Christian Ehnholm

Christian Ehnholm

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Christian Ehnholm

Christian Ehnholm

Publications by authors named "Christian Ehnholm"

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Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin.

J Clin Endocrinol Metab 2015 Oct 23;100(10):E1299-307. Epub 2015 Jul 23.

Minerva Foundation Institute for Medical Research (P.A.N.H., J.S., S.S., R.M., J.P., V.M.O., H.J.-J.), FI-00290 Helsinki, Finland; Public Health Genomics Unit (J.S., J.M., C.E., M.J.), National Institute for Health and Welfare, Helsinki, FI-00290 Helsinki, Finland; Department of Medicine (S.S.), FI-00014 University of Helsinki, Helsinki, Finland; Department of Internal Medicine (F.Q.), University of Texas Southwestern Medical Center, Dallas, Texas 75390; Haartman Institute (A.P., O.R.), FI-00014 University of Helsinki, FI-00029 Helsinki, Finland; Department of Surgery (M.L.), Helsinki University Central Hospital, University of Helsinki, FI-00029 Helsinki, Finland; Department of Biochemistry and Cancer Biology and Center for Diabetes and Endocrine Research (C.M.S.), University of Toledo College of Medicine, Toledo, Ohio 43614; Division of Paediatric Endocrinology and Diabetes, Department of Paediatrics and Adolescent Medicine (P.F.-P., M.W.), University of Ulm, D-89075 Ulm Germany.

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http://dx.doi.org/10.1210/jc.2015-1254DOI Listing
October 2015

HDL biogenesis, remodeling, and catabolism.

Handb Exp Pharmacol 2015 ;224:53-111

Molecular Genetics, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, 02118, USA,

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http://dx.doi.org/10.1007/978-3-319-09665-0_2DOI Listing
April 2015

Elevated serum angiopoietin-like protein 6 in women with subsequent pregnancy-induced hypertension: a preliminary study.

Hypertens Pregnancy 2013 Aug;32(3):203-13

Department of Obstetrics and Gynecology, Hospital District of Helsinki and Uusimaa, Helsinki, Finland.

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http://dx.doi.org/10.3109/10641955.2013.784783DOI Listing
August 2013

Plasma homocysteine and the risk of venous thromboembolism: insights from the FIELD study.

Clin Chem Lab Med 2012 Dec;50(12):2213-9

Department of Clinical Biochemistry , Royal Prince Alfred Hospital, Sydney, Australia.

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http://dx.doi.org/10.1515/cclm-2012-0078DOI Listing
December 2012

Increased apolipoprotein E level and reduced high-density lipoprotein mean particle size associate with low high-density lipoprotein cholesterol and features of metabolic syndrome.

Metabolism 2010 Oct 6;59(10):1502-9. Epub 2010 Mar 6.

Division of Cardiology, Department of Medicine, University of Helsinki, Helsinki University Central Hospital, Biomedicum, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.metabol.2010.01.015DOI Listing
October 2010

Human apoA-I increases macrophage foam cell derived PLTP activity without affecting the PLTP mass.

Lipids Health Dis 2010 Jun 9;9:59. Epub 2010 Jun 9.

National Institute for Health and Welfare, Public Health Genomics Research Unit and FIMM, Institute for Molecular Medicine Finland, Helsinki, Finland.

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http://dx.doi.org/10.1186/1476-511X-9-59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890626PMC
June 2010

Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample.

J Lipid Res 2010 Apr 13;51(4):824-31. Epub 2009 Oct 13.

Department of Chronic Disease Prevention, National Institute for Health and Welfare, Public Health Genomics Research Unit, Biomedicum, Helsinki, Finland.

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http://dx.doi.org/10.1194/jlr.M002618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842146PMC
April 2010

Genetic association and interaction analysis of USF1 and APOA5 on lipid levels and atherosclerosis.

Arterioscler Thromb Vasc Biol 2010 Feb 12;30(2):346-52. Epub 2009 Nov 12.

Public Health Genomics Unit, National Institute for Health and Welfare and Institute for Molecular Medicine, Helsinki, Finland.

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http://dx.doi.org/10.1161/ATVBAHA.109.188912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224996PMC
February 2010

Relationships of HDL cholesterol, ApoA-I, and ApoA-II with homocysteine and creatinine in patients with type 2 diabetes treated with fenofibrate.

Arterioscler Thromb Vasc Biol 2009 Jun 26;29(6):950-5. Epub 2009 Mar 26.

Department of Medicine, Division of Cardiology, Helsinki University Hospital, Biomedicum, Haartmaninkatu 8, 00029 Helsinki, Finland.

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http://dx.doi.org/10.1161/ATVBAHA.108.178228DOI Listing
June 2009

Anionic phospholipids lose their procoagulant properties when incorporated into high density lipoproteins.

J Biol Chem 2009 Feb 6;284(9):5896-904. Epub 2009 Jan 6.

Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital, SE-20502 Malmö, Sweden.

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http://dx.doi.org/10.1074/jbc.M807286200DOI Listing
February 2009

Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies.

J Lipid Res 2008 Sep 19;49(9):1912-7. Epub 2008 May 19.

Department of Laboratory Medicine, Clinical Chemistry, University of Lund, University Hospital, Malmö, Sweden.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M700471-JLR200
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http://dx.doi.org/10.1194/jlr.M700471-JLR200DOI Listing
September 2008

OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages.

J Biol Chem 2008 Jan 8;283(1):332-40. Epub 2007 Nov 8.

Department of Molecular Medicine, National Public Health Institute, Biomedicum, FI-00251 Helsinki, Finland.

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http://dx.doi.org/10.1074/jbc.M705313200DOI Listing
January 2008

Cholesterol efflux from macrophage foam cells is enhanced by active phospholipid transfer protein through generation of two types of acceptor particles.

Biochemistry 2007 Oct 27;46(42):11979-86. Epub 2007 Sep 27.

National Public Health Institute, Department of Molecular Medicine, Biomedicum, P.O. Box 104, FI-00251 Helsinki, Finland.

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http://dx.doi.org/10.1021/bi700833hDOI Listing
October 2007

Low HDL-C predicts the onset of transplant vasculopathy in pediatric cardiac recipients on pravastatin therapy.

Pediatr Transplant 2007 Aug;11(5):481-90

Hospital for Children and Adolescents, University of Helsinki, FIN-00029 HUS, Helsinki, Finland.

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http://dx.doi.org/10.1111/j.1399-3046.2007.00690.xDOI Listing
August 2007

Expression of human OSBP-related protein 1L in macrophages enhances atherosclerotic lesion development in LDL receptor-deficient mice.

Arterioscler Thromb Vasc Biol 2007 Jul 3;27(7):1618-24. Epub 2007 May 3.

Department of Molecular Medicine, National Public Health Institute, Biomedicum, P.O. Box 104, FI-00251 Helsinki, Finland.

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http://dx.doi.org/10.1161/ATVBAHA.107.144121DOI Listing
July 2007

Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis.

Arterioscler Thromb Vasc Biol 2007 May 15;27(5):1108-14. Epub 2007 Feb 15.

Department of Molecular Medicine, National Public Health Institute, Biomedicum, P.O.Box 104, FI-00251 Helsinki, Finland.

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http://dx.doi.org/10.1161/ATVBAHA.106.138545DOI Listing
May 2007

Lipid transfer protein activities in subjects with impaired glucose tolerance.

Clin Chem Lab Med 2007 ;45(2):237-43

Medical Clinics and Outpatient Department III, University Hospital, Dresden, Germany.

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https://www.degruyter.com/view/j/cclm.2007.45.issue-2/cclm.2
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http://dx.doi.org/10.1515/CCLM.2007.032DOI Listing
April 2007

Altered hepatic lipid status and apolipoprotein A-I metabolism in mice lacking phospholipid transfer protein.

Atherosclerosis 2007 Jan 22;190(1):114-23. Epub 2006 Mar 22.

Department of Molecular Medicine, National Public Health Institute, Biomedicum, P.O. Box 104, FI-00251 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.atherosclerosis.2006.02.037DOI Listing
January 2007

ApoE polymorphism is associated with C-reactive protein in low-HDL family members and in normolipidemic subjects.

Mediators Inflamm 2006 ;2006(3):12587

Department of Internal Medicine, Division of Cardiology, Helsinki University Central Hospital, Haartmaninkatu 4, PO Box 340, 00029 HUS, Finland.

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http://dx.doi.org/10.1155/MI/2006/12587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592602PMC
September 2006

Genetics of familial combined hyperlipidemia.

Curr Opin Lipidol 2006 Jun;17(3):285-90

Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland.

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http://dx.doi.org/10.1097/01.mol.0000226121.27931.3fDOI Listing
June 2006

Plasma phospholipid transfer protein fused with green fluorescent protein is secreted by HepG2 cells and displays phosphatidylcholine transfer activity.

Biochem Cell Biol 2006 Apr;84(2):117-25

Department of Molecular Medicine, National Public HealthInstitute, Biomedicum, Helsinki, Finland.

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http://www.nrcresearchpress.com/doi/10.1139/o05-168
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http://dx.doi.org/10.1139/o05-168DOI Listing
April 2006

Hypertriglyceridemia is associated with prebeta-HDL concentrations in subjects with familial low HDL.

J Lipid Res 2005 Aug 16;46(8):1643-51. Epub 2005 May 16.

Division of Cardiology, Department of Medicine, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1194/jlr.M400480-JLR200DOI Listing
August 2005

Determination of human plasma phospholipid transfer protein mass and activity.

Methods 2005 Jun;36(2):97-101

Department of Molecular Medicine, National Public Health Institute, Biomedicum, Haartmaninkatu 8, FIN-00251 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.ymeth.2004.11.006DOI Listing
June 2005

Phospholipid transfer protein is present in human tear fluid.

Biochemistry 2005 Jun;44(22):8111-6

Department of Molecular Medicine, National Public Health Institute, Biomedicum, Helsinki, Finland.

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http://dx.doi.org/10.1021/bi050151kDOI Listing
June 2005

Apolipoprotein E activates the low-activity form of human phospholipid transfer protein.

Biochem Biophys Res Commun 2005 May;331(1):333-40

Department of Molecular Medicine, National Public Health Institute, Biomedicum, P.O. Box 104, FIN-00251 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.bbrc.2005.03.164DOI Listing
May 2005

Active and low-active forms of serum phospholipid transfer protein in a normal Finnish population sample.

J Lipid Res 2004 Dec 1;45(12):2303-9. Epub 2004 Sep 1.

Department of Molecular Medicine, National Public Health Institute, Biomedicum, Helsinki, Finland.

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http://dx.doi.org/10.1194/jlr.M400250-JLR200DOI Listing
December 2004

Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).

Nat Genet 2004 Apr 29;36(4):371-6. Epub 2004 Feb 29.

Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California 90095-7088, USA.

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http://dx.doi.org/10.1038/ng1320DOI Listing
April 2004

Effects of medium-chain fatty acids and oleic acid on blood lipids, lipoproteins, glucose, insulin, and lipid transfer protein activities.

Am J Clin Nutr 2004 Apr;79(4):564-9

Research Department of Human Nutrition, Center of Advanced Food Research, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark.

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https://academic.oup.com/ajcn/article/79/4/564/4690136
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http://dx.doi.org/10.1093/ajcn/79.4.564DOI Listing
April 2004

Quantitation of the active and low-active forms of human plasma phospholipid transfer protein by ELISA.

J Lipid Res 2004 Feb 16;45(2):387-95. Epub 2003 Nov 16.

Department of Molecular Medicine, National Public Health Institute, Biomedicum, FIN-00251 Helsinki, Finland.

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http://www.jlr.org/lookup/doi/10.1194/jlr.D300023-JLR200
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http://dx.doi.org/10.1194/jlr.D300023-JLR200DOI Listing
February 2004

PLTP secreted by HepG2 cells resembles the high-activity PLTP form in human plasma.

J Lipid Res 2003 Sep 16;44(9):1698-704. Epub 2003 Jun 16.

National Public Health Institute, Department of Molecular Medicine, Biomedicum, P.O. Box 104, FIN-00251 Helsinki, Finland.

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http://dx.doi.org/10.1194/jlr.M300059-JLR200DOI Listing
September 2003

Effect of different forms of dietary hydrogenated fats on LDL particle size.

Am J Clin Nutr 2003 Sep;78(3):370-5

Institute on Nutraceuticals and Functional Foods, Laval University, Quebec, Canada.

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http://dx.doi.org/10.1093/ajcn/78.3.370DOI Listing
September 2003

Phospholipid transfer protein is present in human atherosclerotic lesions and is expressed by macrophages and foam cells.

J Lipid Res 2003 Aug 1;44(8):1453-61. Epub 2003 May 1.

Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1194/jlr.M200281-JLR200DOI Listing
August 2003

Determinants of low HDL levels in familial combined hyperlipidemia.

J Lipid Res 2003 Aug 1;44(8):1536-44. Epub 2003 Jun 1.

Department of Medicine, University of Helsinki, Finland.

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http://dx.doi.org/10.1194/jlr.M300069-JLR200DOI Listing
August 2003

Effect of long-term hormone replacement therapy on atherosclerosis progression in postmenopausal women relates to functional apolipoprotein e genotype.

J Clin Endocrinol Metab 2002 Sep;87(9):4147-53

Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory Medicine, University Hospital of Tampere, Finland.

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http://dx.doi.org/10.1210/jc.2002-020008DOI Listing
September 2002

Isolation and partial characterization of the inactive and active forms of human plasma phospholipid transfer protein (PLTP).

J Biol Chem 2002 May 19;277(18):15413-8. Epub 2002 Feb 19.

Department of Molecular Medicine, National Public Health Institute, Biomedicum, P. O. Box 104, Helsinki FIN-00251, Finland.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112247200
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http://dx.doi.org/10.1074/jbc.M112247200DOI Listing
May 2002

LDL particle size in familial combined hyperlipidemia: effects of serum lipids, lipoprotein-modifying enzymes, and lipid transfer proteins.

J Lipid Res 2002 Apr;43(4):598-603

Department of Medicine, Helsinki University Central Hospital, Haartmaninkatu 4, P.O. Box 340, 00029 HUCH, Helsinki, Finland.

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April 2002

Hemostatic factors as predictors of coronary events and total mortality: The FINRISK '92 Hemostasis Study.

Arterioscler Thromb Vasc Biol 2002 Feb;22(2):353-8

Department of Epidemiology and Health Promotion, KTL-National Public Health Institute, Helsinki, FInland.

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http://dx.doi.org/10.1161/hq0202.104078DOI Listing
February 2002

ORP2, a homolog of oxysterol binding protein, regulates cellular cholesterol metabolism.

J Lipid Res 2002 Feb;43(2):245-55

Department of Molecular Medicine, National Public Health Institute, Biomedicum, P.O. Box 104, FIN-00251 Helsinki, Finland.

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February 2002

Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects.

J Lipid Res 2002 Feb;43(2):264-73

Cardiovascular Nutrition Research Program and Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.

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February 2002