Christian Flotho

Section Translational Cancer Epigenomics, Division Translational Medical Oncology, German Cancer Research Center (DKFZ) & National Center for Tumor Diseases (NCT), Heidelberg, Germany.

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January 2021

Synonymous GATA2 mutations result in selective loss of mutated RNA and are common in patients with GATA2 deficiency.

Leukemia 2020 10 18;34(10):2673-2687. Epub 2020 Jun 18.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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October 2020

Lipid Apheresis to Manage Severe Hypertriglyceridemia during Induction Therapy in a Child with Acute Lymphoblastic Leukemia.

Authors:

Christina Mayerhofer Carsten Speckmann Friedrich Kapp Ulrike Teufel-Schäfer Wolfram Kluwe Johanna Schneider Christian Flotho

Pediatr Hematol Oncol 2020 Sep 6;37(6):530-538. Epub 2020 May 6.

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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September 2020

Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia.

Clin Epigenetics 2019 12 10;11(1):188. Epub 2019 Dec 10.

KiTZ Clinical Trial Unit, Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ) and Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.

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December 2019

Randomized post-induction and delayed intensification therapy in high-risk pediatric acute lymphoblastic leukemia: long-term results of the international AIEOP-BFM ALL 2000 trial.

Leukemia 2020 06 5;34(6):1694-1700. Epub 2019 Dec 5.

Department of Pediatrics, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.

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June 2020

Proteomic Analysis of an Induced Pluripotent Stem Cell Model Reveals Strategies to Treat Juvenile Myelomonocytic Leukemia.

Authors:

Stella Pearson Baoqiang Guo Andrew Pierce Narges Azadbakht Julie A Brazzatti Stefano Patassini Sonia Mulero-Navarro Stefan Meyer Christian Flotho Bruce D Gelb Anthony D Whetton

J Proteome Res 2020 01 12;19(1):194-203. Epub 2019 Nov 12.

Stem Cell and Leukaemia Proteomics Laboratory, Manchester Academic Health Science Centre , The University of Manchester, Wolfson Molecular Imaging Centre , 27 Palatine Road , Withington, Manchester M20 3LJ , U.K.

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January 2020

Outcome of adolescent patients with acute lymphoblastic leukaemia aged 10-14 years as compared with those aged 15-17 years: Long-term results of 1094 patients of the AIEOP-BFM ALL 2000 study.

Eur J Cancer 2019 11 17;122:61-71. Epub 2019 Oct 17.

Department of Pediatrics, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.

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November 2019

Noonan syndrome-associated myeloproliferative disorder with somatically acquired monosomy 7: impact on clinical decision making.

Authors:

Mattias Hofmans Rieke Schröder Tim Lammens Christian Flotho Charlotte Niemeyer Nadine Van Roy Wim Decaluwe Jan Philippé Barbara De Moerloose

Br J Haematol 2019 11 15;187(4):E83-E86. Epub 2019 Oct 15.

Division of Paediatric Haematology-Oncology and Stem Cell Transplantation, Department of Paediatrics, Ghent University Hospital, Ghent, Belgium.

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November 2019

Genotyping circulating tumor DNA of pediatric Hodgkin lymphoma.

Leukemia 2020 01 20;34(1):151-166. Epub 2019 Aug 20.

Institute of Pathology, Justus-Liebig-University, Giessen, Germany.

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January 2020

Gene mutations do not operate in a vacuum: the increasing importance of epigenetics in juvenile myelomonocytic leukemia.

Authors:

Christian Flotho

Epigenetics 2019 03 8;14(3):236-244. Epub 2019 Mar 8.

a Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine , University of Freiburg , Freiburg , Germany.

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March 2019

Azacitidine is effective for targeting leukemia-initiating cells in juvenile myelomonocytic leukemia.

Authors:

Christopher F Krombholz Lorena Gallego-Villar Sushree S Sahoo Pritam K Panda Marcin W Wlodarski Konrad Aumann Mark Hartmann Daniel B Lipka Michael Daskalakis Christoph Plass Charlotte M Niemeyer Miriam Erlacher Christian Flotho

Leukemia 2019 07 24;33(7):1805-1810. Epub 2019 Jan 24.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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July 2019

Juvenile myelomonocytic leukemia: who's the driver at the wheel?

Authors:

Charlotte M Niemeyer Christian Flotho

Blood 2019 03 22;133(10):1060-1070. Epub 2019 Jan 22.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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March 2019

The long non-coding RNA landscape in juvenile myelomonocytic leukemia.

Authors:

Mattias Hofmans Tim Lammens Hetty H Helsmoortel Silvia Bresolin Hélène Cavé Christian Flotho Henrik Hasle Marry M van den Heuvel-Eibrink Charlotte Niemeyer Jan Stary Nadine Van Roy Pieter Van Vlierberghe Jan Philippé Barbara De Moerloose

Haematologica 2018 11 1;103(11):e501-e504. Epub 2018 Jun 1.

Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium.

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November 2018

RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia.

Nat Commun 2017 12 19;8(1):2126. Epub 2017 Dec 19.

Cancer Epigenetics Group, Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), INF 280, 69120, Heidelberg, Germany.

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December 2017

Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia.

Authors:

Elliot Stieglitz Tali Mazor Adam B Olshen Huimin Geng Laura C Gelston Jon Akutagawa Daniel B Lipka Christoph Plass Christian Flotho Farid F Chehab Benjamin S Braun Joseph F Costello Mignon L Loh

Nat Commun 2017 12 19;8(1):2127. Epub 2017 Dec 19.

Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, 1450 3rd Street, San Francisco, CA, 94158, USA.

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December 2017

DNA-hypomethylating agents as epigenetic therapy before and after allogeneic hematopoietic stem cell transplantation in myelodysplastic syndromes and juvenile myelomonocytic leukemia.

Authors:

Christian Flotho Sebastian Sommer Michael Lübbert

Semin Cancer Biol 2018 08 9;51:68-79. Epub 2017 Nov 9.

Department of Hematology-Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), Freiburg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.

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August 2018

Epigenetic dysregulation of the erythropoietic transcription factor KLF1 and the β-like globin locus in juvenile myelomonocytic leukemia.

Authors:

Silvia Fluhr Christopher Felix Krombholz Angelina Meier Thomas Epting Oliver Mücke Christoph Plass Charlotte M Niemeyer Christian Flotho

Epigenetics 2017 08 27;12(8):715-723. Epub 2017 Jul 27.

a Department of Pediatrics and Adolescent Medicine , Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg , Freiburg , Germany.

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August 2017

First experience of the AML-Berlin-Frankfurt-Münster group in pediatric patients with standard-risk acute promyelocytic leukemia treated with arsenic trioxide and all-trans retinoid acid.

Authors:

Ursula Creutzig Michael N Dworzak Konrad Bochennek Jörg Faber Christian Flotho Norbert Graf Udo Kontny Claudia Rossig Irene Schmid Arend von Stackelberg Jans-Enno Mueller Christine von Neuhoff Dirk Reinhardt Nils von Neuhoff

Pediatr Blood Cancer 2017 Aug 23;64(8). Epub 2017 Jan 23.

Department of Pediatric Hematology-Oncology, University of Duisburg-Essen, Essen, Germany.

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August 2017

MicroRNA fingerprints in juvenile myelomonocytic leukemia (JMML) identified miR-150-5p as a tumor suppressor and potential target for treatment.

Oncotarget 2016 Aug;7(34):55395-55408

Division of Hematology, Arthur G. James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.

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August 2016

CREBBP is a target of epigenetic, but not genetic, modification in juvenile myelomonocytic leukemia.

Authors:

Silvia Fluhr Melanie Boerries Hauke Busch Aikaterini Symeonidi Tania Witte Daniel B Lipka Oliver Mücke Peter Nöllke Christopher Felix Krombholz Charlotte M Niemeyer Christoph Plass Christian Flotho

Clin Epigenetics 2016 5;8:50. Epub 2016 May 5.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center, Mathildenstrasse 1, 79106 Freiburg, Germany.

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December 2016

LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19.

Haematologica 2016 06 11;101(6):e240-4. Epub 2016 Mar 11.

Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium

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June 2016

Epigenetic silencing of AKAP12 in juvenile myelomonocytic leukemia.

Authors:

Thomas Wilhelm Daniel B Lipka Tania Witte Justyna A Wierzbinska Silvia Fluhr Monika Helf Oliver Mücke Rainer Claus Carolin Konermann Peter Nöllke Charlotte M Niemeyer Christian Flotho Christoph Plass

Epigenetics 2016 18;11(2):110-9. Epub 2016 Feb 18.

a Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center , Heidelberg , Germany.

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December 2016

Long-term serial xenotransplantation of juvenile myelomonocytic leukemia recapitulates human disease in Rag2-/-γc-/- mice.

Authors:

Christopher Felix Krombholz Konrad Aumann Matthias Kollek Daniela Bertele Silvia Fluhr Mirjam Kunze Charlotte M Niemeyer Christian Flotho Miriam Erlacher

Haematologica 2016 05 17;101(5):597-606. Epub 2016 Feb 17.

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center, Freiburg, Germany The German Cancer Consortium, Heidelberg, Germany

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May 2016

Therapy with low-dose azacitidine for MDS in children and young adults: a retrospective analysis of the EWOG-MDS study group.

Authors:

Annamaria M Cseh Charlotte M Niemeyer Ayami Yoshimi Albert Catala Michael C Frühwald Henrik Hasle Mary M van den Heuvel-Eibrink Melchior Lauten Barbara De Moerloose Owen P Smith Toralf Bernig Bernd Gruhn Andreas E Kulozik Markus Metzler Lale Olcay Meinolf Suttorp Ingrid Furlan Brigitte Strahm Christian Flotho

Br J Haematol 2016 Mar 13;172(6):930-6. Epub 2016 Jan 13.

Division of Paediatric Haematology-Oncology, Department of Paediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany.

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March 2016

LIN28B overexpression defines a novel fetal-like subgroup of juvenile myelomonocytic leukemia.

Blood 2016 Mar 28;127(9):1163-72. Epub 2015 Dec 28.

Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium;

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March 2016

Bridging to transplant with azacitidine in juvenile myelomonocytic leukemia: a retrospective analysis of the EWOG-MDS study group.

Authors:

Annamaria Cseh Charlotte M Niemeyer Ayami Yoshimi Michael Dworzak Henrik Hasle Marry M van den Heuvel-Eibrink Franco Locatelli Riccardo Masetti Markus Schmugge Ute Groß-Wieltsch Andrea Candás Andreas E Kulozik Lale Olcay Meinolf Suttorp Ingrid Furlan Brigitte Strahm Christian Flotho

Blood 2015 Apr;125(14):2311-3

Division of Pediatric Hematology-Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany German Cancer Consortium (DKTK), Heidelberg, Germany.

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April 2015

Criteria for evaluating response and outcome in clinical trials for children with juvenile myelomonocytic leukemia.

Haematologica 2015 Jan;100(1):17-22

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology University of Freiburg, Germany.

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January 2015

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