M Niemeyer Martin Zenker

Blood 2010 Jan;115(4):913

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http://dx.doi.org/10.1182/blood-2009-10-250779DOI Listing
January 2010

Methylation of the PTEN gene CpG island is infrequent in juvenile myelomonocytic leukemia: Comments on "PTEN deficiency is a common defect in juvenile myelomonocytic leukemia" [Leuk. Res. 2009;33:671-677 (Epub 2008 November 17)].

Authors:
Christiane Batz Inga Sandrock Charlotte M Niemeyer Christian Flotho

Leuk Res 2009 Nov 31;33(11):1578-9; author reply 1580. Epub 2009 May 31.

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http://dx.doi.org/10.1016/j.leukres.2009.04.040DOI Listing
November 2009

Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants.

Authors:
Zhenyun Yang Takako Kondo Cara S Voorhorst Sarah C Nabinger Leila Ndong Fuqin Yin Edward M Chan Menggang Yu Oliver Würstlin Christian P Kratz Charlotte M Niemeyer Christian Flotho Eri Hashino Rebecca J Chan

Mol Cell Biol 2009 Aug 15;29(16):4376-93. Epub 2009 Jun 15.

Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1128/MCB.01330-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725726PMC
August 2009

Mutations in CBL occur frequently in juvenile myelomonocytic leukemia.

Authors:
Mignon L Loh Debbie S Sakai Christian Flotho Michelle Kang Manfred Fliegauf Sophie Archambeault Charles G Mullighan Leslie Chen Eva Bergstraesser Carlos E Bueso-Ramos Peter D Emanuel Henrik Hasle Jean-Pierre Issa Marry M van den Heuvel-Eibrink Franco Locatelli Jan Stary Monica Trebo Marcin Wlodarski Marco Zecca Kevin M Shannon Charlotte M Niemeyer

Blood 2009 Aug 1;114(9):1859-63. Epub 2009 Jul 1.

Department of Pediatrics and the Comprehensive Cancer Center, University of California, San Francisco, California, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2009-01-19
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http://dx.doi.org/10.1182/blood-2009-01-198416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738571PMC
August 2009

Intriguing response to azacitidine in a patient with juvenile myelomonocytic leukemia and monosomy 7.

Authors:
Ingrid Furlan Christiane Batz Christian Flotho Brigitte Mohr Michael Lübbert Meinolf Suttorp Charlotte M Niemeyer

Blood 2009 Mar;113(12):2867-8

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-12-19
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http://dx.doi.org/10.1182/blood-2008-12-195693DOI Listing
March 2009

Development of an allele-specific minimal residual disease assay for patients with juvenile myelomonocytic leukemia.

Authors:
Sophie Archambeault Nikki J Flores Ayami Yoshimi Christian P Kratz Miriam Reising Alexandra Fischer Peter Noellke Franco Locatelli Petr Sedlacek Christian Flotho Marco Zecca Peter D Emanuel Robert P Castleberry Charlotte M Niemeyer Peter Bader Mignon L Loh

Blood 2008 Feb 13;111(3):1124-7. Epub 2007 Nov 13.

Department of Pediatrics, University of California, San Francisco, CA 94143, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2007-06-09
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http://dx.doi.org/10.1182/blood-2007-06-093302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2214753PMC
February 2008

Genotype-phenotype correlation in cases of juvenile myelomonocytic leukemia with clonal RAS mutations.

Authors:
Christian Flotho Christian P Kratz Eva Bergsträsser Henrik Hasle Jan Starý Monika Trebo Marry M van den Heuvel-Eibrink Dorota Wójcik Marco Zecca Franco Locatelli Charlotte M Niemeyer

Blood 2008 Jan;111(2):966-7; author reply 967-8

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http://dx.doi.org/10.1182/blood-2007-09-111831DOI Listing
January 2008

How a rare pediatric neoplasia can give important insights into biological concepts: a perspective on juvenile myelomonocytic leukemia.

Authors:
Christian Flotho Christian P Kratz Charlotte M Niemeyer

Haematologica 2007 Nov;92(11):1441-6

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http://dx.doi.org/10.3324/haematol.11280DOI Listing
November 2007

AKAP12, a gene with tumour suppressor properties, is a target of promoter DNA methylation in childhood myeloid malignancies.

Authors:
Christian Flotho Annika Paulun Christiane Batz Charlotte M Niemeyer

Br J Haematol 2007 Sep;138(5):644-50

Division of Paediatric Haematology-Oncology, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1111/j.1365-2141.2007.06709.xDOI Listing
September 2007

A set of genes that regulate cell proliferation predicts treatment outcome in childhood acute lymphoblastic leukemia.

Authors:
Christian Flotho Elaine Coustan-Smith Deqing Pei Cheng Cheng Guangchun Song Ching-Hon Pui James R Downing Dario Campana

Blood 2007 Aug 24;110(4):1271-7. Epub 2007 Apr 24.

Departments of Pathology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1182/blood-2007-01-068478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1939904PMC
August 2007

Is childhood MDS an epigenetic disease?

Authors:
Christian Flotho

Leuk Res 2007 Jun 13;31(6):743. Epub 2006 Dec 13.

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http://dx.doi.org/10.1016/j.leukres.2006.11.002DOI Listing
June 2007

Targeting RAS signaling pathways in juvenile myelomonocytic leukemia.

Authors:
Christian Flotho Christian Kratz Charlotte M Niemeyer

Curr Drug Targets 2007 Jun;8(6):715-25

Division of Pediatric Hematology/Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Germany.

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http://dx.doi.org/10.2174/138945007780830773DOI Listing
June 2007

Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2.

Authors:
Christian Flotho Elaine Coustan-Smith Deqing Pei Shotaro Iwamoto Guangchun Song Cheng Cheng Ching-Hon Pui James R Downing Dario Campana

Blood 2006 Aug 20;108(3):1050-7. Epub 2006 Apr 20.

Department of Pathology, St Jude Children's Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2006-01-03
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http://dx.doi.org/10.1182/blood-2006-01-0322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895863PMC
August 2006

Genomic assessment of pediatric acute leukemia.

Authors:
Charles G Mullighan Christian Flotho James R Downing

Cancer J 2005 Jul-Aug;11(4):268-82

Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1097/00130404-200507000-00003DOI Listing
December 2005

Expression analysis of alpha-NAC and ANX2 in juvenile myelomonocytic leukemia using SMART polymerase chain reaction and "virtual Northern" hybridization.

Authors:
Klaus Hämmerle Parviz Shayan Charlotte M Niemeyer Christian Flotho

Cancer Genet Cytogenet 2003 Apr;142(2):149-52

Division of Pediatric Hematology/Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, University Children's Hospital, Germany.

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http://dx.doi.org/10.1016/s0165-4608(02)00841-5DOI Listing
April 2003

Stem cell transplantation for paroxysmal nocturnal haemoglobinuria in childhood.

Authors:
Christian Flotho Brigitte Strahm Udo Kontny Ulrich Duffner Anke M J Peters Wolfgang Dupuis Charlotte M Niemeyer

Br J Haematol 2002 Jul;118(1):124-7

Children's Hospital, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1046/j.1365-2141.2002.03543.xDOI Listing
July 2002