Publications by authors named "Christian Flotho"

61 Publications

International Consensus Definition of DNA Methylation Subgroups in Juvenile Myelomonocytic Leukemia.

Clin Cancer Res 2021 Jan 2;27(1):158-168. Epub 2020 Nov 2.

Section Translational Cancer Epigenomics, Division Translational Medical Oncology, German Cancer Research Center (DKFZ) & National Center for Tumor Diseases (NCT), Heidelberg, Germany.

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January 2021

Lipid Apheresis to Manage Severe Hypertriglyceridemia during Induction Therapy in a Child with Acute Lymphoblastic Leukemia.

Pediatr Hematol Oncol 2020 Sep 6;37(6):530-538. Epub 2020 May 6.

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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September 2020

Proteomic Analysis of an Induced Pluripotent Stem Cell Model Reveals Strategies to Treat Juvenile Myelomonocytic Leukemia.

J Proteome Res 2020 01 12;19(1):194-203. Epub 2019 Nov 12.

Stem Cell and Leukaemia Proteomics Laboratory, Manchester Academic Health Science Centre , The University of Manchester, Wolfson Molecular Imaging Centre , 27 Palatine Road , Withington, Manchester M20 3LJ , U.K.

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January 2020

Noonan syndrome-associated myeloproliferative disorder with somatically acquired monosomy 7: impact on clinical decision making.

Br J Haematol 2019 11 15;187(4):E83-E86. Epub 2019 Oct 15.

Division of Paediatric Haematology-Oncology and Stem Cell Transplantation, Department of Paediatrics, Ghent University Hospital, Ghent, Belgium.

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November 2019

Gene mutations do not operate in a vacuum: the increasing importance of epigenetics in juvenile myelomonocytic leukemia.

Authors:
Christian Flotho

Epigenetics 2019 03 8;14(3):236-244. Epub 2019 Mar 8.

a Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine , University of Freiburg , Freiburg , Germany.

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March 2019

Azacitidine is effective for targeting leukemia-initiating cells in juvenile myelomonocytic leukemia.

Leukemia 2019 07 24;33(7):1805-1810. Epub 2019 Jan 24.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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July 2019

Juvenile myelomonocytic leukemia: who's the driver at the wheel?

Blood 2019 03 22;133(10):1060-1070. Epub 2019 Jan 22.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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March 2019

Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia.

Nat Commun 2017 12 19;8(1):2127. Epub 2017 Dec 19.

Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, 1450 3rd Street, San Francisco, CA, 94158, USA.

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December 2017

DNA-hypomethylating agents as epigenetic therapy before and after allogeneic hematopoietic stem cell transplantation in myelodysplastic syndromes and juvenile myelomonocytic leukemia.

Semin Cancer Biol 2018 08 9;51:68-79. Epub 2017 Nov 9.

Department of Hematology-Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK), Freiburg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.

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August 2018

Epigenetic dysregulation of the erythropoietic transcription factor KLF1 and the β-like globin locus in juvenile myelomonocytic leukemia.

Epigenetics 2017 08 27;12(8):715-723. Epub 2017 Jul 27.

a Department of Pediatrics and Adolescent Medicine , Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg , Freiburg , Germany.

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August 2017

CREBBP is a target of epigenetic, but not genetic, modification in juvenile myelomonocytic leukemia.

Clin Epigenetics 2016 5;8:50. Epub 2016 May 5.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center, Mathildenstrasse 1, 79106 Freiburg, Germany.

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December 2016

Long-term serial xenotransplantation of juvenile myelomonocytic leukemia recapitulates human disease in Rag2-/-γc-/- mice.

Haematologica 2016 05 17;101(5):597-606. Epub 2016 Feb 17.

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center, Freiburg, Germany The German Cancer Consortium, Heidelberg, Germany

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May 2016