Christian Flotho

Christian Flotho

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Christian Flotho

Christian Flotho

Publications by authors named "Christian Flotho"

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Proteomic Analysis of an Induced Pluripotent Stem Cell Model Reveals Strategies to Treat Juvenile Myelomonocytic Leukemia.

J Proteome Res 2020 Jan 12;19(1):194-203. Epub 2019 Nov 12.

Stem Cell and Leukaemia Proteomics Laboratory, Manchester Academic Health Science Centre , The University of Manchester, Wolfson Molecular Imaging Centre , 27 Palatine Road , Withington, Manchester M20 3LJ , U.K.

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http://dx.doi.org/10.1021/acs.jproteome.9b00495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942217PMC
January 2020

Noonan syndrome-associated myeloproliferative disorder with somatically acquired monosomy 7: impact on clinical decision making.

Br J Haematol 2019 Nov 15;187(4):E83-E86. Epub 2019 Oct 15.

Division of Paediatric Haematology-Oncology and Stem Cell Transplantation, Department of Paediatrics, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1111/bjh.16191DOI Listing
November 2019

Azacitidine is effective for targeting leukemia-initiating cells in juvenile myelomonocytic leukemia.

Leukemia 2019 07 24;33(7):1805-1810. Epub 2019 Jan 24.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1038/s41375-018-0343-2DOI Listing
July 2019

Juvenile myelomonocytic leukemia: who's the driver at the wheel?

Blood 2019 03 22;133(10):1060-1070. Epub 2019 Jan 22.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1182/blood-2018-11-844688DOI Listing
March 2019

Gene mutations do not operate in a vacuum: the increasing importance of epigenetics in juvenile myelomonocytic leukemia.

Authors:
Christian Flotho

Epigenetics 2019 Mar 8;14(3):236-244. Epub 2019 Mar 8.

a Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine , University of Freiburg , Freiburg , Germany.

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http://dx.doi.org/10.1080/15592294.2019.1583039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557547PMC
March 2019

DNA-hypomethylating agents as epigenetic therapy before and after allogeneic hematopoietic stem cell transplantation in myelodysplastic syndromes and juvenile myelomonocytic leukemia.

Semin Cancer Biol 2018 08 9;51:68-79. Epub 2017 Nov 9.

Department of Hematology-Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), Freiburg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.semcancer.2017.10.011DOI Listing
August 2018

Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia.

Nat Commun 2017 12 19;8(1):2127. Epub 2017 Dec 19.

Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, 1450 3rd Street, San Francisco, CA, 94158, USA.

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http://dx.doi.org/10.1038/s41467-017-02178-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736624PMC
December 2017

Epigenetic dysregulation of the erythropoietic transcription factor KLF1 and the β-like globin locus in juvenile myelomonocytic leukemia.

Epigenetics 2017 08 27;12(8):715-723. Epub 2017 Jul 27.

a Department of Pediatrics and Adolescent Medicine , Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg , Freiburg , Germany.

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http://dx.doi.org/10.1080/15592294.2017.1356959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687323PMC
August 2017

CREBBP is a target of epigenetic, but not genetic, modification in juvenile myelomonocytic leukemia.

Clin Epigenetics 2016 5;8:50. Epub 2016 May 5.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center, Mathildenstrasse 1, 79106 Freiburg, Germany.

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http://dx.doi.org/10.1186/s13148-016-0216-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858931PMC
December 2016

Long-term serial xenotransplantation of juvenile myelomonocytic leukemia recapitulates human disease in Rag2-/-γc-/- mice.

Haematologica 2016 05 17;101(5):597-606. Epub 2016 Feb 17.

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center, Freiburg, Germany The German Cancer Consortium, Heidelberg, Germany

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http://dx.doi.org/10.3324/haematol.2015.138545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004370PMC
May 2016

AKAP12, a gene with tumour suppressor properties, is a target of promoter DNA methylation in childhood myeloid malignancies.

Br J Haematol 2007 Sep;138(5):644-50

Division of Paediatric Haematology-Oncology, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1111/j.1365-2141.2007.06709.xDOI Listing
September 2007

Is childhood MDS an epigenetic disease?

Authors:
Christian Flotho

Leuk Res 2007 Jun 13;31(6):743. Epub 2006 Dec 13.

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http://dx.doi.org/10.1016/j.leukres.2006.11.002DOI Listing
June 2007

Targeting RAS signaling pathways in juvenile myelomonocytic leukemia.

Curr Drug Targets 2007 Jun;8(6):715-25

Division of Pediatric Hematology/Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Germany.

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http://dx.doi.org/10.2174/138945007780830773DOI Listing
June 2007

Genomic assessment of pediatric acute leukemia.

Cancer J 2005 Jul-Aug;11(4):268-82

Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1097/00130404-200507000-00003DOI Listing
December 2005

Expression analysis of alpha-NAC and ANX2 in juvenile myelomonocytic leukemia using SMART polymerase chain reaction and "virtual Northern" hybridization.

Cancer Genet Cytogenet 2003 Apr;142(2):149-52

Division of Pediatric Hematology/Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, University Children's Hospital, Germany.

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http://dx.doi.org/10.1016/s0165-4608(02)00841-5DOI Listing
April 2003

Stem cell transplantation for paroxysmal nocturnal haemoglobinuria in childhood.

Br J Haematol 2002 Jul;118(1):124-7

Children's Hospital, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1046/j.1365-2141.2002.03543.xDOI Listing
July 2002