Christian Chabannon

Christian Chabannon

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Christian Chabannon

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Identification of hurdles in the development of cell-based therapies.

Cytotherapy 2020 Feb;22(2):53-56

Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jcyt.2019.12.009DOI Listing
February 2020

CD19 chimeric antigen receptor-T cells in B-cell leukemia and lymphoma: current status and perspectives.

Leukemia 2019 Dec 5;33(12):2767-2778. Epub 2019 Nov 5.

Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/s41375-019-0615-5DOI Listing
December 2019

[Reporting data of patients receiving CAR T cell therapy into the EBMT registry: Guidelines of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].

Bull Cancer 2019 Dec 9. Epub 2019 Dec 9.

Hôpital Lyon Sud, service d'hématologie, société francophone de greffe de moelle et de thérapie cellulaire, 165, chemin du grand Revoyet, 69310 Pierre-Bénite, France. Electronic address:

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http://dx.doi.org/10.1016/j.bulcan.2019.10.003DOI Listing
December 2019

Validation of a semi automatic device to standardize quantification of Colony-Forming Unit (CFU) on hematopoietic stem cell products.

Cytotherapy 2019 Aug 28;21(8):820-823. Epub 2019 Jun 28.

Insitut Paoli-Calmettes, Département de Biologie du Cancer, Marseille, France; Inserm CBT1409 Centre d'Investigations Cliniques en Biothérapie, Marseille, France.

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https://linkinghub.elsevier.com/retrieve/pii/S14653249193078
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http://dx.doi.org/10.1016/j.jcyt.2019.06.005DOI Listing
August 2019

Réglementations applicables aux CAR-T cells : comment les établissements de santé français peuvent-ils s’organiser pour participer à la production et permettre la délivrance de ces immunothérapies innovantes ?

Bull Cancer 2018 Dec;105 Suppl 2:S198-S204

AP-HP, Hôpital Saint-Louis, Unité de Thérapie Cellulaire & Inserm CBT-501, Centre d'Investigations Cliniques en Biothérapies, 75010 Paris, France.

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https://linkinghub.elsevier.com/retrieve/pii/S00074551193005
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http://dx.doi.org/10.1016/S0007-4551(19)30050-5DOI Listing
December 2018

Cost-effectiveness analysis of haploidentical vs matched unrelated allogeneic hematopoietic stem cells transplantation in patients older than 55 years.

Bone Marrow Transplant 2018 09 9;53(9):1096-1104. Epub 2018 Mar 9.

Aix-Marseille Univ, INSERM, IRD, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM), Marseille, France.

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http://dx.doi.org/10.1038/s41409-018-0133-5DOI Listing
September 2018

Considerations pertaining to cell collection and administration of industry-manufactured autologous CAR-T cells, in relation to French healthcare organization and regulations.

Curr Res Transl Med 2018 05 4;66(2):59-61. Epub 2018 Apr 4.

AP-HP, Hôpital Saint-Louis, Unité de Thérapie Cellulaire & Inserm CBT-501, Centre d'Investigations Cliniques en Biothérapies, Paris, France.

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http://dx.doi.org/10.1016/j.retram.2018.03.002DOI Listing
May 2018

From clinical proof-of-concept to commercialization of CAR T cells.

Drug Discov Today 2018 Apr 6;23(4):758-762. Epub 2018 Jan 6.

CBT-1409: INSERM, Aix Marseille Univ, Institut Paoli-Calmettes, AP-HM, Marseille, France; Cell Processing and Cell Collection Facility/Tissue Establishment, Institut Paoli-Calmettes, Marseille, France; EBMT Cell Therapy & Immunobiology Working Party. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13596446173045
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http://dx.doi.org/10.1016/j.drudis.2018.01.024DOI Listing
April 2018

Hematopoietic stem cell transplantation in its 60s: A platform for cellular therapies.

Sci Transl Med 2018 04;10(436)

Experimental Hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, University Vita-Salute San Raffaele and Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy.

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http://dx.doi.org/10.1126/scitranslmed.aap9630DOI Listing
April 2018

Killer Cell Immunoglobulin-Like Receptor-Ligand Mismatch in Donor versus Recipient Direction Provides Better Graft-versus-Tumor Effect in Patients with Hematologic Malignancies Undergoing Allogeneic T Cell-Replete Haploidentical Transplantation Followed by Post-Transplant Cyclophosphamide.

Biol Blood Marrow Transplant 2018 03 13;24(3):549-554. Epub 2017 Dec 13.

Department of Hematology, Institut Paoli-Calmettes, Marseille, France; Centre de Recherche en Cancérologie de Marseille (CRCM), Inserm U1068, CNRS UMR 7258, Marseille, France; Medical Faculty, Aix-Marseille University, UM 105, Marseille, France. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2017.11.042DOI Listing
March 2018

Plerixafor in poor mobilizers with non-Hodgkin's lymphoma: a multi-center time-motion analysis.

Bone Marrow Transplant 2018 03 18;53(3):246-254. Epub 2017 Dec 18.

Department of Internal Medicine, University Hospital of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1038/s41409-017-0033-0DOI Listing
March 2018

Pre-clinical assessment of the Lovo device for dimethyl sulfoxide removal and cell concentration in thawed hematopoietic progenitor cell grafts.

Cytotherapy 2017 12 14;19(12):1501-1508. Epub 2017 Oct 14.

Institut Paoli-Calmettes, Marseille, France; Inserm CBT 1409, Centre d'Investigations Cliniques en Biothérapie, Marseille, France. Electronic address:

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http://dx.doi.org/10.1016/j.jcyt.2017.09.001DOI Listing
December 2017

[Non eligibility criteria for hematopoietic stem cell donors: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].

Bull Cancer 2017 Dec 22;104(12S):S76-S83. Epub 2017 Nov 22.

Aix-Marseille université, département de biologie du cancer, département d'oncohematologie, institut Paoli-Calmettes, centre de thérapie cellulaire, centre de lutte contre le cancer, unité de transplantation et de thérapie cellulaire, Inserm CBT-1409, 232, boulevard Sainte-Marguerite, 13273 Marseille cedex 9, France.

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https://linkinghub.elsevier.com/retrieve/pii/S00074551173028
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http://dx.doi.org/10.1016/j.bulcan.2017.06.022DOI Listing
December 2017

[Prerequisite for hematopoietic cellular therapy programs to set up chimeric antigen receptor T-cell therapy (CAR T-cells): Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].

Bull Cancer 2017 Dec 23;104(12S):S43-S58. Epub 2017 Nov 23.

Aix-Marseille université, Inserm CBT-1409, institut Paoli-Calmettes, centre de thérapie cellulaire, unité de transplantation et de thérapie cellulaire, département de biologie du cancer, 13273 Marseille cedex 9, France; EBMT cell therapy & immunobiology working party (CTIWP), 08005 Barcelone, Espagne. Electronic address:

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http://dx.doi.org/10.1016/j.bulcan.2017.10.017DOI Listing
December 2017

[The biological complexity of Polycomb group proteins: the case of EZH2].

Med Sci (Paris) 2017 May 14;33(5):499-505. Epub 2017 Jun 14.

Centre de recherche en cancérologie de Marseille, U1068 Inserm, UMR 7258 CNRS, Aix-Marseille Université, 27, boulevard Lei Roure, CS30059, 13273 Marseille Cedex 09, France.

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http://dx.doi.org/10.1051/medsci/20173305013DOI Listing
May 2017

[Impact of Her2 and BRCA1/2 status in high-dose chemotherapy and autologous stem cells transplantation in the treatment of breast cancer: The Institut Paoli Calmettes' experience].

Bull Cancer 2017 Apr 16;104(4):332-343. Epub 2017 Feb 16.

Institut Paoli-Calmettes (IPC), département d'oncologie médicale, 232, boulevard de Sainte-Marguerite, 13009 Marseille cedex 9, France; Centre de recherches en cancérologie de Marseille (CRCM), UMR Inserm 1068/CNRS 7258/AMU 105/IPC, 232, boulevard de Sainte-Marguerite, 13009 Marseille, France; Aix-Marseille université, Jardin du Pharo, 58, boulevard Charles-Livon, 13284 Marseille, France. Electronic address:

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http://dx.doi.org/10.1016/j.bulcan.2016.12.007DOI Listing
April 2017

Corrigendum to "Immunohistochemical subtypes predict survival in metastatic breast cancer receiving high-dose chemotherapy with autologous haematopoietic stem cell transplantation" [Eur J Cancer 57 (April 2016) 118-126].

Eur J Cancer 2016 11 24;67:223. Epub 2016 Sep 24.

Département d'Oncologie Médicale, Institut Paoli-Calmettes (IPC), Marseille, F-13273, France; Centre de Recherches en Cancérologie de Marseille (CRCM), UMR Inserm 1068/CNRS 7258/AMU 105/IPC, Marseille, F-13009, France; Aix-Marseille Université, Marseille, F-13284, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09598049163240
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http://dx.doi.org/10.1016/j.ejca.2016.09.002DOI Listing
November 2016

Manufacturing Natural Killer Cells as Medicinal Products.

Front Immunol 2016 15;7:504. Epub 2016 Nov 15.

CBT-1409: INSERM, Aix Marseille Univ, Institut Paoli-Calmettes, AP-HM, Marseille, France; CRCM: INSERM, CNRS, Aix Marseille Univ, Institut Paoli-Calmettes, CRCM, Marseille, France.

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http://dx.doi.org/10.3389/fimmu.2016.00504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108783PMC
November 2016

Prognostic impact of hormone receptor- and HER2-defined subtypes in inflammatory breast cancer treated with high-dose chemotherapy: a retrospective study.

J Cancer 2016 23;7(14):2077-2084. Epub 2016 Oct 23.

Aix-Marseille Université, Marseille, F-13284, France.; Centre de Thérapie Cellulaire, Département de Biologie du Cancer, Institut Paoli-Calmettes, Marseille, F-13273, France.; Centre d'Investigations Cliniques en Biothérapies, Inserm CBT-1409, Marseille, F-13009, France.

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http://dx.doi.org/10.7150/jca.15797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118671PMC
October 2016

Immunohistochemical subtypes predict survival in metastatic breast cancer receiving high-dose chemotherapy with autologous haematopoietic stem cell transplantation.

Eur J Cancer 2016 04 23;57:118-26. Epub 2016 Feb 23.

Département d'Oncologie Médicale, Institut Paoli-Calmettes (IPC), Marseille, F-13273, France; Centre de Recherches en Cancérologie de Marseille (CRCM), UMR Inserm 1068/CNRS 7258/AMU 105/IPC, Marseille, F-13009, France; Aix-Marseille Université, Marseille, F-13284, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.01.005DOI Listing
April 2016

Frequency and Dynamics of Leukemia-Initiating Cells during Short-term Ex Vivo Culture Informs Outcomes in Acute Myeloid Leukemia Patients.

Cancer Res 2016 04 9;76(8):2082-6. Epub 2016 Mar 9.

Cancer Research UK, London Research Institute, The Francis Crick Institute, London, United Kingdom. Haematopoeitic Stem Cell Laboratory, The Francis Crick Institute, London, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2063DOI Listing
April 2016

Haploidentical T Cell-Replete Transplantation with Post-Transplantation Cyclophosphamide for Patients in or above the Sixth Decade of Age Compared with Allogeneic Hematopoietic Stem Cell Transplantation from an Human Leukocyte Antigen-Matched Related or Unrelated Donor.

Biol Blood Marrow Transplant 2016 Jan 1;22(1):119-24. Epub 2015 Sep 1.

Transplant and Cellular Therapy Unit, Institut Paoli Calmettes, Marseille, France; Hematology Department, Institut Paoli Calmettes, Marseille, France; Transplant unit, Department of Hemato-oncology, Humanitas Cancer Center, Milano, Italy.

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http://dx.doi.org/10.1016/j.bbmt.2015.08.029DOI Listing
January 2016

Safety, tolerability and potential efficacy of injection of autologous adipose-derived stromal vascular fraction in the fingers of patients with systemic sclerosis: an open-label phase I trial.

Ann Rheum Dis 2015 Dec 11;74(12):2175-82. Epub 2014 Aug 11.

Plastic Surgery Department, Assistance Publique Hôpitaux de Marseilles (AP-HM), Aix-Marseilles University, Marseilles, France Culture and Cell Therapy Laboratory, INSERM CBT 510, Assistance Publique Hôpitaux de Marseilles (AP-HM), Aix-Marseilles University, Marseilles, France.

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http://dx.doi.org/10.1136/annrheumdis-2014-205681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680117PMC
December 2015

Hepatitis B virus reactivation in HBsAg-negative patients is associated with emergence of viral strains with mutated HBsAg and reverse transcriptase.

Virology 2015 Oct 14;484:354-63. Epub 2015 Jul 14.

Service d'Hépato-Gastroentérologie Centre Hospitalo-Universitaire Timone, Assistance Publique-Hôpitaux de Marseille, Marseille, France; Aix-Marseille Université UMR INSERM 911. Facultés de Médecine et de Pharmacie, Marseille, France. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2015.06.017DOI Listing
October 2015

Reconstitution of natural killer cells in HLA-matched HSCT after reduced-intensity conditioning: impact on clinical outcome.

Biol Blood Marrow Transplant 2015 Mar 9;21(3):429-39. Epub 2015 Jan 9.

Inserm, U1068, Centre Recherche en Cancérologie de Marseille, Institut Paoli-Calmettes, CNRS, UMR7258, Aix-Marseille University, Marseille, France. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2014.11.681DOI Listing
March 2015

Reduced-toxicity conditioning prior to allogeneic stem cell transplantation improves outcome in patients with myeloid malignancies.

Haematologica 2014 Nov 1;99(11):1762-8. Epub 2014 Aug 1.

Département d'Hématologie, Institut Paoli Calmettes, Marseille, France Aix-Marseille University, Marseille, France Centre de Recherche en Cancérologie de Marseille (CRCM), Marseille, France

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http://dx.doi.org/10.3324/haematol.2014.105981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222478PMC
November 2014

Poor outcome with nonmyeloablative conditioning regimen before cord blood transplantation for patients with high-risk acute myeloid leukemia compared with matched related or unrelated donor transplantation.

Biol Blood Marrow Transplant 2014 Oct 14;20(10):1560-5. Epub 2014 Jun 14.

Hematology Department, Transplantation Program, Institut Paoli Calmettes, Marseille, France; Aix-Marseille Université, Marseille, France; Inserm UMR 1068/Centre de Recherche en Cancérologie de Marseille, Marseille, France.

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http://dx.doi.org/10.1016/j.bbmt.2014.06.006DOI Listing
October 2014

Human XCR1+ dendritic cells derived in vitro from CD34+ progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells.

J Immunol 2014 Aug 9;193(4):1622-35. Epub 2014 Jul 9.

Centre d'Immunologie de Marseille-Luminy, UNIV UM2, Aix-Marseille Université, Parc Scientifique et Technologique de Luminy, 13288 Marseille, France; INSERM, Unité Mixte de Recherche 1104, 13288 Marseille, France; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7280, 13288 Marseille, France; LabEx DCBIOL, 13288 Marseille, France

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http://dx.doi.org/10.4049/jimmunol.1401243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120898PMC
August 2014

Preferences of older adults with cancer for involvement in decision-making about research participation.

J Am Geriatr Soc 2014 Jun;62(6):1191-3

Aix Marseille Université, Inserm, IRD, UM 62 SESSTIM, Marseille, France; Assistance Publique - Hôspitaux de Marseille, Hôpital de la Timone, BiosTIC, Marseille, France.

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http://dx.doi.org/10.1111/jgs.12820DOI Listing
June 2014

Bone marrow compared with peripheral blood stem cells for haploidentical transplantation with a nonmyeloablative conditioning regimen and post-transplantation cyclophosphamide.

Biol Blood Marrow Transplant 2014 May 13;20(5):724-9. Epub 2014 Feb 13.

Department of Hematology, Transplantation Program, Institut Paoli Calmettes, Marseille, France; Aix-Marseille Université, Marseille, France; Centre de Recherche en Cancérologie de Marseille (CRCM), Marseille, France.

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http://dx.doi.org/10.1016/j.bbmt.2014.02.001DOI Listing
May 2014

[Academic cell therapy facilities are challenged by European regulation on advanced therapy medicinal products].

Med Sci (Paris) 2014 May 13;30(5):576-83. Epub 2014 Jun 13.

Inserm UMR 1027, épidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps, équipe génomique, biothérapies et santé publique-approche interdisciplinaire, Toulouse, France - université Paul Sabatier-Toulouse 3, Toulouse, France - Institut de recherche en droit européen, international et comparé (IRDEIC), université Toulouse 1-Capitole, Toulouse, France.

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http://dx.doi.org/10.1051/medsci/20143005022DOI Listing
May 2014

Assessing the HLA diversity of cord blood units collected from a birth clinic caring for pregnant women in an ethnically diverse metropolitan area.

Transfusion 2014 Apr 14;54(4):1046-54. Epub 2013 Aug 14.

Cell Therapy Facility, Institut Paoli-Calmettes, Marseille; Cord Blood Bank, Marseille; Inserm CBT-510, Centre d'Investigations Cliniques en Biothérapie, Marseille.

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http://dx.doi.org/10.1111/trf.12379DOI Listing
April 2014

Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells.

Stem Cells 2014 Apr;32(4):1043-54

Centre de Recherche en Cancérologie de Marseille, Inserm, UMR1068, Marseille, France; Institut Paoli-Calmettes, Marseille, France; Aix-Marseille Université, Marseille, France; CNRS, UMR7258, Marseille, France.

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http://dx.doi.org/10.1002/stem.1624DOI Listing
April 2014

Antithymocyte globulin in reduced-intensity conditioning regimen allows a high disease-free survival exempt of long-term chronic graft-versus-host disease.

Biol Blood Marrow Transplant 2014 Mar 4;20(3):370-4. Epub 2013 Dec 4.

Hematology Department, Transplantation Program, Institut Paoli Calmettes, Marseille, France; Aix-Marseille Université, Marseille, France; Centre de Recherche en Cancérologie de Marseille (CRCM), Marseille, France. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2013.11.030DOI Listing
March 2014

Increase the quality of banked cord blood units without limiting HLA diversity: how cord blood banks could face this dilemma.

Transfusion 2014 Feb;54(2):495-6

Cell Therapy Facility, Institut Paoli-Calmettes, Cord Blood Bank, Inserm CBT-510, Centre d'Investigations Cliniques en Biothérapie, Marseille, France.

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http://dx.doi.org/10.1111/trf.12439DOI Listing
February 2014

A conditioning platform based on fludarabine, busulfan, and 2 days of rabbit antithymocyte globulin results in promising results in patients undergoing allogeneic transplantation from both matched and mismatched unrelated donor.

Am J Hematol 2014 Jan;89(1):83-7

Département d'Onco-Hématologie, Institut Paoli-Calmettes, Unité de Transplantation et de Thérapie Cellulaire, F-13273, Marseille, France; Aix-Marseille Université, F-13007, Marseille, France; Inserm UMR1068, Centre de Recherche en Cancérologie de Marseille (CRCM), F-13009, Marseille, France.

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http://dx.doi.org/10.1002/ajh.23592DOI Listing
January 2014

Acute GVHD is a strong predictor of full donor CD3+ T cell chimerism after reduced intensity conditioning allogeneic stem cell transplantation.

Am J Hematol 2012 Dec 22;87(12):1074-8. Epub 2012 Aug 22.

Unité de Transplantation et de Thérapie Cellulaire (U2T), Département d'Onco-Hématologie, Institut Paoli-Calmettes, Marseille, France.

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http://dx.doi.org/10.1002/ajh.23319DOI Listing
December 2012

Are there candidates for high-dose chemotherapy in ovarian carcinoma?

J Exp Clin Cancer Res 2012 Oct 16;31:87. Epub 2012 Oct 16.

Department of Medical Oncology, Institut Paoli-Calmettes, 232 Bd Ste-Marguerite, Marseille 13273, France.

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http://dx.doi.org/10.1186/1756-9966-31-87DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523074PMC
October 2012